Development Level

Tbio 1,302 | 11,651
Tdark 596 | 6,593
Tchem 79 | 1,388
Tclin 31 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 106 | 979
preweaning lethality, incomple... 54 | 499
embryonic lethality prior to t... 36 | 278
abnormal embryo size 29 | 220
abnormal bone structure 25 | 187
decreased total body fat amoun... 23 | 207
enlarged heart 23 | 210
abnormal behavior 22 | 298
embryonic lethality prior to o... 22 | 239
decreased vertical activity 20 | 208
increased lean body mass 20 | 172
decreased bone mineral density 18 | 126
abnormal heart morphology 17 | 162
increased bone mineral content 17 | 108
decreased body weight 15 | 161
decreased lean body mass 15 | 135
hypoactivity 15 | 132
decreased circulating triglyce... 14 | 79
increased total body fat amoun... 14 | 134
decreased bone mineral content 13 | 151
decreased circulating glucose ... 13 | 126
increased bone mineral density 13 | 72
increased startle reflex 13 | 112
decreased prepulse inhibition 12 | 82
embryonic growth retardation 12 | 106
increased circulating alkaline... 12 | 122
decreased body length 11 | 101
decreased grip strength 11 | 116
prenatal lethality prior to he... 11 | 87
abnormal gait 10 | 69
abnormal seminal vesicle morph... 10 | 114
decreased circulating serum al... 10 | 82
decreased hemoglobin content 10 | 68
increased mean corpuscular vol... 10 | 92
increased or absent threshold ... 10 | 101
abnormal retina morphology 9 | 71
decreased erythrocyte cell num... 9 | 62
increased mean corpuscular hem... 9 | 96
male infertility 9 | 123
abnormal behavioral response t... 8 | 66
abnormal eye morphology 8 | 68
decreased blood urea nitrogen ... 8 | 51
decreased circulating choleste... 8 | 93
decreased circulating insulin ... 8 | 76
decreased lymphocyte cell numb... 8 | 83
female infertility 8 | 60
hyperactivity 8 | 148
impaired glucose tolerance 8 | 75
increased monocyte cell number 8 | 63
small superior vagus ganglion 8 | 74
abnormal kidney morphology 7 | 65
decreased caudal vertebrae num... 7 | 53
increased circulating HDL chol... 7 | 80
increased circulating sodium l... 7 | 71
increased circulating triglyce... 7 | 42
increased fasted circulating g... 7 | 76
abnormal neural tube closure 6 | 46
abnormal sleep behavior 6 | 70
decreased circulating HDL chol... 6 | 68
decreased circulating total pr... 6 | 49
decreased mean corpuscular vol... 6 | 79
improved glucose tolerance 6 | 79
increased body temperature 6 | 9
increased circulating choleste... 6 | 66
increased neutrophil cell numb... 6 | 46
prenatal lethality 6 | 28
short tibia 6 | 97
thrombocytopenia 6 | 56
abnormal bone mineralization 5 | 38
abnormal cornea morphology 5 | 31
abnormal craniofacial morpholo... 5 | 33
abnormal spleen morphology 5 | 55
abnormal tooth morphology 5 | 24
anophthalmia 5 | 33
cataract 5 | 92
decreased T cell number 5 | 15
decreased circulating alanine ... 5 | 47
decreased leukocyte cell numbe... 5 | 73
decreased startle reflex 5 | 75
increased grip strength 5 | 41
increased hemoglobin content 5 | 45
increased mean corpuscular hem... 5 | 36
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
abnormal locomotor activation 4 | 16
corneal opacity 4 | 32
decreased circulating alkaline... 4 | 46
decreased circulating amylase ... 4 | 28
decreased circulating aspartat... 4 | 34
decreased hematocrit 4 | 46
decreased mean corpuscular hem... 4 | 50
decreased neutrophil cell numb... 4 | 42
hydrometra 4 | 53
increased body length 4 | 32
increased circulating chloride... 4 | 41
increased heart weight 4 | 62
increased prepulse inhibition 4 | 32
microphthalmia 4 | 26
pale yolk sac 4 | 25
vertebral fusion 4 | 23

