Development Level

Tbio 2,095 | 11,445
Tchem 392 | 1,598
Tclin 253 | 613
Tdark 64 | 6,588

Collection

RFA-RM-18-021 32 | 328
Ion Channel: IDG Consortium (T... 14 | 99
Kinase: IDG Consortium (Target... 12 | 125
GPCR: IDG Consortium (Targets) 6 | 126
Kinase: IDG Consortium (Comple... 6 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 306 | 979
preweaning lethality, incomple... 108 | 499
embryonic lethality prior to t... 85 | 278
embryonic lethality prior to o... 75 | 239
abnormal behavior 69 | 298
abnormal embryo size 64 | 220
decreased body weight 51 | 161
decreased vertical activity 46 | 208
enlarged heart 44 | 210
hypoactivity 41 | 132
abnormal bone structure 34 | 187
decreased total body fat amoun... 34 | 207
increased circulating alkaline... 34 | 122
increased total body fat amoun... 34 | 134
embryonic growth retardation 32 | 106
decreased bone mineral content 31 | 151
decreased bone mineral density 29 | 126
increased startle reflex 29 | 112
abnormal heart morphology 28 | 162
decreased lean body mass 28 | 135
hyperactivity 28 | 148
increased mean corpuscular hem... 27 | 96
increased lean body mass 26 | 172
prenatal lethality prior to he... 26 | 87
abnormal seminal vesicle morph... 25 | 114
decreased grip strength 24 | 116
impaired glucose tolerance 24 | 75
decreased mean corpuscular vol... 23 | 79
decreased startle reflex 23 | 75
male infertility 23 | 123
short tibia 22 | 97
decreased circulating glucose ... 21 | 126
decreased erythrocyte cell num... 21 | 62
decreased prepulse inhibition 21 | 82
increased or absent threshold ... 21 | 101
small superior vagus ganglion 21 | 74
abnormal retina morphology 20 | 71
decreased circulating triglyce... 20 | 79
increased fasted circulating g... 20 | 76
abnormal eye morphology 19 | 68
abnormal lens morphology 19 | 81
cataract 19 | 92
decreased circulating choleste... 19 | 93
decreased hemoglobin content 19 | 68
abnormal gait 18 | 69
decreased body length 18 | 101
increased bone mineral content 18 | 108
increased circulating sodium l... 18 | 71
edema 17 | 59
increased circulating HDL chol... 17 | 80
increased heart weight 17 | 62
decreased circulating HDL chol... 16 | 68
improved glucose tolerance 16 | 79
increased circulating choleste... 16 | 66
increased leukocyte cell numbe... 16 | 47
decreased blood urea nitrogen ... 15 | 51
decreased circulating serum al... 15 | 82
decreased fasted circulating g... 15 | 65
hydrometra 15 | 53
increased blood urea nitrogen ... 15 | 48
increased mean corpuscular vol... 15 | 92
thrombocytopenia 15 | 56
abnormal coat-hair pigmentatio... 14 | 64
decreased circulating amylase ... 14 | 28
enlarged lymph nodes 14 | 37
abnormal skin morphology 13 | 50
decreased lymphocyte cell numb... 13 | 83
small testis 13 | 58
abnormal kidney morphology 12 | 65
abnormal neural tube closure 12 | 46
decreased circulating alkaline... 12 | 46
decreased heart weight 12 | 27
decreased neutrophil cell numb... 12 | 42
increased bone mineral density 12 | 72
increased circulating triglyce... 12 | 42
pallor 12 | 34
abnormal behavioral response t... 11 | 66
abnormal bone mineralization 11 | 38
decreased mean corpuscular hem... 11 | 50
increased circulating potassiu... 11 | 29
increased erythrocyte cell num... 11 | 39
increased hemoglobin content 11 | 45
increased lymphocyte cell numb... 11 | 32
increased mean platelet volume 11 | 45
pale yolk sac 11 | 25
persistence of hyaloid vascula... 11 | 33
abnormal retinal vasculature m... 10 | 27
cardiovascular system phenotyp... 10 | 36
decreased circulating LDL chol... 10 | 38
decreased circulating aspartat... 10 | 34
decreased red blood cell distr... 10 | 41
female infertility 10 | 60
increased circulating chloride... 10 | 41
prolonged QT interval 10 | 38
tremors 10 | 39
abnormal sleep behavior 9 | 70
decreased circulating creatini... 9 | 39
decreased circulating fructosa... 9 | 30
decreased circulating insulin ... 9 | 76
decreased circulating total pr... 9 | 49

