Development Level
Tbio | 722 | 10,625 | |
Tdark | 119 | 7,003 | |
Tchem | 86 | 1,890 | |
Tclin | 16 | 602 |
Collection
Eligible Kinase Proteins | 8 | 134 | |
Eligible Ion Channel Proteins | 2 | 117 | |
Eligible non-olfactory GPCR Proteins | 2 | 145 |
IMPC Term
preweaning lethality, complete... | 54 | 633 | |
preweaning lethality, incomple... | 28 | 260 | |
decreased body weight | 16 | 174 | |
abnormal embryo size | 15 | 112 | |
embryonic lethality prior to t... | 15 | 187 | |
decreased lean body mass | 14 | 195 | |
abnormal behavior | 12 | 226 | |
increased or absent threshold ... | 11 | 128 | |
abnormal bone structure | 10 | 131 | |
decreased grip strength | 10 | 123 | |
enlarged heart | 10 | 111 | |
prenatal lethality prior to he... | 10 | 64 | |
increased grip strength | 9 | 83 | |
decreased bone mineral content | 8 | 157 | |
decreased bone mineral density | 8 | 126 | |
decreased circulating choleste... | 8 | 85 | |
decreased circulating triglyce... | 8 | 83 | |
increased circulating alkaline... | 8 | 119 | |
abnormal sleep behavior | 7 | 63 | |
decreased total body fat amoun... | 7 | 186 | |
increased lean body mass | 7 | 107 | |
abnormal bone mineralization | 6 | 55 | |
decreased circulating glucose ... | 6 | 121 | |
limb grasping | 6 | 35 | |
abnormal gait | 5 | 51 | |
abnormal hindbrain development | 5 | 24 | |
abnormal midbrain development | 5 | 22 | |
abnormal neural tube closure | 5 | 37 | |
decreased circulating HDL chol... | 5 | 77 | |
decreased circulating free fat... | 5 | 39 | |
decreased rib number | 5 | 59 | |
impaired glucose tolerance | 5 | 52 | |
improved glucose tolerance | 5 | 56 | |
increased blood urea nitrogen ... | 5 | 44 | |
increased mean corpuscular vol... | 5 | 91 | |
increased startle reflex | 5 | 38 | |
abnormal eye morphology | 4 | 38 | |
abnormal forebrain development | 4 | 18 | |
abnormal pericardium morpholog... | 4 | 11 | |
abnormal retina morphology | 4 | 100 | |
anophthalmia | 4 | 20 | |
decreased body length | 4 | 108 | |
decreased circulating LDL chol... | 4 | 37 | |
decreased circulating alkaline... | 4 | 41 | |
decreased prepulse inhibition | 4 | 52 | |
hydrops fetalis | 4 | 22 | |
increased body weight | 4 | 42 | |
increased exploration in new e... | 4 | 56 | |
pale yolk sac | 4 | 12 | |
prenatal lethality | 4 | 16 | |
short tibia | 4 | 82 | |
abnormal coat/hair pigmentatio... | 3 | 54 | |
abnormal heart morphology | 3 | 51 | |
abnormal retinal pigmentation | 3 | 61 | |
abnormal seminal vesicle morph... | 3 | 47 | |
abnormal snout morphology | 3 | 18 | |
absent heartbeat | 3 | 6 | |
cleft palate | 3 | 6 | |
corneal opacity | 3 | 25 | |
decreased circulating alanine ... | 3 | 53 | |
decreased circulating calcium ... | 3 | 33 | |
decreased circulating insulin ... | 3 | 75 | |
decreased circulating total pr... | 3 | 41 | |
decreased eosinophil cell numb... | 3 | 41 | |
decreased erythrocyte cell num... | 3 | 43 | |
decreased fasted circulating g... | 3 | 49 | |
decreased hemoglobin content | 3 | 53 | |
decreased lumbar vertebrae num... | 3 | 62 | |
decreased startle reflex | 3 | 48 | |
enlarged kidney | 3 | 7 | |
female infertility | 3 | 34 | |
hyperactivity | 3 | 108 | |
increased bone mineral content | 3 | 92 | |
increased circulating chloride... | 3 | 43 | |
increased circulating creatini... | 3 | 29 | |
increased fasted circulating g... | 3 | 68 | |
increased heart weight | 3 | 37 | |
increased leukocyte cell numbe... | 3 | 37 | |
increased total body fat amoun... | 3 | 57 | |
irregularly shaped pupil | 3 | 7 | |
male infertility | 3 | 62 | |
pallor | 3 | 13 | |
abnormal behavioral response t... | 2 | 52 | |
abnormal cranium morphology | 2 | 32 | |
abnormal locomotor activation | 2 | 26 | |
abnormal optic disc morphology | 2 | 10 | |
abnormal tail movements | 2 | 12 | |
abnormal tooth morphology | 2 | 24 | |
cardiovascular system phenotyp... | 2 | 35 | |
decreased IgG1 level | 2 | 4 | |
decreased T cell number | 2 | 31 | |
decreased caudal vertebrae num... | 2 | 49 | |
decreased circulating chloride... | 2 | 32 | |
decreased circulating iron lev... | 2 | 25 | |
decreased circulating serum al... | 2 | 79 | |
