Development Level

Tbio 1,976 | 10,625
Tchem 503 | 1,890
Tdark 226 | 7,003
Tclin 147 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 3 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 127 | 633
preweaning lethality, incomple... 45 | 260
embryonic lethality prior to t... 40 | 187
abnormal behavior 39 | 226
embryonic lethality prior to o... 39 | 148
decreased lean body mass 34 | 195
decreased total body fat amoun... 31 | 186
decreased body weight 30 | 174
decreased bone mineral content 29 | 157
enlarged heart 28 | 111
decreased bone mineral density 27 | 126
abnormal embryo size 26 | 112
increased mean corpuscular vol... 24 | 91
abnormal bone structure 23 | 131
increased circulating alkaline... 23 | 119
increased or absent threshold ... 21 | 128
decreased circulating glucose ... 20 | 121
decreased body length 18 | 108
abnormal lens morphology 17 | 73
decreased circulating insulin ... 17 | 75
decreased grip strength 17 | 123
increased mean corpuscular hem... 17 | 93
abnormal retina morphology 16 | 100
decreased circulating triglyce... 16 | 83
hyperactivity 16 | 108
increased lean body mass 16 | 107
hypoactivity 15 | 89
decreased fasted circulating g... 14 | 49
abnormal seminal vesicle morph... 13 | 47
short tibia 13 | 82
decreased circulating choleste... 12 | 85
increased fasted circulating g... 12 | 68
increased grip strength 12 | 83
abnormal bone mineralization 11 | 55
decreased erythrocyte cell num... 11 | 43
decreased mean corpuscular vol... 11 | 50
impaired glucose tolerance 11 | 52
increased exploration in new e... 11 | 56
increased heart weight 11 | 37
abnormal heart morphology 10 | 51
abnormal sleep behavior 10 | 63
decreased circulating serum al... 10 | 79
decreased hemoglobin content 10 | 53
decreased leukocyte cell numbe... 10 | 54
increased blood urea nitrogen ... 10 | 44
increased circulating sodium l... 10 | 71
increased hemoglobin content 10 | 45
increased leukocyte cell numbe... 10 | 37
thrombocytopenia 10 | 46
abnormal gait 9 | 51
cardiovascular system phenotyp... 9 | 35
decreased circulating HDL chol... 9 | 77
improved glucose tolerance 9 | 56
abnormal behavioral response t... 8 | 52
abnormal coat/hair pigmentatio... 8 | 54
abnormal retinal pigmentation 8 | 61
abnormal skin morphology 8 | 23
decreased caudal vertebrae num... 8 | 49
decreased circulating alanine ... 8 | 53
decreased circulating alkaline... 8 | 41
decreased circulating fructosa... 8 | 31
decreased heart weight 8 | 44
increased circulating phosphat... 8 | 24
prenatal lethality prior to he... 8 | 64
abnormal tooth morphology 7 | 24
cataract 7 | 26
decreased circulating sodium l... 7 | 18
decreased circulating total pr... 7 | 41
decreased monocyte cell number 7 | 28
decreased prepulse inhibition 7 | 52
decreased startle reflex 7 | 48
enlarged epididymis 7 | 27
increased bone mineral content 7 | 92
increased circulating HDL chol... 7 | 63
increased circulating chloride... 7 | 43
increased circulating total pr... 7 | 20
increased startle reflex 7 | 38
male infertility 7 | 62
small testis 7 | 37
straub tail 7 | 26
tremors 7 | 34
abnormal coping response 6 | 12
abnormal cranium morphology 6 | 32
abnormal epididymis morphology 6 | 31
abnormal spleen morphology 6 | 36
abnormal testis morphology 6 | 30
decreased circulating amylase ... 6 | 24
decreased circulating calcium ... 6 | 33
decreased mean corpuscular hem... 6 | 34
decreased rib number 6 | 59
impaired righting response 6 | 19
increased circulating free fat... 6 | 17
increased circulating potassiu... 6 | 31
increased effector memory CD8-... 6 | 14
increased hematocrit 6 | 36
increased total body fat amoun... 6 | 57
pallor 6 | 13
vertebral fusion 6 | 23
decreased NK T cell number 5 | 28
decreased circulating free fat... 5 | 39

