1. Home
  2. Targets
Target Filters...

Development Level

Tbio 774 | 11,445
Tdark 103 | 6,588
Tchem 70 | 1,598
Tclin 18 | 613

Collection

RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Target... 8 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 70 | 979
preweaning lethality, incomple... 41 | 499
abnormal embryo size 22 | 220
embryonic lethality prior to t... 22 | 278
abnormal behavior 19 | 298
enlarged heart 18 | 210
decreased body weight 16 | 161
decreased vertical activity 16 | 208
abnormal bone structure 14 | 187
increased lean body mass 13 | 172
abnormal heart morphology 11 | 162
prenatal lethality prior to he... 11 | 87
decreased lean body mass 10 | 135
increased circulating alkaline... 10 | 122
decreased prepulse inhibition 9 | 82
decreased total body fat amoun... 9 | 207
impaired glucose tolerance 9 | 75
increased bone mineral content 9 | 108
embryonic lethality prior to o... 8 | 239
increased startle reflex 8 | 112
increased total body fat amoun... 8 | 134
abnormal seminal vesicle morph... 7 | 114
decreased circulating triglyce... 7 | 79
embryonic growth retardation 7 | 106
hyperactivity 7 | 148
hypoactivity 7 | 132
improved glucose tolerance 7 | 79
male infertility 7 | 123
abnormal gait 6 | 69
abnormal kidney morphology 6 | 65
abnormal sleep behavior 6 | 70
decreased circulating choleste... 6 | 93
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased mean corpuscular vol... 6 | 79
limb grasping 6 | 41
abnormal retina morphology 5 | 71
abnormal snout morphology 5 | 23
decreased body length 5 | 101
decreased circulating LDL chol... 5 | 38
hydrometra 5 | 53
increased fasted circulating g... 5 | 76
mammalian phenotype 5 | 17
pallor 5 | 34
prenatal lethality 5 | 28
small superior vagus ganglion 5 | 74
abnormal neural tube closure 4 | 46
abnormal pericardium morpholog... 4 | 26
anophthalmia 4 | 33
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating insulin ... 4 | 76
decreased circulating iron lev... 4 | 32
decreased circulating total pr... 4 | 49
decreased hemoglobin content 4 | 68
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
edema 4 | 59
female infertility 4 | 60
increased blood urea nitrogen ... 4 | 48
increased circulating creatini... 4 | 38
increased circulating triglyce... 4 | 42
increased grip strength 4 | 41
pale yolk sac 4 | 25
short tibia 4 | 97
abnormal bone mineralization 3 | 38
abnormal craniofacial morpholo... 3 | 33
abnormal eye morphology 3 | 68
abnormal facial morphology 3 | 17
abnormal placenta size 3 | 20
abnormal tail movements 3 | 12
cataract 3 | 92
cleft palate 3 | 8
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating serum al... 3 | 82
decreased erythrocyte cell num... 3 | 62
decreased fasted circulating g... 3 | 65
decreased hematocrit 3 | 46
decreased neutrophil cell numb... 3 | 42
enlarged kidney 3 | 14
enlarged lymph nodes 3 | 37
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased heart weight 3 | 62
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
prolonged QT interval 3 | 38
thrombocytopenia 3 | 56
abnormal retinal vasculature m... 2 | 27
abnormal vertebrae morphology 2 | 18
decreased circulating calcium ... 2 | 36
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
microphthalmia 2 | 26

