Development Level

Tbio 2,584 | 11,445
Tdark 1,139 | 6,588
Tchem 552 | 1,598
Tclin 348 | 613

Collection

RFA-RM-18-021 141 | 328
GPCR: IDG Consortium (Targets) 109 | 126
Ion Channel: IDG Consortium (T... 54 | 99
GPCR: IDG Consortium (Complete... 23 | 25
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, incomple... 113 | 499
preweaning lethality, complete... 108 | 979
decreased vertical activity 68 | 208
enlarged heart 63 | 210
abnormal behavior 60 | 298
abnormal heart morphology 44 | 162
abnormal seminal vesicle morph... 44 | 114
abnormal bone structure 41 | 187
decreased total body fat amoun... 41 | 207
embryonic lethality prior to t... 36 | 278
increased circulating alkaline... 33 | 122
increased total body fat amoun... 33 | 134
decreased bone mineral content 32 | 151
hyperactivity 31 | 148
abnormal embryo size 30 | 220
increased lean body mass 30 | 172
decreased body weight 28 | 161
hypoactivity 28 | 132
decreased circulating glucose ... 27 | 126
short tibia 27 | 97
decreased bone mineral density 26 | 126
decreased grip strength 24 | 116
improved glucose tolerance 24 | 79
abnormal kidney morphology 23 | 65
decreased lean body mass 23 | 135
decreased circulating serum al... 22 | 82
small superior vagus ganglion 22 | 74
abnormal gait 21 | 69
decreased mean corpuscular vol... 21 | 79
impaired glucose tolerance 21 | 75
increased bone mineral content 21 | 108
abnormal eye morphology 20 | 68
decreased lymphocyte cell numb... 20 | 83
increased startle reflex 20 | 112
cataract 19 | 92
decreased body length 19 | 101
decreased circulating choleste... 18 | 93
decreased circulating insulin ... 18 | 76
increased circulating triglyce... 18 | 42
increased mean corpuscular vol... 18 | 92
abnormal epididymis morphology 17 | 42
abnormal sleep behavior 17 | 70
decreased fasted circulating g... 17 | 65
decreased leukocyte cell numbe... 17 | 73
embryonic lethality prior to o... 17 | 239
increased circulating HDL chol... 17 | 80
increased circulating sodium l... 17 | 71
decreased startle reflex 16 | 75
increased mean corpuscular hem... 16 | 96
increased monocyte cell number 16 | 63
increased or absent threshold ... 16 | 101
abnormal lens morphology 15 | 81
increased circulating choleste... 15 | 66
increased fasted circulating g... 15 | 76
increased leukocyte cell numbe... 15 | 47
abnormal testis morphology 14 | 43
decreased heart weight 14 | 27
decreased prepulse inhibition 14 | 82
enlarged epididymis 14 | 31
hydrometra 14 | 53
abnormal skin morphology 13 | 50
abnormal spleen morphology 13 | 55
decreased circulating triglyce... 13 | 79
decreased erythrocyte cell num... 13 | 62
increased blood urea nitrogen ... 13 | 48
increased bone mineral density 13 | 72
increased heart weight 13 | 62
small testis 13 | 58
decreased circulating HDL chol... 12 | 68
decreased circulating creatini... 12 | 39
decreased circulating total pr... 12 | 49
embryonic growth retardation 12 | 106
limb grasping 12 | 41
male infertility 12 | 123
abnormal retina morphology 11 | 71
cardiovascular system phenotyp... 11 | 36
decreased hemoglobin content 11 | 68
increased circulating chloride... 11 | 41
increased circulating creatini... 11 | 38
increased neutrophil cell numb... 11 | 46
prolonged ST segment 11 | 36
thrombocytopenia 11 | 56
abnormal behavioral response t... 10 | 66
abnormal coat-hair pigmentatio... 10 | 64
abnormal lung morphology 10 | 26
decreased blood urea nitrogen ... 10 | 51
decreased mean corpuscular hem... 10 | 50
enlarged spleen 10 | 41
increased circulating total pr... 10 | 28
increased erythrocyte cell num... 10 | 39
increased hematocrit 10 | 46
tremors 10 | 39
abnormal vibrissa morphology 9 | 25
impaired pupillary reflex 9 | 26
increased circulating calcium ... 9 | 34
increased hemoglobin content 9 | 45
increased mean corpuscular hem... 9 | 36
increased mean platelet volume 9 | 45
prenatal lethality prior to he... 9 | 87
prolonged QT interval 9 | 38

