Development Level

Tbio 1,230 | 10,625
Tdark 631 | 7,003
Tchem 106 | 1,890
Tclin 31 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 66 | 633
preweaning lethality, incomple... 33 | 260
embryonic lethality prior to t... 27 | 187
decreased lean body mass 20 | 195
abnormal behavior 19 | 226
abnormal bone structure 18 | 131
decreased total body fat amoun... 18 | 186
abnormal embryo size 16 | 112
embryonic lethality prior to o... 16 | 148
decreased bone mineral content 15 | 157
increased lean body mass 15 | 107
decreased body weight 14 | 174
decreased body length 13 | 108
decreased bone mineral density 13 | 126
decreased grip strength 13 | 123
increased bone mineral content 13 | 92
abnormal retina morphology 12 | 100
decreased circulating triglyce... 12 | 83
hypoactivity 12 | 89
increased or absent threshold ... 12 | 128
decreased hemoglobin content 11 | 53
increased mean corpuscular vol... 10 | 91
abnormal retinal pigmentation 9 | 61
decreased caudal vertebrae num... 9 | 49
decreased circulating serum al... 9 | 79
increased circulating alkaline... 9 | 119
prenatal lethality prior to he... 9 | 64
abnormal eye morphology 8 | 38
abnormal sleep behavior 8 | 63
decreased circulating HDL chol... 8 | 77
decreased circulating choleste... 8 | 85
decreased circulating glucose ... 8 | 121
enlarged heart 8 | 111
hyperactivity 8 | 108
increased grip strength 8 | 83
abnormal neural tube closure 7 | 37
decreased circulating insulin ... 7 | 75
decreased erythrocyte cell num... 7 | 43
increased circulating HDL chol... 7 | 63
increased circulating sodium l... 7 | 71
increased fasted circulating g... 7 | 68
increased mean corpuscular hem... 7 | 93
increased startle reflex 7 | 38
short tibia 7 | 82
abnormal behavioral response t... 6 | 52
abnormal bone mineralization 6 | 55
abnormal hindbrain development 6 | 24
decreased prepulse inhibition 6 | 52
female infertility 6 | 34
increased bone mineral density 6 | 52
increased circulating triglyce... 6 | 24
increased sacral vertebrae num... 6 | 62
abnormal coat/hair pigmentatio... 5 | 54
abnormal cornea morphology 5 | 24
abnormal forebrain development 5 | 18
abnormal gait 5 | 51
abnormal lens morphology 5 | 73
decreased blood urea nitrogen ... 5 | 31
decreased circulating alanine ... 5 | 53
decreased circulating total pr... 5 | 41
decreased hematocrit 5 | 25
decreased lumbar vertebrae num... 5 | 62
increased circulating choleste... 5 | 53
increased total body fat amoun... 5 | 57
straub tail 5 | 26
thrombocytopenia 5 | 46
abnormal heart morphology 4 | 51
abnormal locomotor activation 4 | 26
abnormal midbrain development 4 | 22
abnormal spleen morphology 4 | 36
abnormal tooth morphology 4 | 24
corneal opacity 4 | 25
decreased T cell number 4 | 31
decreased circulating alkaline... 4 | 41
decreased circulating aspartat... 4 | 27
decreased circulating chloride... 4 | 32
decreased circulating creatini... 4 | 31
decreased circulating fructosa... 4 | 31
decreased effector memory CD8-... 4 | 24
decreased mature B cell number 4 | 25
decreased mean corpuscular vol... 4 | 50
decreased rib number 4 | 59
decreased threshold for audito... 4 | 32
increased exploration in new e... 4 | 56
increased hemoglobin content 4 | 45
increased mean corpuscular hem... 4 | 25
male infertility 4 | 62
prenatal lethality 4 | 16
vertebral fusion 4 | 23
anophthalmia 3 | 20
decreased circulating glycerol... 3 | 19
decreased fasted circulating g... 3 | 49
impaired glucose tolerance 3 | 52
increased body weight 3 | 42
increased circulating chloride... 3 | 43
increased heart weight 3 | 37
increased prepulse inhibition 3 | 21
persistence of hyaloid vascula... 3 | 22
small testis 3 | 37
tremors 3 | 34

