Development Level

Tbio 2,379 | 10,625
Tdark 1,238 | 7,003
Tchem 653 | 1,890
Tclin 342 | 602

Collection

Eligible non-olfactory GPCR Proteins 126 | 143
Eligible Ion Channel Proteins 68 | 117
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 80 | 633
preweaning lethality, incomple... 58 | 260
abnormal behavior 43 | 226
decreased lean body mass 40 | 195
decreased total body fat amoun... 40 | 186
decreased bone mineral content 37 | 157
decreased bone mineral density 37 | 126
enlarged heart 37 | 111
increased circulating alkaline... 34 | 119
decreased body weight 31 | 174
abnormal bone structure 27 | 131
decreased grip strength 27 | 123
decreased body length 25 | 108
decreased circulating glucose ... 25 | 121
increased or absent threshold ... 23 | 128
short tibia 22 | 82
abnormal seminal vesicle morph... 21 | 47
decreased circulating insulin ... 21 | 75
embryonic lethality prior to t... 21 | 187
hypoactivity 21 | 89
increased lean body mass 21 | 107
hyperactivity 20 | 108
decreased circulating serum al... 18 | 79
impaired glucose tolerance 18 | 52
increased bone mineral content 18 | 92
increased mean corpuscular hem... 18 | 93
increased mean corpuscular vol... 18 | 91
abnormal embryo size 17 | 112
improved glucose tolerance 17 | 56
abnormal gait 16 | 51
abnormal lens morphology 16 | 73
abnormal retina morphology 16 | 100
increased circulating sodium l... 16 | 71
increased grip strength 16 | 83
increased blood urea nitrogen ... 15 | 44
abnormal heart morphology 14 | 51
decreased circulating alanine ... 14 | 53
decreased circulating triglyce... 14 | 83
decreased heart weight 14 | 44
decreased rib number 14 | 59
increased bone mineral density 14 | 52
increased circulating HDL chol... 14 | 63
increased exploration in new e... 14 | 56
decreased circulating choleste... 13 | 85
decreased eosinophil cell numb... 13 | 41
enlarged epididymis 13 | 27
increased fasted circulating g... 13 | 68
increased hemoglobin content 13 | 45
abnormal sleep behavior 12 | 63
decreased fasted circulating g... 12 | 49
decreased prepulse inhibition 12 | 52
abnormal epididymis morphology 11 | 31
decreased circulating HDL chol... 11 | 77
decreased mean corpuscular vol... 11 | 50
increased circulating choleste... 11 | 53
increased total body fat amoun... 11 | 57
small testis 11 | 37
thrombocytopenia 11 | 46
tremors 11 | 34
abnormal spleen morphology 10 | 36
cardiovascular system phenotyp... 10 | 35
decreased erythrocyte cell num... 10 | 43
decreased hemoglobin content 10 | 53
decreased leukocyte cell numbe... 10 | 54
increased body weight 10 | 42
increased circulating potassiu... 10 | 31
increased hematocrit 10 | 36
increased leukocyte cell numbe... 10 | 37
abnormal coat/hair pigmentatio... 9 | 54
abnormal eye morphology 9 | 38
abnormal kidney morphology 9 | 30
abnormal testis morphology 9 | 30
decreased caudal vertebrae num... 9 | 49
decreased circulating total pr... 9 | 41
decreased mean corpuscular hem... 9 | 34
impaired righting response 9 | 19
increased circulating calcium ... 9 | 32
increased circulating chloride... 9 | 43
increased circulating triglyce... 9 | 24
abnormal behavioral response t... 8 | 52
abnormal bone mineralization 8 | 55
abnormal retinal pigmentation 8 | 61
abnormal vibrissa morphology 8 | 17
decreased circulating free fat... 8 | 39
embryonic lethality prior to o... 8 | 148
enlarged spleen 8 | 26
female infertility 8 | 34
persistence of hyaloid vascula... 8 | 22
straub tail 8 | 26
abnormal QRS complex 7 | 25
decreased T cell number 7 | 31
decreased lumbar vertebrae num... 7 | 62
decreased monocyte cell number 7 | 28
decreased startle reflex 7 | 48
enlarged lymph nodes 7 | 27
increased circulating creatini... 7 | 29
increased erythrocyte cell num... 7 | 26
increased sacral vertebrae num... 7 | 62
limb grasping 7 | 35
male infertility 7 | 62

