Development Level

Tbio 23 | 11,445
Tchem 7 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal QT variability 2 | 10
decreased total body fat amoun... 2 | 207
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal kidney morphology 1 | 65
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 23 | 11,493
ovarian cancer 16 | 8,520
Autosomal recessive predisposition 12 | 1,442
pancreatic cancer 12 | 2,398
psoriasis 12 | 6,694
lung cancer 11 | 4,740
glioblastoma 10 | 5,792
lung adenocarcinoma 10 | 2,716
Cancer 9 | 2,499
ependymoma 9 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
medulloblastoma, large-cell 9 | 6,241
non-small cell lung cancer 9 | 2,890
osteosarcoma 9 | 7,950
Icterus 8 | 82
astrocytic glioma 8 | 2,597
atypical teratoid / rhabdoid tumor 8 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Adenocarcinoma of lung 6 | 142
Cholecystitis 6 | 18
Cholelithiasis 6 | 33
Congenital hemolytic anemia 6 | 32
Glycogen storage disease 6 | 39
Multiple myeloma 6 | 1,332
Splenomegaly 6 | 190
adult high grade glioma 6 | 3,801
dermatomyositis 6 | 966
group 3 medulloblastoma 6 | 4,104
oligodendroglioma 6 | 2,850
Disease Models, Animal 5 | 155
Kidney cancer 5 | 2,613
Osteoporosis 5 | 363
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
primary pancreatic ductal adenocarcinoma 5 | 1,109
Alzheimer's disease 4 | 658
Breast cancer 4 | 3,578
Carcinoma, Hepatocellular 4 | 228
Carcinoma, Squamous Cell 4 | 110
Cognitive delay 4 | 608
Diabetes Mellitus, Experimental 4 | 108
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Impaired exercise tolerance 4 | 42
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Low intelligence 4 | 645
Male infertility 4 | 206
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Mouth Neoplasms 4 | 55
Myocardial Ischemia 4 | 169
Neurogenic Muscular Atrophy 4 | 139
Neurogenic muscle atrophy, especially in the lower limbs 4 | 139
Neuropathy 4 | 261
Nonspherocytic hemolytic anemia 4 | 6
Normochromic anemia 4 | 6
Normocytic anemia 4 | 6
Pick disease 4 | 1,894
Poor school performance 4 | 645
Reticulocytosis 4 | 20
Schizophrenia 4 | 1,160
Skeletal muscle atrophy 4 | 139
Squamous cell carcinoma 4 | 129
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
group 4 medulloblastoma 4 | 1,855
muscle degeneration 4 | 139
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer Disease 3 | 83
Animal Mammary Neoplasms 3 | 136
Astrocytoma, Pilocytic 3 | 3,081
Breast Neoplasms 3 | 445
Cerebellar Ataxia 3 | 304
Epilepsy 3 | 792
Mammary Neoplasms 3 | 425
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Muscle Weakness 3 | 170
Muscle cramps with exertion 3 | 7
Muscle hypotonia 3 | 571
Myopathy 3 | 185
Neoplasm Invasiveness 3 | 161
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Seizures 3 | 596
Stomach Neoplasms 3 | 300
active ulcerative colitis 3 | 764
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745

Tissue

Endocrine System 31 | 18,159
Male tissues 31 | 17,142
Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Female tissues 30 | 17,400
Nervous System 30 | 16,725
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Liver and Pancreas 29 | 16,750
Respiratory system 28 | 16,393
Cardiovascular System 26 | 15,192

Target Family

Enzyme 18 | 4,145
Kinase 13 | 634

UniProt Keyword

Glycolysis 31 | 31
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
2-oxoglutarate dehydrogenase-like, mitochondrial OGDHL Tbio Enzyme -0.59292 3.63 46
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
ATP-dependent 6-phosphofructokinase, muscle type PFKM Tbio Kinase -2.50086 308.0 311
2-oxoglutarate dehydrogenase, mitochondrial OGDH Tbio Enzyme -2.47825 290.5 147
Triosephosphate isomerase TPI1 Tbio Enzyme -2.88127 742.8 315
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial DHTKD1 Tbio Enzyme -0.96606 9.64 87
Enolase 4 ENO4 Tdark Enzyme -0.21160 1.85 71
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749