Development Level

Tbio 2,045 | 11,651
Tdark 891 | 6,593
Tchem 379 | 1,388
Tclin 284 | 612

Collection

RFA-RM-18-021 82 | 328
GPCR: IDG Consortium (Targets) 53 | 126
Ion Channel: IDG Consortium (T... 30 | 99
GPCR: IDG Consortium (Complete... 17 | 25
Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 75 | 979
preweaning lethality, incomple... 73 | 499
decreased vertical activity 59 | 208
enlarged heart 59 | 210
abnormal heart morphology 45 | 162
abnormal behavior 40 | 298
decreased total body fat amoun... 35 | 207
abnormal seminal vesicle morph... 33 | 114
abnormal bone structure 28 | 187
increased lean body mass 26 | 172
decreased bone mineral content 24 | 151
embryonic lethality prior to t... 24 | 278
small superior vagus ganglion 23 | 74
hypoactivity 22 | 132
decreased body weight 20 | 161
decreased circulating glucose ... 20 | 126
increased bone mineral content 20 | 108
abnormal kidney morphology 19 | 65
increased total body fat amoun... 19 | 134
abnormal embryo size 18 | 220
decreased bone mineral density 18 | 126
decreased lean body mass 18 | 135
short tibia 18 | 97
decreased grip strength 17 | 116
hyperactivity 17 | 148
abnormal eye morphology 16 | 68
cataract 15 | 92
hydrometra 15 | 53
improved glucose tolerance 15 | 79
increased mean corpuscular vol... 15 | 92
abnormal gait 14 | 69
abnormal sleep behavior 14 | 70
decreased circulating insulin ... 14 | 76
decreased circulating serum al... 14 | 82
decreased circulating choleste... 13 | 93
embryonic lethality prior to o... 13 | 239
increased circulating sodium l... 13 | 71
decreased body length 12 | 101
decreased leukocyte cell numbe... 12 | 73
decreased mean corpuscular vol... 12 | 79
increased leukocyte cell numbe... 12 | 47
increased mean corpuscular hem... 12 | 96
abnormal skin morphology 11 | 50
decreased circulating triglyce... 11 | 79
decreased fasted circulating g... 11 | 65
decreased lymphocyte cell numb... 11 | 83
decreased neutrophil cell numb... 11 | 42
decreased startle reflex 11 | 75
impaired glucose tolerance 11 | 75
increased blood urea nitrogen ... 11 | 48
increased circulating alkaline... 11 | 122
male infertility 11 | 123
abnormal epididymis morphology 10 | 42
abnormal testis morphology 10 | 43
abnormal vibrissa morphology 10 | 25
decreased erythrocyte cell num... 10 | 62
decreased heart weight 10 | 27
embryonic growth retardation 10 | 106
enlarged spleen 10 | 41
female infertility 10 | 60
increased circulating choleste... 10 | 66
increased circulating triglyce... 10 | 42
increased fasted circulating g... 10 | 76
increased heart weight 10 | 62
increased hemoglobin content 10 | 45
increased monocyte cell number 10 | 63
increased or absent threshold ... 10 | 101
increased startle reflex 10 | 112
prolonged ST segment 10 | 36
small testis 10 | 58
abnormal coat-hair pigmentatio... 9 | 64
abnormal spleen morphology 9 | 55
cardiovascular system phenotyp... 9 | 36
decreased circulating HDL chol... 9 | 68
decreased circulating creatini... 9 | 39
decreased circulating total pr... 9 | 49
increased circulating HDL chol... 9 | 80
increased circulating chloride... 9 | 41
increased lymphocyte cell numb... 9 | 32
prolonged QT interval 9 | 38
thrombocytopenia 9 | 56
decreased blood urea nitrogen ... 8 | 51
decreased prepulse inhibition 8 | 82
increased circulating iron lev... 8 | 30
increased hematocrit 8 | 46
tremors 8 | 39
abnormal lens morphology 7 | 81
decreased T cell number 7 | 15
decreased eosinophil cell numb... 7 | 24
decreased hemoglobin content 7 | 68
decreased mean corpuscular hem... 7 | 31
increased bone mineral density 7 | 72
increased mean platelet volume 7 | 45
pallor 7 | 34
decreased circulating alkaline... 6 | 46
decreased circulating free fat... 6 | 31
increased circulating potassiu... 6 | 29
pale yolk sac 6 | 25
prenatal lethality prior to he... 6 | 87
thrombocytosis 6 | 27

