Development Level

Tbio 467 | 10,625
Tdark 104 | 7,003
Tchem 77 | 1,890
Tclin 13 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 26 | 633
preweaning lethality, incomple... 25 | 260
decreased lean body mass 15 | 195
abnormal behavior 13 | 226
decreased body weight 12 | 174
abnormal bone structure 11 | 131
increased or absent threshold ... 11 | 128
decreased circulating glucose ... 9 | 121
abnormal embryo size 8 | 112
decreased bone mineral content 8 | 157
decreased rib number 8 | 59
embryonic lethality prior to t... 8 | 187
abnormal retina morphology 7 | 100
decreased grip strength 7 | 123
enlarged heart 7 | 111
increased grip strength 7 | 83
increased lean body mass 7 | 107
decreased bone mineral density 6 | 126
decreased circulating triglyce... 6 | 83
decreased total body fat amoun... 6 | 186
improved glucose tolerance 6 | 56
male infertility 6 | 62
abnormal bone mineralization 5 | 55
abnormal retinal pigmentation 5 | 61
decreased caudal vertebrae num... 5 | 49
decreased circulating choleste... 5 | 85
hyperactivity 5 | 108
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased mean corpuscular vol... 5 | 91
prenatal lethality prior to he... 5 | 64
abnormal coat/hair pigmentatio... 4 | 54
abnormal sleep behavior 4 | 63
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased erythrocyte cell num... 4 | 43
decreased lumbar vertebrae num... 4 | 62
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
increased blood urea nitrogen ... 4 | 44
increased body length 4 | 20
increased exploration in new e... 4 | 56
increased leukocyte cell numbe... 4 | 37
limb grasping 4 | 35
small testis 4 | 37
abnormal eye morphology 3 | 38
abnormal gait 3 | 51
abnormal hindbrain development 3 | 24
abnormal maxilla morphology 3 | 16
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal rib morphology 3 | 28
abnormal seminal vesicle morph... 3 | 47
abnormal snout morphology 3 | 18
abnormal testis morphology 3 | 30
decreased T cell number 3 | 31
decreased circulating alanine ... 3 | 53
decreased circulating alkaline... 3 | 41
decreased circulating calcium ... 3 | 33
decreased circulating free fat... 3 | 39
decreased circulating total pr... 3 | 41
decreased hemoglobin content 3 | 53
decreased startle reflex 3 | 48
enlarged kidney 3 | 7
female infertility 3 | 34
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating sodium l... 3 | 71
increased rib number 3 | 41
increased startle reflex 3 | 38
abnormal cranium morphology 2 | 32
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal optic disc morphology 2 | 10
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased circulating LDL chol... 2 | 37
decreased circulating chloride... 2 | 32
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased fasted circulating g... 2 | 49
decreased neutrophil cell numb... 2 | 37
impaired glucose tolerance 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating glucose ... 2 | 16
increased erythrocyte cell num... 2 | 26
increased heart weight 2 | 37
increased mean corpuscular hem... 2 | 93
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15

