Development Level

Tbio 34 | 11,178
Tdark 8 | 6,569
Tchem 7 | 1,885
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 4 | 278
embryonic lethality prior to o... 3 | 239
abnormal embryo turning 2 | 31
preweaning lethality, incomple... 2 | 499
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal clavicle morphology 1 | 6
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal rib morphology 1 | 10
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased caudal vertebrae num... 1 | 53
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
pale yolk sac 1 | 25
pallor 1 | 34

Disease

osteosarcoma 33 | 7,766
Carcinoma 32 | 11,192
ovarian cancer 24 | 8,297
group 3 medulloblastoma 20 | 4,002
psoriasis 17 | 6,514
medulloblastoma, large-cell 16 | 6,086
lung cancer 13 | 4,607
glioblastoma 11 | 5,635
malignant mesothelioma 10 | 3,135
primitive neuroectodermal tumor 10 | 2,957
Breast cancer 9 | 3,469
atypical teratoid / rhabdoid tumor 9 | 4,971
ependymoma 9 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,204
Cancer 8 | 2,388
Kidney cancer 8 | 2,548
invasive ductal carcinoma 7 | 2,867
Multiple myeloma 6 | 1,296
non-small cell lung cancer 6 | 2,799
oligodendroglioma 6 | 2,768
Autosomal recessive predisposition 5 | 1,407
diabetes mellitus 5 | 1,683
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
lung adenocarcinoma 5 | 2,627
pituitary cancer 5 | 1,915
Pick disease 4 | 1,856
Telangiectasis 4 | 35
Werner syndrome 4 | 29
adult high grade glioma 4 | 3,701
astrocytic glioma 4 | 2,530
cutaneous lupus erythematosus 4 | 1,016
ductal carcinoma in situ 4 | 1,686
group 4 medulloblastoma 4 | 1,806
juvenile dermatomyositis 4 | 1,147
pancreatic cancer 4 | 2,322
subependymal giant cell astrocytoma 4 | 2,230
Aicardi-Goutieres syndrome 3 | 18
Astrocytoma, Pilocytic 3 | 3,006
Colorectal Neoplasms 3 | 235
Dyskeratosis congenita 3 | 24
Fanconi anemia 3 | 56
Liver Cirrhosis, Experimental 3 | 733
Lynch syndrome 3 | 34
Microphthalmia with limb anomalies 3 | 39
Neurodegenerative disease 3 | 402
Perlman syndrome 3 | 8
Progressive disorder 3 | 139
Rheumatoid arthritis 3 | 1,156
Seizures 3 | 584
Skin Ulcer 3 | 48
Spider Veins 3 | 17
Waldenstrons macroglobulinemia 3 | 742
adrenocortical carcinoma 3 | 1,385
astrocytoma 3 | 1,113
colon cancer 3 | 1,428
non primary Sjogren syndrome sicca 3 | 861
pancreatic carcinoma 3 | 555
progressive supranuclear palsy 3 | 656
tuberculosis 3 | 1,963
ulcerative colitis 3 | 1,765
Adult onset 2 | 81
Carcinoma, Hepatocellular 2 | 217
Cerebral atrophy 2 | 175
Cockayne syndrome 2 | 59
Decreased platelet count 2 | 110
Dysarthria 2 | 190
Dystonia 2 | 163
Dystonic disease 2 | 105
Elevated hepatic transaminases 2 | 79
Endometriosis 2 | 521
Epilepsy 2 | 775
Heart disease 2 | 288
Hepatic enzyme increased 2 | 79
Leukodystrophy 2 | 55
Liver Dysfunction 2 | 97
Liver carcinoma 2 | 229
Liver enzymes abnormal 2 | 79
Liver function test increased 2 | 79
Liver function tests abnormal finding 2 | 79
Malabsorption 2 | 81
Multiple Sclerosis 2 | 527
Muscle Hypertonia 2 | 88
Myocardial Infarction 2 | 142
Osteoporosis 2 | 348
Polyhydramnios 2 | 106
Proteinuria 2 | 143
Subclinical abnormal liver function tests 2 | 79
Systemic lupus erythematosus 2 | 191
Thrombocytopenia 2 | 193
Transaminases increased 2 | 79
acute quadriplegic myopathy 2 | 1,133
atypical teratoid/rhabdoid tumor 2 | 349
dermatomyositis 2 | 941
hepatocellular carcinoma 2 | 536
nasopharyngeal carcinoma 2 | 1,024
pediatric high grade glioma 2 | 1,035
sonic hedgehog group medulloblastoma 2 | 459
spina bifida 2 | 1,053
tuberculosis and treatment for 6 months 2 | 399

Tissue

Blood and immune system 49 | 16,909
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Skin and soft tissues 49 | 17,230
Cardiovascular System 48 | 15,192
Respiratory system 48 | 16,393
Urinary Tract 48 | 16,678

Target Family

Enzyme 37 | 4,145
Non-IDG 13 | 12,091

UniProt Keyword

Exonuclease 50 | 50
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon-stimulated 20 kDa exonuclease-like 2 ISG20L2 Tdark Enzyme -0.46736 2.65 25
RNA exonuclease 1 homolog REXO1 Tdark Enzyme 0.25 0.75 150
2',5'-phosphodiesterase 12 PDE12 Tbio Enzyme -1.46115 31.6 90
RNA exonuclease 4 REXO4 Tbio Enzyme -1.59595 38.8 87
DIS3-like exonuclease 1 DIS3L Tdark Enzyme -0.68418 3.89 94
Three prime repair exonuclease 2 TREX2 Tbio Enzyme -0.17609 1.25 87
Telomerase RNA component interacting RNase TRIR Tdark Non-IDG 0.00000 1.00 22
CCR4-NOT transcription complex subunit 6-like CNOT6L Tbio Non-IDG -0.89586 7.91 51
CCR4-NOT transcription complex subunit 8 CNOT8 Tbio Non-IDG -2.83783 687.5 209
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263