Development Level

Tbio 19 | 11,445
Tdark 6 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal joint morphology 1 | 23
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydroencephaly 1 | 14
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
syndactyly 1 | 23

Disease

Carcinoma 14 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 11 | 8,520
Intellectual disability 9 | 1,016
lung cancer 8 | 4,740
medulloblastoma, large-cell 7 | 6,241
Epilepsy 6 | 792
psoriasis 6 | 6,694
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Hyperphosphatasia with Mental Retardation 5 | 5
Iridogoniodysgenesis syndrome 5 | 9
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
Cerebral atrophy 4 | 178
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Muscle hypotonia 4 | 571
Seizures 4 | 596
ependymoma 4 | 4,679
tuberculosis 4 | 2,010
Big calvaria 3 | 147
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Large for gestational age 3 | 11
Mental and motor retardation 3 | 608
Multiple myeloma 3 | 1,332
Overfolded helix 3 | 24
Paroxysmal nocturnal hemoglobinuria 3 | 10
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
primitive neuroectodermal tumor 3 | 3,035
Absent speech 2 | 43
Anteverted nostril 2 | 191
Atrial Septal Defects 2 | 85
Bilateral fifth finger clinodactyly 2 | 110
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Cerebellar Hypoplasia 2 | 61
Coarse facial features 2 | 108
Congenital Epicanthus 2 | 177
Congenital diaphragmatic hernia 2 | 67
Curvature of little finger 2 | 110
Degenerative brain disorder 2 | 100
Dull intelligence 2 | 645
Hydronephrosis 2 | 89
Hyperreflexia 2 | 209
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Inverted V-shaped upper lip 2 | 19
Long philtrum 2 | 137
Low intelligence 2 | 645
Macrostomia 2 | 72
Malar flattening 2 | 129
Mandibular hypoplasia 2 | 275
Melanoma 2 | 711
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Micrognathism 2 | 275
Narrow forehead 2 | 34
Nasal bridge wide 2 | 236
Nystagmus 2 | 317
Orbital separation excessive 2 | 244
Patent ductus arteriosus 2 | 90
Pick disease 2 | 1,894
Poor school performance 2 | 645
Prenatal onset 2 | 139
Proteinuria 2 | 144
Severe mental retardation (I.Q. 20-34) 2 | 99
Short neck 2 | 140
Short philtrum 2 | 53
Somatic mutation 2 | 61
Supratentorial atrophy 2 | 94
Tented mouth 2 | 19
Tented upper lip 2 | 19
Tetralogy of Fallot 2 | 63
Thickened facial skin with coarse facial features 2 | 108
Upward slant of palpebral fissure 2 | 75
Uranostaphyloschisis 2 | 167
West Syndrome 2 | 28
Wide skull shape 2 | 88
acute myeloid leukemia 2 | 783
aldosterone-producing adenoma 2 | 665
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
hepatocellular carcinoma 2 | 547
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
nonverbal 2 | 43
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819

Tissue

Digestive Tract 25 | 17,369
Blood and immune system 24 | 16,909
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192
Nervous System 23 | 16,725

Target Family

Enzyme 17 | 4,145
Non-IDG 8 | 12,091

UniProt Keyword

GPI-anchor biosynthesis 25 | 25
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIGY Tdark Enzyme -0.25795 2.85 56
GPI mannosyltransferase 2 PIGV Tbio Enzyme -1.07565 13.4 71
Post-GPI attachment to proteins factor 2 PGAP2 Tbio Non-IDG -1.08727 12.0 64
GPI transamidase component PIG-S PIGS Tdark Enzyme -0.42822 1.54 84
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C PIGC Tbio Enzyme -1.62741 41.3 50
GPI mannosyltransferase 3 PIGB Tbio Enzyme -1.30392 19.1 79
Phosphatidylinositol-glycan biosynthesis class W protein PIGW Tbio Non-IDG -1.19496 14.3 53
PGAP2-interacting protein CWH43 Tdark Non-IDG -0.61730 4.47 29
Phosphatidylinositol glycan anchor biosynthesis class U protein PIGU Tbio Non-IDG -0.98044 9.33 20