Development Level

Tbio 153 | 10,625
Tchem 23 | 1,890
Tclin 13 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

increased or absent threshold ... 13 | 128
preweaning lethality, complete... 12 | 633
decreased prepulse inhibition 8 | 52
embryonic lethality prior to t... 8 | 187
decreased startle reflex 6 | 48
abnormal behavior 5 | 226
absent startle reflex 5 | 15
decreased body length 5 | 108
decreased lean body mass 5 | 195
abnormal embryo size 4 | 112
absent pinna reflex 4 | 21
decreased body weight 4 | 174
decreased circulating amylase ... 4 | 24
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
enlarged heart 4 | 111
increased circulating sodium l... 4 | 71
increased mean corpuscular hem... 4 | 93
preweaning lethality, incomple... 4 | 260
abnormal ear morphology 3 | 5
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased hemoglobin content 3 | 53
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
increased circulating alkaline... 3 | 119
persistence of hyaloid vascula... 3 | 22
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal embryo turning 2 | 15
abnormal glucose homeostasis 2 | 5
abnormal kidney morphology 2 | 30
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal tibia morphology 2 | 14
abnormal vibrissa morphology 2 | 17
abnormal vitreous body morphol... 2 | 7
cataract 2 | 26
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating glycerol... 2 | 19
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
embryonic growth retardation 2 | 28
female infertility 2 | 34
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating phosphat... 2 | 24
increased mean corpuscular vol... 2 | 91
increased mean platelet volume 2 | 19
increased startle reflex 2 | 38
limb grasping 2 | 35
polycystic kidney 2 | 9
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
small adrenal glands 2 | 15
stereotypic behavior 2 | 3
thrombocytopenia 2 | 46
tremors 2 | 34
trunk curl 2 | 15
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal cranium morphology 1 | 32
abnormal gait 1 | 51
abnormal locomotor activation 1 | 26
abnormal motor coordination/ b... 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased circulating creatini... 1 | 31
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
hydrops fetalis 1 | 22
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased eosinophil cell numb... 1 | 9
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
straub tail 1 | 26

Disease

ovarian cancer 97 | 8,484
Nonsyndromic deafness 92 | 121
psoriasis 84 | 6,685
osteosarcoma 82 | 7,933
medulloblastoma, large-cell 75 | 6,234
Sensorineural hearing loss 72 | 107
lung cancer 68 | 4,466
glioblastoma 58 | 5,572
Carcinoma 54 | 2,147
pilocytic astrocytoma 46 | 3,086
atypical teratoid / rhabdoid tumor 45 | 4,369
Breast cancer 44 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
non-small cell lung cancer 43 | 2,798
pituitary cancer 41 | 1,972
lung carcinoma 40 | 2,844
malignant mesothelioma 40 | 3,162
invasive ductal carcinoma 39 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
interstitial cystitis 37 | 2,299
oligodendroglioma 37 | 2,849
ependymoma 36 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
lung adenocarcinoma 35 | 2,713
Cancer 34 | 2,346
pediatric high grade glioma 34 | 2,712
primitive neuroectodermal tumor 34 | 3,031
cystic fibrosis 29 | 1,665
breast carcinoma 26 | 1,614
group 4 medulloblastoma 26 | 1,875
ulcerative colitis 26 | 2,087
adult high grade glioma 25 | 2,148
ductal carcinoma in situ 25 | 1,745
subependymal giant cell astrocytoma 25 | 2,287
colon cancer 24 | 1,475
pancreatic cancer 24 | 2,300
Intellectual disability 23 | 573
Pick disease 23 | 1,893
adrenocortical carcinoma 23 | 1,427
astrocytic glioma 23 | 2,241
astrocytoma 23 | 1,493
group 3 medulloblastoma 23 | 2,254
spina bifida 22 | 1,064
Hodgkin's lymphoma, nodular sclerosis 21 | 24
Neuropathy 21 | 210
atypical teratoid/rhabdoid tumor 21 | 1,095
sonic hedgehog group medulloblastoma 19 | 1,482
tuberculosis 19 | 1,557
diabetes mellitus 18 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
posterior fossa group A ependymoma 18 | 1,511
Multiple myeloma 17 | 1,327
Retinitis pigmentosa 17 | 153
acute quadriplegic myopathy 17 | 1,157
medulloblastoma 17 | 1,524
Neurodegenerative disease 16 | 383
Cataract 15 | 104
Rheumatoid Arthritis 15 | 1,160
Usher syndrome 15 | 34
Blindness 14 | 84
posterior fossa group B ependymoma 14 | 1,530
primary pancreatic ductal adenocarcinoma 14 | 1,271
Craniofacial Abnormalities 13 | 147
Down syndrome 13 | 548
dermatomyositis 13 | 933
nasopharyngeal carcinoma 13 | 1,056
Deafness 12 | 18
fibroadenoma 12 | 557
juvenile dermatomyositis 12 | 1,189
Kidney disease 11 | 396
gastric carcinoma 11 | 832
Atopic dermatitis 10 | 944
active Crohn's disease 10 | 918
cutaneous lupus erythematosus 10 | 1,056
Cleft palate 9 | 125
Epilepsy 9 | 346
Heart disease 9 | 279
Melanoma 9 | 261
Prostatic Neoplasms 9 | 471
Alport syndrome 8 | 21
Alzheimer's disease 8 | 644
Cardiomyopathy 8 | 110
Duchenne muscular dystrophy 8 | 602
Endometriosis 8 | 535
Lung Neoplasms 8 | 171
Waardenburg's syndrome 8 | 16
esophageal adenocarcinoma 8 | 737
non-small cell lung carcinoma 8 | 413
Hypertension 7 | 287
Mammary Neoplasms, Experimental 7 | 150
Multiple Sclerosis 7 | 498
Neoplasm Invasiveness 7 | 127
Obesity 7 | 616
Osteoarthritis 7 | 96
Perrault syndrome 7 | 12
Renal Cell Carcinoma 7 | 199
Sensorineural Hearing Loss (disorder) 7 | 11
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
mucosa-associated lymphoid tissue lymphoma 7 | 480
non primary Sjogren syndrome sicca 7 | 840

Tissue

Digestive Tract 197 | 18,473
Endocrine System 197 | 18,512
Female tissues 197 | 18,647
Nervous System 197 | 18,561
Urinary Tract 197 | 18,444
Liver and Pancreas 194 | 18,136
Skin and soft tissues 194 | 18,115
Cardiovascular System 193 | 17,958
Blood and immune system 192 | 17,995
Respiratory system 190 | 17,484
Male tissues 189 | 17,969

Target Family

Non-IDG 111 | 11,971
Enzyme 41 | 4,146
Transcription Factor 14 | 1,400
Ion Channel 11 | 341
Transporter 10 | 473
Kinase 6 | 634
GPCR 3 | 406
Nuclear Receptor 2 | 48

UniProt Keyword

Deafness 198 | 198
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Stereocilin STRC Tbio Non-IDG 35.9 7
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Otoancorin OTOA Tdark Non-IDG -1.29628 19.3 48
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -1.97274 103.1 38