Development Level

Tbio 47 | 11,445
Tchem 14 | 1,598
Tclin 14 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 4 | 161
decreased vertical activity 4 | 208
abnormal behavior 3 | 298
cataract 3 | 92
decreased circulating choleste... 3 | 93
impaired glucose tolerance 3 | 75
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal glucose homeostasis 2 | 4
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
decreased circulating LDL chol... 2 | 38
decreased circulating glucose ... 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total retina thickne... 1 | 4
macrophthalmia 1 | 2
male infertility 1 | 123
mammalian phenotype 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

diabetes mellitus 76 | 1,728
Carcinoma 55 | 11,493
Diabetes Mellitus, Non-Insulin-Dependent 35 | 145
psoriasis 33 | 6,694
Diabetes Mellitus, Type 2 29 | 142
ovarian cancer 28 | 8,520
osteosarcoma 27 | 7,950
Obesity 24 | 678
Autosomal recessive predisposition 23 | 1,442
Cancer 22 | 2,499
Diabetes Mellitus, Noninsulin-Dependent 22 | 31
Hyperglycemia 22 | 137
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Insulin Resistance 20 | 72
lung cancer 20 | 4,740
Hyperinsulinism 18 | 133
ependymoma 18 | 4,679
Intellectual disability 17 | 1,016
Polycystic ovary syndrome 17 | 360
glioblastoma 17 | 5,792
maturity-onset diabetes of the young 17 | 32
medulloblastoma, large-cell 17 | 6,241
Hepatomegaly 16 | 285
invasive ductal carcinoma 16 | 2,951
lung carcinoma 16 | 2,843
adult high grade glioma 15 | 3,801
atypical teratoid / rhabdoid tumor 15 | 5,112
Epilepsy 14 | 792
Type 2 diabetes mellitus 14 | 272
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Diabetes Mellitus, Insulin-Dependent 13 | 48
Dull intelligence 13 | 645
Hypertensive disease 13 | 292
Lipodystrophy 13 | 40
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
Short stature 13 | 531
interstitial cystitis 13 | 2,312
Acanthosis Nigricans 12 | 27
Alzheimer's disease 12 | 658
Breast cancer 12 | 3,578
Diabetes Mellitus, Experimental 12 | 108
Type 1 diabetes mellitus 12 | 109
breast carcinoma 12 | 1,638
malignant mesothelioma 12 | 3,232
Atherosclerosis 11 | 291
Hypersensitivity reaction type II disease 11 | 253
Hypertension 11 | 396
Maturity onset diabetes mellitus in young 11 | 11
Neuropathy 11 | 261
Seizures 11 | 596
ductal carcinoma in situ 11 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Bipolar Disorder 10 | 666
Diabetes Mellitus, Type 1 10 | 43
Gestational diabetes 10 | 26
Heart failure 10 | 162
Hypoglycemia 10 | 152
Kidney cancer 10 | 2,613
Lipid metabolism disorder 10 | 114
Multiple Sclerosis 10 | 540
Prostatic Neoplasms 10 | 495
Weight decreased 10 | 103
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Arthritis 9 | 290
Asthma 9 | 385
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Hypertriglyceridemia result 9 | 37
Liver Cirrhosis, Experimental 9 | 769
Liver disease 9 | 237
Mental and motor retardation 9 | 608
group 4 medulloblastoma 9 | 1,855
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
pituitary cancer 9 | 1,972
subependymal giant cell astrocytoma 9 | 2,287
Advanced bone age 8 | 35
Astrocytoma, Pilocytic 8 | 3,081
Atopic dermatitis 8 | 952
Blepharoptosis 8 | 231
Diarrhea 8 | 253
Glycosuria 8 | 29
Hyperhidrosis disorder 8 | 81
Hypothyroidism 8 | 122
Increased sweating 8 | 81
Kidney disease 8 | 430
Peripheral Neuropathy 8 | 134
Pick disease 8 | 1,894
Recurrent respiratory infections 8 | 141
Steatohepatitis 8 | 44
Sweating 8 | 81
dermatomyositis 8 | 966
oligodendroglioma 8 | 2,850

Tissue

Endocrine System 76 | 18,159
Digestive Tract 75 | 17,369
Female tissues 73 | 17,400
Liver and Pancreas 73 | 16,750
Skin and soft tissues 71 | 17,230
Male tissues 70 | 17,142
Blood and immune system 69 | 16,909
Urinary Tract 69 | 16,678
Cardiovascular System 68 | 15,192
Nervous System 68 | 16,725
Respiratory system 67 | 16,393

Target Family

Non-IDG 24 | 12,091
Enzyme 19 | 4,145
Transcription Factor 12 | 1,400
Kinase 8 | 634
Transporter 6 | 473
GPCR 3 | 408
Ion Channel 2 | 344
Nuclear Receptor 2 | 48

UniProt Keyword

Diabetes mellitus 76 | 76
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Calpain-10 CAPN10 Tbio Non-IDG -2.27096 197.8 112
Zinc finger protein 57 homolog ZFP57 Tbio Transcription Factor -1.62133 0.00000 136
Zinc transporter 8 SLC30A8 Tbio Transporter -2.20313 168.0 122
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 CD38 Tclin Enzyme -3.44680 2663.1 1493
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
Wolframin WFS1 Tbio Non-IDG -2.40006 260.2 118
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.36871 1.81 80