Disease

Carcinoma 2,053 | 11,493
ovarian cancer 1,469 | 8,520
osteosarcoma 1,282 | 7,950
psoriasis 1,139 | 6,694
Autosomal recessive predisposition 1,130 | 1,442
medulloblastoma, large-cell 1,002 | 6,241
glioblastoma 968 | 5,792
lung cancer 941 | 4,740
atypical teratoid / rhabdoid tumor 839 | 5,112
ependymoma 812 | 4,679
Intellectual disability 705 | 1,016
group 3 medulloblastoma 700 | 4,104
Breast cancer 679 | 3,578
malignant mesothelioma 658 | 3,232
Kidney cancer 633 | 2,613
adult high grade glioma 611 | 3,801
Cancer 603 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 573 | 3,291
Epilepsy 565 | 792
non-small cell lung cancer 549 | 2,890
Astrocytoma, Pilocytic 547 | 3,081
invasive ductal carcinoma 535 | 2,951
lung adenocarcinoma 527 | 2,716
lung carcinoma 516 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 511 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 509 | 2,989
Dull intelligence 507 | 645
Low intelligence 507 | 645
Mental Retardation 507 | 645
Mental deficiency 507 | 645
Poor school performance 507 | 645
primitive neuroectodermal tumor 500 | 3,035
oligodendroglioma 489 | 2,850
Cognitive delay 472 | 608
Global developmental delay 472 | 608
Mental and motor retardation 472 | 608
pancreatic cancer 461 | 2,398
Seizures 460 | 596
Muscle hypotonia 446 | 571
astrocytic glioma 426 | 2,597
Short stature 406 | 531
pancreatic ductal adenocarcinoma liver metastasis 405 | 1,962
interstitial cystitis 404 | 2,312
subependymal giant cell astrocytoma 397 | 2,287
diabetes mellitus 356 | 1,728
pituitary cancer 349 | 1,972
ulcerative colitis 339 | 1,819
Pick disease 338 | 1,894
breast carcinoma 337 | 1,638
ductal carcinoma in situ 337 | 1,745
tuberculosis 336 | 2,010
colon cancer 316 | 1,478
cystic fibrosis 314 | 1,696
Failure to gain weight 308 | 365
Pediatric failure to thrive 308 | 365
group 4 medulloblastoma 299 | 1,855
Schizophrenia 280 | 1,160
Small head 277 | 374
Neurodegenerative disease 273 | 414
adrenocortical carcinoma 271 | 1,428
Nystagmus 264 | 317
Obesity 248 | 678
Cerebellar Ataxia 242 | 304
astrocytoma 235 | 1,146
Multiple myeloma 231 | 1,332
Sensorineural Hearing Loss (disorder) 231 | 284
Cataract 230 | 297
Curvature of spine 227 | 282
Acquired scoliosis 226 | 281
Hepatomegaly 222 | 285
Cryptorchidism 220 | 296
acute quadriplegic myopathy 213 | 1,158
Hypoplastic mandible condyle 212 | 275
Mandibular hypoplasia 212 | 275
Micrognathism 212 | 275
Melanoma 206 | 711
Strabismus 205 | 270
juvenile dermatomyositis 200 | 1,187
Infantile onset 199 | 238
Anemia 198 | 365
Orbital separation excessive 196 | 244
Rheumatoid arthritis 195 | 1,191
Lens Opacities 192 | 231
Optic Atrophy 191 | 242
cutaneous lupus erythematosus 191 | 1,057
Neuropathy 188 | 261
primary pancreatic ductal adenocarcinoma 188 | 1,109
pediatric high grade glioma 186 | 1,064
nasopharyngeal carcinoma 185 | 1,058
Blepharoptosis 182 | 231
Atopic dermatitis 181 | 952
Depressive disorder 178 | 409
Liver cancer 178 | 604
Hypertensive disease 176 | 292
Broad flat nasal bridge 174 | 236
Nasal bridge wide 174 | 236
dermatomyositis 173 | 966
Deafness 168 | 198
hearing impairment 168 | 199
Depressed nasal bridge 166 | 195

Tissue

Endocrine System 2,748 | 18,159
Digestive Tract 2,699 | 17,369
Skin and soft tissues 2,665 | 17,230
Female tissues 2,658 | 17,400
Male tissues 2,637 | 17,142
Blood and immune system 2,612 | 16,909
Liver and Pancreas 2,612 | 16,750
Urinary Tract 2,605 | 16,678
Nervous System 2,604 | 16,725
Respiratory system 2,534 | 16,393
Cardiovascular System 2,389 | 15,192

Target Family

Non-IDG 1,297 | 12,091
Enzyme 838 | 4,145
Transcription Factor 194 | 1,400
Kinase 139 | 634
Ion Channel 117 | 344
Transporter 116 | 473
GPCR 42 | 408
Epigenetic 34 | 242
Nuclear Receptor 19 | 48
TF/Epigenetic 8 | 38

UniProt Keyword

Disease mutation 2,804 | 2,804
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Zinc finger SWIM domain-containing protein 6 ZSWIM6 Tbio Non-IDG -1.22042 16.2 67