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Target Filters...

Development Level

Tbio 722 | 10,625
Tdark 119 | 7,003
Tchem 86 | 1,890
Tclin 16 | 602

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 54 | 633
preweaning lethality, incomple... 28 | 260
decreased body weight 16 | 174
abnormal embryo size 15 | 112
embryonic lethality prior to t... 15 | 187
decreased lean body mass 14 | 195
abnormal behavior 12 | 226
increased or absent threshold ... 11 | 128
abnormal bone structure 10 | 131
decreased grip strength 10 | 123
enlarged heart 10 | 111
prenatal lethality prior to he... 10 | 64
increased grip strength 9 | 83
decreased bone mineral content 8 | 157
decreased bone mineral density 8 | 126
decreased circulating choleste... 8 | 85
decreased circulating triglyce... 8 | 83
increased circulating alkaline... 8 | 119
abnormal sleep behavior 7 | 63
decreased total body fat amoun... 7 | 186
increased lean body mass 7 | 107
abnormal bone mineralization 6 | 55
decreased circulating glucose ... 6 | 121
limb grasping 6 | 35
abnormal gait 5 | 51
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
abnormal neural tube closure 5 | 37
decreased circulating HDL chol... 5 | 77
decreased circulating free fat... 5 | 39
decreased rib number 5 | 59
impaired glucose tolerance 5 | 52
improved glucose tolerance 5 | 56
increased blood urea nitrogen ... 5 | 44
increased mean corpuscular vol... 5 | 91
increased startle reflex 5 | 38
abnormal eye morphology 4 | 38
abnormal forebrain development 4 | 18
abnormal pericardium morpholog... 4 | 11
abnormal retina morphology 4 | 100
anophthalmia 4 | 20
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating alkaline... 4 | 41
decreased prepulse inhibition 4 | 52
hydrops fetalis 4 | 22
increased body weight 4 | 42
increased exploration in new e... 4 | 56
pale yolk sac 4 | 12
prenatal lethality 4 | 16
short tibia 4 | 82
abnormal coat/hair pigmentatio... 3 | 54
abnormal heart morphology 3 | 51
abnormal retinal pigmentation 3 | 61
abnormal seminal vesicle morph... 3 | 47
abnormal snout morphology 3 | 18
absent heartbeat 3 | 6
cleft palate 3 | 6
corneal opacity 3 | 25
decreased circulating alanine ... 3 | 53
decreased circulating calcium ... 3 | 33
decreased circulating insulin ... 3 | 75
decreased circulating total pr... 3 | 41
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased startle reflex 3 | 48
enlarged kidney 3 | 7
female infertility 3 | 34
hyperactivity 3 | 108
increased bone mineral content 3 | 92
increased circulating chloride... 3 | 43
increased circulating creatini... 3 | 29
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased leukocyte cell numbe... 3 | 37
increased total body fat amoun... 3 | 57
irregularly shaped pupil 3 | 7
male infertility 3 | 62
pallor 3 | 13
abnormal behavioral response t... 2 | 52
abnormal cranium morphology 2 | 32
abnormal locomotor activation 2 | 26
abnormal optic disc morphology 2 | 10
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 35
decreased IgG1 level 2 | 4
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating chloride... 2 | 32
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased mean corpuscular vol... 2 | 50
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
small testis 2 | 37
thrombocytopenia 2 | 46

