Development Level

Tbio 413 | 11,651
Tdark 50 | 6,593
Tchem 38 | 1,388
Tclin 24 | 612

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 40 | 979
abnormal behavior 15 | 298
preweaning lethality, incomple... 15 | 499
hypoactivity 10 | 132
abnormal embryo size 9 | 220
embryonic lethality prior to o... 9 | 239
abnormal bone structure 7 | 187
decreased mean corpuscular hem... 7 | 50
decreased prepulse inhibition 7 | 82
hyperactivity 7 | 148
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
increased circulating alkaline... 6 | 122
increased fasted circulating g... 6 | 76
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
decreased bone mineral density 5 | 126
decreased circulating choleste... 5 | 93
decreased leukocyte cell numbe... 5 | 73
increased circulating HDL chol... 5 | 80
increased lean body mass 5 | 172
increased mean corpuscular vol... 5 | 92
increased or absent threshold ... 5 | 101
abnormal behavioral response t... 4 | 66
abnormal craniofacial morpholo... 4 | 33
abnormal neural tube closure 4 | 46
cataract 4 | 92
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased lymphocyte cell numb... 4 | 83
increased bone mineral density 4 | 72
increased circulating choleste... 4 | 66
increased startle reflex 4 | 112
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
abnormal hindbrain morphology 3 | 10
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
decreased blood urea nitrogen ... 3 | 51
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased mean corpuscular vol... 3 | 79
decreased total retina thickne... 3 | 17
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased body length 3 | 32
increased body weight 3 | 25
increased bone mineral content 3 | 108
increased circulating LDL chol... 3 | 13
increased circulating calcium ... 3 | 34
increased circulating iron lev... 3 | 30
increased circulating serum al... 3 | 22
increased circulating total pr... 3 | 28
increased heart weight 3 | 62
increased neutrophil cell numb... 3 | 46
short tibia 3 | 97
thrombocytosis 3 | 27
abnormal body wall morphology 2 | 9
abnormal bone mineralization 2 | 38
abnormal embryo turning 2 | 31
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal midbrain development 2 | 20
abnormal midbrain morphology 2 | 10
abnormal pelvic girdle bone mo... 2 | 12
abnormal seminal vesicle morph... 2 | 114
abnormal vertebrae morphology 2 | 18
abnormal vibrissa morphology 2 | 25
absent startle reflex 2 | 24
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating potassiu... 2 | 29
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
small superior vagus ganglion 2 | 74

Disease

Carcinoma 313 | 11,493
ovarian cancer 307 | 8,520
osteosarcoma 255 | 7,950
medulloblastoma, large-cell 220 | 6,241
glioblastoma 210 | 5,792
psoriasis 195 | 6,694
atypical teratoid / rhabdoid tumor 176 | 5,112
lung cancer 149 | 4,740
ependymoma 146 | 4,679
adult high grade glioma 122 | 3,801
non-small cell lung cancer 110 | 2,890
invasive ductal carcinoma 109 | 2,951
Astrocytoma, Pilocytic 107 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 104 | 3,291
Breast cancer 102 | 3,578
oligodendroglioma 99 | 2,850
malignant mesothelioma 98 | 3,232
group 3 medulloblastoma 97 | 4,104
lung adenocarcinoma 92 | 2,716
lung carcinoma 91 | 2,843
Kidney cancer 89 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 89 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 89 | 2,989
tuberculosis 86 | 2,010
subependymal giant cell astrocytoma 84 | 2,287
pancreatic cancer 82 | 2,398
astrocytic glioma 81 | 2,597
primitive neuroectodermal tumor 80 | 3,035
Cancer 75 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 74 | 1,962
group 4 medulloblastoma 73 | 1,855
Pick disease 70 | 1,894
interstitial cystitis 70 | 2,312
breast carcinoma 63 | 1,638
ulcerative colitis 61 | 1,819
Multiple myeloma 60 | 1,332
Rheumatoid arthritis 59 | 1,191
diabetes mellitus 59 | 1,728
ductal carcinoma in situ 59 | 1,745
pituitary cancer 57 | 1,972
juvenile dermatomyositis 55 | 1,187
dermatomyositis 48 | 966
primary pancreatic ductal adenocarcinoma 48 | 1,109
adrenocortical carcinoma 47 | 1,428
cystic fibrosis 47 | 1,696
Schizophrenia 45 | 1,160
astrocytoma 43 | 1,146
colon cancer 43 | 1,478
pediatric high grade glioma 43 | 1,064
Autosomal recessive predisposition 41 | 1,442
active Crohn's disease 39 | 922
primary Sjogren syndrome 39 | 735
spina bifida 39 | 1,074
Neurodegenerative disease 38 | 414
acute quadriplegic myopathy 38 | 1,158
esophageal adenocarcinoma 37 | 737
Alzheimer's disease 35 | 658
Intellectual disability 35 | 1,016
cutaneous lupus erythematosus 35 | 1,057
non primary Sjogren syndrome sicca 34 | 891
Down syndrome 32 | 499
gastric carcinoma 32 | 807
Multiple Sclerosis 31 | 540
Waldenstrons macroglobulinemia 28 | 765
active ulcerative colitis 28 | 764
Epilepsy 27 | 792
pancreatic carcinoma 26 | 562
Bipolar Disorder 25 | 666
Duchenne muscular dystrophy 24 | 601
Liver Cirrhosis, Experimental 24 | 769
aldosterone-producing adenoma 24 | 665
sarcoidosis 24 | 370
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
hereditary spastic paraplegia 23 | 318
progressive supranuclear palsy 23 | 676
acute myeloid leukemia 22 | 783
Atopic dermatitis 21 | 952
Parkinson's disease 21 | 392
Systemic lupus erythematosus 21 | 194
Melanoma 20 | 711
fibroadenoma 20 | 559
mucosa-associated lymphoid tissue lymphoma 20 | 484
posterior fossa group A ependymoma 20 | 468
Obesity 19 | 678
Seizures 19 | 596
Breast Neoplasms 18 | 445
Cognitive delay 18 | 608
Depressive disorder 18 | 409
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 510
hepatocellular carcinoma 18 | 547
medulloblastoma 18 | 720
Crohn's disease 17 | 321
Prostatic Neoplasms 17 | 495
Skin cancer 17 | 469

Tissue

Endocrine System 503 | 18,159
Digestive Tract 501 | 17,369
Skin and soft tissues 499 | 17,230
Female tissues 498 | 17,400
Male tissues 498 | 17,142
Nervous System 497 | 16,725
Respiratory system 497 | 16,393
Liver and Pancreas 496 | 16,750
Blood and immune system 494 | 16,909
Urinary Tract 494 | 16,678
Cardiovascular System 471 | 15,192

Target Family

Non-IDG 354 | 12,091
Enzyme 95 | 4,145
Kinase 24 | 634
Transporter 22 | 473
GPCR 14 | 408
Ion Channel 13 | 344
Transcription Factor 3 | 1,400

UniProt Keyword

Endosome 525 | 525
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
C-type lectin domain family 18 member B CLEC18B Tdark Non-IDG 0.35 0.31 6
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Sodium-dependent serotonin transporter SLC6A4 Tclin Transporter -3.63283 4453.8 245
Cathepsin E CTSE Tchem Enzyme -2.33724 227.7 192
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124