Development Level

Tbio 708 | 10,625
Tdark 171 | 7,003
Tchem 152 | 1,890
Tclin 40 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 4 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 46 | 633
preweaning lethality, incomple... 18 | 260
decreased lean body mass 17 | 195
embryonic lethality prior to t... 14 | 187
decreased bone mineral content 13 | 157
abnormal behavior 11 | 226
decreased body weight 11 | 174
decreased total body fat amoun... 11 | 186
decreased bone mineral density 10 | 126
abnormal retina morphology 9 | 100
decreased circulating glucose ... 9 | 121
decreased grip strength 9 | 123
embryonic lethality prior to o... 9 | 148
increased mean corpuscular hem... 9 | 93
decreased circulating insulin ... 8 | 75
decreased circulating triglyce... 8 | 83
hypoactivity 8 | 89
increased lean body mass 8 | 107
increased or absent threshold ... 8 | 128
abnormal embryo size 7 | 112
decreased circulating HDL chol... 7 | 77
decreased circulating choleste... 7 | 85
increased bone mineral content 7 | 92
increased mean corpuscular vol... 7 | 91
increased total body fat amoun... 7 | 57
abnormal bone structure 6 | 131
abnormal retinal pigmentation 6 | 61
abnormal seminal vesicle morph... 6 | 47
decreased circulating alanine ... 6 | 53
abnormal bone mineralization 5 | 55
abnormal neural tube closure 5 | 37
abnormal testis morphology 5 | 30
decreased T cell number 5 | 31
decreased body length 5 | 108
decreased circulating aspartat... 5 | 27
decreased mean corpuscular vol... 5 | 50
enlarged heart 5 | 111
hyperactivity 5 | 108
increased heart weight 5 | 37
increased leukocyte cell numbe... 5 | 37
small testis 5 | 37
thrombocytopenia 5 | 46
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
decreased circulating LDL chol... 4 | 37
decreased circulating calcium ... 4 | 33
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
increased B cell number 4 | 23
increased circulating alkaline... 4 | 119
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
prenatal lethality prior to he... 4 | 64
abnormal coat appearance 3 | 25
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal sleep behavior 3 | 63
decreased B cell number 3 | 30
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased NK cell number 3 | 16
decreased blood urea nitrogen ... 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating free fat... 3 | 39
decreased circulating phosphat... 3 | 15
decreased granulocyte number 3 | 8
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased monocyte cell number 3 | 28
decreased rib number 3 | 59
decreased vertical activity 3 | 22
increased T cell number 3 | 15
increased blood urea nitrogen ... 3 | 44
increased body length 3 | 20
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 25
increased mean platelet volume 3 | 19
increased rib number 3 | 41
limb grasping 3 | 35
short tibia 3 | 82
shortened RR interval 3 | 19
vertebral fusion 3 | 23
abnormal epididymis morphology 2 | 31
abnormal hair growth 2 | 8
abnormal lung morphology 2 | 15
cardiovascular system phenotyp... 2 | 35
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
impaired glucose tolerance 2 | 52
increased circulating bilirubi... 2 | 16
increased circulating potassiu... 2 | 31

