Development Level

Tbio 807 | 11,651
Tdark 163 | 6,593
Tchem 109 | 1,388
Tclin 40 | 612

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 66 | 979
preweaning lethality, incomple... 41 | 499
embryonic lethality prior to t... 23 | 278
abnormal embryo size 19 | 220
embryonic lethality prior to o... 17 | 239
increased total body fat amoun... 15 | 134
abnormal bone structure 14 | 187
decreased lean body mass 14 | 135
increased startle reflex 14 | 112
decreased bone mineral content 13 | 151
abnormal behavior 12 | 298
decreased vertical activity 12 | 208
embryonic growth retardation 12 | 106
decreased body weight 11 | 161
hypoactivity 11 | 132
increased lean body mass 11 | 172
decreased circulating glucose ... 10 | 126
abnormal seminal vesicle morph... 9 | 114
decreased total body fat amoun... 9 | 207
enlarged heart 9 | 210
increased leukocyte cell numbe... 9 | 47
decreased blood urea nitrogen ... 8 | 51
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 68
decreased circulating triglyce... 8 | 79
decreased grip strength 8 | 116
hyperactivity 8 | 148
increased mean corpuscular vol... 8 | 92
abnormal heart morphology 7 | 162
decreased circulating choleste... 7 | 93
abnormal retina morphology 6 | 71
abnormal testis morphology 6 | 43
decreased circulating insulin ... 6 | 76
decreased prepulse inhibition 6 | 82
increased circulating alkaline... 6 | 122
increased or absent threshold ... 6 | 101
increased prepulse inhibition 6 | 32
thrombocytopenia 6 | 56
abnormal gait 5 | 69
decreased circulating alanine ... 5 | 47
decreased hemoglobin content 5 | 68
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased mean corpuscular hem... 5 | 96
pallor 5 | 34
small testis 5 | 58
abnormal eye morphology 4 | 68
abnormal joint morphology 4 | 23
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
abnormal sleep behavior 4 | 70
cataract 4 | 92
decreased body length 4 | 101
decreased circulating LDL chol... 4 | 38
decreased circulating alkaline... 4 | 46
decreased circulating aspartat... 4 | 34
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased erythrocyte cell num... 4 | 62
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular vol... 4 | 79
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
increased circulating choleste... 4 | 66
increased mean platelet volume 4 | 45
increased monocyte cell number 4 | 63
increased red blood cell distr... 4 | 34
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
syndactyly 4 | 23
vertebral fusion 4 | 23
abnormal embryo turning 3 | 31
abnormal epididymis morphology 3 | 42
abnormal hair growth 3 | 10
abnormal kidney morphology 3 | 65
abnormal lung morphology 3 | 26
abnormal vibrissa morphology 3 | 25
anophthalmia 3 | 33
decreased T cell number 3 | 15
decreased caudal vertebrae num... 3 | 53
decreased circulating amylase ... 3 | 28
decreased circulating creatini... 3 | 39
decreased circulating sodium l... 3 | 22
decreased circulating total pr... 3 | 49
decreased eosinophil cell numb... 3 | 24
decreased fasted circulating g... 3 | 65
decreased hematocrit 3 | 46
impaired glucose tolerance 3 | 75
impaired pupillary reflex 3 | 26
improved glucose tolerance 3 | 79
increased anti-nuclear antigen... 3 | 19
increased circulating HDL chol... 3 | 80
increased circulating calcium ... 3 | 34
increased circulating free fat... 3 | 20
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
pale yolk sac 3 | 25