Disease

osteosarcoma 901 | 7,933
ovarian cancer 833 | 8,484
psoriasis 687 | 6,685
medulloblastoma, large-cell 649 | 6,234
glioblastoma 534 | 5,572
lung cancer 513 | 4,466
atypical teratoid / rhabdoid tumor 436 | 4,369
malignant mesothelioma 388 | 3,162
Cancer 369 | 2,346
primitive neuroectodermal tumor 362 | 3,031
Breast cancer 356 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 312 | 3,289
invasive ductal carcinoma 295 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 291 | 2,988
group 3 medulloblastoma 278 | 2,254
group 4 medulloblastoma 278 | 1,875
pediatric high grade glioma 262 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 255 | 2,956
oligodendroglioma 246 | 2,849
non-small cell lung cancer 243 | 2,798
lung adenocarcinoma 239 | 2,713
Carcinoma 229 | 2,147
ependymoma 223 | 2,514
pilocytic astrocytoma 214 | 3,086
pancreatic cancer 198 | 2,300
lung carcinoma 196 | 2,844
pituitary cancer 191 | 1,972
sonic hedgehog group medulloblastoma 181 | 1,482
interstitial cystitis 178 | 2,299
subependymal giant cell astrocytoma 178 | 2,287
ductal carcinoma in situ 174 | 1,745
astrocytic glioma 173 | 2,241
adult high grade glioma 169 | 2,148
breast carcinoma 169 | 1,614
Pick disease 166 | 1,893
adrenocortical carcinoma 166 | 1,427
ulcerative colitis 164 | 2,087
astrocytoma 161 | 1,493
colon cancer 150 | 1,475
Rheumatoid Arthritis 149 | 1,160
cystic fibrosis 149 | 1,665
tuberculosis 139 | 1,557
medulloblastoma 138 | 1,524
posterior fossa group A ependymoma 138 | 1,511
juvenile dermatomyositis 129 | 1,189
diabetes mellitus 126 | 1,663
Multiple myeloma 124 | 1,327
spina bifida 121 | 1,064
acute quadriplegic myopathy 115 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 115 | 1,795
atypical teratoid/rhabdoid tumor 113 | 1,095
posterior fossa group B ependymoma 113 | 1,530
acute myeloid leukemia 110 | 780
primary pancreatic ductal adenocarcinoma 107 | 1,271
cutaneous lupus erythematosus 104 | 1,056
dermatomyositis 96 | 933
nasopharyngeal carcinoma 94 | 1,056
Waldenstrons macroglobulinemia 93 | 765
primary Sjogren syndrome 88 | 789
Mammary Neoplasms 82 | 410
tuberculosis and treatment for 6 months 81 | 686
non primary Sjogren syndrome sicca 80 | 840
Intellectual disability 79 | 573
hepatocellular carcinoma 72 | 532
aldosterone-producing adenoma 70 | 664
gastric carcinoma 70 | 832
Atopic dermatitis 69 | 944
Endometriosis 64 | 535
gastric cancer 64 | 430
Prostatic Neoplasms 62 | 471
active Crohn's disease 61 | 918
progressive supranuclear palsy 61 | 674
Obesity 58 | 616
Craniofacial Abnormalities 55 | 147
inflammatory breast cancer 55 | 404
pancreatic carcinoma 54 | 567
Down syndrome 50 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 50 | 499
esophageal adenocarcinoma 50 | 737
Alzheimer's disease 49 | 644
Amyotrophic Lateral Sclerosis 49 | 431
Multiple Sclerosis 47 | 498
Stomach Neoplasms 46 | 282
chronic rhinosinusitis 45 | 512
Acquired metabolic disease 42 | 267
Peripheral Neuropathy 42 | 303
fibroadenoma 41 | 557
glioblastoma multiforme 41 | 347
Cleft palate 40 | 125
Liver carcinoma 39 | 217
Crohn's disease 38 | 304
Melanoma 37 | 261
Schizophrenia 37 | 501
active ulcerative colitis 37 | 477
non-small cell lung carcinoma 37 | 413
sarcoidosis 36 | 358
IGA Glomerulonephritis 35 | 454
Duchenne muscular dystrophy 34 | 602
chronic lymphosyte leukemia 34 | 232
facioscapulohumeral dystrophy 34 | 286

Tissue

Female tissues 1,935 | 18,647
Nervous System 1,926 | 18,561
Digestive Tract 1,923 | 18,473
Endocrine System 1,922 | 18,512
Urinary Tract 1,904 | 18,444
Male tissues 1,896 | 17,969
Liver and Pancreas 1,888 | 18,136
Blood and immune system 1,887 | 17,995
Cardiovascular System 1,877 | 17,958
Skin and soft tissues 1,875 | 18,115
Respiratory system 1,808 | 17,484

Target Family

Transcription Factor 1,311 | 1,400
Non-IDG 444 | 11,971
Enzyme 120 | 4,146
Nuclear Receptor 46 | 48
Epigenetic 44 | 242
TF/Epigenetic 23 | 38
Kinase 9 | 634
Transporter 1 | 473

UniProt Keyword

DNA-binding 1,998 | 1,998
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Class A basic helix-loop-helix protein 15 BHLHA15 Tbio Transcription Factor -1.24086 19.1 70