Disease

ovarian cancer 591 | 8,484
osteosarcoma 498 | 7,933
psoriasis 398 | 6,685
medulloblastoma, large-cell 385 | 6,234
glioblastoma 378 | 5,572
lung cancer 297 | 4,466
atypical teratoid / rhabdoid tumor 269 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 263 | 3,289
invasive ductal carcinoma 226 | 2,950
pilocytic astrocytoma 225 | 3,086
Breast cancer 212 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 209 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 199 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 193 | 1,795
lung adenocarcinoma 192 | 2,713
pediatric high grade glioma 189 | 2,712
non-small cell lung cancer 187 | 2,798
pancreatic cancer 187 | 2,300
malignant mesothelioma 183 | 3,162
lung carcinoma 180 | 2,844
oligodendroglioma 166 | 2,849
interstitial cystitis 161 | 2,299
primitive neuroectodermal tumor 157 | 3,031
subependymal giant cell astrocytoma 153 | 2,287
ulcerative colitis 151 | 2,087
ependymoma 149 | 2,514
pituitary cancer 149 | 1,972
Pick disease 133 | 1,893
ductal carcinoma in situ 133 | 1,745
diabetes mellitus 130 | 1,663
Multiple myeloma 129 | 1,327
group 4 medulloblastoma 127 | 1,875
active Crohn's disease 123 | 918
tuberculosis 120 | 1,557
adult high grade glioma 118 | 2,148
breast carcinoma 118 | 1,614
cystic fibrosis 118 | 1,665
Cancer 116 | 2,346
astrocytoma 115 | 1,493
astrocytic glioma 113 | 2,241
group 3 medulloblastoma 112 | 2,254
posterior fossa group A ependymoma 107 | 1,511
primary pancreatic ductal adenocarcinoma 98 | 1,271
adrenocortical carcinoma 95 | 1,427
juvenile dermatomyositis 92 | 1,189
medulloblastoma 89 | 1,524
Rheumatoid Arthritis 81 | 1,160
acute quadriplegic myopathy 80 | 1,157
colon cancer 79 | 1,475
Carcinoma 78 | 2,147
posterior fossa group B ependymoma 74 | 1,530
cutaneous lupus erythematosus 71 | 1,056
esophageal adenocarcinoma 68 | 737
sonic hedgehog group medulloblastoma 68 | 1,482
non primary Sjogren syndrome sicca 64 | 840
dermatomyositis 62 | 933
Atopic dermatitis 60 | 944
Prostatic Neoplasms 60 | 471
pancreatic carcinoma 59 | 567
atypical teratoid/rhabdoid tumor 58 | 1,095
nasopharyngeal carcinoma 57 | 1,056
spina bifida 56 | 1,064
Neurodegenerative disease 55 | 383
Alzheimer's disease 54 | 644
Obesity 54 | 616
primary Sjogren syndrome 54 | 789
Waldenstrons macroglobulinemia 53 | 765
progressive supranuclear palsy 52 | 674
acute myeloid leukemia 49 | 780
gastric carcinoma 49 | 832
tuberculosis and treatment for 6 months 48 | 686
Down syndrome 47 | 548
aldosterone-producing adenoma 47 | 664
Intellectual disability 44 | 573
Duchenne muscular dystrophy 43 | 602
active ulcerative colitis 43 | 477
IGA Glomerulonephritis 41 | 454
hepatocellular carcinoma 41 | 532
Multiple Sclerosis 40 | 498
hereditary spastic paraplegia 38 | 313
fibroadenoma 37 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 499
gastric cancer 36 | 430
Schizophrenia 35 | 501
chronic rhinosinusitis 35 | 512
Endometriosis 33 | 535
Peripheral Neuropathy 33 | 303
Epilepsy 29 | 346
Asthma 27 | 349
sarcoidosis 26 | 358
Amyotrophic Lateral Sclerosis 25 | 431
Congenital disorder of glycosylation 25 | 53
Liver disease 25 | 219
urothelial carcinoma 25 | 318
Liver carcinoma 24 | 217
Parkinson's disease 24 | 364
Polycystic Ovary Syndrome 24 | 332
glioblastoma multiforme 24 | 347
mucosa-associated lymphoid tissue lymphoma 24 | 480
inflammatory breast cancer 23 | 404

Tissue

Female tissues 1,044 | 18,647
Nervous System 1,044 | 18,561
Blood and immune system 1,042 | 17,995
Urinary Tract 1,038 | 18,444
Digestive Tract 1,036 | 18,473
Liver and Pancreas 1,036 | 18,136
Endocrine System 1,031 | 18,512
Male tissues 1,021 | 17,969
Skin and soft tissues 1,021 | 18,115
Cardiovascular System 1,017 | 17,958
Respiratory system 1,010 | 17,484

Target Family

Non-IDG 514 | 11,971
Enzyme 443 | 4,146
Transporter 37 | 473
Ion Channel 25 | 341
Kinase 24 | 634
Transcription Factor 21 | 1,400
GPCR 5 | 406
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Endoplasmic reticulum 1,071 | 1,071
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.67490 51004.8 5255
Epidermal growth factor receptor EGFR Tclin Kinase -3.95948 9318.1 4989
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.14885 123.8 1935
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.72307 534.1 222
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.80360 6900.5 966
Presenilin-1 PSEN1 Tchem Enzyme -3.52148 3533.8 593
Serine/threonine-protein kinase Sgk1 SGK1 Tchem Kinase -2.58862 469.9 578
Protein PML PML Tbio Non-IDG -2.57769 345.2 417
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.67244 536.6 655