Development Level

Tbio 144 | 11,445
Tdark 49 | 6,588
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 7 | 499
abnormal behavior 4 | 298
decreased circulating glucose ... 4 | 126
hyperactivity 4 | 148
increased mean corpuscular hem... 4 | 96
increased startle reflex 4 | 112
abnormal embryo size 3 | 220
cataract 3 | 92
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
improved glucose tolerance 3 | 79
increased circulating alkaline... 3 | 122
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
increased red blood cell distr... 3 | 34
microphthalmia 3 | 26
prolonged PR interval 3 | 15
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal forebrain morphology 2 | 10
abnormal gait 2 | 69
abnormal midbrain morphology 2 | 10
abnormal sensory capabilities-... 2 | 8
absent pinna reflex 2 | 23
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased circulating serum al... 2 | 82
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged RR interval 1 | 8
shortened PQ interval 1 | 7
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 146 | 11,493
osteosarcoma 100 | 7,950
ovarian cancer 90 | 8,520
medulloblastoma, large-cell 76 | 6,241
glioblastoma 73 | 5,792
atypical teratoid / rhabdoid tumor 64 | 5,112
ependymoma 60 | 4,679
psoriasis 56 | 6,694
adult high grade glioma 55 | 3,801
lung cancer 54 | 4,740
Kidney cancer 52 | 2,613
oligodendroglioma 45 | 2,850
Breast cancer 44 | 3,578
primitive neuroectodermal tumor 44 | 3,035
Astrocytoma, Pilocytic 42 | 3,081
group 3 medulloblastoma 42 | 4,104
invasive ductal carcinoma 40 | 2,951
malignant mesothelioma 38 | 3,232
non-small cell lung cancer 37 | 2,890
subependymal giant cell astrocytoma 37 | 2,287
astrocytic glioma 36 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
lung carcinoma 36 | 2,843
group 4 medulloblastoma 35 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
lung adenocarcinoma 33 | 2,716
tuberculosis 32 | 2,010
Pick disease 27 | 1,894
interstitial cystitis 25 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
pancreatic cancer 21 | 2,398
ulcerative colitis 21 | 1,819
Cancer 20 | 2,499
pituitary cancer 20 | 1,972
cystic fibrosis 19 | 1,696
ductal carcinoma in situ 18 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Intellectual disability 17 | 1,016
Schizophrenia 17 | 1,160
astrocytoma 17 | 1,146
juvenile dermatomyositis 17 | 1,187
breast carcinoma 16 | 1,638
spina bifida 16 | 1,074
acute quadriplegic myopathy 15 | 1,158
diabetes mellitus 15 | 1,728
dermatomyositis 13 | 966
primary Sjogren syndrome 13 | 735
Rheumatoid arthritis 12 | 1,191
adrenocortical carcinoma 12 | 1,428
sonic hedgehog group medulloblastoma 12 | 467
Melanoma 11 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
colon cancer 11 | 1,478
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
cutaneous lupus erythematosus 10 | 1,057
pediatric high grade glioma 10 | 1,064
Atopic dermatitis 9 | 952
Duchenne muscular dystrophy 9 | 601
active Crohn's disease 9 | 922
gastric carcinoma 9 | 807
non primary Sjogren syndrome sicca 9 | 891
Amyotrophic lateral sclerosis 8 | 451
Liver Cirrhosis, Experimental 8 | 769
Waldenstrons macroglobulinemia 8 | 765
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Liver cancer 7 | 604
Mental and motor retardation 7 | 608
Multiple myeloma 7 | 1,332
active ulcerative colitis 7 | 764
mucosa-associated lymphoid tissue lymphoma 7 | 484
primary pancreatic ductal adenocarcinoma 7 | 1,109
Attention deficit hyperactivity disorder 6 | 278
Muscle hypotonia 6 | 571
Polycystic ovary syndrome 6 | 360
Short stature 6 | 531
aldosterone-producing adenoma 6 | 665
nasopharyngeal carcinoma 6 | 1,058
Acquired scoliosis 5 | 281
Alzheimer's disease 5 | 658
Autistic Disorder 5 | 364
Curvature of spine 5 | 282
Endometriosis 5 | 540
Gaucher disease type 1 5 | 180
HIV Infections 5 | 102
Obesity 5 | 678
Parkinson's disease 5 | 392
Skin cancer 5 | 469
Small head 5 | 374
Type 2 diabetes mellitus 5 | 272
Warburg micro syndrome 5 | 18
esophageal adenocarcinoma 5 | 737
fibroadenoma 5 | 559
pancreatic carcinoma 5 | 562
progressive supranuclear palsy 5 | 676

Tissue

Endocrine System 192 | 18,159
Blood and immune system 188 | 16,909
Male tissues 187 | 17,142
Skin and soft tissues 187 | 17,230
Female tissues 186 | 17,400
Liver and Pancreas 186 | 16,750
Digestive Tract 185 | 17,369
Urinary Tract 185 | 16,678
Respiratory system 184 | 16,393
Nervous System 182 | 16,725
Cardiovascular System 178 | 15,192

Target Family

Non-IDG 118 | 12,091
Enzyme 78 | 4,145
Kinase 1 | 634

UniProt Keyword

GTPase activation 197 | 197
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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