Development Level

Tdark 468 | 7,003
Tbio 138 | 10,625
Tchem 128 | 1,890
Tclin 96 | 602

Collection

Eligible non-olfactory GPCR Proteins 143 | 145

IMPC Term

decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 195
preweaning lethality, complete... 6 | 633
hyperactivity 5 | 108
increased or absent threshold ... 5 | 128
preweaning lethality, incomple... 5 | 260
abnormal behavior 4 | 226
decreased body weight 4 | 174
decreased grip strength 4 | 123
improved glucose tolerance 4 | 56
increased grip strength 4 | 83
abnormal behavioral response t... 3 | 52
abnormal epididymis morphology 3 | 31
decreased body length 3 | 108
decreased circulating glucose ... 3 | 121
decreased prepulse inhibition 3 | 52
decreased startle reflex 3 | 48
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating creatini... 3 | 29
increased mean corpuscular vol... 3 | 91
increased total body fat amoun... 3 | 57
abnormal bone structure 2 | 131
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal seminal vesicle morph... 2 | 47
abnormal skin coloration 2 | 18
abnormal sleep behavior 2 | 63
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
enlarged epididymis 2 | 27
female infertility 2 | 34
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased gamma-delta T cell n... 2 | 16
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased monocyte cell number 2 | 27
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal lymph node morphology 1 | 3
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
convulsive seizures 1 | 11
decreased Ly6C high monocyte n... 1 | 18
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating triglyce... 1 | 83
decreased hematocrit 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
hydrops fetalis 1 | 22
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
oligodactyly 1 | 14
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened PQ interval 1 | 6
small kidney 1 | 10
small thymus 1 | 11
thrombocytopenia 1 | 46

Disease

psoriasis 175 | 6,685
osteosarcoma 143 | 7,933
medulloblastoma, large-cell 131 | 6,234
ovarian cancer 122 | 8,492
diabetes mellitus 116 | 1,663
glioblastoma 93 | 5,572
atypical teratoid / rhabdoid tumor 83 | 4,369
interstitial cystitis 77 | 2,299
lung carcinoma 75 | 2,844
lung cancer 71 | 4,473
pilocytic astrocytoma 71 | 3,086
lung adenocarcinoma 66 | 2,714
Carcinoma 60 | 2,147
invasive ductal carcinoma 59 | 2,950
adult high grade glioma 56 | 2,148
primitive neuroectodermal tumor 56 | 3,031
oligodendroglioma 55 | 2,849
malignant mesothelioma 53 | 3,163
ependymoma 51 | 2,514
ulcerative colitis 49 | 2,087
Breast cancer 48 | 3,099
Schizophrenia 48 | 503
non-small cell lung cancer 48 | 2,798
pediatric high grade glioma 48 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
Cancer 45 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,956
Obesity 43 | 616
ductal carcinoma in situ 43 | 1,745
pituitary cancer 42 | 1,972
astrocytic glioma 39 | 2,241
Asthma 36 | 349
breast carcinoma 36 | 1,614
pancreatic cancer 35 | 2,300
posterior fossa group A ependymoma 35 | 1,511
colon cancer 33 | 1,475
medulloblastoma 33 | 1,524
tuberculosis 33 | 1,563
subependymal giant cell astrocytoma 32 | 2,287
cutaneous lupus erythematosus 31 | 1,056
Parkinson's disease 28 | 364
adrenocortical carcinoma 28 | 1,427
group 3 medulloblastoma 28 | 2,254
astrocytoma 27 | 1,493
sonic hedgehog group medulloblastoma 27 | 1,482
cystic fibrosis 26 | 1,670
group 4 medulloblastoma 26 | 1,875
Allergic rhinitis 25 | 92
Multiple Sclerosis 25 | 498
primary Sjogren syndrome 25 | 789
Epilepsy 24 | 346
Rheumatoid Arthritis 22 | 1,171
Attention deficit hyperactivity disorder 21 | 156
Migraine 21 | 79
Nasal congestion 21 | 24
Alcohol dependence 20 | 107
Common cold 20 | 63
Nasal discharge 20 | 26
atypical teratoid/rhabdoid tumor 20 | 1,095
gastric carcinoma 20 | 832
mucosa-associated lymphoid tissue lymphoma 20 | 480
posterior fossa group B ependymoma 20 | 1,530
Major Depressive Disorder 19 | 106
Pick disease 19 | 1,893
Autistic Disorder 18 | 320
Bipolar Disorder 18 | 266
Cocaine-Related Disorders 18 | 88
Atopic dermatitis 17 | 944
Pain 17 | 70
Pain agnosia 17 | 99
non-small cell lung carcinoma 16 | 413
Status Epilepticus 15 | 85
Substance Withdrawal Syndrome 15 | 55
esophageal adenocarcinoma 15 | 737
primary pancreatic ductal adenocarcinoma 15 | 1,271
Asthma management 14 | 20
Hypertension 14 | 293
Hypertensive disease 14 | 193
Vascular disease 14 | 281
fibroadenoma 14 | 557
glioblastoma multiforme 14 | 347
hepatocellular carcinoma 14 | 550
non primary Sjogren syndrome sicca 14 | 840
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Atherosclerosis 13 | 275
Bronchitis 13 | 44
Endometriosis 13 | 535
Hemolytic anemia 13 | 70
Pulmonary emphysema 13 | 34
Alzheimer's disease 12 | 644
Cerebrovascular disease 12 | 231
Hyperalgesia 12 | 71
Hypertensive disorder 12 | 58
Panic disorder 12 | 55
Seizures 12 | 95
active Crohn's disease 12 | 918
acute myeloid leukemia 12 | 785
head and neck cancer and chronic obstructive pulmonary disease 12 | 237
pancreatic carcinoma 12 | 567

Tissue

Female tissues 702 | 18,647
Urinary Tract 674 | 18,444
Nervous System 621 | 18,561
Endocrine System 619 | 18,512
Digestive Tract 591 | 18,473
Skin and soft tissues 554 | 18,115
Liver and Pancreas 479 | 18,136
Cardiovascular System 457 | 17,958
Blood and immune system 456 | 17,995
Male tissues 423 | 17,969
Respiratory system 393 | 17,484

Target Family

oGPCR 421 | 421
GPCR 405 | 408
Non-IDG 4 | 11,969

UniProt Keyword

G-protein coupled receptor 830 | 830
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chemokine-like receptor 1 CMKLR1 Tchem GPCR -2.09993 116.0 343
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.32485 207.4 140
Metabotropic glutamate receptor 7 GRM7 Tbio GPCR -2.23649 186.6 266
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.29074 177.0 254
Neuromedin-B receptor NMBR Tchem GPCR -1.67874 41.6 157
Smoothened homolog SMO Tclin GPCR -1.11229 12.5 388
Olfactory receptor 6C6 OR6C6 Tdark oGPCR 0.00000 24
Olfactory receptor 2W1 OR2W1 Tdark oGPCR 0.15 0.39 63
G-protein coupled receptor 35 GPR35 Tchem GPCR -1.71148 57.6 159
Relaxin receptor 1 RXFP1 Tbio GPCR -2.19169 168.6 199