Disease

Carcinoma 2,165 | 11,493
psoriasis 1,386 | 6,694
ovarian cancer 1,206 | 8,520
osteosarcoma 1,157 | 7,950
glioblastoma 963 | 5,792
lung cancer 959 | 4,740
medulloblastoma, large-cell 943 | 6,241
lung carcinoma 780 | 2,843
Cancer 771 | 2,499
atypical teratoid / rhabdoid tumor 761 | 5,112
ependymoma 750 | 4,679
Breast cancer 702 | 3,578
adult high grade glioma 686 | 3,801
interstitial cystitis 680 | 2,312
lung adenocarcinoma 680 | 2,716
Astrocytoma, Pilocytic 669 | 3,081
invasive ductal carcinoma 660 | 2,951
non-small cell lung cancer 660 | 2,890
malignant mesothelioma 620 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 617 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 597 | 3,291
pancreatic cancer 587 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 581 | 2,989
group 3 medulloblastoma 557 | 4,104
Kidney cancer 532 | 2,613
diabetes mellitus 519 | 1,728
ulcerative colitis 499 | 1,819
cystic fibrosis 473 | 1,696
tuberculosis 468 | 2,010
oligodendroglioma 457 | 2,850
pituitary cancer 428 | 1,972
primitive neuroectodermal tumor 403 | 3,035
subependymal giant cell astrocytoma 396 | 2,287
breast carcinoma 392 | 1,638
ductal carcinoma in situ 392 | 1,745
Autosomal recessive predisposition 386 | 1,442
astrocytic glioma 367 | 2,597
Schizophrenia 358 | 1,160
cutaneous lupus erythematosus 348 | 1,057
colon cancer 345 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 332 | 1,962
Rheumatoid arthritis 299 | 1,191
adrenocortical carcinoma 295 | 1,428
group 4 medulloblastoma 281 | 1,855
primary pancreatic ductal adenocarcinoma 260 | 1,109
Atopic dermatitis 256 | 952
Melanoma 236 | 711
Liver Cirrhosis, Experimental 220 | 769
Pick disease 219 | 1,894
Bipolar Disorder 217 | 666
active Crohn's disease 216 | 922
gastric carcinoma 213 | 807
Kidney disease 210 | 430
nasopharyngeal carcinoma 208 | 1,058
astrocytoma 207 | 1,146
juvenile dermatomyositis 204 | 1,187
Multiple Sclerosis 199 | 540
Arthritis 194 | 290
esophageal adenocarcinoma 194 | 737
primary Sjogren syndrome 194 | 735
Duchenne muscular dystrophy 192 | 601
Obesity 188 | 678
Asthma 186 | 385
Hypersensitivity reaction type II disease 184 | 253
pediatric high grade glioma 182 | 1,064
active ulcerative colitis 180 | 764
Skin cancer 179 | 469
Epilepsy 174 | 792
mucosa-associated lymphoid tissue lymphoma 168 | 484
Hypertension 165 | 396
dermatomyositis 163 | 966
Atherosclerosis 160 | 291
Liver cancer 159 | 604
fibroadenoma 156 | 559
Alzheimer's disease 153 | 658
acute quadriplegic myopathy 147 | 1,158
non primary Sjogren syndrome sicca 145 | 891
Depressive disorder 144 | 409
autosomal dominant Emery-Dreifuss muscular dystrophy 144 | 510
Anemia 142 | 365
Coronary artery disease 142 | 268
Multiple myeloma 142 | 1,332
Intellectual disability 136 | 1,016
Autistic Disorder 132 | 364
Endometriosis 132 | 540
spina bifida 132 | 1,074
Prostatic Neoplasms 127 | 495
Seizures 124 | 596
Liver disease 123 | 237
Vascular disease 123 | 319
periodontitis 123 | 293
Cerebrovascular disease 120 | 238
Down syndrome 118 | 499
medulloblastoma 118 | 720
Hypertensive disease 117 | 292
Alcoholic Intoxication, Chronic 116 | 289
Breast Neoplasms 115 | 445
Human immunodeficiency virus infectious disease 114 | 138
Major Depressive Disorder 114 | 301
Mammary Neoplasms 113 | 425

Tissue

Endocrine System 2,862 | 18,159
Female tissues 2,716 | 17,400
Digestive Tract 2,711 | 17,369
Skin and soft tissues 2,658 | 17,230
Male tissues 2,653 | 17,142
Blood and immune system 2,621 | 16,909
Urinary Tract 2,553 | 16,678
Liver and Pancreas 2,545 | 16,750
Nervous System 2,520 | 16,725
Respiratory system 2,459 | 16,393
Cardiovascular System 2,144 | 15,192

Target Family

Non-IDG 2,043 | 12,091
Enzyme 635 | 4,145
oGPCR 388 | 421
GPCR 284 | 408
Ion Channel 118 | 344
Kinase 71 | 634
Transporter 50 | 473
Transcription Factor 7 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Disulfide bond 3,599 | 3,599
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255