Development Level

Tbio 524 | 11,651
Tdark 104 | 6,593
Tchem 60 | 1,388
Tclin 15 | 612

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 37 | 499
preweaning lethality, complete... 34 | 979
abnormal behavior 17 | 298
abnormal bone structure 16 | 187
male infertility 13 | 123
decreased body weight 11 | 161
decreased lean body mass 11 | 135
decreased vertical activity 11 | 208
abnormal embryo size 10 | 220
embryonic lethality prior to t... 10 | 278
enlarged heart 10 | 210
increased lean body mass 10 | 172
abnormal seminal vesicle morph... 8 | 114
abnormal retina morphology 7 | 71
decreased circulating glucose ... 7 | 126
decreased total body fat amoun... 7 | 207
embryonic lethality prior to o... 7 | 239
improved glucose tolerance 7 | 79
increased bone mineral content 7 | 108
increased circulating alkaline... 7 | 122
decreased prepulse inhibition 6 | 82
increased grip strength 6 | 41
prenatal lethality prior to he... 6 | 87
small superior vagus ganglion 6 | 74
abnormal sleep behavior 5 | 70
decreased body length 5 | 101
decreased bone mineral content 5 | 151
decreased grip strength 5 | 116
decreased mean corpuscular vol... 5 | 79
female infertility 5 | 60
hyperactivity 5 | 148
impaired glucose tolerance 5 | 75
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
increased total body fat amoun... 5 | 134
short tibia 5 | 97
small testis 5 | 58
abnormal coat-hair pigmentatio... 4 | 64
abnormal eye morphology 4 | 68
abnormal heart morphology 4 | 162
abnormal kidney morphology 4 | 65
abnormal testis morphology 4 | 43
decreased caudal vertebrae num... 4 | 53
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
decreased red blood cell distr... 4 | 41
embryonic growth retardation 4 | 106
enlarged kidney 4 | 14
hydrometra 4 | 53
increased blood urea nitrogen ... 4 | 48
increased body length 4 | 32
increased circulating triglyce... 4 | 42
increased monocyte cell number 4 | 63
increased or absent threshold ... 4 | 101
limb grasping 4 | 41
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
abnormal gait 3 | 69
abnormal tail morphology 3 | 25
anophthalmia 3 | 33
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 46
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased circulating phosphat... 3 | 27
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
decreased threshold for audito... 3 | 26
edema 3 | 59
increased circulating glucose ... 3 | 24
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased leukocyte cell numbe... 3 | 47
increased vertical activity 3 | 24
abnormal craniofacial morpholo... 2 | 33
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal spleen morphology 2 | 55
abnormal vertebrae morphology 2 | 18
decreased T cell number 2 | 15
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
hypoactivity 2 | 132
increased circulating chloride... 2 | 41
increased circulating iron lev... 2 | 30
increased heart weight 2 | 62
increased prepulse inhibition 2 | 32
pale yolk sac 2 | 25
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
thin ventricular wall 2 | 24
tremors 2 | 39