Disease

Carcinoma 687 | 11,493
ovarian cancer 617 | 8,520
osteosarcoma 521 | 7,950
psoriasis 414 | 6,694
glioblastoma 412 | 5,792
medulloblastoma, large-cell 403 | 6,241
atypical teratoid / rhabdoid tumor 327 | 5,112
lung cancer 311 | 4,740
ependymoma 288 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 271 | 3,291
Breast cancer 240 | 3,578
Astrocytoma, Pilocytic 239 | 3,081
adult high grade glioma 232 | 3,801
invasive ductal carcinoma 230 | 2,951
group 3 medulloblastoma 227 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 217 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 215 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 202 | 2,955
pancreatic cancer 198 | 2,398
non-small cell lung cancer 196 | 2,890
malignant mesothelioma 195 | 3,232
lung adenocarcinoma 194 | 2,716
lung carcinoma 182 | 2,843
oligodendroglioma 172 | 2,850
interstitial cystitis 164 | 2,312
primitive neuroectodermal tumor 164 | 3,035
subependymal giant cell astrocytoma 157 | 2,287
tuberculosis 155 | 2,010
pituitary cancer 152 | 1,972
Pick disease 138 | 1,894
diabetes mellitus 137 | 1,728
Autosomal recessive predisposition 136 | 1,442
astrocytic glioma 135 | 2,597
ductal carcinoma in situ 135 | 1,745
Multiple myeloma 133 | 1,332
ulcerative colitis 133 | 1,819
group 4 medulloblastoma 130 | 1,855
cystic fibrosis 127 | 1,696
Cancer 126 | 2,499
active Crohn's disease 126 | 922
Kidney cancer 124 | 2,613
breast carcinoma 122 | 1,638
astrocytoma 104 | 1,146
adrenocortical carcinoma 99 | 1,428
Rheumatoid arthritis 94 | 1,191
juvenile dermatomyositis 93 | 1,187
pediatric high grade glioma 92 | 1,064
acute quadriplegic myopathy 85 | 1,158
primary pancreatic ductal adenocarcinoma 85 | 1,109
colon cancer 84 | 1,478
Intellectual disability 74 | 1,016
Schizophrenia 74 | 1,160
cutaneous lupus erythematosus 73 | 1,057
non primary Sjogren syndrome sicca 73 | 891
active ulcerative colitis 71 | 764
esophageal adenocarcinoma 70 | 737
Epilepsy 66 | 792
Prostatic Neoplasms 63 | 495
Atopic dermatitis 61 | 952
spina bifida 60 | 1,074
Alzheimer's disease 59 | 658
dermatomyositis 59 | 966
nasopharyngeal carcinoma 59 | 1,058
Neurodegenerative disease 58 | 414
Obesity 58 | 678
pancreatic carcinoma 58 | 562
Liver Cirrhosis, Experimental 55 | 769
acute myeloid leukemia 54 | 783
Waldenstrons macroglobulinemia 53 | 765
progressive supranuclear palsy 53 | 676
primary Sjogren syndrome 52 | 735
gastric carcinoma 50 | 807
Seizures 49 | 596
Muscle hypotonia 48 | 571
Dull intelligence 47 | 645
Low intelligence 47 | 645
Mental Retardation 47 | 645
Mental deficiency 47 | 645
Poor school performance 47 | 645
aldosterone-producing adenoma 47 | 665
Down syndrome 45 | 499
hepatocellular carcinoma 45 | 547
Duchenne muscular dystrophy 44 | 601
Cognitive delay 42 | 608
Global developmental delay 42 | 608
Mental and motor retardation 42 | 608
Multiple Sclerosis 41 | 540
Bipolar Disorder 40 | 666
hereditary spastic paraplegia 40 | 318
medulloblastoma 39 | 720
sarcoidosis 38 | 370
Melanoma 37 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 37 | 510
fibroadenoma 37 | 559
gastric cancer 37 | 459
posterior fossa group A ependymoma 36 | 468
chronic rhinosinusitis 35 | 512
Endometriosis 34 | 540
Hypertension 34 | 396
Chemical and Drug Induced Liver Injury 33 | 195

Tissue

Endocrine System 1,057 | 18,159
Digestive Tract 1,056 | 17,369
Female tissues 1,052 | 17,400
Skin and soft tissues 1,047 | 17,230
Liver and Pancreas 1,045 | 16,750
Male tissues 1,042 | 17,142
Urinary Tract 1,034 | 16,678
Blood and immune system 1,030 | 16,909
Nervous System 1,024 | 16,725
Respiratory system 1,013 | 16,393
Cardiovascular System 958 | 15,192

Target Family

Non-IDG 548 | 12,091
Enzyme 454 | 4,145
Transporter 38 | 473
Ion Channel 27 | 344
Kinase 24 | 634
Transcription Factor 21 | 1,400
GPCR 5 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Endoplasmic reticulum 1,119 | 1,119
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.20455 130.6 2273
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Protein PML PML Tbio Non-IDG -2.63785 373.8 470
Serine/threonine-protein kinase Sgk1 SGK1 Tchem Kinase -2.67979 543.7 642
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766