Development Level

Tdark 465 | 6,588
Tchem 142 | 1,598
Tbio 127 | 11,445
Tclin 96 | 613

Collection

GPCR: IDG Consortium (Targets) 124 | 126
RFA-RM-18-021 100 | 328
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

decreased vertical activity 16 | 208
enlarged heart 11 | 210
abnormal behavior 9 | 298
preweaning lethality, complete... 9 | 979
abnormal heart morphology 8 | 162
hyperactivity 8 | 148
preweaning lethality, incomple... 8 | 499
decreased bone mineral content 6 | 151
decreased bone mineral density 6 | 126
decreased total body fat amoun... 6 | 207
increased lean body mass 5 | 172
increased total body fat amoun... 5 | 134
abnormal bone structure 4 | 187
abnormal kidney morphology 4 | 65
abnormal seminal vesicle morph... 4 | 114
decreased lean body mass 4 | 135
decreased startle reflex 4 | 75
improved glucose tolerance 4 | 79
increased circulating sodium l... 4 | 71
abnormal behavioral response t... 3 | 66
abnormal epididymis morphology 3 | 42
abnormal skin coloration 3 | 25
abnormal skin morphology 3 | 50
decreased body weight 3 | 161
decreased heart weight 3 | 27
decreased prepulse inhibition 3 | 82
embryonic lethality prior to t... 3 | 278
female infertility 3 | 60
impaired glucose tolerance 3 | 75
increased circulating creatini... 3 | 38
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
small superior vagus ganglion 3 | 74
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal liver morphology 2 | 17
abnormal sleep behavior 2 | 70
absent startle reflex 2 | 24
decreased circulating alanine ... 2 | 47
decreased circulating insulin ... 2 | 76
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
male infertility 2 | 123
microphthalmia 2 | 26
polycystic kidney 2 | 15
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal lymph node morphology 1 | 3
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged uterus 1 | 11
hydrometra 1 | 53
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating lipase l... 1 | 3
increased circulating magnesiu... 1 | 10
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
limb grasping 1 | 41
prenatal lethality 1 | 28
scaly skin 1 | 4
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
thick skin 1 | 4
urinary bladder obstruction 1 | 4

Disease

Carcinoma 620 | 11,493
psoriasis 175 | 6,694
osteosarcoma 143 | 7,950
medulloblastoma, large-cell 130 | 6,241
ovarian cancer 121 | 8,520
diabetes mellitus 118 | 1,728
glioblastoma 100 | 5,792
lung cancer 100 | 4,740
atypical teratoid / rhabdoid tumor 95 | 5,112
ependymoma 93 | 4,679
adult high grade glioma 89 | 3,801
Schizophrenia 77 | 1,160
interstitial cystitis 77 | 2,312
lung carcinoma 75 | 2,843
Astrocytoma, Pilocytic 70 | 3,081
Kidney cancer 67 | 2,613
lung adenocarcinoma 66 | 2,716
group 3 medulloblastoma 64 | 4,104
Breast cancer 59 | 3,578
invasive ductal carcinoma 59 | 2,951
primitive neuroectodermal tumor 56 | 3,035
oligodendroglioma 55 | 2,850
malignant mesothelioma 54 | 3,232
non-small cell lung cancer 53 | 2,890
Bipolar Disorder 51 | 666
Cancer 50 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
astrocytic glioma 46 | 2,597
Obesity 45 | 678
tuberculosis 45 | 2,010
ulcerative colitis 45 | 1,819
Depressive disorder 44 | 409
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,955
ductal carcinoma in situ 43 | 1,745
pituitary cancer 42 | 1,972
Alcoholic Intoxication, Chronic 39 | 289
breast carcinoma 36 | 1,638
pancreatic cancer 36 | 2,398
Asthma 35 | 385
Mood Disorders 35 | 184
Mental Depression 33 | 333
colon cancer 33 | 1,478
Major Depressive Disorder 32 | 301
subependymal giant cell astrocytoma 32 | 2,287
cutaneous lupus erythematosus 31 | 1,057
Multiple Sclerosis 29 | 540
Parkinson's disease 28 | 392
adrenocortical carcinoma 28 | 1,428
cystic fibrosis 27 | 1,696
group 4 medulloblastoma 27 | 1,855
Epilepsy 26 | 792
primary Sjogren syndrome 25 | 735
Allergic rhinitis 23 | 94
Rheumatoid arthritis 23 | 1,191
Hypertension 22 | 396
Melanoma 22 | 711
Unipolar Depression 22 | 250
Attention deficit hyperactivity disorder 21 | 278
Migraine 21 | 83
Alcohol dependence 20 | 107
astrocytoma 20 | 1,146
mucosa-associated lymphoid tissue lymphoma 20 | 484
Autistic Disorder 19 | 364
Autosomal recessive predisposition 19 | 1,442
Common cold 19 | 67
Pick disease 19 | 1,894
Cocaine-Related Disorders 18 | 92
Nasal congestion 18 | 21
Nasal discharge 18 | 24
Pain agnosia 18 | 104
Skin cancer 18 | 469
Atopic dermatitis 17 | 952
Liver cancer 17 | 604
Pain 17 | 103
gastric carcinoma 17 | 807
Seizures 16 | 596
medulloblastoma 16 | 720
Status Epilepticus 15 | 98
Substance Withdrawal Syndrome 15 | 55
esophageal adenocarcinoma 15 | 737
primary pancreatic ductal adenocarcinoma 15 | 1,109
Acquired metabolic disease 14 | 336
Liver Cirrhosis, Experimental 14 | 769
Vascular disease 14 | 319
fibroadenoma 14 | 559
hepatocellular carcinoma 14 | 547
non primary Sjogren syndrome sicca 14 | 891
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pediatric high grade glioma 14 | 1,064
Alzheimer's disease 13 | 658
Atherosclerosis 13 | 291
Bronchitis 13 | 43
Cerebrovascular disease 13 | 238
Endometriosis 13 | 540
Hemolytic anemia 13 | 77
Hyperalgesia 13 | 83
Hypertensive disease 13 | 292
Panic disorder 13 | 61
Pulmonary emphysema 13 | 48

Tissue

Endocrine System 464 | 18,159
Female tissues 375 | 17,400
Digestive Tract 351 | 17,369
Nervous System 350 | 16,725
Male tissues 349 | 17,142
Blood and immune system 342 | 16,909
Skin and soft tissues 340 | 17,230
Urinary Tract 313 | 16,678
Liver and Pancreas 310 | 16,750
Respiratory system 296 | 16,393
Cardiovascular System 251 | 15,192

Target Family

oGPCR 421 | 421
GPCR 405 | 408
Non-IDG 4 | 12,091

UniProt Keyword

G-protein coupled receptor 830 | 830
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Olfactory receptor 5B2 OR5B2 Tdark oGPCR 0.00000 1
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248