Development Level

Tbio 163 | 10,625
Tdark 37 | 7,003
Tchem 28 | 1,890
Tclin 6 | 602

Collection

Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 8 | 633
enlarged heart 5 | 111
decreased body weight 4 | 174
decreased circulating glucose ... 4 | 121
abnormal behavior 3 | 226
cardiovascular system phenotyp... 3 | 35
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased total body fat amoun... 3 | 186
increased blood urea nitrogen ... 3 | 44
abnormal bone structure 2 | 131
abnormal heart morphology 2 | 51
abnormal snout morphology 2 | 18
abnormal tooth morphology 2 | 24
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating insulin ... 2 | 75
decreased circulating total pr... 2 | 41
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased lean body mass 2 | 195
decreased prepulse inhibition 2 | 52
embryonic lethality prior to t... 2 | 187
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal brain morphology 1 | 6
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal heart left ventricle ... 1 | 20
abnormal limb bud morphology 1 | 15
abnormal liver morphology 1 | 5
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal pericardium morpholog... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin appearance 1 | 8
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 14
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating free fat... 1 | 39
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased pulmonary respirator... 1 | 4
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
edema 1 | 11
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
enlarged stomach 1 | 2
female infertility 1 | 34
hydroencephaly 1 | 6
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased spleen weight 1 | 3
increased total body fat amoun... 1 | 57
lethargy 1 | 5
long tibia 1 | 13
male infertility 1 | 62
pallor 1 | 13
short snout 1 | 4
short tibia 1 | 82
small testis 1 | 37
small thymus 1 | 11
tremors 1 | 34

Disease

psoriasis 117 | 6,685
glioblastoma 94 | 5,572
ovarian cancer 92 | 8,484
Carcinoma 85 | 2,147
medulloblastoma, large-cell 84 | 6,234
lung carcinoma 83 | 2,844
osteosarcoma 82 | 7,933
lung cancer 77 | 4,466
invasive ductal carcinoma 74 | 2,950
lung adenocarcinoma 74 | 2,713
atypical teratoid / rhabdoid tumor 71 | 4,369
pilocytic astrocytoma 70 | 3,086
interstitial cystitis 65 | 2,299
Breast cancer 63 | 3,094
non-small cell lung cancer 63 | 2,798
Cancer 57 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
oligodendroglioma 54 | 2,849
malignant mesothelioma 52 | 3,162
pancreatic cancer 52 | 2,300
pediatric high grade glioma 52 | 2,712
pituitary cancer 52 | 1,972
cystic fibrosis 43 | 1,665
breast carcinoma 42 | 1,614
ulcerative colitis 41 | 2,087
ductal carcinoma in situ 40 | 1,745
ependymoma 40 | 2,514
primary pancreatic ductal adenocarcinoma 39 | 1,271
subependymal giant cell astrocytoma 39 | 2,287
colon cancer 38 | 1,475
primitive neuroectodermal tumor 38 | 3,031
posterior fossa group A ependymoma 37 | 1,511
adrenocortical carcinoma 36 | 1,427
group 4 medulloblastoma 36 | 1,875
astrocytic glioma 35 | 2,241
adult high grade glioma 34 | 2,148
group 3 medulloblastoma 34 | 2,254
diabetes mellitus 32 | 1,663
cutaneous lupus erythematosus 31 | 1,056
Atopic dermatitis 30 | 944
gastric carcinoma 29 | 832
astrocytoma 27 | 1,493
sonic hedgehog group medulloblastoma 27 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
posterior fossa group B ependymoma 25 | 1,530
Pick disease 24 | 1,893
Duchenne muscular dystrophy 23 | 602
juvenile dermatomyositis 19 | 1,189
Vascular disease 18 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
medulloblastoma 18 | 1,524
mucosa-associated lymphoid tissue lymphoma 18 | 480
nasopharyngeal carcinoma 17 | 1,056
fibroadenoma 16 | 557
primary Sjogren syndrome 16 | 789
Alzheimer's disease 15 | 644
Mammary Neoplasms 15 | 410
atypical teratoid/rhabdoid tumor 15 | 1,095
non-small cell lung carcinoma 15 | 413
Kidney disease 14 | 396
dermatomyositis 14 | 933
esophageal adenocarcinoma 14 | 737
tuberculosis 14 | 1,557
Asthma 13 | 349
Rheumatoid Arthritis 13 | 1,160
Kidney cancer 12 | 118
non-inflammatory breast cancer 12 | 208
pancreatic carcinoma 12 | 567
Cerebrovascular disease 11 | 231
Heart disease 11 | 279
spina bifida 11 | 1,064
Atherosclerosis 10 | 275
Autistic Disorder 10 | 320
Coronary artery disease 10 | 240
Endometriosis 10 | 535
Hypertension 10 | 287
Multiple Sclerosis 10 | 498
Obesity 10 | 616
active Crohn's disease 10 | 918
acute quadriplegic myopathy 10 | 1,157
glioblastoma multiforme 10 | 347
nephrosclerosis 10 | 329
non primary Sjogren syndrome sicca 10 | 840
urothelial carcinoma 10 | 318
Prostatic Neoplasms 9 | 471
Schizophrenia 9 | 501
Thrombophilia 9 | 36
Thrombosis 9 | 42
acute myeloid leukemia 9 | 780
aldosterone-producing adenoma 9 | 664
head and neck cancer 9 | 270
Acquired metabolic disease 8 | 267
Becker muscular dystrophy 8 | 187
Down syndrome 8 | 548
IGA Glomerulonephritis 8 | 454
Juvenile arthritis 8 | 124
Peripheral Neuropathy 8 | 303
active ulcerative colitis 8 | 477

Tissue

Liver and Pancreas 227 | 18,136
Male tissues 226 | 17,969
Nervous System 226 | 18,561
Digestive Tract 225 | 18,473
Endocrine System 224 | 18,512
Female tissues 224 | 18,647
Urinary Tract 224 | 18,444
Cardiovascular System 222 | 17,958
Skin and soft tissues 221 | 18,115
Blood and immune system 219 | 17,995
Respiratory system 215 | 17,484

Target Family

Non-IDG 183 | 11,971
Enzyme 40 | 4,146
GPCR 9 | 406
Kinase 2 | 634

UniProt Keyword

EGF-like domain 234 | 234
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Tenascin-N TNN Tbio Non-IDG -1.77329 68.8 63
Hyaluronidase-3 HYAL3 Tbio Enzyme -0.90097 7.70 99
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.32178 220.1 155
Signal peptide, CUB and EGF-like domain-containing protein 1 SCUBE1 Tbio Non-IDG -1.25952 24.9 65
Delta-like protein 3 DLL3 Tbio Non-IDG -1.58510 42.7 181
Contactin-associated protein-like 5 CNTNAP5 Tdark Non-IDG -0.52403 3.89 4
Complement component C9 C9 Tbio Non-IDG -1.85517 71.0 229