Disease

ovarian cancer 1,559 | 8,484
psoriasis 1,233 | 6,685
osteosarcoma 1,225 | 7,933
lung cancer 1,067 | 4,466
glioblastoma 948 | 5,572
medulloblastoma, large-cell 931 | 6,234
Cancer 784 | 2,346
atypical teratoid / rhabdoid tumor 656 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 630 | 3,289
Breast cancer 604 | 3,094
non-small cell lung cancer 597 | 2,798
malignant mesothelioma 591 | 3,162
lung adenocarcinoma 590 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 569 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 560 | 2,956
invasive ductal carcinoma 560 | 2,950
pancreatic cancer 551 | 2,300
lung carcinoma 548 | 2,844
pilocytic astrocytoma 505 | 3,086
ulcerative colitis 487 | 2,087
diabetes mellitus 481 | 1,663
Multiple myeloma 472 | 1,327
pediatric high grade glioma 470 | 2,712
interstitial cystitis 462 | 2,299
oligodendroglioma 442 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 417 | 1,795
primitive neuroectodermal tumor 403 | 3,031
subependymal giant cell astrocytoma 396 | 2,287
ependymoma 391 | 2,514
cystic fibrosis 387 | 1,665
tuberculosis 360 | 1,557
astrocytoma 358 | 1,493
colon cancer 357 | 1,475
group 3 medulloblastoma 355 | 2,254
breast carcinoma 343 | 1,614
primary pancreatic ductal adenocarcinoma 329 | 1,271
pituitary cancer 315 | 1,972
adult high grade glioma 309 | 2,148
ductal carcinoma in situ 308 | 1,745
acute quadriplegic myopathy 306 | 1,157
astrocytic glioma 306 | 2,241
Waldenstrons macroglobulinemia 298 | 765
Carcinoma 293 | 2,147
group 4 medulloblastoma 286 | 1,875
dermatomyositis 283 | 933
Pick disease 280 | 1,893
juvenile dermatomyositis 276 | 1,189
posterior fossa group A ependymoma 268 | 1,511
cutaneous lupus erythematosus 264 | 1,056
adrenocortical carcinoma 244 | 1,427
Rheumatoid Arthritis 242 | 1,160
sonic hedgehog group medulloblastoma 224 | 1,482
nasopharyngeal carcinoma 220 | 1,056
Atopic dermatitis 212 | 944
Duchenne muscular dystrophy 205 | 602
gastric carcinoma 205 | 832
medulloblastoma 200 | 1,524
esophageal adenocarcinoma 197 | 737
active Crohn's disease 186 | 918
primary Sjogren syndrome 182 | 789
Prostatic Neoplasms 179 | 471
atypical teratoid/rhabdoid tumor 177 | 1,095
acute myeloid leukemia 170 | 780
posterior fossa group B ependymoma 168 | 1,530
Alzheimer's disease 167 | 644
Obesity 164 | 616
Kidney disease 162 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 151 | 499
Mammary Neoplasms 148 | 410
non primary Sjogren syndrome sicca 147 | 840
Down syndrome 146 | 548
mucosa-associated lymphoid tissue lymphoma 143 | 480
spina bifida 142 | 1,064
Atherosclerosis 140 | 275
Asthma 139 | 349
Hypertension 133 | 287
Endometriosis 132 | 535
IGA Glomerulonephritis 131 | 454
pancreatic carcinoma 125 | 567
aldosterone-producing adenoma 124 | 664
Coronary artery disease 122 | 240
Multiple Sclerosis 122 | 498
Stomach Neoplasms 122 | 282
Heart disease 118 | 279
tuberculosis and treatment for 6 months 116 | 686
fibroadenoma 115 | 557
Anemia 114 | 252
Cerebrovascular disease 112 | 231
Vascular disease 108 | 281
Arthritis 107 | 248
Neurodegenerative disease 103 | 383
non-small cell lung carcinoma 103 | 413
Polycystic Ovary Syndrome 102 | 332
Liver carcinoma 101 | 217
periodontitis 100 | 269
progressive supranuclear palsy 100 | 674
Liver disease 99 | 219
hepatocellular carcinoma 98 | 532
Intellectual disability 96 | 573
Hypersensitivity reaction type II disease 94 | 235

Tissue

Female tissues 2,804 | 18,647
Digestive Tract 2,802 | 18,473
Endocrine System 2,794 | 18,512
Nervous System 2,793 | 18,561
Urinary Tract 2,787 | 18,444
Blood and immune system 2,773 | 17,995
Liver and Pancreas 2,772 | 18,136
Cardiovascular System 2,763 | 17,958
Skin and soft tissues 2,762 | 18,115
Male tissues 2,745 | 17,969
Respiratory system 2,742 | 17,484

Target Family

Non-IDG 1,818 | 11,971
Enzyme 819 | 4,146
Kinase 87 | 634
Transcription Factor 52 | 1,400
Epigenetic 25 | 242
GPCR 17 | 406
Transporter 16 | 473
Ion Channel 12 | 341
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

UniProt Keyword

Direct protein sequencing 2,852 | 2,852
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682