Development Level

Tbio 243 | 10,625
Tdark 51 | 7,003
Tchem 29 | 1,890
Tclin 15 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
abnormal behavior 9 | 226
preweaning lethality, incomple... 9 | 260
decreased bone mineral content 7 | 157
decreased lean body mass 6 | 195
abnormal bone structure 5 | 131
decreased body weight 5 | 174
decreased mean corpuscular vol... 5 | 50
enlarged heart 5 | 111
increased heart weight 5 | 37
decreased bone mineral density 4 | 126
decreased grip strength 4 | 123
increased blood urea nitrogen ... 4 | 44
increased circulating alkaline... 4 | 119
abnormal bone mineralization 3 | 55
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
abnormal retina morphology 3 | 100
corneal opacity 3 | 25
decreased body length 3 | 108
decreased circulating triglyce... 3 | 83
decreased mean corpuscular hem... 3 | 34
decreased rib number 3 | 59
embryonic lethality prior to t... 3 | 187
increased circulating calcium ... 3 | 32
increased circulating total pr... 3 | 20
increased erythrocyte cell num... 3 | 26
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
increased total body fat amoun... 3 | 57
abnormal QRS complex 2 | 25
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal head morphology 2 | 10
abnormal locomotor activation 2 | 26
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal snout morphology 2 | 18
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased blood urea nitrogen ... 2 | 31
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating phosphat... 2 | 15
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased hemoglobin content 2 | 45
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal embryo size 1 | 112
abnormal neural tube closure 1 | 37
abnormal tail movements 1 | 12
abnormal thoracic vertebrae mo... 1 | 16
absent pinna reflex 1 | 21
absent teeth 1 | 4
decreased alpha-beta T cell nu... 1 | 12
decreased cervical vertebrae n... 1 | 12
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased thoracic vertebrae n... 1 | 7
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased bone mineral density 1 | 52
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
lethargy 1 | 5
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
small thymus 1 | 11

Disease

ovarian cancer 176 | 8,484
osteosarcoma 153 | 7,933
medulloblastoma, large-cell 146 | 6,234
glioblastoma 132 | 5,572
psoriasis 121 | 6,685
atypical teratoid / rhabdoid tumor 92 | 4,369
lung cancer 90 | 4,466
pilocytic astrocytoma 81 | 3,086
invasive ductal carcinoma 72 | 2,950
malignant mesothelioma 68 | 3,162
Breast cancer 67 | 3,094
lung carcinoma 67 | 2,844
oligodendroglioma 67 | 2,849
primitive neuroectodermal tumor 67 | 3,031
Pick disease 65 | 1,893
pediatric high grade glioma 65 | 2,712
subependymal giant cell astrocytoma 64 | 2,287
non-small cell lung cancer 63 | 2,798
pancreatic cancer 61 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,988
astrocytic glioma 56 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,956
ependymoma 54 | 2,514
ulcerative colitis 54 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,289
lung adenocarcinoma 53 | 2,713
Cancer 50 | 2,346
adult high grade glioma 49 | 2,148
breast carcinoma 47 | 1,614
interstitial cystitis 47 | 2,299
group 4 medulloblastoma 45 | 1,875
astrocytoma 43 | 1,493
Multiple myeloma 41 | 1,327
ductal carcinoma in situ 39 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
primary pancreatic ductal adenocarcinoma 37 | 1,271
colon cancer 36 | 1,475
group 3 medulloblastoma 36 | 2,254
juvenile dermatomyositis 35 | 1,189
medulloblastoma 35 | 1,524
pituitary cancer 35 | 1,972
sonic hedgehog group medulloblastoma 35 | 1,482
dermatomyositis 32 | 933
primary Sjogren syndrome 32 | 789
acute quadriplegic myopathy 29 | 1,157
cystic fibrosis 29 | 1,665
posterior fossa group B ependymoma 29 | 1,530
posterior fossa group A ependymoma 28 | 1,511
tuberculosis 27 | 1,557
atypical teratoid/rhabdoid tumor 26 | 1,095
cutaneous lupus erythematosus 26 | 1,056
diabetes mellitus 23 | 1,663
spina bifida 22 | 1,064
active Crohn's disease 21 | 918
Rheumatoid Arthritis 20 | 1,160
Carcinoma 19 | 2,147
acute myeloid leukemia 19 | 780
nasopharyngeal carcinoma 19 | 1,056
gastric cancer 18 | 430
gastric carcinoma 18 | 832
tuberculosis and treatment for 6 months 18 | 686
Duchenne muscular dystrophy 17 | 602
Waldenstrons macroglobulinemia 17 | 765
hepatocellular carcinoma 17 | 532
progressive supranuclear palsy 17 | 674
pancreatic carcinoma 16 | 567
non primary Sjogren syndrome sicca 15 | 840
sarcoidosis 15 | 358
Parkinson's disease 14 | 364
aldosterone-producing adenoma 14 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
Hypertensive disorder 13 | 58
adrenocortical carcinoma 13 | 1,427
hereditary spastic paraplegia 13 | 313
Alzheimer's disease 12 | 644
Intellectual disability 12 | 573
Neuroblastoma 12 | 78
esophageal adenocarcinoma 12 | 737
mucosa-associated lymphoid tissue lymphoma 12 | 480
Amyotrophic Lateral Sclerosis 11 | 431
Myocardial Ischemia 11 | 169
Neurodegenerative disease 11 | 383
Obesity 11 | 616
facioscapulohumeral dystrophy 11 | 286
fibroadenoma 11 | 557
glioblastoma multiforme 11 | 347
Atopic dermatitis 10 | 944
Down syndrome 10 | 548
HER2-positive carcinoma of breast 9 | 10
Kaposi's sarcoma 9 | 20
Liposarcoma 9 | 20
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Melanoma 9 | 261
Nephroblastoma 9 | 45
Rhabdomyosarcoma 9 | 29
Secondary malignant neoplasm of pancreas 9 | 10
Transitional cell carcinoma 9 | 18
active ulcerative colitis 9 | 477
inflammatory breast cancer 9 | 404

Tissue

Digestive Tract 330 | 18,473
Blood and immune system 328 | 17,995
Liver and Pancreas 328 | 18,136
Male tissues 328 | 17,969
Nervous System 328 | 18,561
Urinary Tract 328 | 18,444
Cardiovascular System 327 | 17,958
Endocrine System 327 | 18,512
Female tissues 327 | 18,647
Respiratory system 326 | 17,484
Skin and soft tissues 324 | 18,115

Target Family

Enzyme 200 | 4,146
Non-IDG 126 | 11,971
Kinase 12 | 634

UniProt Keyword

GTP-binding 338 | 338
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
ADP-ribosylation factor-like protein 16 ARL16 Tdark Enzyme -0.13389 1.44 17
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Putative GTP-binding protein 6 GTPBP6 Tdark Non-IDG -1.08636 13.1 0
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.22946 184.9 247
Septin-1 SEPT1 Tdark Non-IDG -1.92957 87.4 0