Development Level

Tbio 2,154 | 11,651
Tchem 367 | 1,388
Tdark 201 | 6,593
Tclin 150 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 202 | 979
preweaning lethality, incomple... 91 | 499
embryonic lethality prior to o... 64 | 239
embryonic lethality prior to t... 62 | 278
abnormal behavior 49 | 298
enlarged heart 46 | 210
abnormal embryo size 44 | 220
decreased vertical activity 43 | 208
decreased total body fat amoun... 37 | 207
abnormal heart morphology 33 | 162
abnormal seminal vesicle morph... 32 | 114
abnormal bone structure 29 | 187
increased lean body mass 27 | 172
decreased circulating glucose ... 26 | 126
decreased body weight 25 | 161
decreased bone mineral content 25 | 151
increased circulating alkaline... 25 | 122
increased mean corpuscular vol... 25 | 92
hyperactivity 24 | 148
embryonic growth retardation 23 | 106
increased startle reflex 23 | 112
decreased bone mineral density 22 | 126
hypoactivity 22 | 132
short tibia 21 | 97
decreased grip strength 19 | 116
increased total body fat amoun... 19 | 134
decreased circulating choleste... 18 | 93
decreased circulating triglyce... 18 | 79
decreased lymphocyte cell numb... 18 | 83
increased bone mineral content 18 | 108
increased or absent threshold ... 18 | 101
small superior vagus ganglion 18 | 74
cataract 17 | 92
decreased fasted circulating g... 17 | 65
decreased lean body mass 16 | 135
increased heart weight 16 | 62
abnormal gait 15 | 69
abnormal lens morphology 15 | 81
decreased circulating insulin ... 15 | 76
decreased mean corpuscular vol... 15 | 79
hydrometra 15 | 53
improved glucose tolerance 15 | 79
increased fasted circulating g... 15 | 76
increased leukocyte cell numbe... 15 | 47
increased monocyte cell number 15 | 63
male infertility 15 | 123
increased mean corpuscular hem... 14 | 96
abnormal eye morphology 13 | 68
abnormal retina morphology 13 | 71
abnormal sleep behavior 13 | 70
decreased prepulse inhibition 13 | 82
impaired glucose tolerance 13 | 75
increased neutrophil cell numb... 13 | 46
pallor 13 | 34
abnormal skin morphology 12 | 50
decreased leukocyte cell numbe... 12 | 73
prolonged ST segment 12 | 36
thrombocytopenia 12 | 56
abnormal kidney morphology 11 | 65
decreased blood urea nitrogen ... 11 | 51
decreased circulating HDL chol... 11 | 68
decreased erythrocyte cell num... 11 | 62
edema 11 | 59
increased circulating choleste... 11 | 66
increased lymphocyte cell numb... 11 | 32
prenatal lethality prior to he... 11 | 87
decreased circulating serum al... 10 | 82
decreased circulating total pr... 10 | 49
decreased mean corpuscular hem... 10 | 31
decreased startle reflex 10 | 75
impaired righting response 10 | 26
prolonged QT interval 10 | 38
abnormal behavioral response t... 9 | 66
abnormal embryo turning 9 | 31
abnormal epididymis morphology 9 | 42
abnormal neural tube closure 9 | 46
abnormal testis morphology 9 | 43
cardiovascular system phenotyp... 9 | 36
decreased body length 9 | 101
decreased circulating fructosa... 9 | 30
increased blood urea nitrogen ... 9 | 48
increased circulating sodium l... 9 | 71
increased erythrocyte cell num... 9 | 39
abnormal coat-hair pigmentatio... 8 | 64
abnormal spleen morphology 8 | 55
decreased circulating creatini... 8 | 39
decreased hemoglobin content 8 | 68
decreased neutrophil cell numb... 8 | 42
increased circulating HDL chol... 8 | 80
increased circulating phosphat... 8 | 26
increased circulating total pr... 8 | 28
increased hematocrit 8 | 46
increased mean platelet volume 8 | 45
limb grasping 8 | 41
small testis 8 | 58
tremors 8 | 39
abnormal bone mineralization 7 | 38
decreased circulating alkaline... 7 | 46
decreased circulating aspartat... 7 | 34
pale yolk sac 7 | 25

