Development Level

Tbio 257 | 11,445
Tdark 47 | 6,588
Tchem 20 | 1,598
Tclin 15 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 13 | 499
decreased bone mineral content 8 | 151
abnormal bone structure 7 | 187
decreased lean body mass 6 | 135
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
decreased body length 5 | 101
decreased body weight 5 | 161
enlarged heart 5 | 210
increased heart weight 5 | 62
increased startle reflex 5 | 112
short tibia 5 | 97
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
cataract 4 | 92
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased circulating calcium ... 4 | 34
increased circulating choleste... 4 | 66
prolonged QT interval 4 | 38
abnormal cornea morphology 3 | 31
abnormal cranium morphology 3 | 36
abnormal heart morphology 3 | 162
abnormal sleep behavior 3 | 70
corneal opacity 3 | 32
decreased circulating phosphat... 3 | 27
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased blood urea nitrogen ... 3 | 48
increased circulating free fat... 3 | 20
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased erythrocyte cell num... 3 | 39
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased neutrophil cell numb... 3 | 46
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal joint morphology 2 | 23
abnormal locomotor activation 2 | 16
abnormal rib morphology 2 | 10
abnormal snout morphology 2 | 23
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 179 | 11,493
ovarian cancer 178 | 8,520
osteosarcoma 152 | 7,950
medulloblastoma, large-cell 148 | 6,241
glioblastoma 141 | 5,792
psoriasis 121 | 6,694
atypical teratoid / rhabdoid tumor 114 | 5,112
ependymoma 101 | 4,679
lung cancer 94 | 4,740
adult high grade glioma 90 | 3,801
group 3 medulloblastoma 79 | 4,104
Astrocytoma, Pilocytic 77 | 3,081
invasive ductal carcinoma 73 | 2,951
Breast cancer 72 | 3,578
astrocytic glioma 70 | 2,597
malignant mesothelioma 68 | 3,232
lung carcinoma 67 | 2,843
oligodendroglioma 67 | 2,850
primitive neuroectodermal tumor 67 | 3,035
subependymal giant cell astrocytoma 66 | 2,287
Pick disease 65 | 1,894
non-small cell lung cancer 63 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,989
pancreatic cancer 61 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
lung adenocarcinoma 53 | 2,716
group 4 medulloblastoma 50 | 1,855
Cancer 49 | 2,499
breast carcinoma 49 | 1,638
interstitial cystitis 47 | 2,312
ulcerative colitis 46 | 1,819
Multiple myeloma 41 | 1,332
ductal carcinoma in situ 40 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
tuberculosis 38 | 2,010
colon cancer 36 | 1,478
juvenile dermatomyositis 35 | 1,187
pituitary cancer 35 | 1,972
primary pancreatic ductal adenocarcinoma 35 | 1,109
dermatomyositis 32 | 966
Kidney cancer 31 | 2,613
primary Sjogren syndrome 31 | 735
acute quadriplegic myopathy 29 | 1,158
astrocytoma 29 | 1,146
cystic fibrosis 29 | 1,696
Autosomal recessive predisposition 27 | 1,442
cutaneous lupus erythematosus 26 | 1,057
Intellectual disability 25 | 1,016
diabetes mellitus 24 | 1,728
pediatric high grade glioma 24 | 1,064
spina bifida 22 | 1,074
Epilepsy 21 | 792
active Crohn's disease 21 | 922
Rheumatoid arthritis 19 | 1,191
acute myeloid leukemia 19 | 783
nasopharyngeal carcinoma 19 | 1,058
Schizophrenia 18 | 1,160
Seizures 18 | 596
gastric cancer 18 | 459
gastric carcinoma 18 | 807
Duchenne muscular dystrophy 17 | 601
Liver Cirrhosis, Experimental 17 | 769
Waldenstrons macroglobulinemia 17 | 765
hepatocellular carcinoma 17 | 547
progressive supranuclear palsy 17 | 676
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Parkinson's disease 16 | 392
Poor school performance 16 | 645
active ulcerative colitis 16 | 764
non primary Sjogren syndrome sicca 16 | 891
pancreatic carcinoma 16 | 562
Melanoma 15 | 711
Muscle hypotonia 15 | 571
sarcoidosis 15 | 370
Small head 14 | 374
aldosterone-producing adenoma 14 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 510
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Hypertensive disorder 13 | 56
Mental and motor retardation 13 | 608
adrenocortical carcinoma 13 | 1,428
hereditary spastic paraplegia 13 | 318
medulloblastoma 13 | 720
Amyotrophic lateral sclerosis 12 | 451
Griscelli syndrome 12 | 24
Neuroblastoma 12 | 80
Obesity 12 | 678
Rhabdomyosarcoma 12 | 39
esophageal adenocarcinoma 12 | 737
mucosa-associated lymphoid tissue lymphoma 12 | 484
Myocardial Ischemia 11 | 169
Nystagmus 11 | 317
Short stature 11 | 531
fibroadenoma 11 | 559
sonic hedgehog group medulloblastoma 11 | 467

Tissue

Endocrine System 327 | 18,159
Digestive Tract 322 | 17,369
Female tissues 321 | 17,400
Skin and soft tissues 319 | 17,230
Male tissues 318 | 17,142
Blood and immune system 317 | 16,909
Liver and Pancreas 316 | 16,750
Urinary Tract 315 | 16,678
Nervous System 314 | 16,725
Respiratory system 311 | 16,393
Cardiovascular System 299 | 15,192

Target Family

Enzyme 199 | 4,145
Non-IDG 128 | 12,091
Kinase 12 | 634

UniProt Keyword

GTP-binding 339 | 339
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Probable tRNA(His) guanylyltransferase THG1L Tbio Enzyme -0.60206 3.69 71
ADP-ribosylation factor-like protein 5A ARL5A Tbio Enzyme -1.27307 18.8 53
ADP-ribosylation factor-related protein 1 ARFRP1 Tbio Enzyme -1.22088 20.8 63
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
Ras-related protein Rab-40C RAB40C Tbio Non-IDG -0.89913 7.57 111
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121