Disease

Carcinoma 1,327 | 11,493
osteosarcoma 904 | 7,950
ovarian cancer 840 | 8,520
psoriasis 688 | 6,694
medulloblastoma, large-cell 653 | 6,241
glioblastoma 562 | 5,792
lung cancer 545 | 4,740
group 3 medulloblastoma 524 | 4,104
atypical teratoid / rhabdoid tumor 508 | 5,112
Breast cancer 416 | 3,578
Cancer 398 | 2,499
malignant mesothelioma 393 | 3,232
ependymoma 392 | 4,679
primitive neuroectodermal tumor 363 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 314 | 3,291
adult high grade glioma 303 | 3,801
Kidney cancer 297 | 2,613
invasive ductal carcinoma 295 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 292 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 255 | 2,955
non-small cell lung cancer 248 | 2,890
oligodendroglioma 246 | 2,850
lung adenocarcinoma 239 | 2,716
Astrocytoma, Pilocytic 220 | 3,081
group 4 medulloblastoma 217 | 1,855
pancreatic cancer 212 | 2,398
astrocytic glioma 203 | 2,597
lung carcinoma 198 | 2,843
pituitary cancer 192 | 1,972
tuberculosis 182 | 2,010
interstitial cystitis 180 | 2,312
subependymal giant cell astrocytoma 177 | 2,287
ductal carcinoma in situ 174 | 1,745
breast carcinoma 172 | 1,638
Pick disease 167 | 1,894
adrenocortical carcinoma 165 | 1,428
colon cancer 150 | 1,478
cystic fibrosis 150 | 1,696
ulcerative colitis 148 | 1,819
Rheumatoid arthritis 146 | 1,191
Intellectual disability 144 | 1,016
diabetes mellitus 136 | 1,728
astrocytoma 134 | 1,146
juvenile dermatomyositis 131 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 129 | 1,962
pediatric high grade glioma 128 | 1,064
Multiple myeloma 126 | 1,332
spina bifida 124 | 1,074
Autosomal recessive predisposition 121 | 1,442
acute quadriplegic myopathy 116 | 1,158
acute myeloid leukemia 115 | 783
Schizophrenia 104 | 1,160
cutaneous lupus erythematosus 104 | 1,057
Dull intelligence 103 | 645
Low intelligence 103 | 645
Mental Retardation 103 | 645
Mental deficiency 103 | 645
Poor school performance 103 | 645
dermatomyositis 99 | 966
Short stature 98 | 531
primary pancreatic ductal adenocarcinoma 96 | 1,109
Waldenstrons macroglobulinemia 93 | 765
nasopharyngeal carcinoma 93 | 1,058
Breast Neoplasms 88 | 445
non primary Sjogren syndrome sicca 87 | 891
Cognitive delay 85 | 608
Global developmental delay 85 | 608
Mental and motor retardation 85 | 608
Mammary Neoplasms 83 | 425
medulloblastoma 82 | 720
primary Sjogren syndrome 81 | 735
hepatocellular carcinoma 76 | 547
Epilepsy 75 | 792
Obesity 75 | 678
Muscle hypotonia 74 | 571
Bipolar Disorder 71 | 666
Prostatic Neoplasms 71 | 495
Small head 71 | 374
aldosterone-producing adenoma 71 | 665
Atopic dermatitis 69 | 952
gastric cancer 68 | 459
gastric carcinoma 67 | 807
Endometriosis 65 | 540
Seizures 64 | 596
Cleft Palate 63 | 271
Melanoma 62 | 711
Cryptorchidism 61 | 296
active Crohn's disease 61 | 922
progressive supranuclear palsy 61 | 676
Strabismus 56 | 270
Alzheimer's disease 55 | 658
Craniofacial Abnormalities 55 | 151
active ulcerative colitis 55 | 764
Liver cancer 54 | 604
sonic hedgehog group medulloblastoma 54 | 467
tuberculosis and treatment for 6 months 54 | 409
Acquired metabolic disease 52 | 336
Multiple Sclerosis 52 | 540
esophageal adenocarcinoma 51 | 737
pancreatic carcinoma 51 | 562

Tissue

Endocrine System 1,906 | 18,159
Digestive Tract 1,822 | 17,369
Skin and soft tissues 1,814 | 17,230
Female tissues 1,808 | 17,400
Male tissues 1,793 | 17,142
Nervous System 1,770 | 16,725
Blood and immune system 1,767 | 16,909
Urinary Tract 1,740 | 16,678
Liver and Pancreas 1,732 | 16,750
Respiratory system 1,707 | 16,393
Cardiovascular System 1,611 | 15,192

Target Family

Transcription Factor 1,312 | 1,400
Non-IDG 449 | 12,091
Enzyme 124 | 4,145
Nuclear Receptor 46 | 48
Epigenetic 44 | 242
TF/Epigenetic 23 | 38
Kinase 9 | 634
Transporter 1 | 473

UniProt Keyword

DNA-binding 2,008 | 2,008
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Serine-protein kinase ATM ATM Tchem Kinase -3.57054 3681.6 1024
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.33049 2009.0 1596
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610