Development Level

Tbio 249 | 11,178
Tdark 46 | 6,569
Tchem 29 | 1,885
Tclin 15 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 13 | 499
decreased bone mineral content 8 | 151
abnormal bone structure 7 | 187
decreased lean body mass 6 | 135
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
decreased body length 5 | 101
decreased body weight 5 | 161
enlarged heart 5 | 210
increased heart weight 5 | 62
increased startle reflex 5 | 112
short tibia 5 | 97
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
cataract 4 | 92
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased circulating calcium ... 4 | 34
increased circulating choleste... 4 | 66
prolonged QT interval 4 | 38
abnormal cornea morphology 3 | 31
abnormal cranium morphology 3 | 36
abnormal heart morphology 3 | 162
abnormal sleep behavior 3 | 70
corneal opacity 3 | 32
decreased circulating phosphat... 3 | 27
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased blood urea nitrogen ... 3 | 48
increased circulating free fat... 3 | 20
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased erythrocyte cell num... 3 | 39
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased neutrophil cell numb... 3 | 46
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal joint morphology 2 | 23
abnormal locomotor activation 2 | 16
abnormal rib morphology 2 | 10
abnormal snout morphology 2 | 23
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 179 | 11,192
ovarian cancer 178 | 8,297
osteosarcoma 152 | 7,766
medulloblastoma, large-cell 148 | 6,086
glioblastoma 141 | 5,635
psoriasis 121 | 6,514
atypical teratoid / rhabdoid tumor 114 | 4,971
ependymoma 101 | 4,559
lung cancer 94 | 4,607
adult high grade glioma 90 | 3,701
group 3 medulloblastoma 79 | 4,002
Astrocytoma, Pilocytic 77 | 3,006
invasive ductal carcinoma 73 | 2,867
Breast cancer 72 | 3,469
astrocytic glioma 70 | 2,530
malignant mesothelioma 68 | 3,135
lung carcinoma 67 | 2,755
oligodendroglioma 67 | 2,768
primitive neuroectodermal tumor 67 | 2,957
subependymal giant cell astrocytoma 66 | 2,230
Pick disease 65 | 1,856
non-small cell lung cancer 63 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,902
pancreatic cancer 61 | 2,322
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,204
lung adenocarcinoma 53 | 2,627
group 4 medulloblastoma 50 | 1,806
Cancer 49 | 2,388
breast carcinoma 49 | 1,589
interstitial cystitis 47 | 2,237
ulcerative colitis 46 | 1,765
Multiple myeloma 41 | 1,296
ductal carcinoma in situ 40 | 1,686
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,911
tuberculosis 38 | 1,963
colon cancer 36 | 1,428
juvenile dermatomyositis 35 | 1,147
pituitary cancer 35 | 1,915
primary pancreatic ductal adenocarcinoma 35 | 1,071
dermatomyositis 32 | 941
Kidney cancer 31 | 2,548
primary Sjogren syndrome 31 | 710
acute quadriplegic myopathy 29 | 1,133
astrocytoma 29 | 1,113
cystic fibrosis 29 | 1,629
Autosomal recessive predisposition 27 | 1,407
cutaneous lupus erythematosus 26 | 1,016
Intellectual disability 25 | 998
diabetes mellitus 24 | 1,683
pediatric high grade glioma 24 | 1,035
spina bifida 22 | 1,053
Epilepsy 21 | 775
active Crohn's disease 21 | 882
Rheumatoid arthritis 19 | 1,156
acute myeloid leukemia 19 | 760
nasopharyngeal carcinoma 19 | 1,024
Schizophrenia 18 | 1,136
Seizures 18 | 584
gastric cancer 18 | 445
gastric carcinoma 18 | 781
Duchenne muscular dystrophy 17 | 587
Liver Cirrhosis, Experimental 17 | 733
Waldenstrons macroglobulinemia 17 | 742
hepatocellular carcinoma 17 | 536
progressive supranuclear palsy 17 | 656
Dull intelligence 16 | 634
Low intelligence 16 | 634
Mental Retardation 16 | 634
Mental deficiency 16 | 634
Parkinson's disease 16 | 378
Poor school performance 16 | 634
active ulcerative colitis 16 | 736
non primary Sjogren syndrome sicca 16 | 861
pancreatic carcinoma 16 | 555
Melanoma 15 | 689
Muscle hypotonia 15 | 562
sarcoidosis 15 | 357
Small head 14 | 366
aldosterone-producing adenoma 14 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 492
Cognitive delay 13 | 596
Global developmental delay 13 | 596
Hypertensive disorder 13 | 56
Mental and motor retardation 13 | 596
adrenocortical carcinoma 13 | 1,385
hereditary spastic paraplegia 13 | 313
medulloblastoma 13 | 702
Amyotrophic lateral sclerosis 12 | 437
Griscelli syndrome 12 | 24
Neuroblastoma 12 | 79
Obesity 12 | 655
Rhabdomyosarcoma 12 | 39
esophageal adenocarcinoma 12 | 696
mucosa-associated lymphoid tissue lymphoma 12 | 473
Myocardial Ischemia 11 | 162
Nystagmus 11 | 309
Short stature 11 | 514
fibroadenoma 11 | 538
sonic hedgehog group medulloblastoma 11 | 459

Tissue

Endocrine System 327 | 18,159
Digestive Tract 322 | 17,369
Female tissues 321 | 17,400
Skin and soft tissues 319 | 17,230
Male tissues 318 | 17,142
Blood and immune system 317 | 16,909
Liver and Pancreas 316 | 16,750
Urinary Tract 315 | 16,678
Nervous System 314 | 16,725
Respiratory system 311 | 16,393
Cardiovascular System 299 | 15,192

Target Family

Enzyme 199 | 4,145
Non-IDG 128 | 12,091
Kinase 12 | 634

UniProt Keyword

GTP-binding 339 | 339
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-3B RAB3B Tbio Enzyme -1.38932 26.8 121
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
GTP-binding protein Di-Ras1 DIRAS1 Tbio Enzyme -0.70186 0.00000 175
Ras-related protein Rab-6A RAB6A Tbio Enzyme -2.09488 134.5 207
Rho-related GTP-binding protein RhoU RHOU Tbio Enzyme -1.30084 24.8 95
Eukaryotic translation initiation factor 5 EIF5 Tbio Non-IDG -1.93055 83.2 159
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
Ras-related protein Rab-12 RAB12 Tbio Enzyme -1.21868 13.9 73