Disease

Carcinoma 462 | 11,493
ovarian cancer 303 | 8,520
osteosarcoma 278 | 7,950
medulloblastoma, large-cell 266 | 6,241
psoriasis 259 | 6,694
glioblastoma 251 | 5,792
atypical teratoid / rhabdoid tumor 226 | 5,112
ependymoma 221 | 4,679
lung cancer 216 | 4,740
group 3 medulloblastoma 190 | 4,104
adult high grade glioma 168 | 3,801
Breast cancer 163 | 3,578
oligodendroglioma 156 | 2,850
Astrocytoma, Pilocytic 155 | 3,081
malignant mesothelioma 154 | 3,232
Cancer 153 | 2,499
Kidney cancer 148 | 2,613
invasive ductal carcinoma 145 | 2,951
non-small cell lung cancer 143 | 2,890
primitive neuroectodermal tumor 137 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 133 | 2,955
lung adenocarcinoma 133 | 2,716
lung carcinoma 133 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 131 | 2,989
astrocytic glioma 128 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,291
interstitial cystitis 109 | 2,312
subependymal giant cell astrocytoma 106 | 2,287
pancreatic cancer 102 | 2,398
ductal carcinoma in situ 95 | 1,745
pituitary cancer 94 | 1,972
cystic fibrosis 86 | 1,696
breast carcinoma 84 | 1,638
tuberculosis 81 | 2,010
ulcerative colitis 81 | 1,819
colon cancer 80 | 1,478
Pick disease 79 | 1,894
Schizophrenia 79 | 1,160
group 4 medulloblastoma 76 | 1,855
adrenocortical carcinoma 66 | 1,428
diabetes mellitus 59 | 1,728
cutaneous lupus erythematosus 55 | 1,057
nasopharyngeal carcinoma 54 | 1,058
pediatric high grade glioma 50 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,962
juvenile dermatomyositis 48 | 1,187
Intellectual disability 47 | 1,016
Male infertility 47 | 206
spina bifida 47 | 1,074
Melanoma 46 | 711
Rheumatoid arthritis 45 | 1,191
Autosomal recessive predisposition 44 | 1,442
primary pancreatic ductal adenocarcinoma 44 | 1,109
Multiple myeloma 43 | 1,332
astrocytoma 43 | 1,146
acute quadriplegic myopathy 41 | 1,158
Bipolar Disorder 40 | 666
dermatomyositis 39 | 966
Alzheimer's disease 38 | 658
Atopic dermatitis 38 | 952
gastric carcinoma 38 | 807
Infertility 37 | 188
active Crohn's disease 36 | 922
medulloblastoma 36 | 720
Skin cancer 35 | 469
Down syndrome 34 | 499
Liver cancer 34 | 604
fibroadenoma 34 | 559
Obesity 33 | 678
Endometriosis 31 | 540
esophageal adenocarcinoma 31 | 737
Breast Neoplasms 30 | 445
Mammary Neoplasms 30 | 425
chronic rhinosinusitis 30 | 512
non primary Sjogren syndrome sicca 30 | 891
sonic hedgehog group medulloblastoma 30 | 467
aldosterone-producing adenoma 29 | 665
Cleft Palate 28 | 271
Cryptorchidism 28 | 296
Dull intelligence 28 | 645
Low intelligence 28 | 645
Mental Retardation 28 | 645
Mental deficiency 28 | 645
Parkinson's disease 28 | 392
Poor school performance 28 | 645
acute myeloid leukemia 28 | 783
Duchenne muscular dystrophy 27 | 601
Epilepsy 27 | 792
Cognitive delay 26 | 608
Global developmental delay 26 | 608
Mental and motor retardation 26 | 608
Short stature 26 | 531
Depressive disorder 25 | 409
Muscle hypotonia 25 | 571
Orbital separation excessive 25 | 244
active ulcerative colitis 25 | 764
primary Sjogren syndrome 25 | 735
Osteoporosis 24 | 363
atypical teratoid/rhabdoid tumor 24 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 510

Tissue

Endocrine System 681 | 18,159
Digestive Tract 627 | 17,369
Skin and soft tissues 618 | 17,230
Female tissues 614 | 17,400
Male tissues 606 | 17,142
Nervous System 601 | 16,725
Blood and immune system 594 | 16,909
Liver and Pancreas 580 | 16,750
Urinary Tract 578 | 16,678
Respiratory system 569 | 16,393
Cardiovascular System 505 | 15,192

Target Family

Non-IDG 436 | 12,091
Transcription Factor 123 | 1,400
Enzyme 61 | 4,145
Kinase 42 | 634
Epigenetic 20 | 242
Transporter 7 | 473
GPCR 5 | 408
Ion Channel 4 | 344
TF/Epigenetic 3 | 38
Nuclear Receptor 2 | 48

UniProt Keyword

Differentiation 703 | 703
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104
BTB/POZ domain-containing protein 18 BTBD18 Tdark Non-IDG -0.42597 2.79 11
Thymidine phosphorylase TYMP Tclin Enzyme -2.83170 677.8 514
Striated muscle preferentially expressed protein kinase SPEG Tbio Kinase -2.50316 309.8 65
Unconventional myosin-VIIb MYO7B Tbio Non-IDG -0.65885 5.07 14
EP300-interacting inhibitor of differentiation 2 EID2 Tbio Non-IDG -1.36642 21.1 65
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422