Disease

Carcinoma 3,187 | 11,493
psoriasis 1,792 | 6,694
ovarian cancer 1,713 | 8,520
osteosarcoma 1,624 | 7,950
glioblastoma 1,413 | 5,792
medulloblastoma, large-cell 1,365 | 6,241
lung cancer 1,190 | 4,740
atypical teratoid / rhabdoid tumor 1,189 | 5,112
ependymoma 1,128 | 4,679
lung carcinoma 1,020 | 2,843
adult high grade glioma 970 | 3,801
Astrocytoma, Pilocytic 969 | 3,081
Breast cancer 946 | 3,578
group 3 medulloblastoma 847 | 4,104
interstitial cystitis 846 | 2,312
non-small cell lung cancer 846 | 2,890
Cancer 842 | 2,499
lung adenocarcinoma 837 | 2,716
Kidney cancer 834 | 2,613
invasive ductal carcinoma 832 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 823 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 815 | 2,955
malignant mesothelioma 795 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 783 | 2,989
pancreatic cancer 742 | 2,398
oligodendroglioma 671 | 2,850
primitive neuroectodermal tumor 635 | 3,035
ulcerative colitis 615 | 1,819
pituitary cancer 613 | 1,972
cystic fibrosis 598 | 1,696
diabetes mellitus 597 | 1,728
astrocytic glioma 564 | 2,597
subependymal giant cell astrocytoma 563 | 2,287
tuberculosis 561 | 2,010
ductal carcinoma in situ 525 | 1,745
Autosomal recessive predisposition 486 | 1,442
breast carcinoma 477 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 458 | 1,962
Schizophrenia 419 | 1,160
colon cancer 412 | 1,478
cutaneous lupus erythematosus 408 | 1,057
group 4 medulloblastoma 405 | 1,855
adrenocortical carcinoma 398 | 1,428
Rheumatoid arthritis 370 | 1,191
Pick disease 352 | 1,894
primary pancreatic ductal adenocarcinoma 340 | 1,109
Atopic dermatitis 319 | 952
Melanoma 311 | 711
gastric carcinoma 282 | 807
active Crohn's disease 280 | 922
astrocytoma 280 | 1,146
Liver Cirrhosis, Experimental 270 | 769
nasopharyngeal carcinoma 264 | 1,058
pediatric high grade glioma 259 | 1,064
juvenile dermatomyositis 257 | 1,187
Epilepsy 246 | 792
Skin cancer 244 | 469
Multiple Sclerosis 243 | 540
Bipolar Disorder 240 | 666
esophageal adenocarcinoma 239 | 737
Kidney disease 237 | 430
Liver cancer 236 | 604
active ulcerative colitis 231 | 764
Obesity 230 | 678
Duchenne muscular dystrophy 224 | 601
primary Sjogren syndrome 222 | 735
Intellectual disability 215 | 1,016
Alzheimer's disease 207 | 658
dermatomyositis 202 | 966
fibroadenoma 201 | 559
acute quadriplegic myopathy 198 | 1,158
mucosa-associated lymphoid tissue lymphoma 196 | 484
non primary Sjogren syndrome sicca 193 | 891
Hypertension 190 | 396
Asthma 187 | 385
Hypersensitivity reaction type II disease 184 | 253
spina bifida 179 | 1,074
Multiple myeloma 176 | 1,332
Arthritis 173 | 290
Seizures 168 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 167 | 510
medulloblastoma 167 | 720
Anemia 166 | 365
Atherosclerosis 166 | 291
Endometriosis 165 | 540
Depressive disorder 162 | 409
aldosterone-producing adenoma 160 | 665
Down syndrome 154 | 499
Autistic Disorder 151 | 364
Prostatic Neoplasms 149 | 495
posterior fossa group A ependymoma 149 | 468
Coronary artery disease 148 | 268
Liver disease 145 | 237
Dull intelligence 143 | 645
Low intelligence 143 | 645
Mental Retardation 143 | 645
Mental deficiency 143 | 645
Poor school performance 143 | 645
Muscle hypotonia 142 | 571
Alcoholic Intoxication, Chronic 139 | 289

Tissue

Endocrine System 3,977 | 18,159
Female tissues 3,797 | 17,400
Digestive Tract 3,782 | 17,369
Skin and soft tissues 3,710 | 17,230
Male tissues 3,696 | 17,142
Blood and immune system 3,643 | 16,909
Urinary Tract 3,604 | 16,678
Liver and Pancreas 3,596 | 16,750
Nervous System 3,583 | 16,725
Respiratory system 3,448 | 16,393
Cardiovascular System 3,043 | 15,192

Target Family

Non-IDG 2,423 | 12,091
Enzyme 867 | 4,145
oGPCR 392 | 421
GPCR 375 | 408
Transporter 242 | 473
Ion Channel 219 | 344
Kinase 82 | 634
Transcription Factor 19 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 2 | 48

UniProt Keyword

Glycoprotein 4,623 | 4,623
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88
Zona pellucida-binding protein 1 ZPBP Tdark Non-IDG -1.44041 27.1 43
Protocadherin gamma-A9 PCDHGA9 Tdark Non-IDG 0.51 0.72 31
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396