Development Level

Tbio 83 | 11,651
Tchem 18 | 1,388
Tclin 10 | 612
Tdark 10 | 6,593

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 5 | 298
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
abnormal epididymis morphology 2 | 42
abnormal stomach morphology 2 | 10
hyperactivity 2 | 148
increased circulating sodium l... 2 | 71
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
small kidney 2 | 16
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tail bud morphology 1 | 8
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased caudal vertebrae num... 1 | 53
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased spleen weight 1 | 10
increased vertical activity 1 | 24
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
tremors 1 | 39

Disease

Carcinoma 90 | 11,493
ovarian cancer 58 | 8,520
osteosarcoma 57 | 7,950
psoriasis 51 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,962
medulloblastoma, large-cell 39 | 6,241
Autosomal recessive predisposition 35 | 1,442
glioblastoma 34 | 5,792
lung cancer 34 | 4,740
non-small cell lung cancer 33 | 2,890
ependymoma 30 | 4,679
atypical teratoid / rhabdoid tumor 29 | 5,112
invasive ductal carcinoma 28 | 2,951
lung carcinoma 27 | 2,843
malignant mesothelioma 27 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
group 3 medulloblastoma 23 | 4,104
Breast cancer 22 | 3,578
Muscle hypotonia 22 | 571
adult high grade glioma 22 | 3,801
lung adenocarcinoma 21 | 2,716
Cognitive delay 20 | 608
Epilepsy 20 | 792
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
interstitial cystitis 20 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Astrocytoma, Pilocytic 19 | 3,081
Seizures 19 | 596
adrenocortical carcinoma 19 | 1,428
ductal carcinoma in situ 19 | 1,745
Liver Cirrhosis, Experimental 18 | 769
breast carcinoma 17 | 1,638
tuberculosis 17 | 2,010
ulcerative colitis 17 | 1,819
Schizophrenia 16 | 1,160
pancreatic cancer 16 | 2,398
Failure to gain weight 15 | 365
Pediatric failure to thrive 15 | 365
Pick disease 15 | 1,894
pituitary cancer 15 | 1,972
subependymal giant cell astrocytoma 15 | 2,287
Hypoglycemia 14 | 152
astrocytic glioma 14 | 2,597
cystic fibrosis 14 | 1,696
oligodendroglioma 14 | 2,850
Cancer 13 | 2,499
Intellectual disability 13 | 1,016
active Crohn's disease 13 | 922
colon cancer 13 | 1,478
diabetes mellitus 13 | 1,728
primitive neuroectodermal tumor 13 | 3,035
Bipolar Disorder 11 | 666
Dull intelligence 11 | 645
Lethargy 11 | 77
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Depressive disorder 10 | 409
Hypertension 10 | 396
Kidney cancer 10 | 2,613
Multiple acyl-CoA dehydrogenase deficiency 10 | 25
Nystagmus 10 | 317
nasopharyngeal carcinoma 10 | 1,058
Infantile onset 9 | 238
Kidney disease 9 | 430
Obesity 9 | 678
Vomiting 9 | 116
aldosterone-producing adenoma 9 | 665
cutaneous lupus erythematosus 9 | 1,057
gastric carcinoma 9 | 807
group 4 medulloblastoma 9 | 1,855
nephrosclerosis 9 | 333
Acidosis, Lactic 8 | 97
Autistic Disorder 8 | 364
Diabetes Mellitus, Experimental 8 | 108
Hepatomegaly 8 | 285
Highly variable clinical phenotype 8 | 150
Highly variable phenotype and severity 8 | 150
Highly variable phenotype, even within families 8 | 150
Lactic acidemia 8 | 95
Leigh disease 8 | 100
Multiple myeloma 8 | 1,332
Muscle Spasticity 8 | 195
Muscle Weakness 8 | 170
Phenotypic variability 8 | 150
Prostatic Neoplasms 8 | 495
Sensorineural Hearing Loss (disorder) 8 | 284
Strabismus 8 | 270
Atherosclerosis 7 | 291
Mental Depression 7 | 333
Rheumatoid arthritis 7 | 1,191
Small head 7 | 374
active ulcerative colitis 7 | 764
acute quadriplegic myopathy 7 | 1,158
medulloblastoma 7 | 720
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074

Tissue

Endocrine System 120 | 18,159
Liver and Pancreas 120 | 16,750
Urinary Tract 120 | 16,678
Blood and immune system 119 | 16,909
Digestive Tract 119 | 17,369
Female tissues 118 | 17,400
Male tissues 118 | 17,142
Nervous System 118 | 16,725
Skin and soft tissues 118 | 17,230
Respiratory system 116 | 16,393
Cardiovascular System 111 | 15,192

Target Family

Enzyme 108 | 4,145
Non-IDG 10 | 12,091
Epigenetic 2 | 242
Ion Channel 1 | 344

UniProt Keyword

Flavoprotein 121 | 121
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275