Development Level

Tbio 354 | 10,625
Tdark 62 | 7,003
Tchem 51 | 1,890
Tclin 21 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 22 | 633
decreased grip strength 9 | 123
preweaning lethality, incomple... 8 | 260
decreased lean body mass 7 | 195
hypoactivity 7 | 89
abnormal behavior 6 | 226
decreased body length 6 | 108
decreased total body fat amoun... 6 | 186
increased circulating alkaline... 6 | 119
decreased bone mineral density 5 | 126
decreased mean corpuscular hem... 5 | 34
increased fasted circulating g... 5 | 68
increased or absent threshold ... 5 | 128
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased circulating LDL chol... 4 | 37
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
abnormal kidney morphology 3 | 30
abnormal sleep behavior 3 | 63
decreased blood urea nitrogen ... 3 | 31
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased rib number 3 | 59
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating LDL chol... 3 | 15
increased circulating choleste... 3 | 53
increased circulating serum al... 3 | 25
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
thrombocytosis 3 | 23
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal pelvic girdle bone mo... 2 | 11
abnormal respiratory quotient 2 | 9
abnormal rib morphology 2 | 28
abnormal thoracic cage shape 2 | 3
abnormal vertebrae morphology 2 | 14
decreased Ly6C low monocyte nu... 2 | 23
decreased NK T cell number 2 | 28
decreased circulating bilirubi... 2 | 14
decreased circulating potassiu... 2 | 17
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
decreased total retina thickne... 2 | 20
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
increased body weight 2 | 42
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased circulating potassiu... 2 | 31
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased mature B cell number 2 | 12
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal motor capabilities/co... 1 | 4
abnormal retinal inner nuclear... 1 | 5
abnormal skin morphology 1 | 23
abnormal thoracic vertebrae mo... 1 | 16
decreased T cell number 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased red blood cell distr... 1 | 11
enlarged spleen 1 | 26
female infertility 1 | 34
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating fructosa... 1 | 11
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
straub tail 1 | 26

Disease

ovarian cancer 288 | 8,484
osteosarcoma 239 | 7,933
medulloblastoma, large-cell 202 | 6,234
glioblastoma 185 | 5,572
psoriasis 175 | 6,685
atypical teratoid / rhabdoid tumor 136 | 4,369
lung cancer 132 | 4,466
invasive ductal carcinoma 101 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 98 | 3,289
non-small cell lung cancer 96 | 2,798
pilocytic astrocytoma 94 | 3,086
malignant mesothelioma 91 | 3,162
oligodendroglioma 89 | 2,849
pediatric high grade glioma 88 | 2,712
lung adenocarcinoma 86 | 2,713
ependymoma 84 | 2,514
Breast cancer 83 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 83 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 81 | 2,956
lung carcinoma 79 | 2,844
subependymal giant cell astrocytoma 77 | 2,287
pancreatic cancer 72 | 2,300
primitive neuroectodermal tumor 70 | 3,031
Cancer 67 | 2,346
tuberculosis 65 | 1,557
adult high grade glioma 62 | 2,148
astrocytic glioma 62 | 2,241
group 4 medulloblastoma 62 | 1,875
interstitial cystitis 62 | 2,299
ulcerative colitis 62 | 2,087
Pick disease 61 | 1,893
Carcinoma 60 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,795
Multiple myeloma 56 | 1,327
breast carcinoma 54 | 1,614
ductal carcinoma in situ 54 | 1,745
astrocytoma 53 | 1,493
diabetes mellitus 52 | 1,663
juvenile dermatomyositis 52 | 1,189
primary pancreatic ductal adenocarcinoma 50 | 1,271
pituitary cancer 49 | 1,972
Rheumatoid Arthritis 48 | 1,160
medulloblastoma 46 | 1,524
dermatomyositis 45 | 933
cystic fibrosis 42 | 1,665
posterior fossa group A ependymoma 42 | 1,511
group 3 medulloblastoma 41 | 2,254
adrenocortical carcinoma 40 | 1,427
primary Sjogren syndrome 39 | 789
colon cancer 38 | 1,475
acute quadriplegic myopathy 37 | 1,157
atypical teratoid/rhabdoid tumor 36 | 1,095
spina bifida 35 | 1,064
Alzheimer's disease 34 | 644
active Crohn's disease 34 | 918
cutaneous lupus erythematosus 34 | 1,056
sonic hedgehog group medulloblastoma 34 | 1,482
Neurodegenerative disease 33 | 383
esophageal adenocarcinoma 33 | 737
posterior fossa group B ependymoma 33 | 1,530
Down syndrome 30 | 548
gastric carcinoma 29 | 832
Waldenstrons macroglobulinemia 28 | 765
non primary Sjogren syndrome sicca 28 | 840
Multiple Sclerosis 27 | 498
tuberculosis and treatment for 6 months 24 | 686
Duchenne muscular dystrophy 23 | 602
aldosterone-producing adenoma 23 | 664
pancreatic carcinoma 23 | 567
progressive supranuclear palsy 22 | 674
fibroadenoma 20 | 557
hereditary spastic paraplegia 20 | 313
Intellectual disability 19 | 573
Schizophrenia 19 | 501
acute myeloid leukemia 19 | 780
IGA Glomerulonephritis 18 | 454
active ulcerative colitis 18 | 477
mucosa-associated lymphoid tissue lymphoma 18 | 480
Atopic dermatitis 17 | 944
Obesity 17 | 616
Parkinson's disease 17 | 364
Asthma 16 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
Amyotrophic Lateral Sclerosis 15 | 431
Mammary Neoplasms 15 | 410
hepatocellular carcinoma 14 | 532
Dementia 13 | 129
Prostatic Neoplasms 13 | 471
interstitial lung disease 13 | 291
Autistic Disorder 12 | 320
Crohn's disease 12 | 304
Epilepsy 12 | 346
Hypersensitivity reaction type II disease 12 | 235
chronic rhinosinusitis 12 | 512
gastric cancer 12 | 430
nasopharyngeal carcinoma 12 | 1,056
sarcoidosis 12 | 358
tuberculosis and treatment for 3 months 12 | 327
Coronary artery disease 11 | 240
Hermansky-Pudlak syndrome 11 | 43

Tissue

Nervous System 474 | 18,561
Digestive Tract 473 | 18,473
Urinary Tract 473 | 18,444
Female tissues 472 | 18,647
Liver and Pancreas 472 | 18,136
Endocrine System 471 | 18,512
Male tissues 471 | 17,969
Respiratory system 470 | 17,484
Blood and immune system 469 | 17,995
Cardiovascular System 469 | 17,958
Skin and soft tissues 465 | 18,115

Target Family

Non-IDG 334 | 11,971
Enzyme 87 | 4,146
Kinase 24 | 634
Transporter 20 | 473
GPCR 12 | 406
Ion Channel 10 | 341
Transcription Factor 1 | 1,400

UniProt Keyword

Endosome 488 | 488
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Equilibrative nucleoside transporter 3 SLC29A3 Tbio Transporter -2.36515 247.3 58
Late secretory pathway protein AVL9 homolog AVL9 Tdark Non-IDG -0.62267 4.03 45
Protein DENND6B DENND6B Tbio Non-IDG 0.90 0.11 29
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ankyrin repeat domain-containing protein 13D ANKRD13D Tdark Non-IDG 0.00000 36
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91