Development Level

Tbio 102 | 11,445
Tclin 31 | 613
Tchem 18 | 1,598
Tdark 3 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
abnormal gait 4 | 69
improved glucose tolerance 4 | 79
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
increased leukocyte cell numbe... 3 | 47
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal locomotor behavior 2 | 24
abnormal sensory capabilities-... 2 | 8
decreased body length 2 | 101
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating creatini... 2 | 38
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
limb grasping 2 | 41
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
absent vibrissae 1 | 12
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16

Disease

Epilepsy 154 | 792
Carcinoma 123 | 11,493
glioblastoma 87 | 5,792
medulloblastoma, large-cell 84 | 6,241
atypical teratoid / rhabdoid tumor 79 | 5,112
ovarian cancer 77 | 8,520
ependymoma 76 | 4,679
osteosarcoma 71 | 7,950
Intellectual disability 70 | 1,016
psoriasis 65 | 6,694
adult high grade glioma 64 | 3,801
Seizures 60 | 596
group 3 medulloblastoma 58 | 4,104
Astrocytoma, Pilocytic 56 | 3,081
oligodendroglioma 55 | 2,850
primitive neuroectodermal tumor 54 | 3,035
astrocytic glioma 50 | 2,597
lung cancer 49 | 4,740
Cognitive delay 45 | 608
Global developmental delay 45 | 608
Kidney cancer 45 | 2,613
Mental and motor retardation 45 | 608
Muscle hypotonia 43 | 571
Pick disease 43 | 1,894
Autosomal recessive predisposition 42 | 1,442
lung carcinoma 41 | 2,843
subependymal giant cell astrocytoma 41 | 2,287
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Poor school performance 35 | 645
Schizophrenia 35 | 1,160
malignant mesothelioma 33 | 3,232
Breast cancer 31 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Autistic Disorder 26 | 364
Myoclonus 26 | 74
Neurodegenerative disease 26 | 414
Epileptic encephalopathy 25 | 26
invasive ductal carcinoma 25 | 2,951
Cerebellar Ataxia 24 | 304
Tonic - clonic seizures 24 | 44
Bipolar Disorder 23 | 666
Cerebral atrophy 23 | 178
pituitary cancer 23 | 1,972
Infantile onset 22 | 238
Myoclonic Epilepsies, Progressive 22 | 44
group 4 medulloblastoma 22 | 1,855
lung adenocarcinoma 21 | 2,716
non-small cell lung cancer 21 | 2,890
Electroencephalogram abnormal 20 | 101
Small head 19 | 374
Parkinson's disease 18 | 392
Status Epilepticus 18 | 98
astrocytoma 18 | 1,146
colon cancer 18 | 1,478
Cancer 17 | 2,499
Depressive disorder 17 | 409
Tremor 17 | 113
Absence Epilepsy 16 | 22
Degenerative brain disorder 16 | 100
Alzheimer's disease 15 | 658
Developmental regression 15 | 95
Hypoplasia of corpus callosum 15 | 90
Liver cancer 15 | 604
Loss of developmental milestones 15 | 95
Mental Depression 15 | 333
Mental deterioration in childhood 15 | 95
Neurodevelopmental regression 15 | 95
Psychomotor regression 15 | 95
Psychomotor regression beginning in infancy 15 | 95
Psychomotor regression in infants 15 | 95
Psychomotor regression, progressive 15 | 95
Supratentorial atrophy 15 | 94
interstitial cystitis 15 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
tuberculosis 15 | 2,010
Endometrial cancer 14 | 311
Nystagmus 14 | 317
West Syndrome 14 | 28
ductal carcinoma in situ 14 | 1,745
Atrophy of cerebellum 13 | 103
Cerebellar degeneration 13 | 103
Epilepsies, Myoclonic 13 | 32
Generalized myoclonic seizures 13 | 30
Highly variable severity 13 | 157
Infratentorial atrophy 13 | 103
Melanoma 13 | 711
Severe mental retardation (I.Q. 20-34) 13 | 99
Variable expressivity 13 | 157
breast carcinoma 13 | 1,638
Attention deficit hyperactivity disorder 12 | 278
Skin cancer 12 | 469
cystic fibrosis 12 | 1,696
primary pancreatic ductal adenocarcinoma 12 | 1,109
progressive supranuclear palsy 12 | 676
ulcerative colitis 12 | 1,819

Tissue

Endocrine System 153 | 18,159
Nervous System 153 | 16,725
Digestive Tract 151 | 17,369
Female tissues 151 | 17,400
Liver and Pancreas 150 | 16,750
Skin and soft tissues 149 | 17,230
Blood and immune system 148 | 16,909
Male tissues 147 | 17,142
Urinary Tract 145 | 16,678
Respiratory system 140 | 16,393
Cardiovascular System 134 | 15,192

Target Family

Non-IDG 61 | 12,091
Enzyme 35 | 4,145
Ion Channel 32 | 344
Transporter 12 | 473
Transcription Factor 5 | 1,400
Kinase 4 | 634
Epigenetic 2 | 242
GPCR 2 | 408
TF/Epigenetic 1 | 38

UniProt Keyword

Epilepsy 154 | 154
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Inosine triphosphate pyrophosphatase ITPA Tbio Enzyme -2.54659 339.8 215
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.09649 1238.5 222
CAD protein CAD Tchem Non-IDG -2.23887 168.4 224
Pyridoxine-5'-phosphate oxidase PNPO Tchem Enzyme -1.95803 90.7 200
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 Tclin Ion Channel -2.13205 136.0 202
Proton-associated sugar transporter A SLC45A1 Tdark Transporter -0.53372 3.40 9
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS Tbio Enzyme -2.11362 120.5 120