Development Level

Tbio 119 | 11,445
Tchem 18 | 1,598
Tclin 6 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to o... 8 | 239
decreased lean body mass 7 | 135
decreased bone mineral content 6 | 151
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
increased total body fat amoun... 5 | 134
abnormal lens morphology 4 | 81
decreased body length 4 | 101
decreased body weight 4 | 161
decreased bone mineral density 4 | 126
abnormal bone structure 3 | 187
abnormal femur morphology 3 | 14
abnormal joint morphology 3 | 23
cataract 3 | 92
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
increased or absent threshold ... 3 | 101
male infertility 3 | 123
abnormal humerus morphology 2 | 11
abnormal tibia morphology 2 | 14
abnormal ulna morphology 2 | 8
cardiovascular system phenotyp... 2 | 36
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
female infertility 2 | 60
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased grip strength 2 | 41
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
brachydactyly 1 | 19
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
mammalian phenotype 1 | 17
prolonged RR interval 1 | 8
short tibia 1 | 97
syndactyly 1 | 23
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 111 | 11,493
ovarian cancer 89 | 8,520
Autosomal recessive predisposition 80 | 1,442
osteosarcoma 70 | 7,950
Short stature 68 | 531
lung cancer 58 | 4,740
medulloblastoma, large-cell 58 | 6,241
psoriasis 56 | 6,694
glioblastoma 53 | 5,792
Intellectual disability 52 | 1,016
atypical teratoid / rhabdoid tumor 49 | 5,112
Breast cancer 43 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
Hypoplastic mandible condyle 41 | 275
Mandibular hypoplasia 41 | 275
Micrognathism 41 | 275
Kidney cancer 39 | 2,613
group 3 medulloblastoma 39 | 4,104
invasive ductal carcinoma 39 | 2,951
malignant mesothelioma 39 | 3,232
Dull intelligence 38 | 645
Low intelligence 38 | 645
Mental Retardation 38 | 645
Mental deficiency 38 | 645
Poor school performance 38 | 645
ependymoma 38 | 4,679
Delayed bone age 37 | 136
Astrocytoma, Pilocytic 36 | 3,081
Acquired scoliosis 35 | 281
Curvature of spine 35 | 282
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
Brachydactyly 34 | 156
Cancer 34 | 2,499
adult high grade glioma 34 | 3,801
Fetal Growth Retardation 33 | 189
Infant, Small for Gestational Age 33 | 176
Intrauterine retardation 33 | 176
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
Cognitive delay 32 | 608
Global developmental delay 32 | 608
Mental and motor retardation 32 | 608
Cryptorchidism 31 | 296
Frontal bossing 31 | 157
Small head 30 | 374
non-small cell lung cancer 30 | 2,890
lung adenocarcinoma 29 | 2,716
pituitary cancer 29 | 1,972
Hypotrophic malar bone 28 | 129
Malar flattening 28 | 129
Short neck 27 | 140
Concave bridge of nose 26 | 195
Depressed nasal bridge 26 | 195
Depressed nasal root/bridge 26 | 195
Micromelia 26 | 58
Muscle hypotonia 26 | 571
ductal carcinoma in situ 26 | 1,745
Dwarfism 25 | 37
Platyspondyly 25 | 56
primitive neuroectodermal tumor 25 | 3,035
Anteverted nostril 24 | 191
Short nose 24 | 132
Small nose 24 | 132
colon cancer 24 | 1,478
pancreatic cancer 24 | 2,398
Cataract 23 | 297
Long philtrum 23 | 137
breast carcinoma 23 | 1,638
oligodendroglioma 23 | 2,850
Orbital separation excessive 22 | 244
Sensorineural Hearing Loss (disorder) 22 | 284
Short hands 22 | 50
adrenocortical carcinoma 22 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Bilateral fifth finger clinodactyly 21 | 110
Curvature of little finger 21 | 110
Joint hyperflexibility 21 | 78
Kyphosis deformity of spine 21 | 114
Pick disease 21 | 1,894
Broad flat nasal bridge 20 | 236
Hyperkyphosis 20 | 111
Lens Opacities 20 | 231
Nasal bridge wide 20 | 236
diabetes mellitus 20 | 1,728
Decreased projection of midface 19 | 105
Hypotrophic midface 19 | 105
Joint stiffness 19 | 84
Midface retrusion 19 | 105
Short metacarpal 19 | 43
Small midface 19 | 105
Hypoplastic feet 18 | 66
Low set ears 18 | 181
Osteoarthritis 18 | 184
astrocytic glioma 18 | 2,597
tuberculosis 18 | 2,010
Exophthalmos 17 | 112
Failure to gain weight 17 | 365
Pediatric failure to thrive 17 | 365
Prominent eyes 17 | 96
Protruding eyes 17 | 96
juvenile dermatomyositis 17 | 1,187

Tissue

Endocrine System 142 | 18,159
Digestive Tract 139 | 17,369
Female tissues 136 | 17,400
Liver and Pancreas 136 | 16,750
Male tissues 136 | 17,142
Blood and immune system 135 | 16,909
Nervous System 135 | 16,725
Skin and soft tissues 135 | 17,230
Urinary Tract 135 | 16,678
Respiratory system 134 | 16,393
Cardiovascular System 128 | 15,192

Target Family

Non-IDG 73 | 12,091
Enzyme 39 | 4,145
Transcription Factor 18 | 1,400
Kinase 9 | 634
GPCR 3 | 408
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

UniProt Keyword

Dwarfism 145 | 145
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Protein arginine N-methyltransferase 7 PRMT7 Tchem Epigenetic -1.32370 24.3 163
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Latent-transforming growth factor beta-binding protein 2 LTBP2 Tbio Non-IDG -1.22721 18.2 100
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Mitochondrial import inner membrane translocase subunit TIM16 PAM16 Tbio Enzyme -2.36396 227.6 45
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102