Development Level

Tbio 122 | 11,445
Tdark 22 | 6,588
Tchem 5 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 6 | 499
abnormal behavior 4 | 298
increased circulating alkaline... 3 | 122
abnormal bone structure 2 | 187
decreased IgG1 level 2 | 8
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
hyperactivity 2 | 148
increased lean body mass 2 | 172
short tibia 2 | 97
abnormal brain morphology 1 | 13
abnormal eye morphology 1 | 68
abnormal motor capabilities-co... 1 | 5
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal spinal cord morpholog... 1 | 9
abnormal vibrissa morphology 1 | 25
decreased B cell number 1 | 5
decreased IgE level 1 | 6
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased granulocyte number 1 | 6
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mature B cell number 1 | 1
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 134 | 11,493
osteosarcoma 87 | 7,950
ovarian cancer 82 | 8,520
medulloblastoma, large-cell 76 | 6,241
atypical teratoid / rhabdoid tumor 67 | 5,112
glioblastoma 64 | 5,792
Kidney cancer 59 | 2,613
ependymoma 55 | 4,679
psoriasis 54 | 6,694
adult high grade glioma 51 | 3,801
group 3 medulloblastoma 47 | 4,104
primitive neuroectodermal tumor 44 | 3,035
Astrocytoma, Pilocytic 43 | 3,081
lung cancer 43 | 4,740
non-small cell lung cancer 43 | 2,890
invasive ductal carcinoma 40 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
Breast cancer 37 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
lung adenocarcinoma 36 | 2,716
oligodendroglioma 36 | 2,850
lung carcinoma 34 | 2,843
subependymal giant cell astrocytoma 33 | 2,287
malignant mesothelioma 32 | 3,232
astrocytic glioma 30 | 2,597
interstitial cystitis 29 | 2,312
ductal carcinoma in situ 26 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
tuberculosis 21 | 2,010
ulcerative colitis 21 | 1,819
Pick disease 20 | 1,894
group 4 medulloblastoma 20 | 1,855
pituitary cancer 20 | 1,972
pancreatic cancer 19 | 2,398
spina bifida 19 | 1,074
Cancer 18 | 2,499
cystic fibrosis 18 | 1,696
cutaneous lupus erythematosus 17 | 1,057
Liver cancer 16 | 604
Intellectual disability 14 | 1,016
breast carcinoma 13 | 1,638
aldosterone-producing adenoma 12 | 665
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
primary Sjogren syndrome 11 | 735
adrenocortical carcinoma 10 | 1,428
colon cancer 10 | 1,478
juvenile dermatomyositis 10 | 1,187
primary pancreatic ductal adenocarcinoma 10 | 1,109
Atopic dermatitis 9 | 952
Chronic Lymphocytic Leukemia 9 | 262
Endometrial cancer 9 | 311
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
active Crohn's disease 9 | 922
astrocytoma 9 | 1,146
diabetes mellitus 8 | 1,728
mucosa-associated lymphoid tissue lymphoma 8 | 484
pediatric high grade glioma 8 | 1,064
progressive supranuclear palsy 8 | 676
Aarskog syndrome 7 | 12
Amyotrophic lateral sclerosis 7 | 451
Bipolar Disorder 7 | 666
Cardiovascular system disease 7 | 246
acute quadriplegic myopathy 7 | 1,158
medulloblastoma 7 | 720
Autosomal recessive predisposition 6 | 1,442
Melanoma 6 | 711
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 459
gastric carcinoma 6 | 807
nasopharyngeal carcinoma 6 | 1,058
sarcoidosis 6 | 370
Crohn's disease 5 | 321
Dull intelligence 5 | 645
Liver Cirrhosis, Experimental 5 | 769
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple Sclerosis 5 | 540
Neurodegenerative disease 5 | 414
Neuropathy 5 | 261
Poor school performance 5 | 645
Skin cancer 5 | 469
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
sonic hedgehog group medulloblastoma 5 | 467
urothelial carcinoma 5 | 318
Acquired scoliosis 4 | 281
Chronic obstructive pulmonary disease 4 | 184
Curvature of spine 4 | 282
Epilepsy 4 | 792
Prostatic Neoplasms 4 | 495
Short stature 4 | 531
Substance-Related Disorders 4 | 115
chronic rhinosinusitis 4 | 512
hepatocellular carcinoma 4 | 547
hereditary spastic paraplegia 4 | 318
posterior fossa group B ependymoma 4 | 416

Tissue

Digestive Tract 150 | 17,369
Endocrine System 150 | 18,159
Female tissues 150 | 17,400
Liver and Pancreas 150 | 16,750
Male tissues 150 | 17,142
Urinary Tract 150 | 16,678
Blood and immune system 149 | 16,909
Nervous System 149 | 16,725
Respiratory system 149 | 16,393
Skin and soft tissues 149 | 17,230
Cardiovascular System 148 | 15,192

Target Family

Non-IDG 139 | 12,091
Enzyme 9 | 4,145
Kinase 2 | 634

UniProt Keyword

Guanine-nucleotide releasing f... 150 | 150
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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