Development Level

Tbio 32 | 10,625
Tdark 8 | 7,003
Tchem 7 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased fasted circulating g... 1 | 49
decreased heart left ventricle... 1 | 2
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
embryonic lethality prior to o... 1 | 148
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased exploration in new e... 1 | 56
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
preweaning lethality, incomple... 1 | 260

Disease

osteosarcoma 32 | 7,933
ovarian cancer 22 | 8,492
psoriasis 16 | 6,685
medulloblastoma, large-cell 14 | 6,234
group 3 medulloblastoma 13 | 2,254
lung cancer 13 | 4,473
Breast cancer 10 | 3,099
glioblastoma 10 | 5,572
malignant mesothelioma 9 | 3,163
primitive neuroectodermal tumor 9 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
Cancer 7 | 2,346
atypical teratoid / rhabdoid tumor 7 | 4,369
invasive ductal carcinoma 7 | 2,950
Multiple myeloma 6 | 1,328
ependymoma 6 | 2,514
non-small cell lung cancer 6 | 2,798
oligodendroglioma 6 | 2,849
sonic hedgehog group medulloblastoma 6 | 1,482
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
lung adenocarcinoma 5 | 2,714
pediatric high grade glioma 5 | 2,712
pituitary cancer 5 | 1,972
Carcinoma 4 | 2,147
Pick disease 4 | 1,893
astrocytic glioma 4 | 2,241
atypical teratoid/rhabdoid tumor 4 | 1,095
cutaneous lupus erythematosus 4 | 1,056
diabetes mellitus 4 | 1,663
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,189
pancreatic cancer 4 | 2,300
subependymal giant cell astrocytoma 4 | 2,287
Aicardi-Goutieres syndrome 3 | 18
Colorectal Neoplasms 3 | 217
Fanconi's anemia 3 | 50
Lynch syndrome 3 | 35
Neurodegenerative disease 3 | 383
Peripheral Neuropathy 3 | 303
Perlman syndrome 3 | 9
Rheumatoid Arthritis 3 | 1,171
Waldenstrons macroglobulinemia 3 | 765
Werner syndrome 3 | 29
astrocytoma 3 | 1,493
colon cancer 3 | 1,475
pancreatic carcinoma 3 | 567
pilocytic astrocytoma 3 | 3,086
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
ulcerative colitis 3 | 2,087
Cockayne syndrome 2 | 54
Connective tissue disease 2 | 59
Dyskeratosis congenita 2 | 24
Endometriosis 2 | 535
HOYERAAL-HREIDARSSON SYNDROME 2 | 7
Liver carcinoma 2 | 217
Nephroblastoma 2 | 45
Nijmegen breakage syndrome 2 | 23
Polyhydramnios 2 | 29
Xeroderma pigmentosum 2 | 41
acute quadriplegic myopathy 2 | 1,157
adrenocortical carcinoma 2 | 1,427
dermatomyositis 2 | 967
hepatocellular carcinoma 2 | 550
nasopharyngeal carcinoma 2 | 1,056
non primary Sjogren syndrome sicca 2 | 840
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 789
spina bifida 2 | 1,064
systemic lupus erythematosus 2 | 172
tuberculosis and treatment for 3 months 2 | 327
Acute lymphoid leukemia 1 | 25
Acute stress disorder 1 | 6
Alveolar echinococcosis 1 | 5
Asphyxiating thoracic dystrophy 1 | 34
Ataxia telangiectasia 1 | 32
Axonal neuropathy 1 | 17
Cornea plana 1 | 12
Corneal ectasia 1 | 9
Cryptosporidiosis 1 | 12
Dengue Shock Syndrome 1 | 7
Enamel erosion 1 | 15
Heart Diseases 1 | 42
Hepatitis 1 | 61
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Idiopathic Membranous Glomerulonephritis 1 | 18
Idiopathic pulmonary fibrosis 1 | 21
Keratoconus 1 | 49
Meningeal Leukemia 1 | 7
Microsporidiosis 1 | 12
Myocardial Infarction 1 | 126
Obstructive sleep apnea 1 | 28
Ollier disease 1 | 15
Pharyngitis 1 | 17
Pulmonary Fibrosis 1 | 66
RAPADILINO syndrome 1 | 7
Rothmund-Thomson syndrome 1 | 22
Toxic shock syndrome 1 | 28

Tissue

Female tissues 47 | 18,647
Male tissues 47 | 17,969
Nervous System 47 | 18,561
Respiratory system 47 | 17,484
Blood and immune system 46 | 17,995
Cardiovascular System 46 | 17,958
Digestive Tract 46 | 18,473
Endocrine System 46 | 18,512
Liver and Pancreas 46 | 18,136
Skin and soft tissues 46 | 18,115
Urinary Tract 46 | 18,444

Target Family

Enzyme 36 | 4,146
Non-IDG 12 | 11,969

UniProt Keyword

Exonuclease 48 | 48
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
PAB-dependent poly(A)-specific ribonuclease subunit PAN2 PAN2 Tbio Enzyme -0.60206 3.89 74
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.03905 126.5 179
Mitochondrial genome maintenance exonuclease 1 MGME1 Tbio Enzyme -0.86557 7.27 37
Apoptosis-enhancing nuclease AEN Tbio Enzyme -1.57962 38.5 48
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.13819 136.3 864
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.44060 2815.1 550
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.13508 139.2 93
Exonuclease mut-7 homolog EXD3 Tdark Enzyme -0.45611 3.91 57
Fanconi-associated nuclease 1 FAN1 Tbio Enzyme -2.03507 106.0 79