Development Level

Tbio 38 | 11,651
Tdark 2 | 6,593
Tclin 1 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

increased or absent threshold ... 7 | 101
absent pinna reflex 3 | 23
absent startle reflex 3 | 24
decreased prepulse inhibition 3 | 82
increased circulating sodium l... 3 | 71
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased startle reflex 2 | 75
impaired righting response 2 | 26
increased lean body mass 2 | 172
increased thermal nociceptive ... 2 | 9
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal ear morphology 1 | 9
abnormal locomotor activation 1 | 16
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
increased urine magnesium leve... 1 | 2
increased vertical activity 1 | 24
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Nonsyndromic deafness 35 | 142
Carcinoma 34 | 11,493
Sensorineural hearing loss 22 | 106
Autosomal recessive predisposition 18 | 1,442
psoriasis 18 | 6,694
ovarian cancer 15 | 8,520
Sensorineural Hearing Loss (disorder) 13 | 284
osteosarcoma 13 | 7,950
medulloblastoma, large-cell 12 | 6,241
Deafness 11 | 198
Kidney cancer 11 | 2,613
Breast cancer 10 | 3,578
Hodgkin's lymphoma, nodular sclerosis 10 | 22
Usher syndrome 10 | 32
ependymoma 10 | 4,679
atypical teratoid / rhabdoid tumor 9 | 5,112
lung carcinoma 9 | 2,843
Blindness 8 | 88
Liver cancer 8 | 604
Melanoma 8 | 711
Retinitis Pigmentosa 8 | 226
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung cancer 8 | 4,740
spina bifida 8 | 1,074
Astrocytoma, Pilocytic 7 | 3,081
Skin cancer 7 | 469
adult high grade glioma 7 | 3,801
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
pituitary cancer 7 | 1,972
Cataract 6 | 297
Congenital deafness 6 | 185
Hearing Loss, Partial 6 | 185
Lens Opacities 6 | 231
Usher Syndrome, Type 1 6 | 7
hearing impairment 6 | 199
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
oligodendroglioma 6 | 2,850
Abnormal vision 5 | 52
Difficulties with night vision 5 | 87
Dull intelligence 5 | 645
Electroretinogram abnormal 5 | 95
Hearing loss, progressive sensorineural 5 | 23
Hemianopsia 5 | 15
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Myopia 5 | 176
Night Blindness 5 | 101
Pigmentary iris degeneration 5 | 20
Poor school performance 5 | 645
Retinal blind spot 5 | 11
Scotoma 5 | 22
Usher Syndrome, Type I 5 | 6
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
malignant mesothelioma 5 | 3,232
tuberculosis 5 | 2,010
Atopic dermatitis 4 | 952
Conductive hearing loss 4 | 123
Endometrial cancer 4 | 311
Large intestine cancer 4 | 126
Low Vision 4 | 174
Photodysphoria 4 | 121
Photophobia 4 | 121
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
Visual Impairment 4 | 174
fibroadenoma 4 | 559
group 4 medulloblastoma 4 | 1,855
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Blind Vision 3 | 111
Blindness, Legal 3 | 110
Cerebellar Ataxia 3 | 304
Cognitive delay 3 | 608
Epilepsy 3 | 792
Glaucoma 3 | 239
Global developmental delay 3 | 608
Infantile onset 3 | 238
Mental and motor retardation 3 | 608
Neuropathy 3 | 261
Optic Atrophy 3 | 242
Rheumatoid arthritis 3 | 1,191
Tinnitus 3 | 19
Usher Syndrome, Type II 3 | 5
Usher syndrome type 2 3 | 5
esophageal adenocarcinoma 3 | 737
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 41 | 18,159
Male tissues 40 | 17,142
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Nervous System 38 | 16,725
Skin and soft tissues 37 | 17,230
Liver and Pancreas 36 | 16,750
Blood and immune system 35 | 16,909
Respiratory system 34 | 16,393
Urinary Tract 34 | 16,678
Cardiovascular System 26 | 15,192

Target Family

Non-IDG 30 | 12,091
Ion Channel 4 | 344
Transporter 3 | 473
Enzyme 2 | 4,145
Kinase 2 | 634

UniProt Keyword

Hearing 41 | 41
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Usher syndrome type-1G protein USH1G Tbio Non-IDG -1.64281 40.2 24
Taperin TPRN Tbio Non-IDG -0.79018 6.82 33
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -2.00898 110.3 57
Unconventional myosin-VI MYO6 Tbio Non-IDG -1.72509 54.2 108
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Low-density lipoprotein receptor-related protein 2 LRP2 Tbio Non-IDG -2.69021 515.4 164
Espin-like protein ESPNL Tdark Non-IDG 0.04 0.97 65
Myosin-IIIa MYO3A Tbio Kinase -1.25280 20.1 130
Prestin SLC26A5 Tbio Transporter -3.10401 1263.0 99