Development Level

Tbio 12 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal heart morphology 1 | 162
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 10 | 7,950
group 3 medulloblastoma 7 | 4,104
ovarian cancer 7 | 8,520
Carcinoma 4 | 11,493
psoriasis 4 | 6,694
colon cancer 3 | 1,478
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
Autosomal recessive predisposition 2 | 1,442
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Kidney cancer 2 | 2,613
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Myositis 2 | 30
Neurodegenerative disease 2 | 414
Perlman syndrome 2 | 9
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
Systemic scleroderma 2 | 60
X-linked cerebral adrenoleukodystrophy 2 | 116
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
Absent speech 1 | 43
Alopecia 1 | 115
Atrophy of cerebellum 1 | 103
Axial hypotonia 1 | 46
Brachydactyly 1 | 156
Cachexia 1 | 50
Cerebellar degeneration 1 | 103
Congenital deafness 1 | 185
Contracture 1 | 96
Contracture of joint 1 | 93
Deafness 1 | 198
Degenerative brain disorder 1 | 100
Dermatitis 1 | 157
Disease Progression 1 | 136
Dyskeratosis congenita 1 | 24
Failure to gain weight 1 | 365
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Gastric antral vascular ectasia 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Highly variable severity 1 | 157
Hyperplasia 1 | 27
Hyperreflexia 1 | 209
Hypoplasia of corpus callosum 1 | 90
Inflammation 1 | 120
Infratentorial atrophy 1 | 103
Leukemia 1 | 104
Liver neoplasms 1 | 130
Low Vision 1 | 174
Muscle Spasticity 1 | 195
Muscle Weakness 1 | 170
Neoplasm Invasiveness 1 | 161
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Pediatric failure to thrive 1 | 365
Polyhydramnios 1 | 108
Poor growth 1 | 114
Prenatal onset 1 | 139
Respiratory Failure 1 | 104
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Spinal muscular atrophy 1 | 34
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Supratentorial atrophy 1 | 94
Systemic lupus erythematosus 1 | 194
Telangiectasis 1 | 36
Variable expressivity 1 | 157
Very poor growth 1 | 114
Visual Impairment 1 | 174
Waldenstrons macroglobulinemia 1 | 765
astrocytoma 1 | 1,146
breast carcinoma 1 | 1,638
fibroadenoma 1 | 559
glioblastoma multiforme 1 | 142
hearing impairment 1 | 199
hepatocellular carcinoma 1 | 547
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298
muscle degeneration 1 | 139
nonverbal 1 | 43
pancreatic carcinoma 1 | 562
tuberculosis 1 | 2,010
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 8 | 4,145
Non-IDG 5 | 12,091

UniProt Keyword

Exosome 13 | 13
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
DIS3-like exonuclease 1 DIS3L Tdark Enzyme -0.68418 3.89 94
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.42848 236.6 0