Development Level

Tbio 1,825 | 10,625
Tchem 419 | 1,890
Tclin 226 | 602
Tdark 70 | 7,003

Collection

Eligible Ion Channel Proteins 17 | 117
Eligible Kinase Proteins 11 | 134
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 184 | 633
preweaning lethality, incomple... 61 | 260
embryonic lethality prior to t... 53 | 187
decreased body weight 48 | 174
abnormal behavior 46 | 226
decreased lean body mass 42 | 195
embryonic lethality prior to o... 42 | 148
decreased bone mineral content 37 | 157
decreased total body fat amoun... 35 | 186
abnormal embryo size 33 | 112
increased circulating alkaline... 30 | 119
abnormal retina morphology 28 | 100
decreased bone mineral density 28 | 126
increased mean corpuscular hem... 27 | 93
hypoactivity 25 | 89
decreased body length 24 | 108
decreased grip strength 24 | 123
abnormal bone structure 23 | 131
enlarged heart 23 | 111
increased or absent threshold ... 23 | 128
decreased circulating triglyce... 22 | 83
decreased circulating HDL chol... 21 | 77
decreased hemoglobin content 20 | 53
decreased circulating glucose ... 19 | 121
increased circulating sodium l... 19 | 71
increased total body fat amoun... 19 | 57
decreased circulating choleste... 18 | 85
abnormal bone mineralization 17 | 55
hyperactivity 17 | 108
increased mean corpuscular vol... 17 | 91
prenatal lethality prior to he... 17 | 64
abnormal lens morphology 16 | 73
abnormal retinal pigmentation 15 | 61
decreased erythrocyte cell num... 15 | 43
decreased prepulse inhibition 15 | 52
increased blood urea nitrogen ... 15 | 44
increased bone mineral content 15 | 92
short tibia 15 | 82
decreased circulating alanine ... 14 | 53
increased grip strength 14 | 83
increased lean body mass 14 | 107
male infertility 14 | 62
thrombocytopenia 14 | 46
abnormal gait 13 | 51
abnormal seminal vesicle morph... 13 | 47
cataract 13 | 26
decreased circulating insulin ... 13 | 75
decreased eosinophil cell numb... 13 | 41
decreased heart weight 13 | 44
decreased mean corpuscular vol... 13 | 50
decreased startle reflex 13 | 48
impaired glucose tolerance 13 | 52
increased circulating HDL chol... 13 | 63
abnormal neural tube closure 12 | 37
decreased circulating LDL chol... 12 | 37
decreased circulating amylase ... 12 | 24
increased body weight 12 | 42
increased circulating choleste... 12 | 53
increased hemoglobin content 12 | 45
abnormal coat/hair pigmentatio... 11 | 54
abnormal eye morphology 11 | 38
decreased circulating serum al... 11 | 79
decreased mean corpuscular hem... 11 | 34
decreased rib number 11 | 59
enlarged lymph nodes 11 | 27
persistence of hyaloid vascula... 11 | 22
cardiovascular system phenotyp... 10 | 35
improved glucose tolerance 10 | 56
increased circulating calcium ... 10 | 32
increased circulating chloride... 10 | 43
increased fasted circulating g... 10 | 68
increased heart weight 10 | 37
small testis 10 | 37
decreased circulating calcium ... 9 | 33
decreased fasted circulating g... 9 | 49
hydrops fetalis 9 | 22
increased sacral vertebrae num... 9 | 62
increased startle reflex 9 | 38
tremors 9 | 34
abnormal hindbrain development 8 | 24
abnormal midbrain development 8 | 22
decreased caudal vertebrae num... 8 | 49
decreased circulating alkaline... 8 | 41
decreased circulating free fat... 8 | 39
decreased circulating fructosa... 8 | 31
decreased circulating total pr... 8 | 41
decreased leukocyte cell numbe... 8 | 54
increased bone mineral density 8 | 52
increased hematocrit 8 | 36
increased leukocyte cell numbe... 8 | 37
abnormal behavioral response t... 7 | 52
abnormal tooth morphology 7 | 24
decreased circulating glycerol... 7 | 19
decreased circulating iron lev... 7 | 25
decreased lumbar vertebrae num... 7 | 62
decreased neutrophil cell numb... 7 | 37
female infertility 7 | 34
increased circulating potassiu... 7 | 31
increased prepulse inhibition 7 | 21
thrombocytosis 7 | 23