decreased mean corpuscular vol... | 2 | 50 | |
increased body length | 2 | 20 | |
increased circulating HDL chol... | 2 | 63 | |
small testis | 2 | 37 | |
thrombocytopenia | 2 | 46 |
Disease
Tissue
Endocrine System | 933 | 18,512 | |
Female tissues | 928 | 18,647 | |
Digestive Tract | 926 | 18,473 | |
Nervous System | 923 | 18,561 | |
Male tissues | 911 | 17,969 | |
Skin and soft tissues | 910 | 18,115 | |
Urinary Tract | 909 | 18,444 | |
Liver and Pancreas | 898 | 18,136 | |
Cardiovascular System | 895 | 17,958 | |
Blood and immune system | 884 | 17,995 | |
Respiratory system | 844 | 17,484 |
Target Family
Non-IDG | 513 | 11,969 | |
Transcription Factor | 278 | 1,400 | |
Enzyme | 56 | 4,146 | |
Kinase | 45 | 634 | |
GPCR | 20 | 408 | |
Epigenetic | 11 | 242 | |
Ion Channel | 7 | 341 | |
Transporter | 6 | 473 | |
TF/Epigenetic | 4 | 38 | |
Nuclear Receptor | 3 | 48 |
UniProt Keyword
Developmental protein | 943 | 943 | |
Complete proteome | 20,114 | 20,114 | |
Reference proteome | 20,114 | 20,114 | |
Polymorphism | 12,039 | 12,039 | |
Alternative splicing | 10,512 | 10,512 | |
Phosphoprotein | 8,194 | 8,194 | |
Membrane | 7,179 | 7,179 | |
3D-structure | 5,887 | 5,887 | |
Transmembrane | 5,214 | 5,214 | |
Transmembrane helix | 5,194 | 5,194 | |
Nucleus | 5,156 | 5,156 | |
Repeat | 4,899 | 4,899 | |
Cytoplasm | 4,782 | 4,782 | |
Glycoprotein | 4,612 | 4,612 | |
Metal-binding | 3,614 | 3,614 | |
Signal | 3,487 | 3,487 | |
Disulfide bond | 3,472 | 3,472 | |
Acetylation | 3,372 | 3,372 | |
Cell membrane | 3,182 | 3,182 | |
Direct protein sequencing | 2,852 | 2,852 | |
Disease mutation | 2,540 | 2,540 | |
Transcription | 2,375 | 2,375 | |
Zinc | 2,340 | 2,340 | |
Transcription regulation | 2,309 | 2,309 | |
Coiled coil | 2,142 | 2,142 | |
DNA-binding | 1,998 | 1,998 | |
Transport | 1,964 | 1,964 | |
Secreted | 1,941 | 1,941 | |
Zinc-finger | 1,784 | 1,784 | |
Nucleotide-binding | 1,769 | 1,769 | |
Ubl conjugation | 1,741 | 1,741 | |
Hydrolase | 1,640 | 1,640 | |
Transferase | 1,592 | 1,592 | |
Receptor | 1,496 | 1,496 | |
ATP-binding | 1,377 | 1,377 | |
Cytoskeleton | 1,130 | 1,130 | |
Mitochondrion | 1,115 | 1,115 | |
Isopeptide bond | 1,112 | 1,112 | |
Endoplasmic reticulum | 1,071 | 1,071 | |
Methylation | 962 | 962 | |
Transducer | 886 | 886 | |
Calcium | 864 | 864 | |
G-protein coupled receptor | 830 | 830 | |
Golgi apparatus | 819 | 819 | |
Lipoprotein | 813 | 813 | |
Cell projection | 718 | 718 | |
Cell junction | 672 | 672 | |
Ubl conjugation pathway | 669 | 669 | |
RNA-binding | 663 | 663 | |
Differentiation | 661 | 661 | |
Activator | 657 | 657 | |
Cell cycle | 637 | 637 | |
Kinase | 637 | 637 | |
Ion transport | 628 | 628 | |
Protein transport | 604 | 604 | |
Sensory transduction | 600 | 600 | |
Repressor | 589 | 589 | |
Immunity | 571 | 571 | |
Oxidoreductase | 571 | 571 | |
Immunoglobulin domain | 546 | 546 | |
Magnesium | 543 | 543 | |
Transit peptide | 535 | 535 | |
Protease | 531 | 531 | |
Apoptosis | 529 | 529 | |
Endosome | 488 | 488 | |
Cytoplasmic vesicle | 487 | 487 | |
Cell adhesion | 482 | 482 | |
Host-virus interaction | 452 | 452 | |
Signal-anchor | 452 | 452 | |
Olfaction | 436 | 436 | |
Lipid metabolism | 427 | 427 | |
Serine/threonine-protein kinas... | 388 | 388 | |
Cell division | 372 | 372 | |
Chromosome | 361 | 361 | |
Synapse | 356 | 356 | |
Ion channel | 349 | 349 | |
DNA damage | 347 | 347 | |
GTP-binding | 338 | 338 | |
Ligase | 332 | 332 | |
mRNA processing | 326 | 326 | |
Palmitate | 322 | 322 | |
Chromosomal rearrangement | 320 | 320 | |
Iron | 318 | 318 | |
Leucine-rich repeat | 310 | 310 | |
Mental retardation | 299 | 299 | |
Cleavage on pair of basic resi... | 296 | 296 | |
Neurodegeneration | 292 | 292 | |
DNA repair | 288 | 288 | |
Chromatin regulator | 285 | 285 | |
Ribonucleoprotein | 280 | 280 | |
Microtubule | 279 | 279 | |
WD repeat | 278 | 278 | |
Lysosome | 275 | 275 | |
Actin-binding | 271 | 271 | |
Mitochondrion inner membrane | 268 | 268 | |
Mitosis | 262 | 262 | |
ANK repeat | 258 | 258 | |
Extracellular matrix | 258 | 258 | |
Innate immunity | 256 | 256 | |
mRNA splicing | 255 | 255 |
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