Development Level

Tbio 32 | 10,625
Tdark 8 | 7,003
Tchem 7 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased fasted circulating g... 1 | 49
decreased heart left ventricle... 1 | 2
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
embryonic lethality prior to o... 1 | 148
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased exploration in new e... 1 | 56
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
preweaning lethality, incomple... 1 | 260

Disease

osteosarcoma 32 | 7,933
ovarian cancer 22 | 8,484
psoriasis 16 | 6,685
medulloblastoma, large-cell 14 | 6,234
group 3 medulloblastoma 13 | 2,254
lung cancer 13 | 4,466
Breast cancer 10 | 3,094
glioblastoma 10 | 5,572
malignant mesothelioma 9 | 3,162
primitive neuroectodermal tumor 9 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
Cancer 7 | 2,346
atypical teratoid / rhabdoid tumor 7 | 4,369
invasive ductal carcinoma 7 | 2,950
Multiple myeloma 6 | 1,327
ependymoma 6 | 2,514
non-small cell lung cancer 6 | 2,798
oligodendroglioma 6 | 2,849
sonic hedgehog group medulloblastoma 6 | 1,482
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
lung adenocarcinoma 5 | 2,713
pediatric high grade glioma 5 | 2,712
pituitary cancer 5 | 1,972
Carcinoma 4 | 2,147
Pick disease 4 | 1,893
astrocytic glioma 4 | 2,241
atypical teratoid/rhabdoid tumor 4 | 1,095
cutaneous lupus erythematosus 4 | 1,056
diabetes mellitus 4 | 1,663
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,189
pancreatic cancer 4 | 2,300
subependymal giant cell astrocytoma 4 | 2,287
Aicardi-Goutieres syndrome 3 | 18
Colorectal Neoplasms 3 | 217
Fanconi's anemia 3 | 50
Neurodegenerative disease 3 | 383
Peripheral Neuropathy 3 | 303
Perlman syndrome 3 | 9
Rheumatoid Arthritis 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
Werner syndrome 3 | 29
astrocytoma 3 | 1,493
colon cancer 3 | 1,475
pancreatic carcinoma 3 | 567
pilocytic astrocytoma 3 | 3,086
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
ulcerative colitis 3 | 2,087
Cockayne syndrome 2 | 54
Connective tissue disease 2 | 59
Dyskeratosis congenita 2 | 24
Endometriosis 2 | 535
Liver carcinoma 2 | 217
Lynch syndrome 2 | 33
Nephroblastoma 2 | 45
Nijmegen breakage syndrome 2 | 23
Polyhydramnios 2 | 29
Xeroderma pigmentosum 2 | 41
acute quadriplegic myopathy 2 | 1,157
adrenocortical carcinoma 2 | 1,427
dermatomyositis 2 | 933
hepatocellular carcinoma 2 | 532
nasopharyngeal carcinoma 2 | 1,056
non primary Sjogren syndrome sicca 2 | 840
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 789
spina bifida 2 | 1,064
systemic lupus erythematosus 2 | 156
tuberculosis and treatment for 3 months 2 | 327
Acute lymphoid leukemia 1 | 25
Acute myeloid leukemia, disease 1 | 16
Asphyxiating thoracic dystrophy 1 | 32
Axonal neuropathy 1 | 17
Brain Diseases 1 | 22
Calcinosis 1 | 62
Candidiasis 1 | 48
Cornea plana 1 | 12
Corneal ectasia 1 | 9
Dengue Shock Syndrome 1 | 7
Familial adenomatous polyposis 1 | 31
Heart Diseases 1 | 42
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Keratoconus 1 | 47
Kidney cancer 1 | 118
Lupus Erythematosus, Systemic 1 | 73
Lupus erythematosus 1 | 80
Metastatic Breast Carcinoma 1 | 21
Mixed connective tissue disease 1 | 16
Myocardial Infarction 1 | 126
Myositis 1 | 24
Obstructive sleep apnea 1 | 28
Ollier disease 1 | 15
Pulmonary Fibrosis 1 | 66
Radiculopathy 1 | 15
Systemic scleroderma 1 | 66
Toxic shock syndrome 1 | 28
Ventricular septal defect 1 | 15

Tissue

Female tissues 47 | 18,647
Male tissues 47 | 17,969
Nervous System 47 | 18,561
Respiratory system 47 | 17,484
Blood and immune system 46 | 17,995
Cardiovascular System 46 | 17,958
Digestive Tract 46 | 18,473
Endocrine System 46 | 18,512
Liver and Pancreas 46 | 18,136
Skin and soft tissues 46 | 18,115
Urinary Tract 46 | 18,444

Target Family

Enzyme 36 | 4,146
Non-IDG 12 | 11,971

UniProt Keyword

Exonuclease 48 | 48
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225
Putative exonuclease GOR REXO1L1P Tdark Enzyme -1.75891 56.6 0
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.06818 114.2 45
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.95631 90.0 412
5'-3' exoribonuclease 2 XRN2 Tbio Enzyme -1.48143 31.3 110
ERI1 exoribonuclease 3 ERI3 Tdark Enzyme -0.60206 3.67 56
CCR4-NOT transcription complex subunit 6 CNOT6 Tchem Non-IDG -1.21486 17.4 101
Nocturnin NOCT Tbio Non-IDG -1.54197 34.3 83
Exosome component 10 EXOSC10 Tbio Non-IDG -2.41526 265.3 118
Exonuclease 1 EXO1 Tbio Enzyme -2.58414 403.9 226