Disease

ovarian cancer 1,304 | 8,484
osteosarcoma 1,152 | 7,933
psoriasis 1,041 | 6,685
medulloblastoma, large-cell 894 | 6,234
glioblastoma 814 | 5,572
lung cancer 801 | 4,466
atypical teratoid / rhabdoid tumor 631 | 4,369
malignant mesothelioma 577 | 3,162
Cancer 531 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 526 | 3,289
Breast cancer 507 | 3,094
Carcinoma 497 | 2,147
invasive ductal carcinoma 493 | 2,950
pilocytic astrocytoma 492 | 3,086
lung adenocarcinoma 482 | 2,713
non-small cell lung cancer 480 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 466 | 2,956
lung carcinoma 465 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 457 | 2,988
primitive neuroectodermal tumor 456 | 3,031
pediatric high grade glioma 444 | 2,712
oligodendroglioma 433 | 2,849
pancreatic cancer 395 | 2,300
interstitial cystitis 366 | 2,299
subependymal giant cell astrocytoma 360 | 2,287
ependymoma 359 | 2,514
ulcerative colitis 358 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 345 | 1,795
group 3 medulloblastoma 343 | 2,254
Intellectual disability 331 | 573
pituitary cancer 322 | 1,972
astrocytic glioma 313 | 2,241
ductal carcinoma in situ 312 | 1,745
Pick disease 301 | 1,893
diabetes mellitus 294 | 1,663
breast carcinoma 291 | 1,614
colon cancer 285 | 1,475
group 4 medulloblastoma 283 | 1,875
cystic fibrosis 280 | 1,665
adult high grade glioma 274 | 2,148
astrocytoma 269 | 1,493
posterior fossa group A ependymoma 267 | 1,511
adrenocortical carcinoma 247 | 1,427
tuberculosis 247 | 1,557
Neurodegenerative disease 240 | 383
sonic hedgehog group medulloblastoma 230 | 1,482
medulloblastoma 211 | 1,524
posterior fossa group B ependymoma 209 | 1,530
primary pancreatic ductal adenocarcinoma 204 | 1,271
Multiple myeloma 198 | 1,327
acute quadriplegic myopathy 189 | 1,157
atypical teratoid/rhabdoid tumor 188 | 1,095
juvenile dermatomyositis 180 | 1,189
cutaneous lupus erythematosus 179 | 1,056
Epilepsy 177 | 346
Rheumatoid Arthritis 177 | 1,160
Obesity 170 | 616
nasopharyngeal carcinoma 169 | 1,056
Atopic dermatitis 164 | 944
dermatomyositis 153 | 933
gastric carcinoma 146 | 832
Alzheimer's disease 142 | 644
Kidney disease 142 | 396
Neuropathy 141 | 210
active Crohn's disease 141 | 918
spina bifida 139 | 1,064
primary Sjogren syndrome 138 | 789
Duchenne muscular dystrophy 129 | 602
Prostatic Neoplasms 120 | 471
aldosterone-producing adenoma 119 | 664
Mammary Neoplasms 117 | 410
esophageal adenocarcinoma 116 | 737
acute myeloid leukemia 115 | 780
fibroadenoma 115 | 557
non primary Sjogren syndrome sicca 113 | 840
Anemia 109 | 252
progressive supranuclear palsy 108 | 674
Waldenstrons macroglobulinemia 106 | 765
Endometriosis 102 | 535
Retinitis pigmentosa 102 | 153
Amyotrophic Lateral Sclerosis 101 | 431
Autistic Disorder 101 | 320
Heart disease 101 | 279
Parkinson's disease 101 | 364
Multiple Sclerosis 100 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 99 | 499
Cardiomyopathy 98 | 110
Craniofacial Abnormalities 98 | 147
Down syndrome 98 | 548
Hypertension 98 | 287
Schizophrenia 94 | 501
IGA Glomerulonephritis 90 | 454
Microcephaly 89 | 149
pancreatic carcinoma 88 | 567
Peripheral Neuropathy 87 | 303
Cerebrovascular disease 86 | 231
non-small cell lung carcinoma 85 | 413
Vascular disease 82 | 281
hereditary spastic paraplegia 82 | 313
Hypertensive disease 81 | 193

Tissue

Nervous System 2,526 | 18,561
Endocrine System 2,522 | 18,512
Digestive Tract 2,520 | 18,473
Female tissues 2,520 | 18,647
Urinary Tract 2,515 | 18,444
Liver and Pancreas 2,501 | 18,136
Skin and soft tissues 2,501 | 18,115
Blood and immune system 2,498 | 17,995
Cardiovascular System 2,498 | 17,958
Male tissues 2,489 | 17,969
Respiratory system 2,452 | 17,484

Target Family

Non-IDG 1,169 | 11,971
Enzyme 761 | 4,146
Transcription Factor 177 | 1,400
Kinase 124 | 634
Ion Channel 111 | 341
Transporter 107 | 473
GPCR 38 | 406
Epigenetic 28 | 242
Nuclear Receptor 18 | 48
TF/Epigenetic 7 | 38

UniProt Keyword

Disease mutation 2,540 | 2,540
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788