Development Level

Tbio 661 | 11,651
Tdark 107 | 6,593
Tchem 60 | 1,388
Tclin 10 | 612

Collection

RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Target... 7 | 125
Ion Channel: IDG Consortium (T... 4 | 99

IMPC Phenotype

preweaning lethality, complete... 56 | 979
preweaning lethality, incomple... 28 | 499
embryonic lethality prior to t... 19 | 278
decreased total body fat amoun... 17 | 207
abnormal embryo size 14 | 220
abnormal bone structure 13 | 187
increased lean body mass 13 | 172
abnormal behavior 12 | 298
decreased body weight 10 | 161
decreased bone mineral content 10 | 151
decreased circulating serum al... 10 | 82
decreased vertical activity 10 | 208
embryonic lethality prior to o... 10 | 239
increased bone mineral content 10 | 108
abnormal eye morphology 9 | 68
abnormal kidney morphology 9 | 65
abnormal sleep behavior 9 | 70
hypoactivity 9 | 132
increased mean corpuscular hem... 9 | 96
increased mean corpuscular vol... 9 | 92
abnormal seminal vesicle morph... 8 | 114
decreased circulating choleste... 8 | 93
decreased lean body mass 8 | 135
enlarged heart 8 | 210
increased startle reflex 8 | 112
decreased circulating glucose ... 7 | 126
decreased grip strength 7 | 116
embryonic growth retardation 7 | 106
hyperactivity 7 | 148
abnormal behavioral response t... 6 | 66
abnormal heart morphology 6 | 162
abnormal retina morphology 6 | 71
decreased body length 6 | 101
decreased bone mineral density 6 | 126
decreased circulating HDL chol... 6 | 68
decreased circulating LDL chol... 6 | 38
decreased circulating triglyce... 6 | 79
increased bone mineral density 6 | 72
male infertility 6 | 123
abnormal gait 5 | 69
cataract 5 | 92
decreased circulating insulin ... 5 | 76
decreased leukocyte cell numbe... 5 | 73
edema 5 | 59
increased blood urea nitrogen ... 5 | 48
increased circulating alkaline... 5 | 122
increased total body fat amoun... 5 | 134
short tibia 5 | 97
abnormal lens morphology 4 | 81
abnormal limb morphology 4 | 13
abnormal lung morphology 4 | 26
abnormal neural tube closure 4 | 46
abnormal spleen morphology 4 | 55
decreased circulating alanine ... 4 | 47
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 50
increased body weight 4 | 25
increased circulating serum al... 4 | 22
increased fasted circulating g... 4 | 76
increased mean platelet volume 4 | 45
increased monocyte cell number 4 | 63
increased or absent threshold ... 4 | 101
increased red blood cell distr... 4 | 34
abnormal craniofacial morpholo... 3 | 33
abnormal cranium morphology 3 | 36
abnormal joint morphology 3 | 23
abnormal limb bud morphology 3 | 17
abnormal skin morphology 3 | 50
abnormal tail movements 3 | 12
abnormal testis morphology 3 | 43
abnormal vibrissa morphology 3 | 25
brachydactyly 3 | 19
decreased blood urea nitrogen ... 3 | 51
decreased circulating fructosa... 3 | 30
decreased circulating total pr... 3 | 49
decreased fasted circulating g... 3 | 65
decreased hemoglobin content 3 | 68
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased grip strength 3 | 41
increased heart rate 3 | 23
increased heart weight 3 | 62
increased prepulse inhibition 3 | 32
limb grasping 3 | 41
pallor 3 | 34
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
small superior vagus ganglion 3 | 74
syndactyly 3 | 23
thrombocytosis 3 | 27
tremors 3 | 39
abnormal locomotor behavior 2 | 24
anophthalmia 2 | 33

