Development Level

Tdark 466 | 6,593
Tbio 157 | 11,651
Tchem 111 | 1,388
Tclin 96 | 612

Collection

GPCR: IDG Consortium (Targets) 124 | 126
RFA-RM-18-021 100 | 328
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

decreased vertical activity 16 | 208
enlarged heart 11 | 210
abnormal behavior 9 | 298
preweaning lethality, complete... 9 | 979
abnormal heart morphology 8 | 162
hyperactivity 8 | 148
preweaning lethality, incomple... 8 | 499
decreased bone mineral content 6 | 151
decreased bone mineral density 6 | 126
decreased total body fat amoun... 6 | 207
increased lean body mass 5 | 172
increased total body fat amoun... 5 | 134
abnormal bone structure 4 | 187
abnormal kidney morphology 4 | 65
abnormal seminal vesicle morph... 4 | 114
decreased lean body mass 4 | 135
decreased startle reflex 4 | 75
improved glucose tolerance 4 | 79
increased circulating sodium l... 4 | 71
abnormal behavioral response t... 3 | 66
abnormal epididymis morphology 3 | 42
abnormal skin coloration 3 | 25
abnormal skin morphology 3 | 50
decreased body weight 3 | 161
decreased heart weight 3 | 27
decreased prepulse inhibition 3 | 82
embryonic lethality prior to t... 3 | 278
female infertility 3 | 60
impaired glucose tolerance 3 | 75
increased circulating creatini... 3 | 38
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
small superior vagus ganglion 3 | 74
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal liver morphology 2 | 17
abnormal sleep behavior 2 | 70
absent startle reflex 2 | 24
decreased circulating alanine ... 2 | 47
decreased circulating insulin ... 2 | 76
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
male infertility 2 | 123
microphthalmia 2 | 26
polycystic kidney 2 | 15
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal lymph node morphology 1 | 3
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged uterus 1 | 11
hydrometra 1 | 53
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating lipase l... 1 | 3
increased circulating magnesiu... 1 | 10
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
limb grasping 1 | 41
prenatal lethality 1 | 28
scaly skin 1 | 4
small kidney 1 | 16
small spleen 1 | 19
small thymus 1 | 16
thick skin 1 | 4
urinary bladder obstruction 1 | 4

Disease

Carcinoma 620 | 11,493
psoriasis 175 | 6,694
osteosarcoma 143 | 7,950
medulloblastoma, large-cell 130 | 6,241
ovarian cancer 121 | 8,520
diabetes mellitus 118 | 1,728
glioblastoma 100 | 5,792
lung cancer 100 | 4,740
atypical teratoid / rhabdoid tumor 95 | 5,112
ependymoma 93 | 4,679
adult high grade glioma 89 | 3,801
Schizophrenia 77 | 1,160
interstitial cystitis 77 | 2,312
lung carcinoma 75 | 2,843
Astrocytoma, Pilocytic 70 | 3,081
Kidney cancer 67 | 2,613
lung adenocarcinoma 66 | 2,716
group 3 medulloblastoma 64 | 4,104
Breast cancer 59 | 3,578
invasive ductal carcinoma 59 | 2,951
primitive neuroectodermal tumor 56 | 3,035
oligodendroglioma 55 | 2,850
malignant mesothelioma 54 | 3,232
non-small cell lung cancer 53 | 2,890
Bipolar Disorder 51 | 666
Cancer 50 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
astrocytic glioma 46 | 2,597
Obesity 45 | 678
tuberculosis 45 | 2,010
ulcerative colitis 45 | 1,819
Depressive disorder 44 | 409
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,955
ductal carcinoma in situ 43 | 1,745
pituitary cancer 42 | 1,972
Alcoholic Intoxication, Chronic 39 | 289
breast carcinoma 36 | 1,638
pancreatic cancer 36 | 2,398
Asthma 35 | 385
Mood Disorders 35 | 184
Mental Depression 33 | 333
colon cancer 33 | 1,478
Major Depressive Disorder 32 | 301
subependymal giant cell astrocytoma 32 | 2,287
cutaneous lupus erythematosus 31 | 1,057
Multiple Sclerosis 29 | 540
Parkinson's disease 28 | 392
adrenocortical carcinoma 28 | 1,428
cystic fibrosis 27 | 1,696
group 4 medulloblastoma 27 | 1,855
Epilepsy 26 | 792
primary Sjogren syndrome 25 | 735
Allergic rhinitis 24 | 95
Rheumatoid arthritis 23 | 1,191
Hypertension 22 | 396
Melanoma 22 | 711
Unipolar Depression 22 | 250
Attention deficit hyperactivity disorder 21 | 278
Common cold 21 | 69
Migraine 21 | 83
Alcohol dependence 20 | 107
Nasal congestion 20 | 23
astrocytoma 20 | 1,146
mucosa-associated lymphoid tissue lymphoma 20 | 484
Autistic Disorder 19 | 364
Autosomal recessive predisposition 19 | 1,442
Nasal discharge 19 | 25
Pick disease 19 | 1,894
Cocaine-Related Disorders 18 | 92
Pain agnosia 18 | 104
Skin cancer 18 | 469
Atopic dermatitis 17 | 952
Liver cancer 17 | 604
Pain 17 | 103
gastric carcinoma 17 | 807
Seizures 16 | 596
medulloblastoma 16 | 720
Status Epilepticus 15 | 98
Substance Withdrawal Syndrome 15 | 55
esophageal adenocarcinoma 15 | 737
primary pancreatic ductal adenocarcinoma 15 | 1,109
Acquired metabolic disease 14 | 336
Liver Cirrhosis, Experimental 14 | 769
Vascular disease 14 | 319
fibroadenoma 14 | 559
hepatocellular carcinoma 14 | 547
non primary Sjogren syndrome sicca 14 | 891
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pediatric high grade glioma 14 | 1,064
Alzheimer's disease 13 | 658
Atherosclerosis 13 | 291
Bronchitis 13 | 43
Cerebrovascular disease 13 | 238
Endometriosis 13 | 540
Hemolytic anemia 13 | 77
Hyperalgesia 13 | 83
Hypertensive disease 13 | 292
Panic disorder 13 | 61
Pulmonary emphysema 13 | 48

Tissue

Endocrine System 464 | 18,159
Female tissues 375 | 17,400
Digestive Tract 351 | 17,369
Nervous System 350 | 16,725
Male tissues 349 | 17,142
Blood and immune system 342 | 16,909
Skin and soft tissues 340 | 17,230
Urinary Tract 313 | 16,678
Liver and Pancreas 310 | 16,750
Respiratory system 296 | 16,393
Cardiovascular System 251 | 15,192

Target Family

oGPCR 421 | 421
GPCR 405 | 408
Non-IDG 4 | 12,091

UniProt Keyword

G-protein coupled receptor 830 | 830
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2
Leukotriene B4 receptor 1 LTB4R Tchem GPCR -2.74171 557.6 365
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
Olfactory receptor 5B21 OR5B21 Tdark oGPCR 0.00000 4
Mas-related G-protein coupled receptor member X1 MRGPRX1 Tchem GPCR -1.21830 18.4 75
G-protein coupled receptor 176 GPR176 Tbio GPCR -2.38327 235.4 133
Opsin-5 OPN5 Tbio GPCR -1.19753 14.2 151
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315