Development Level

Tbio 59 | 11,651
Tdark 15 | 6,593
Tchem 8 | 1,388

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased bone mineral density 3 | 126
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
decreased circulating insulin ... 2 | 76
increased startle reflex 2 | 112
abnormal autopod morphology 1 | 1
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal motor capabilities-co... 1 | 5
abnormal nail morphology 1 | 8
abnormal response to novel obj... 1 | 1
abnormal retina morphology 1 | 71
abnormal spine curvature 1 | 9
abnormal stomach morphology 1 | 10
abnormal tail length 1 | 3
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 18
absent spleen 1 | 3
brachydactyly 1 | 19
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
fusion of vertebral arches 1 | 7
hydrometra 1 | 53
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged ST segment 1 | 36
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

osteosarcoma 44 | 7,950
Carcinoma 40 | 11,493
ovarian cancer 37 | 8,520
psoriasis 30 | 6,694
medulloblastoma, large-cell 28 | 6,241
group 3 medulloblastoma 23 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
lung cancer 21 | 4,740
glioblastoma 20 | 5,792
Cancer 19 | 2,499
atypical teratoid / rhabdoid tumor 18 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Breast cancer 15 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
malignant mesothelioma 14 | 3,232
Autosomal recessive predisposition 12 | 1,442
invasive ductal carcinoma 12 | 2,951
astrocytic glioma 11 | 2,597
colon cancer 11 | 1,478
ependymoma 11 | 4,679
pancreatic cancer 11 | 2,398
Kidney cancer 10 | 2,613
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
primitive neuroectodermal tumor 10 | 3,035
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
oligodendroglioma 9 | 2,850
Waldenstrons macroglobulinemia 8 | 765
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 1,819
Atopic dermatitis 7 | 952
adrenocortical carcinoma 7 | 1,428
astrocytoma 7 | 1,146
non primary Sjogren syndrome sicca 7 | 891
pancreatic carcinoma 7 | 562
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
tuberculosis 7 | 2,010
Fanconi anemia 6 | 56
Multiple myeloma 6 | 1,332
group 4 medulloblastoma 6 | 1,855
hepatocellular carcinoma 6 | 547
interstitial cystitis 6 | 2,312
lung carcinoma 6 | 2,843
nasopharyngeal carcinoma 6 | 1,058
Bloom syndrome 5 | 29
Cockayne syndrome 5 | 60
Fatigue 5 | 182
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
Short stature 5 | 531
Small head 5 | 374
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group F 5 | 22
Xeroderma pigmentosum group G 5 | 16
ductal carcinoma in situ 5 | 1,745
gastric cancer 5 | 459
pituitary cancer 5 | 1,972
Basal cell carcinoma 4 | 54
Basal cell nevi 4 | 23
Cognitive delay 4 | 608
Death in early childhood 4 | 82
Death in infancy 4 | 82
Dull intelligence 4 | 645
Epilepsy 4 | 792
Fetal Growth Retardation 4 | 189
Global developmental delay 4 | 608
Hypoplastic mandible condyle 4 | 275
Infant, Small for Gestational Age 4 | 176
Intellectual disability 4 | 1,016
Intrauterine retardation 4 | 176
Low intelligence 4 | 645
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Micrognathism 4 | 275
Muscle Hypertonia 4 | 88
Muscle Spasticity 4 | 195
Muscle hypotonia 4 | 571
Poor school performance 4 | 645
Thrombocytopenia 4 | 197
breast carcinoma 4 | 1,638
diabetes mellitus 4 | 1,728
inflammatory breast cancer 4 | 286
medulloblastoma 4 | 720
primary Sjogren syndrome 4 | 735
Depressive disorder 3 | 409
Endometriosis 3 | 540
Male infertility 3 | 206
Pick disease 3 | 1,894
acute quadriplegic myopathy 3 | 1,158
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
pediatric high grade glioma 3 | 1,064
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074

Tissue

Digestive Tract 72 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Blood and immune system 70 | 16,909
Male tissues 69 | 17,142
Skin and soft tissues 69 | 17,230
Respiratory system 68 | 16,393
Liver and Pancreas 67 | 16,750
Nervous System 67 | 16,725
Urinary Tract 67 | 16,678
Cardiovascular System 64 | 15,192

Target Family

Enzyme 65 | 4,145
Non-IDG 15 | 12,091
Epigenetic 1 | 242
Kinase 1 | 634

UniProt Keyword

Endonuclease 82 | 82
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Flap endonuclease 1 FEN1 Tchem Enzyme -2.79171 617.0 406
Endoribonuclease Dicer DICER1 Tbio Enzyme -3.34177 2054.3 327
Ras GTPase-activating protein-binding protein 1 G3BP1 Tbio Enzyme -2.01627 111.4 426
DNA repair endonuclease XPF ERCC4 Tbio Enzyme -1.91482 69.2 286
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.47746 2989.0 646
DNA excision repair protein ERCC-1 ERCC1 Tbio Non-IDG -3.02686 1089.9 878
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Mismatch repair endonuclease PMS2 PMS2 Tbio Enzyme -2.19299 339.5 339
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37