Disease

ovarian cancer 286 | 8,484
osteosarcoma 255 | 7,933
medulloblastoma, large-cell 251 | 6,234
psoriasis 241 | 6,685
glioblastoma 232 | 5,572
lung cancer 200 | 4,466
atypical teratoid / rhabdoid tumor 190 | 4,369
Cancer 146 | 2,346
pilocytic astrocytoma 146 | 3,086
oligodendroglioma 143 | 2,849
malignant mesothelioma 141 | 3,162
invasive ductal carcinoma 136 | 2,950
non-small cell lung cancer 134 | 2,798
Breast cancer 130 | 3,094
lung adenocarcinoma 129 | 2,713
lung carcinoma 129 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 127 | 2,956
primitive neuroectodermal tumor 125 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 124 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 123 | 2,988
Carcinoma 119 | 2,147
pediatric high grade glioma 115 | 2,712
interstitial cystitis 104 | 2,299
ependymoma 103 | 2,514
subependymal giant cell astrocytoma 99 | 2,287
astrocytic glioma 95 | 2,241
pituitary cancer 93 | 1,972
adult high grade glioma 91 | 2,148
ductal carcinoma in situ 90 | 1,745
pancreatic cancer 90 | 2,300
group 4 medulloblastoma 89 | 1,875
group 3 medulloblastoma 85 | 2,254
ulcerative colitis 85 | 2,087
breast carcinoma 82 | 1,614
cystic fibrosis 80 | 1,665
colon cancer 77 | 1,475
posterior fossa group B ependymoma 73 | 1,530
Pick disease 72 | 1,893
posterior fossa group A ependymoma 71 | 1,511
sonic hedgehog group medulloblastoma 70 | 1,482
medulloblastoma 67 | 1,524
astrocytoma 64 | 1,493
adrenocortical carcinoma 63 | 1,427
tuberculosis 58 | 1,557
cutaneous lupus erythematosus 51 | 1,056
diabetes mellitus 51 | 1,663
nasopharyngeal carcinoma 51 | 1,056
atypical teratoid/rhabdoid tumor 46 | 1,095
primary pancreatic ductal adenocarcinoma 46 | 1,271
juvenile dermatomyositis 44 | 1,189
spina bifida 43 | 1,064
Rheumatoid Arthritis 42 | 1,160
acute quadriplegic myopathy 39 | 1,157
Multiple myeloma 38 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,795
Male infertility 37 | 170
dermatomyositis 37 | 933
gastric carcinoma 37 | 832
Atopic dermatitis 36 | 944
Schizophrenia 36 | 501
Infertility 35 | 163
active Crohn's disease 35 | 918
Obesity 34 | 616
Alzheimer's disease 33 | 644
fibroadenoma 33 | 557
Down syndrome 32 | 548
Endometriosis 31 | 535
esophageal adenocarcinoma 31 | 737
aldosterone-producing adenoma 29 | 664
Mammary Neoplasms 28 | 410
acute myeloid leukemia 28 | 780
chronic rhinosinusitis 28 | 512
non primary Sjogren syndrome sicca 28 | 840
Intellectual disability 27 | 573
Duchenne muscular dystrophy 26 | 602
Parkinson's disease 24 | 364
non-small cell lung carcinoma 23 | 413
primary Sjogren syndrome 23 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 499
Autistic Disorder 20 | 320
Prostatic Neoplasms 20 | 471
mucosa-associated lymphoid tissue lymphoma 20 | 480
nephrosclerosis 20 | 329
tuberculosis and treatment for 6 months 20 | 686
urothelial carcinoma 20 | 318
Colorectal Neoplasms 19 | 217
Kidney disease 18 | 396
Osteoporosis 18 | 257
head and neck cancer 18 | 270
hepatocellular carcinoma 18 | 532
Melanoma 17 | 261
active ulcerative colitis 17 | 477
glioblastoma multiforme 17 | 347
Cerebrovascular disease 16 | 231
facioscapulohumeral dystrophy 16 | 286
progressive supranuclear palsy 16 | 674
Cleft palate 15 | 125
IGA Glomerulonephritis 15 | 454
Vascular disease 15 | 281
Waldenstrons macroglobulinemia 15 | 765

Tissue

Endocrine System 646 | 18,512
Digestive Tract 644 | 18,473
Female tissues 644 | 18,647
Nervous System 641 | 18,561
Male tissues 637 | 17,969
Urinary Tract 633 | 18,444
Liver and Pancreas 629 | 18,136
Cardiovascular System 628 | 17,958
Skin and soft tissues 626 | 18,115
Blood and immune system 622 | 17,995
Respiratory system 594 | 17,484

Target Family

Non-IDG 409 | 11,971
Transcription Factor 115 | 1,400
Enzyme 57 | 4,146
Kinase 42 | 634
Epigenetic 18 | 242
Transporter 7 | 473
GPCR 4 | 406
Ion Channel 4 | 341
TF/Epigenetic 3 | 38
Nuclear Receptor 2 | 48

UniProt Keyword

Differentiation 661 | 661
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Transcription factor 23 TCF23 Tdark Transcription Factor -0.80163 6.17 21
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.56282 377.5 283
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85
Thrombospondin type-1 domain-containing protein 7A THSD7A Tbio Non-IDG -1.12816 15.9 11