Disease

Carcinoma 1,585 | 11,493
ovarian cancer 1,573 | 8,520
psoriasis 1,240 | 6,694
osteosarcoma 1,235 | 7,950
lung cancer 1,105 | 4,740
glioblastoma 1,000 | 5,792
medulloblastoma, large-cell 935 | 6,241
Cancer 833 | 2,499
atypical teratoid / rhabdoid tumor 776 | 5,112
ependymoma 716 | 4,679
Breast cancer 705 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 633 | 3,291
malignant mesothelioma 626 | 3,232
non-small cell lung cancer 618 | 2,890
group 3 medulloblastoma 606 | 4,104
lung adenocarcinoma 592 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 572 | 2,989
adult high grade glioma 567 | 3,801
pancreatic cancer 566 | 2,398
invasive ductal carcinoma 565 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 563 | 2,955
lung carcinoma 549 | 2,843
Astrocytoma, Pilocytic 501 | 3,081
diabetes mellitus 497 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 477 | 1,962
Multiple myeloma 472 | 1,332
interstitial cystitis 465 | 2,312
oligodendroglioma 445 | 2,850
tuberculosis 434 | 2,010
ulcerative colitis 420 | 1,819
Autosomal recessive predisposition 417 | 1,442
primitive neuroectodermal tumor 407 | 3,035
subependymal giant cell astrocytoma 399 | 2,287
cystic fibrosis 394 | 1,696
astrocytic glioma 382 | 2,597
Kidney cancer 372 | 2,613
colon cancer 359 | 1,478
breast carcinoma 349 | 1,638
pituitary cancer 315 | 1,972
ductal carcinoma in situ 311 | 1,745
acute quadriplegic myopathy 309 | 1,158
Waldenstrons macroglobulinemia 299 | 765
astrocytoma 286 | 1,146
dermatomyositis 284 | 966
Pick disease 282 | 1,894
Schizophrenia 281 | 1,160
group 4 medulloblastoma 280 | 1,855
juvenile dermatomyositis 278 | 1,187
primary pancreatic ductal adenocarcinoma 273 | 1,109
cutaneous lupus erythematosus 265 | 1,057
Rheumatoid arthritis 250 | 1,191
Liver Cirrhosis, Experimental 249 | 769
adrenocortical carcinoma 245 | 1,428
nasopharyngeal carcinoma 220 | 1,058
Atopic dermatitis 216 | 952
pediatric high grade glioma 216 | 1,064
Duchenne muscular dystrophy 205 | 601
gastric carcinoma 200 | 807
esophageal adenocarcinoma 197 | 737
Intellectual disability 196 | 1,016
Obesity 190 | 678
active Crohn's disease 186 | 922
Hypertension 184 | 396
Prostatic Neoplasms 182 | 495
Alzheimer's disease 178 | 658
Kidney disease 173 | 430
Epilepsy 172 | 792
acute myeloid leukemia 171 | 783
non primary Sjogren syndrome sicca 165 | 891
primary Sjogren syndrome 165 | 735
Breast Neoplasms 157 | 445
Anemia 154 | 365
Seizures 154 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 154 | 510
active ulcerative colitis 152 | 764
Mammary Neoplasms 151 | 425
Asthma 147 | 385
Atherosclerosis 145 | 291
Bipolar Disorder 145 | 666
Dull intelligence 145 | 645
Low intelligence 145 | 645
Mental Retardation 145 | 645
Mental deficiency 145 | 645
Poor school performance 145 | 645
spina bifida 145 | 1,074
Short stature 143 | 531
mucosa-associated lymphoid tissue lymphoma 143 | 484
Down syndrome 140 | 499
Muscle hypotonia 139 | 571
Melanoma 136 | 711
Cognitive delay 135 | 608
Global developmental delay 135 | 608
Mental and motor retardation 135 | 608
Endometriosis 134 | 540
Multiple Sclerosis 133 | 540
Coronary artery disease 132 | 268
Arthritis 126 | 290
Stomach Neoplasms 126 | 300
Osteoporosis 125 | 363
pancreatic carcinoma 125 | 562

Tissue

Digestive Tract 2,734 | 17,369
Endocrine System 2,723 | 18,159
Female tissues 2,716 | 17,400
Skin and soft tissues 2,701 | 17,230
Blood and immune system 2,685 | 16,909
Liver and Pancreas 2,682 | 16,750
Male tissues 2,674 | 17,142
Urinary Tract 2,664 | 16,678
Respiratory system 2,608 | 16,393
Nervous System 2,595 | 16,725
Cardiovascular System 2,471 | 15,192

Target Family

Non-IDG 1,833 | 12,091
Enzyme 823 | 4,145
Kinase 87 | 634
Transcription Factor 52 | 1,400
Epigenetic 25 | 242
GPCR 17 | 408
Transporter 16 | 473
Ion Channel 13 | 344
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

UniProt Keyword

Direct protein sequencing 2,872 | 2,872
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Paraneoplastic antigen Ma2 PNMA2 Tbio Non-IDG -2.92781 822.4 113
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Alpha-amylase 2B AMY2B Tbio Enzyme -2.04365 112.9 137