Disease

Carcinoma 639 | 11,493
ovarian cancer 409 | 8,520
osteosarcoma 386 | 7,950
psoriasis 377 | 6,694
medulloblastoma, large-cell 353 | 6,241
glioblastoma 324 | 5,792
atypical teratoid / rhabdoid tumor 305 | 5,112
ependymoma 280 | 4,679
lung cancer 277 | 4,740
group 3 medulloblastoma 254 | 4,104
Breast cancer 253 | 3,578
Cancer 227 | 2,499
adult high grade glioma 220 | 3,801
Astrocytoma, Pilocytic 199 | 3,081
invasive ductal carcinoma 197 | 2,951
oligodendroglioma 196 | 2,850
Kidney cancer 195 | 2,613
malignant mesothelioma 193 | 3,232
non-small cell lung cancer 186 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 177 | 2,989
lung carcinoma 173 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 172 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 172 | 3,291
interstitial cystitis 167 | 2,312
lung adenocarcinoma 167 | 2,716
primitive neuroectodermal tumor 162 | 3,035
astrocytic glioma 160 | 2,597
cystic fibrosis 141 | 1,696
pancreatic cancer 140 | 2,398
pituitary cancer 135 | 1,972
ductal carcinoma in situ 132 | 1,745
subependymal giant cell astrocytoma 126 | 2,287
breast carcinoma 123 | 1,638
colon cancer 113 | 1,478
Schizophrenia 103 | 1,160
ulcerative colitis 99 | 1,819
group 4 medulloblastoma 96 | 1,855
tuberculosis 89 | 2,010
adrenocortical carcinoma 85 | 1,428
Autosomal recessive predisposition 84 | 1,442
Intellectual disability 82 | 1,016
Pick disease 82 | 1,894
spina bifida 70 | 1,074
cutaneous lupus erythematosus 67 | 1,057
primary pancreatic ductal adenocarcinoma 67 | 1,109
Cleft Palate 64 | 271
Rheumatoid arthritis 63 | 1,191
nasopharyngeal carcinoma 63 | 1,058
diabetes mellitus 61 | 1,728
pediatric high grade glioma 61 | 1,064
juvenile dermatomyositis 60 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,962
Short stature 59 | 531
Melanoma 58 | 711
Atopic dermatitis 57 | 952
Epilepsy 56 | 792
Liver cancer 56 | 604
Dull intelligence 54 | 645
Low intelligence 54 | 645
Mental Retardation 54 | 645
Mental deficiency 54 | 645
Poor school performance 54 | 645
Cognitive delay 52 | 608
Global developmental delay 52 | 608
Mental and motor retardation 52 | 608
astrocytoma 52 | 1,146
Alzheimer's disease 51 | 658
gastric carcinoma 51 | 807
Bipolar Disorder 50 | 666
medulloblastoma 50 | 720
Breast Neoplasms 49 | 445
active Crohn's disease 49 | 922
acute quadriplegic myopathy 49 | 1,158
fibroadenoma 49 | 559
Mammary Neoplasms 48 | 425
Obesity 47 | 678
Seizures 47 | 596
Skin cancer 46 | 469
esophageal adenocarcinoma 45 | 737
Cryptorchidism 44 | 296
Muscle hypotonia 44 | 571
Small head 44 | 374
Infertility 43 | 188
active ulcerative colitis 43 | 764
aldosterone-producing adenoma 42 | 665
Craniofacial Abnormalities 41 | 151
Hypoplastic mandible condyle 41 | 275
Mandibular hypoplasia 41 | 275
Micrognathism 41 | 275
Cleft Lip 40 | 141
Osteoporosis 40 | 363
autosomal dominant Emery-Dreifuss muscular dystrophy 40 | 510
dermatomyositis 40 | 966
sonic hedgehog group medulloblastoma 40 | 467
Duchenne muscular dystrophy 39 | 601
Orbital separation excessive 39 | 244
chronic rhinosinusitis 39 | 512
Down syndrome 37 | 499
Male infertility 37 | 206
posterior fossa group A ependymoma 37 | 468

Tissue

Endocrine System 930 | 18,159
Digestive Tract 879 | 17,369
Skin and soft tissues 860 | 17,230
Female tissues 858 | 17,400
Male tissues 843 | 17,142
Blood and immune system 825 | 16,909
Nervous System 817 | 16,725
Urinary Tract 811 | 16,678
Liver and Pancreas 797 | 16,750
Respiratory system 777 | 16,393
Cardiovascular System 687 | 15,192

Target Family

Non-IDG 528 | 12,091
Transcription Factor 280 | 1,400
Enzyme 59 | 4,145
Kinase 45 | 634
GPCR 21 | 408
Epigenetic 12 | 242
Ion Channel 7 | 344
Transporter 6 | 473
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48

UniProt Keyword

Developmental protein 965 | 965
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Speedy protein A SPDYA Tbio Non-IDG -1.58097 42.8 145
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
Four and a half LIM domains protein 1 FHL1 Tbio Non-IDG -2.46134 291.4 312
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
T-complex protein 11 homolog TCP11 Tbio Non-IDG -1.26152 18.0 80
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Upstream-binding factor 1-like protein 1 UBTFL1 Tdark Transcription Factor 0.00000 17
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126