Development Level

Tbio 1,819 | 10,625
Tdark 869 | 7,003
Tchem 517 | 1,890
Tclin 267 | 602

Collection

Eligible non-olfactory GPCR Proteins 61 | 143
Eligible Ion Channel Proteins 40 | 117
Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 55 | 633
preweaning lethality, incomple... 43 | 260
enlarged heart 35 | 111
decreased total body fat amoun... 31 | 186
abnormal behavior 28 | 226
decreased lean body mass 26 | 195
decreased bone mineral density 24 | 126
decreased bone mineral content 23 | 157
decreased grip strength 22 | 123
abnormal bone structure 21 | 131
decreased body weight 21 | 174
decreased circulating glucose ... 21 | 121
short tibia 17 | 82
decreased body length 16 | 108
hypoactivity 16 | 89
increased lean body mass 16 | 107
increased or absent threshold ... 16 | 128
abnormal seminal vesicle morph... 15 | 47
decreased circulating insulin ... 15 | 75
increased bone mineral content 15 | 92
abnormal heart morphology 14 | 51
increased mean corpuscular hem... 14 | 93
increased mean corpuscular vol... 14 | 91
decreased circulating serum al... 13 | 79
decreased circulating triglyce... 13 | 83
increased blood urea nitrogen ... 13 | 44
increased circulating alkaline... 13 | 119
abnormal lens morphology 12 | 73
abnormal retina morphology 12 | 100
improved glucose tolerance 12 | 56
increased circulating sodium l... 12 | 71
decreased circulating alanine ... 11 | 53
impaired glucose tolerance 11 | 52
increased exploration in new e... 11 | 56
increased hemoglobin content 11 | 45
abnormal gait 10 | 51
abnormal sleep behavior 10 | 63
decreased circulating choleste... 10 | 85
decreased heart weight 10 | 44
decreased leukocyte cell numbe... 10 | 54
increased fasted circulating g... 10 | 68
increased grip strength 10 | 83
thrombocytopenia 10 | 46
abnormal behavioral response t... 9 | 52
abnormal embryo size 9 | 112
abnormal kidney morphology 9 | 30
decreased circulating HDL chol... 9 | 77
decreased fasted circulating g... 9 | 49
embryonic lethality prior to t... 9 | 187
female infertility 9 | 34
increased total body fat amoun... 9 | 57
tremors 9 | 34
abnormal coat/hair pigmentatio... 8 | 54
abnormal retinal pigmentation 8 | 61
abnormal vibrissa morphology 8 | 17
decreased circulating free fat... 8 | 39
decreased eosinophil cell numb... 8 | 41
decreased erythrocyte cell num... 8 | 43
decreased hemoglobin content 8 | 53
decreased prepulse inhibition 8 | 52
hyperactivity 8 | 108
increased circulating chloride... 8 | 43
increased circulating choleste... 8 | 53
increased hematocrit 8 | 36
increased leukocyte cell numbe... 8 | 37
abnormal bone mineralization 7 | 55
abnormal eye morphology 7 | 38
abnormal skin morphology 7 | 23
decreased T cell number 7 | 31
decreased monocyte cell number 7 | 28
enlarged epididymis 7 | 27
increased body weight 7 | 42
increased bone mineral density 7 | 52
increased circulating HDL chol... 7 | 63
increased circulating calcium ... 7 | 32
increased circulating potassiu... 7 | 31
abnormal epididymis morphology 6 | 31
abnormal spleen morphology 6 | 36
cardiovascular system phenotyp... 6 | 35
cataract 6 | 26
decreased B cell number 6 | 30
decreased caudal vertebrae num... 6 | 49
decreased circulating creatini... 6 | 31
decreased circulating total pr... 6 | 41
decreased lumbar vertebrae num... 6 | 62
decreased startle reflex 6 | 48
enlarged spleen 6 | 26
increased circulating serum al... 6 | 25
male infertility 6 | 62
small superior vagus ganglion 6 | 20
small testis 6 | 37
straub tail 6 | 26
abnormal tooth morphology 5 | 24
decreased rib number 5 | 59
embryonic lethality prior to o... 5 | 148
increased circulating iron lev... 5 | 25
increased heart weight 5 | 37
increased sacral vertebrae num... 5 | 62
thrombocytosis 5 | 23
vertebral fusion 5 | 23