Disease

psoriasis 1,788 | 6,685
ovarian cancer 1,703 | 8,484
osteosarcoma 1,620 | 7,933
medulloblastoma, large-cell 1,365 | 6,234
glioblastoma 1,343 | 5,572
lung cancer 1,076 | 4,466
lung carcinoma 1,020 | 2,844
atypical teratoid / rhabdoid tumor 1,015 | 4,369
pilocytic astrocytoma 970 | 3,086
interstitial cystitis 844 | 2,299
lung adenocarcinoma 837 | 2,713
invasive ductal carcinoma 831 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 823 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 815 | 2,956
non-small cell lung cancer 800 | 2,798
Cancer 794 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 783 | 2,988
Breast cancer 779 | 3,094
malignant mesothelioma 762 | 3,162
Carcinoma 747 | 2,147
pediatric high grade glioma 702 | 2,712
pancreatic cancer 699 | 2,300
ulcerative colitis 688 | 2,087
oligodendroglioma 670 | 2,849
primitive neuroectodermal tumor 634 | 3,031
pituitary cancer 612 | 1,972
cystic fibrosis 586 | 1,665
diabetes mellitus 581 | 1,663
subependymal giant cell astrocytoma 564 | 2,287
adult high grade glioma 528 | 2,148
ductal carcinoma in situ 525 | 1,745
ependymoma 516 | 2,514
posterior fossa group A ependymoma 509 | 1,511
breast carcinoma 473 | 1,614
astrocytic glioma 463 | 2,241
group 4 medulloblastoma 448 | 1,875
tuberculosis 444 | 1,557
group 3 medulloblastoma 426 | 2,254
colon cancer 411 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 407 | 1,795
cutaneous lupus erythematosus 406 | 1,056
adrenocortical carcinoma 397 | 1,427
primary pancreatic ductal adenocarcinoma 391 | 1,271
sonic hedgehog group medulloblastoma 377 | 1,482
astrocytoma 376 | 1,493
Pick disease 351 | 1,893
Rheumatoid Arthritis 345 | 1,160
posterior fossa group B ependymoma 338 | 1,530
Atopic dermatitis 316 | 944
medulloblastoma 302 | 1,524
gastric carcinoma 295 | 832
active Crohn's disease 279 | 918
nasopharyngeal carcinoma 264 | 1,056
atypical teratoid/rhabdoid tumor 257 | 1,095
juvenile dermatomyositis 257 | 1,189
primary Sjogren syndrome 243 | 789
esophageal adenocarcinoma 240 | 737
Multiple Sclerosis 232 | 498
Duchenne muscular dystrophy 225 | 602
Kidney disease 220 | 396
Obesity 218 | 616
fibroadenoma 201 | 557
acute quadriplegic myopathy 198 | 1,157
mucosa-associated lymphoid tissue lymphoma 197 | 480
Alzheimer's disease 195 | 644
Schizophrenia 193 | 501
Asthma 182 | 349
Hypersensitivity reaction type II disease 178 | 235
non-small cell lung carcinoma 178 | 413
Multiple myeloma 177 | 1,327
spina bifida 175 | 1,064
non primary Sjogren syndrome sicca 172 | 840
dermatomyositis 171 | 933
Down syndrome 168 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 165 | 499
Endometriosis 164 | 535
Atherosclerosis 160 | 275
aldosterone-producing adenoma 160 | 664
Arthritis 156 | 248
Epilepsy 155 | 346
active ulcerative colitis 148 | 477
Prostatic Neoplasms 146 | 471
Hypertension 145 | 287
Autistic Disorder 144 | 320
IGA Glomerulonephritis 140 | 454
Anemia 134 | 252
nephrosclerosis 133 | 329
Liver disease 132 | 219
Mammary Neoplasms 132 | 410
Coronary artery disease 131 | 240
pancreatic carcinoma 131 | 567
acute myeloid leukemia 128 | 780
Heart disease 120 | 279
Cerebrovascular disease 119 | 231
Vascular disease 119 | 281
progressive supranuclear palsy 117 | 674
Ankylosing spondylitis 115 | 138
Intellectual disability 114 | 573
urothelial carcinoma 113 | 318
periodontitis 112 | 269

Tissue

Female tissues 4,294 | 18,647
Urinary Tract 4,259 | 18,444
Nervous System 4,231 | 18,561
Endocrine System 4,209 | 18,512
Digestive Tract 4,192 | 18,473
Skin and soft tissues 4,087 | 18,115
Liver and Pancreas 4,046 | 18,136
Blood and immune system 3,992 | 17,995
Cardiovascular System 3,973 | 17,958
Male tissues 3,939 | 17,969
Respiratory system 3,856 | 17,484

Target Family

Non-IDG 2,414 | 11,971
Enzyme 868 | 4,146
oGPCR 392 | 421
GPCR 373 | 406
Transporter 242 | 473
Ion Channel 218 | 341
Kinase 82 | 634
Transcription Factor 19 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 2 | 48

UniProt Keyword

Glycoprotein 4,612 | 4,612
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell receptor beta chain V region CTL-L17 TCRB Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788