Development Level

Tbio 40 | 11,445
Tclin 5 | 613
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased body weight 2 | 161
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cleft palate 1 | 8
corneal opacity 1 | 32
cyanosis 1 | 7
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
fused cornea and lens 1 | 5
impaired pupillary reflex 1 | 26
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
long tibia 1 | 25
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58

Disease

Carcinoma 38 | 11,493
ovarian cancer 29 | 8,520
psoriasis 26 | 6,694
non-small cell lung cancer 21 | 2,890
osteosarcoma 19 | 7,950
Cancer 18 | 2,499
Breast cancer 17 | 3,578
Palmoplantar keratosis 17 | 74
Kidney cancer 16 | 2,613
lung cancer 16 | 4,740
medulloblastoma, large-cell 16 | 6,241
Autosomal recessive predisposition 15 | 1,442
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 15 | 4,679
glioblastoma 15 | 5,792
Hypodontia 13 | 81
breast carcinoma 13 | 1,638
Dystrophia unguium 12 | 53
Ectodermal Dysplasia 12 | 14
Hypotrichosis 12 | 47
interstitial cystitis 12 | 2,312
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
spina bifida 12 | 1,074
Alopecia 11 | 115
Dental caries 11 | 164
Fine hair 11 | 42
Frontal bossing 11 | 157
Rotting teeth 11 | 73
Short stature 11 | 531
Sparse hair 11 | 59
Thin, sparse hair 11 | 59
adult high grade glioma 11 | 3,801
ductal carcinoma in situ 11 | 1,745
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Ichthyoses 10 | 41
Tooth Abnormalities 10 | 69
Tooth agenesis 10 | 44
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
Downward slant of palpebral fissure 9 | 158
Dry skin 9 | 75
Dystrophic fingernails 9 | 18
Hyperhidrosis disorder 9 | 81
Hypohidrosis 9 | 34
Hypoplastic mandible condyle 9 | 275
Increased sweating 9 | 81
Intellectual disability 9 | 1,016
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Nail dysplasia 9 | 52
Strabismus 9 | 270
Sweating 9 | 81
Xerosis 9 | 75
cystic fibrosis 9 | 1,696
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
primary pancreatic ductal adenocarcinoma 9 | 1,109
subependymal giant cell astrocytoma 9 | 2,287
Blepharoptosis 8 | 231
Brittle hair 8 | 25
Cryptorchidism 8 | 296
Dental abnormalities 8 | 60
Dull intelligence 8 | 645
Fractured hair 8 | 25
Fragile hair 8 | 25
Keratosis 8 | 37
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Onychogryposis 8 | 13
Orbital separation excessive 8 | 244
Poor school performance 8 | 645
Reduced tensile strength of hair 8 | 25
Sparse eyebrow 8 | 42
colon cancer 8 | 1,478
group 4 medulloblastoma 8 | 1,855
primitive neuroectodermal tumor 8 | 3,035
Absence of eyebrows 7 | 31
Anteverted nostril 7 | 191
Aplasia/Hypoplasia of the eyebrow 7 | 31
Brachydactyly 7 | 156
Curvature of spine 7 | 282
High forehead 7 | 102
Hypohidrotic ectodermal dysplasia 7 | 15
Leukoplakia, Oral 7 | 20
Melanoma 7 | 711
Short nose 7 | 132
Skin hyperelastic 7 | 32
Small nose 7 | 132
Sparse or absent eyebrows 7 | 31
Sparse/absent eyebrows 7 | 31
Tall forehead 7 | 102
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
ulcerative colitis 7 | 1,819

Tissue

Endocrine System 48 | 18,159
Female tissues 47 | 17,400
Skin and soft tissues 46 | 17,230
Blood and immune system 45 | 16,909
Digestive Tract 45 | 17,369
Male tissues 45 | 17,142
Urinary Tract 45 | 16,678
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 35 | 12,091
Kinase 7 | 634
Transcription Factor 5 | 1,400
Enzyme 1 | 4,145

UniProt Keyword

Ectodermal dysplasia 48 | 48
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ectodysplasin-A receptor-associated adapter protein EDARADD Tbio Non-IDG -1.44120 23.1 27
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Collagen alpha-1(XI) chain COL11A1 Tbio Non-IDG -2.15516 138.4 96
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Plakophilin-1 PKP1 Tbio Non-IDG -1.86062 76.3 103
Keratinocyte differentiation factor 1 KDF1 Tbio Non-IDG -0.26977 2.27 78
Keratin, type II cytoskeletal 74 KRT74 Tbio Non-IDG -2.24212 165.9 40
Keratin, type II cytoskeletal 6A KRT6A Tbio Non-IDG -1.89234 80.6 339
Keratin, type I cytoskeletal 14 KRT14 Tbio Non-IDG -2.90790 721.6 780