Development Level

Tbio 24 | 11,445
Tdark 10 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal lung morphology 2 | 26
decreased total body fat amoun... 2 | 207
abnormal coat appearance 1 | 31
abnormal ileum morphology 1 | 2
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
edema 1 | 59
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

Carcinoma 21 | 11,493
ependymoma 19 | 4,679
osteosarcoma 16 | 7,950
ovarian cancer 16 | 8,520
Breast cancer 15 | 3,578
Liver cancer 15 | 604
chronic rhinosinusitis 13 | 512
Kidney cancer 12 | 2,613
Primary ciliary dyskinesia 12 | 76
nasopharyngeal carcinoma 12 | 1,058
atypical teratoid / rhabdoid tumor 11 | 5,112
psoriasis 10 | 6,694
Endometrial cancer 9 | 311
medulloblastoma, large-cell 9 | 6,241
Situs Inversus 8 | 65
glioblastoma 8 | 5,792
group 3 medulloblastoma 8 | 4,104
Male infertility 7 | 206
Melanoma 7 | 711
lung adenocarcinoma 7 | 2,716
pancreatic cancer 7 | 2,398
Ciliary Dyskinesia, Primary, 1 6 | 27
Kartagener Syndrome 6 | 38
Pick disease 6 | 1,894
lung carcinoma 6 | 2,843
malignant mesothelioma 6 | 3,232
Ciliary Motility Disorders 5 | 38
DOID:2627 5 | 94
Multiple myeloma 5 | 1,332
Skin cancer 5 | 469
adult high grade glioma 5 | 3,801
lung cancer 5 | 4,740
primitive neuroectodermal tumor 5 | 3,035
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Right atrial isomerism 4 | 29
astrocytic glioma 4 | 2,597
juvenile dermatomyositis 4 | 1,187
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
Bronchiectasis 3 | 64
Craniopharyngioma 3 | 16
Endometriosis 3 | 540
Immune system cancer 3 | 140
Large intestine cancer 3 | 126
Recurrent respiratory infections 3 | 141
Sinusitis 3 | 65
Situs ambiguus 3 | 25
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
cystic fibrosis and chronic rhinosinusitis 3 | 214
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
fibroadenoma 3 | 559
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
Amyotrophic lateral sclerosis 2 | 451
Asphyxiating thoracic dystrophy 2 | 44
Bipolar Disorder 2 | 666
Cardiovascular system disease 2 | 246
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Ellis-Van Creveld syndrome 2 | 19
Jeune thoracic dystrophy 2 | 10
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Nonepidermolytic palmoplantar keratoderma 2 | 12
Polydactyly 2 | 107
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Short Rib-Polydactyly Syndrome 2 | 13
Slow progression 2 | 89
Weight Gain 2 | 100
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
non-small cell lung carcinoma 2 | 317
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group B ependymoma 2 | 416
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
Apathy 1 | 16
Appendicitis 1 | 15
Communicating Hydrocephalus 1 | 8
Complement deficiency 1 | 14
Cri-Du-Chat syndrome 1 | 16
Dyslipidemias 1 | 27
Frequent falls 1 | 12
Immotile cilia 1 | 2
Oculogyric crisis 1 | 4
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Sleeping sickness 1 | 37
Vocal Cord Paralysis 1 | 7

Tissue

Endocrine System 34 | 18,159
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Digestive Tract 32 | 17,369
Female tissues 32 | 17,400
Male tissues 31 | 17,142
Nervous System 30 | 16,725
Urinary Tract 29 | 16,678
Blood and immune system 28 | 16,909
Liver and Pancreas 28 | 16,750
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 34 | 12,091

UniProt Keyword

Dynein 34 | 34
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dynein intermediate chain 1, axonemal DNAI1 Tbio Non-IDG -1.90654 78.9 160
Dynein heavy chain 9, axonemal DNAH9 Tbio Non-IDG -1.53036 32.0 31
Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Tbio Non-IDG -0.61455 3.87 95
Tctex1 domain-containing protein 3 TCTE3 Tdark Non-IDG -0.69992 5.53 22
Dynein light chain Tctex-type 1 DYNLT1 Tbio Non-IDG -2.30647 213.2 45
Dynein heavy chain 7, axonemal DNAH7 Tbio Non-IDG -0.46489 2.39 17
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Dynein light chain Tctex-type 3 DYNLT3 Tbio Non-IDG -0.83800 6.25 70
Dynein heavy chain 10, axonemal DNAH10 Tdark Non-IDG -0.45693 2.56 10
Dynein heavy chain 12, axonemal DNAH12 Tbio Non-IDG -1.22536 17.6 44