Disease

ovarian cancer 399 | 8,484
osteosarcoma 373 | 7,933
psoriasis 367 | 6,685
medulloblastoma, large-cell 347 | 6,234
glioblastoma 309 | 5,572
atypical teratoid / rhabdoid tumor 262 | 4,369
lung cancer 258 | 4,466
Cancer 210 | 2,346
Breast cancer 208 | 3,094
pilocytic astrocytoma 197 | 3,086
invasive ductal carcinoma 195 | 2,950
oligodendroglioma 194 | 2,849
malignant mesothelioma 183 | 3,162
lung carcinoma 173 | 2,844
non-small cell lung cancer 173 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 172 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 170 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 169 | 3,289
lung adenocarcinoma 165 | 2,713
Carcinoma 164 | 2,147
interstitial cystitis 164 | 2,299
primitive neuroectodermal tumor 160 | 3,031
pediatric high grade glioma 158 | 2,712
ependymoma 143 | 2,514
cystic fibrosis 136 | 1,665
astrocytic glioma 132 | 2,241
pituitary cancer 132 | 1,972
ductal carcinoma in situ 131 | 1,745
group 3 medulloblastoma 131 | 2,254
pancreatic cancer 129 | 2,300
subependymal giant cell astrocytoma 124 | 2,287
breast carcinoma 119 | 1,614
adult high grade glioma 118 | 2,148
group 4 medulloblastoma 112 | 1,875
colon cancer 110 | 1,475
sonic hedgehog group medulloblastoma 108 | 1,482
ulcerative colitis 105 | 2,087
posterior fossa group A ependymoma 102 | 1,511
posterior fossa group B ependymoma 89 | 1,530
adrenocortical carcinoma 83 | 1,427
medulloblastoma 83 | 1,524
Pick disease 81 | 1,893
astrocytoma 77 | 1,493
primary pancreatic ductal adenocarcinoma 75 | 1,271
cutaneous lupus erythematosus 67 | 1,056
spina bifida 66 | 1,064
tuberculosis 65 | 1,557
atypical teratoid/rhabdoid tumor 64 | 1,095
Rheumatoid Arthritis 61 | 1,160
nasopharyngeal carcinoma 60 | 1,056
juvenile dermatomyositis 58 | 1,189
diabetes mellitus 56 | 1,663
Atopic dermatitis 55 | 944
gastric carcinoma 52 | 832
pancreatic ductal adenocarcinoma liver metastasis 50 | 1,795
fibroadenoma 49 | 557
active Crohn's disease 48 | 918
Alzheimer's disease 46 | 644
Mammary Neoplasms 46 | 410
acute quadriplegic myopathy 45 | 1,157
esophageal adenocarcinoma 44 | 737
Cleft palate 42 | 125
aldosterone-producing adenoma 42 | 664
Intellectual disability 41 | 573
Craniofacial Abnormalities 40 | 147
dermatomyositis 39 | 933
Duchenne muscular dystrophy 38 | 602
Schizophrenia 38 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 38 | 499
chronic rhinosinusitis 38 | 512
Down syndrome 37 | 548
Obesity 37 | 616
Infertility 35 | 163
non-small cell lung carcinoma 35 | 413
Osteoporosis 34 | 257
active ulcerative colitis 33 | 477
acute myeloid leukemia 33 | 780
Cleft Lip 31 | 91
Endometriosis 31 | 535
Male infertility 31 | 170
Kidney disease 30 | 396
Multiple myeloma 30 | 1,327
facioscapulohumeral dystrophy 30 | 286
non primary Sjogren syndrome sicca 29 | 840
Autistic Disorder 28 | 320
Parkinson's disease 28 | 364
Polydactyly 27 | 93
glioblastoma multiforme 27 | 347
Microphthalmia 26 | 78
Amyotrophic Lateral Sclerosis 25 | 431
urothelial carcinoma 25 | 318
Prostatic Neoplasms 24 | 471
Syndactyly 24 | 56
hepatocellular carcinoma 24 | 532
inflammatory breast cancer 24 | 404
tuberculosis and treatment for 6 months 24 | 686
Colorectal Neoplasms 23 | 217
non-inflammatory breast cancer 23 | 208
primary Sjogren syndrome 23 | 789
Holoprosencephaly 22 | 52

Tissue

Endocrine System 933 | 18,512
Female tissues 928 | 18,647
Digestive Tract 926 | 18,473
Nervous System 923 | 18,561
Male tissues 911 | 17,969
Skin and soft tissues 910 | 18,115
Urinary Tract 909 | 18,444
Liver and Pancreas 898 | 18,136
Cardiovascular System 895 | 17,958
Blood and immune system 884 | 17,995
Respiratory system 844 | 17,484

Target Family

Non-IDG 513 | 11,971
Transcription Factor 278 | 1,400
Enzyme 56 | 4,146
Kinase 45 | 634
GPCR 20 | 406
Epigenetic 11 | 242
Ion Channel 7 | 341
Transporter 6 | 473
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48

UniProt Keyword

Developmental protein 943 | 943
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Transcription factor 23 TCF23 Tdark Transcription Factor -0.80163 6.17 21
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.56282 377.5 283
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85
Class A basic helix-loop-helix protein 9 BHLHA9 Tbio Transcription Factor -1.04597 11.2 52
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508