Disease

Carcinoma 516 | 11,493
ovarian cancer 491 | 8,520
osteosarcoma 411 | 7,950
glioblastoma 339 | 5,792
medulloblastoma, large-cell 333 | 6,241
psoriasis 314 | 6,694
atypical teratoid / rhabdoid tumor 283 | 5,112
ependymoma 255 | 4,679
lung cancer 222 | 4,740
Astrocytoma, Pilocytic 196 | 3,081
Breast cancer 195 | 3,578
adult high grade glioma 195 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 195 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 192 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 183 | 3,291
lung carcinoma 158 | 2,843
malignant mesothelioma 158 | 3,232
group 3 medulloblastoma 157 | 4,104
invasive ductal carcinoma 156 | 2,951
lung adenocarcinoma 154 | 2,716
oligodendroglioma 147 | 2,850
non-small cell lung cancer 142 | 2,890
pancreatic cancer 140 | 2,398
astrocytic glioma 137 | 2,597
group 4 medulloblastoma 135 | 1,855
Kidney cancer 132 | 2,613
primitive neuroectodermal tumor 126 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 117 | 1,962
tuberculosis 115 | 2,010
interstitial cystitis 114 | 2,312
subependymal giant cell astrocytoma 114 | 2,287
Pick disease 112 | 1,894
pituitary cancer 108 | 1,972
Multiple myeloma 89 | 1,332
ulcerative colitis 89 | 1,819
cystic fibrosis 88 | 1,696
ductal carcinoma in situ 88 | 1,745
diabetes mellitus 83 | 1,728
breast carcinoma 82 | 1,638
Autosomal recessive predisposition 79 | 1,442
juvenile dermatomyositis 79 | 1,187
colon cancer 72 | 1,478
Rheumatoid arthritis 71 | 1,191
adrenocortical carcinoma 71 | 1,428
Cancer 70 | 2,499
astrocytoma 70 | 1,146
pediatric high grade glioma 70 | 1,064
primary pancreatic ductal adenocarcinoma 68 | 1,109
active Crohn's disease 65 | 922
spina bifida 65 | 1,074
non primary Sjogren syndrome sicca 62 | 891
Intellectual disability 59 | 1,016
acute quadriplegic myopathy 59 | 1,158
dermatomyositis 57 | 966
Schizophrenia 55 | 1,160
Alzheimer's disease 52 | 658
active ulcerative colitis 49 | 764
cutaneous lupus erythematosus 49 | 1,057
pancreatic carcinoma 46 | 562
primary Sjogren syndrome 45 | 735
progressive supranuclear palsy 45 | 676
nasopharyngeal carcinoma 42 | 1,058
Epilepsy 41 | 792
gastric carcinoma 39 | 807
aldosterone-producing adenoma 38 | 665
esophageal adenocarcinoma 38 | 737
hepatocellular carcinoma 37 | 547
Dull intelligence 36 | 645
Low intelligence 36 | 645
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Poor school performance 36 | 645
sarcoidosis 36 | 370
Waldenstrons macroglobulinemia 35 | 765
Atopic dermatitis 34 | 952
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Liver Cirrhosis, Experimental 34 | 769
Mental and motor retardation 34 | 608
hereditary spastic paraplegia 34 | 318
Down syndrome 32 | 499
Duchenne muscular dystrophy 32 | 601
Melanoma 31 | 711
Seizures 31 | 596
Muscle hypotonia 30 | 571
Neurodegenerative disease 30 | 414
acute myeloid leukemia 30 | 783
gastric cancer 30 | 459
Multiple Sclerosis 29 | 540
Short stature 29 | 531
medulloblastoma 29 | 720
tuberculosis and treatment for 6 months 29 | 409
Bipolar Disorder 28 | 666
mucosa-associated lymphoid tissue lymphoma 28 | 484
fibroadenoma 26 | 559
Obesity 25 | 678
Prostatic Neoplasms 25 | 495
atypical teratoid/rhabdoid tumor 25 | 357
Amyotrophic lateral sclerosis 24 | 451
sonic hedgehog group medulloblastoma 24 | 467

Tissue

Endocrine System 807 | 18,159
Digestive Tract 798 | 17,369
Nervous System 796 | 16,725
Female tissues 794 | 17,400
Male tissues 792 | 17,142
Skin and soft tissues 791 | 17,230
Blood and immune system 789 | 16,909
Liver and Pancreas 789 | 16,750
Urinary Tract 789 | 16,678
Respiratory system 780 | 16,393
Cardiovascular System 747 | 15,192

Target Family

Non-IDG 428 | 12,091
Enzyme 327 | 4,145
Transporter 34 | 473
Kinase 28 | 634
Ion Channel 8 | 344
GPCR 6 | 408
Transcription Factor 5 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Golgi apparatus 838 | 838
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137