Development Level

Tbio 139 | 10,625
Tdark 53 | 7,003
Tchem 3 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, incomple... 6 | 260
preweaning lethality, complete... 5 | 633
decreased circulating glucose ... 4 | 121
increased mean corpuscular hem... 4 | 93
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased circulating insulin ... 3 | 75
hyperactivity 3 | 108
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal gait 2 | 51
absent pinna reflex 2 | 21
decreased CD4-positive, CD25-p... 2 | 24
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased mature B cell number 2 | 25
decreased total body fat amoun... 2 | 186
impaired glucose tolerance 2 | 52
increased Ly6C high monocyte n... 2 | 12
increased body length 2 | 20
increased circulating alkaline... 2 | 119
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
microphthalmia 2 | 15
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal ear morphology 1 | 5
abnormal hair growth 1 | 8
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal motor capabilities-co... 1 | 4
abnormal retinal vasculature m... 1 | 15
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
fused cornea and lens 1 | 4
head bobbing 1 | 3
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased total body fat amoun... 1 | 57
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
prolonged PR interval 1 | 4
rough coat 1 | 1
small seminal vesicle 1 | 6
sparse hair 1 | 6
straub tail 1 | 26
thrombocytopenia 1 | 46
tremors 1 | 34
trunk curl 1 | 15

Disease

osteosarcoma 100 | 7,933
ovarian cancer 90 | 8,491
medulloblastoma, large-cell 76 | 6,234
glioblastoma 69 | 5,572
psoriasis 56 | 6,685
atypical teratoid / rhabdoid tumor 55 | 4,369
lung cancer 53 | 4,473
oligodendroglioma 45 | 2,849
primitive neuroectodermal tumor 44 | 3,031
pilocytic astrocytoma 42 | 3,086
Breast cancer 41 | 3,098
invasive ductal carcinoma 40 | 2,950
Carcinoma 39 | 2,147
malignant mesothelioma 38 | 3,163
non-small cell lung cancer 37 | 2,798
pediatric high grade glioma 37 | 2,712
subependymal giant cell astrocytoma 37 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
lung carcinoma 36 | 2,844
ependymoma 34 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
lung adenocarcinoma 33 | 2,714
group 4 medulloblastoma 32 | 1,875
astrocytic glioma 31 | 2,241
adult high grade glioma 28 | 2,148
Pick disease 27 | 1,893
sonic hedgehog group medulloblastoma 26 | 1,482
interstitial cystitis 25 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
ulcerative colitis 24 | 2,087
tuberculosis 23 | 1,563
astrocytoma 22 | 1,493
medulloblastoma 21 | 1,524
pancreatic cancer 21 | 2,300
Cancer 20 | 2,346
pituitary cancer 20 | 1,972
cystic fibrosis 19 | 1,670
ductal carcinoma in situ 18 | 1,745
posterior fossa group B ependymoma 18 | 1,530
juvenile dermatomyositis 17 | 1,189
breast carcinoma 16 | 1,614
primary Sjogren syndrome 16 | 788
acute quadriplegic myopathy 15 | 1,157
diabetes mellitus 15 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
spina bifida 15 | 1,064
Intellectual disability 14 | 573
group 3 medulloblastoma 14 | 2,254
atypical teratoid/rhabdoid tumor 13 | 1,095
dermatomyositis 13 | 966
adrenocortical carcinoma 12 | 1,427
Rheumatoid Arthritis 11 | 1,170
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
colon cancer 11 | 1,475
posterior fossa group A ependymoma 11 | 1,511
tuberculosis and treatment for 6 months 11 | 686
cutaneous lupus erythematosus 10 | 1,056
primary pancreatic ductal adenocarcinoma 10 | 1,271
Atopic dermatitis 9 | 944
Duchenne muscular dystrophy 9 | 602
active Crohn's disease 9 | 918
gastric carcinoma 9 | 832
Amyotrophic Lateral Sclerosis 8 | 432
Waldenstrons macroglobulinemia 8 | 764
Multiple myeloma 7 | 1,327
mucosa-associated lymphoid tissue lymphoma 7 | 480
Alzheimer's disease 6 | 644
Epilepsy 6 | 346
Melanoma 6 | 261
Polycystic Ovary Syndrome 6 | 334
aldosterone-producing adenoma 6 | 664
nasopharyngeal carcinoma 6 | 1,056
non primary Sjogren syndrome sicca 6 | 840
tuberculosis and treatment for 3 months 6 | 327
Endometriosis 5 | 535
Gaucher disease type 1 5 | 171
HIV Infections 5 | 99
Multiple Sclerosis 5 | 498
Parkinson's disease 5 | 364
Schizophrenia 5 | 503
Type 2 diabetes mellitus 5 | 192
Warburg micro syndrome 5 | 19
esophageal adenocarcinoma 5 | 737
fibroadenoma 5 | 557
glioblastoma multiforme 5 | 347
pancreatic carcinoma 5 | 567
progressive supranuclear palsy 5 | 674
Autistic Disorder 4 | 320
Crohn's disease 4 | 304
IGA Glomerulonephritis 4 | 454
Leukemia, Myelocytic, Acute 4 | 113
Microcephaly 4 | 149
Microphthalmia 4 | 79
Obesity 4 | 616
active ulcerative colitis 4 | 477
interstitial lung disease 4 | 292
urothelial carcinoma 4 | 318
Attention deficit hyperactivity disorder 3 | 156
chronic lymphocytic leukemia 3 | 244
periodontitis 3 | 269

Tissue

Male tissues 187 | 17,968
Cardiovascular System 183 | 17,957
Digestive Tract 183 | 18,472
Female tissues 183 | 18,646
Liver and Pancreas 183 | 18,135
Nervous System 183 | 18,560
Blood and immune system 182 | 17,994
Endocrine System 181 | 18,511
Urinary Tract 181 | 18,443
Respiratory system 179 | 17,483
Skin and soft tissues 179 | 18,114

Target Family

Non-IDG 117 | 11,969
Enzyme 78 | 4,146
Kinase 1 | 634

UniProt Keyword

GTPase activation 196 | 196
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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