Development Level

Tbio 73 | 11,178
Tdark 17 | 6,569
Tchem 3 | 1,885

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 5 | 278
decreased circulating choleste... 4 | 93
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased vertical activity 3 | 208
abnormal embryo size 2 | 220
abnormal seminal vesicle morph... 2 | 114
decreased circulating free fat... 2 | 31
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
increased mean corpuscular hem... 2 | 96
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lymph node morphology 1 | 3
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased cornea thickness 1 | 2
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating free fat... 1 | 20
increased cornea thickness 1 | 1
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
preweaning lethality, incomple... 1 | 499
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

ovarian cancer 66 | 8,297
osteosarcoma 58 | 7,766
Carcinoma 40 | 11,192
glioblastoma 36 | 5,635
medulloblastoma, large-cell 28 | 6,086
atypical teratoid / rhabdoid tumor 25 | 4,971
psoriasis 25 | 6,514
Breast cancer 22 | 3,469
Multiple myeloma 22 | 1,296
ependymoma 22 | 4,559
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,872
lung adenocarcinoma 19 | 2,627
adult high grade glioma 17 | 3,701
lung cancer 16 | 4,607
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,911
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,204
diabetes mellitus 14 | 1,683
group 3 medulloblastoma 14 | 4,002
group 4 medulloblastoma 14 | 1,806
pancreatic cancer 14 | 2,322
Astrocytoma, Pilocytic 13 | 3,006
Kidney cancer 13 | 2,548
acute quadriplegic myopathy 13 | 1,133
astrocytic glioma 13 | 2,530
non primary Sjogren syndrome sicca 13 | 861
primitive neuroectodermal tumor 13 | 2,957
Pick disease 12 | 1,856
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,902
malignant mesothelioma 12 | 3,135
astrocytoma 11 | 1,113
dermatomyositis 11 | 941
invasive ductal carcinoma 11 | 2,867
non-small cell lung cancer 11 | 2,799
juvenile dermatomyositis 10 | 1,147
oligodendroglioma 10 | 2,768
pancreatic carcinoma 10 | 555
tuberculosis 10 | 1,963
Rheumatoid arthritis 9 | 1,156
spina bifida 9 | 1,053
breast carcinoma 8 | 1,589
active Crohn's disease 7 | 882
ulcerative colitis 7 | 1,765
Waldenstrons macroglobulinemia 6 | 742
colon cancer 6 | 1,428
cystic fibrosis 6 | 1,629
pediatric high grade glioma 6 | 1,035
pituitary cancer 6 | 1,915
primary pancreatic ductal adenocarcinoma 6 | 1,071
Alzheimer's disease 5 | 640
Autosomal recessive predisposition 5 | 1,407
Congenital dyserythropoietic anemia 5 | 18
Duchenne muscular dystrophy 5 | 587
acute myeloid leukemia 5 | 760
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 492
cutaneous lupus erythematosus 5 | 1,016
hepatocellular carcinoma 5 | 536
interstitial cystitis 5 | 2,237
lung carcinoma 5 | 2,755
progressive supranuclear palsy 5 | 656
Cancer 4 | 2,388
Chylomicron retention disease 4 | 11
Intellectual disability 4 | 998
gastric cancer 4 | 445
sonic hedgehog group medulloblastoma 4 | 459
tuberculosis and treatment for 6 months 4 | 399
Acquired scoliosis 3 | 274
Big calvaria 3 | 147
Bipolar Disorder 3 | 646
Cognitive delay 3 | 596
Curvature of spine 3 | 275
Dull intelligence 3 | 634
Gaucher disease type 1 3 | 177
Global developmental delay 3 | 596
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Low intelligence 3 | 634
Menkes disease 3 | 19
Mental Retardation 3 | 634
Mental and motor retardation 3 | 596
Mental deficiency 3 | 634
Osteochondrodysplasias 3 | 72
Poor school performance 3 | 634
Short stature 3 | 514
Stomatitis 3 | 21
Type 2 diabetes mellitus 3 | 268
active ulcerative colitis 3 | 736
esophageal adenocarcinoma 3 | 696
gastric carcinoma 3 | 781
hereditary spastic paraplegia 3 | 313
posterior fossa group A ependymoma 3 | 456
posterior fossa group B ependymoma 3 | 406
subependymal giant cell astrocytoma 3 | 2,230
Atopic dermatitis 2 | 915
Attention deficit hyperactivity disorder 2 | 272
Broad flat nasal bridge 2 | 232
Failure to gain weight 2 | 359
Nasal bridge wide 2 | 232
Polycystic ovary syndrome 2 | 348
adrenocortical carcinoma 2 | 1,385

Tissue

Blood and immune system 92 | 16,909
Cardiovascular System 92 | 15,192
Digestive Tract 92 | 17,369
Endocrine System 92 | 18,159
Female tissues 92 | 17,400
Liver and Pancreas 92 | 16,750
Male tissues 92 | 17,142
Nervous System 92 | 16,725
Respiratory system 92 | 16,393
Skin and soft tissues 92 | 17,230
Urinary Tract 92 | 16,678

Target Family

Non-IDG 73 | 12,091
Enzyme 18 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

UniProt Keyword

ER-Golgi transport 93 | 93
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein YIF1A YIF1A Tdark Non-IDG -1.22548 14.6 29
Ras-related protein Rab-6A RAB6A Tbio Enzyme -2.09488 134.5 207
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
Golgi SNAP receptor complex member 1 GOSR1 Tbio Non-IDG -1.32565 21.7 128
A disintegrin and metalloproteinase with thrombospondin motifs 9 ADAMTS9 Tbio Enzyme -1.58561 39.6 48
ADP-ribosylation factor GTPase-activating protein 3 ARFGAP3 Tbio Enzyme -1.32293 23.8 204
Reticulon-3 RTN3 Tbio Non-IDG -1.53823 40.0 137
Vesicle-trafficking protein SEC22a SEC22A Tdark Non-IDG 0.33 0.44 19
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Trafficking protein particle complex subunit 4 TRAPPC4 Tbio Non-IDG -0.87026 9.19 204