Disease

psoriasis 1,357 | 6,685
ovarian cancer 1,180 | 8,484
osteosarcoma 1,131 | 7,933
medulloblastoma, large-cell 926 | 6,234
glioblastoma 895 | 5,572
lung cancer 875 | 4,466
lung carcinoma 765 | 2,844
Cancer 722 | 2,346
interstitial cystitis 664 | 2,299
lung adenocarcinoma 663 | 2,713
pilocytic astrocytoma 660 | 3,086
invasive ductal carcinoma 647 | 2,950
atypical teratoid / rhabdoid tumor 642 | 4,369
non-small cell lung cancer 606 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 605 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 590 | 3,289
malignant mesothelioma 573 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 572 | 2,988
Breast cancer 561 | 3,094
ulcerative colitis 553 | 2,087
pancreatic cancer 547 | 2,300
diabetes mellitus 505 | 1,663
pediatric high grade glioma 476 | 2,712
Carcinoma 473 | 2,147
cystic fibrosis 457 | 1,665
oligodendroglioma 446 | 2,849
pituitary cancer 421 | 1,972
primitive neuroectodermal tumor 396 | 3,031
subependymal giant cell astrocytoma 389 | 2,287
ductal carcinoma in situ 387 | 1,745
adult high grade glioma 383 | 2,148
breast carcinoma 383 | 1,614
posterior fossa group A ependymoma 369 | 1,511
tuberculosis 369 | 1,557
cutaneous lupus erythematosus 344 | 1,056
colon cancer 336 | 1,475
ependymoma 324 | 2,514
group 4 medulloblastoma 319 | 1,875
primary pancreatic ductal adenocarcinoma 303 | 1,271
adrenocortical carcinoma 291 | 1,427
astrocytic glioma 291 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 285 | 1,795
group 3 medulloblastoma 277 | 2,254
Rheumatoid Arthritis 275 | 1,160
astrocytoma 269 | 1,493
Atopic dermatitis 253 | 944
sonic hedgehog group medulloblastoma 249 | 1,482
gastric carcinoma 222 | 832
Pick disease 215 | 1,893
active Crohn's disease 213 | 918
primary Sjogren syndrome 213 | 789
posterior fossa group B ependymoma 210 | 1,530
nasopharyngeal carcinoma 207 | 1,056
juvenile dermatomyositis 203 | 1,189
esophageal adenocarcinoma 194 | 737
Kidney disease 193 | 396
Duchenne muscular dystrophy 192 | 602
Multiple Sclerosis 186 | 498
Asthma 185 | 349
medulloblastoma 183 | 1,524
Obesity 179 | 616
Hypersensitivity reaction type II disease 173 | 235
Arthritis 172 | 248
atypical teratoid/rhabdoid tumor 167 | 1,095
mucosa-associated lymphoid tissue lymphoma 165 | 480
Schizophrenia 156 | 501
fibroadenoma 154 | 557
Atherosclerosis 152 | 275
acute quadriplegic myopathy 147 | 1,157
Alzheimer's disease 146 | 644
non-small cell lung carcinoma 143 | 413
autosomal dominant Emery-Dreifuss muscular dystrophy 139 | 499
Multiple myeloma 138 | 1,327
dermatomyositis 132 | 933
Endometriosis 129 | 535
spina bifida 128 | 1,064
Hypertension 127 | 287
Down syndrome 126 | 548
Prostatic Neoplasms 125 | 471
Coronary artery disease 123 | 240
Autistic Disorder 122 | 320
non primary Sjogren syndrome sicca 119 | 840
Cerebrovascular disease 116 | 231
Liver disease 115 | 219
IGA Glomerulonephritis 113 | 454
Anemia 112 | 252
active ulcerative colitis 111 | 477
Ankylosing spondylitis 110 | 138
Mammary Neoplasms 110 | 410
Vascular disease 110 | 281
periodontitis 110 | 269
aldosterone-producing adenoma 106 | 664
Epilepsy 105 | 346
Heart disease 105 | 279
head and neck cancer and chronic obstructive pulmonary disease 104 | 237
pancreatic carcinoma 103 | 567
acute myeloid leukemia 100 | 780
sarcoidosis 97 | 358
Waldenstrons macroglobulinemia 96 | 765
nephrosclerosis 95 | 329

Tissue

Female tissues 3,146 | 18,647
Urinary Tract 3,107 | 18,444
Nervous System 3,073 | 18,561
Endocrine System 3,057 | 18,512
Digestive Tract 3,049 | 18,473
Skin and soft tissues 2,956 | 18,115
Liver and Pancreas 2,899 | 18,136
Blood and immune system 2,852 | 17,995
Cardiovascular System 2,837 | 17,958
Male tissues 2,817 | 17,969
Respiratory system 2,758 | 17,484

Target Family

Non-IDG 1,942 | 11,971
Enzyme 631 | 4,146
oGPCR 388 | 421
GPCR 279 | 406
Ion Channel 101 | 341
Kinase 71 | 634
Transporter 50 | 473
Transcription Factor 7 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Disulfide bond 3,472 | 3,472
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
T-cell receptor beta chain V region CTL-L17 TCRB Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628