Development Level

Tbio 42 | 11,445
Tchem 27 | 1,598
Tdark 10 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal seminal vesicle morph... 4 | 114
decreased bone mineral density 3 | 126
decreased circulating iron lev... 3 | 32
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal locomotor behavior 2 | 24
abnormal retinal blood vessel ... 2 | 26
decreased grip strength 2 | 116
decreased heart rate 2 | 18
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hydrometra 2 | 53
hyperactivity 2 | 148
increased body length 2 | 32
increased monocyte cell number 2 | 63
prolonged RR interval 2 | 8
small superior vagus ganglion 2 | 74
vertebral transformation 2 | 12
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal femur morphology 1 | 14
abnormal forebrain morphology 1 | 10
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal iris pigmentation 1 | 4
abnormal limb position 1 | 3
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged seminal vesicle 1 | 10
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
mydriasis 1 | 6
polydactyly 1 | 7
thin skin 1 | 2
trunk curl 1 | 16

Disease

Carcinoma 55 | 11,493
ovarian cancer 50 | 8,520
osteosarcoma 38 | 7,950
psoriasis 35 | 6,694
medulloblastoma, large-cell 27 | 6,241
glioblastoma 26 | 5,792
Cancer 24 | 2,499
lung cancer 23 | 4,740
group 3 medulloblastoma 21 | 4,104
non-small cell lung cancer 21 | 2,890
atypical teratoid / rhabdoid tumor 20 | 5,112
subependymal giant cell astrocytoma 19 | 2,287
Breast cancer 18 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
malignant mesothelioma 18 | 3,232
ependymoma 17 | 4,679
lung adenocarcinoma 17 | 2,716
invasive ductal carcinoma 16 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
cystic fibrosis 14 | 1,696
pancreatic cancer 14 | 2,398
Kidney cancer 13 | 2,613
oligodendroglioma 13 | 2,850
primitive neuroectodermal tumor 13 | 3,035
tuberculosis 13 | 2,010
adult high grade glioma 12 | 3,801
astrocytoma 12 | 1,146
interstitial cystitis 12 | 2,312
lung carcinoma 12 | 2,843
ductal carcinoma in situ 11 | 1,745
ulcerative colitis 11 | 1,819
Astrocytoma, Pilocytic 10 | 3,081
Autosomal recessive predisposition 10 | 1,442
Pick disease 9 | 1,894
Rheumatoid arthritis 9 | 1,191
breast carcinoma 9 | 1,638
Intellectual disability 8 | 1,016
acute myeloid leukemia 8 | 783
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
pituitary cancer 8 | 1,972
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
Autistic Disorder 6 | 364
Osteoarthritis 6 | 184
Schizophrenia 6 | 1,160
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
Alzheimer's disease 5 | 658
Endometriosis 5 | 540
Liver Cirrhosis, Experimental 5 | 769
Muscle hypotonia 5 | 571
Seizures 5 | 596
active Crohn's disease 5 | 922
medulloblastoma 5 | 720
pancreatic carcinoma 5 | 562
Acquired metabolic disease 4 | 336
Acquired scoliosis 4 | 281
Actinic keratosis 4 | 21
Amyotrophic lateral sclerosis 4 | 451
Arthritis 4 | 290
Asthma 4 | 385
Atopic dermatitis 4 | 952
Barrett's esophagus 4 | 182
Breast Neoplasms 4 | 445
Congenital clubfoot 4 | 109
Crohn's disease 4 | 321
Curvature of spine 4 | 282
Dull intelligence 4 | 645
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Heart failure 4 | 162
Hyperalgesia 4 | 83
Juvenile rheumatoid arthritis 4 | 111
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Myopia 4 | 176
Obesity 4 | 678
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
acute quadriplegic myopathy 4 | 1,158
cutaneous lupus erythematosus 4 | 1,057
fibroadenoma 4 | 559
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676
sonic hedgehog group medulloblastoma 4 | 467
Bipolar Disorder 3 | 666
Mental Depression 3 | 333
Vascular disease 3 | 319
aldosterone-producing adenoma 3 | 665
nephrosclerosis 3 | 333

Tissue

Digestive Tract 83 | 17,369
Endocrine System 83 | 18,159
Female tissues 83 | 17,400
Blood and immune system 82 | 16,909
Skin and soft tissues 82 | 17,230
Liver and Pancreas 81 | 16,750
Male tissues 81 | 17,142
Nervous System 81 | 16,725
Urinary Tract 81 | 16,678
Respiratory system 80 | 16,393
Cardiovascular System 74 | 15,192

Target Family

Enzyme 53 | 4,145
Epigenetic 19 | 242
Non-IDG 7 | 12,091
TF/Epigenetic 4 | 38

UniProt Keyword

Dioxygenase 83 | 83
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta,beta-carotene 9',10'-oxygenase BCO2 Tbio Enzyme -1.64030 46.1 93
Lysine-specific demethylase 5D KDM5D Tbio TF/Epigenetic -2.38009 240.2 32
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial ALKBH7 Tbio Enzyme -0.53812 4.36 42
Lysine-specific demethylase 5C KDM5C Tchem TF/Epigenetic -1.94004 86.4 135
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
Methylcytosine dioxygenase TET3 TET3 Tbio Enzyme -1.96016 82.2 167
Nucleic acid dioxygenase ALKBH1 ALKBH1 Tbio Enzyme -2.09946 119.6 149
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 ALKBH6 Tdark Enzyme 0.38 0.31 58
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
Transmembrane prolyl 4-hydroxylase P4HTM Tchem Enzyme -2.70235 473.8 159