Development Level

Tbio 248 | 11,651
Tchem 34 | 1,388
Tdark 20 | 6,593
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 33 | 979
embryonic lethality prior to o... 13 | 239
embryonic lethality prior to t... 13 | 278
preweaning lethality, incomple... 10 | 499
abnormal bone structure 7 | 187
decreased body weight 6 | 161
male infertility 6 | 123
abnormal embryo size 5 | 220
decreased bone mineral content 5 | 151
abnormal coat-hair pigmentatio... 4 | 64
abnormal retina morphology 4 | 71
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 135
enlarged heart 4 | 210
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
corneal opacity 3 | 32
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
increased bone mineral density 3 | 72
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
small testis 3 | 58
tremors 3 | 39
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
anophthalmia 2 | 33
cataract 2 | 92
decreased circulating alanine ... 2 | 47
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased lactate dehydrogenas... 2 | 16
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
female infertility 2 | 60
hyperactivity 2 | 148
increased circulating HDL chol... 2 | 80
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
abnormal blood vessel morpholo... 1 | 5
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal lung morphology 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body weight 1 | 25
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
long tibia 1 | 25
prenatal lethality 1 | 28
shortened RR interval 1 | 17
small kidney 1 | 16
small spleen 1 | 19
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 209 | 11,493
ovarian cancer 187 | 8,520
osteosarcoma 168 | 7,950
medulloblastoma, large-cell 120 | 6,241
group 3 medulloblastoma 114 | 4,104
psoriasis 107 | 6,694
lung cancer 101 | 4,740
Cancer 100 | 2,499
glioblastoma 100 | 5,792
atypical teratoid / rhabdoid tumor 91 | 5,112
Breast cancer 87 | 3,578
malignant mesothelioma 78 | 3,232
primitive neuroectodermal tumor 78 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 65 | 3,291
ependymoma 64 | 4,679
Kidney cancer 59 | 2,613
adult high grade glioma 53 | 3,801
Intellectual disability 51 | 1,016
Autosomal recessive predisposition 50 | 1,442
non-small cell lung cancer 50 | 2,890
lung adenocarcinoma 49 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,989
Fanconi anemia 47 | 56
oligodendroglioma 46 | 2,850
invasive ductal carcinoma 43 | 2,951
Dull intelligence 42 | 645
Low intelligence 42 | 645
Mental Retardation 42 | 645
Mental deficiency 42 | 645
Poor school performance 42 | 645
Short stature 41 | 531
astrocytic glioma 40 | 2,597
Pick disease 39 | 1,894
Small head 38 | 374
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
Xeroderma pigmentosum 36 | 43
Cockayne syndrome 34 | 60
Cognitive delay 33 | 608
Global developmental delay 33 | 608
Mental and motor retardation 33 | 608
Waldenstrons macroglobulinemia 30 | 765
tuberculosis 29 | 2,010
adrenocortical carcinoma 28 | 1,428
colon cancer 28 | 1,478
Multiple myeloma 27 | 1,332
breast carcinoma 27 | 1,638
juvenile dermatomyositis 27 | 1,187
diabetes mellitus 26 | 1,728
nasopharyngeal carcinoma 26 | 1,058
Cryptorchidism 25 | 296
pituitary cancer 24 | 1,972
Astrocytoma, Pilocytic 23 | 3,081
Chromosome Breakage 23 | 36
hypopigmented skin patch 23 | 59
pancreatic cancer 23 | 2,398
Rheumatoid arthritis 22 | 1,191
acute quadriplegic myopathy 22 | 1,158
dermatomyositis 22 | 966
progressive supranuclear palsy 22 | 676
Acquired scoliosis 21 | 281
Bloom syndrome 21 | 29
Breast Neoplasms 21 | 445
Curvature of spine 21 | 282
Mammary Neoplasms 21 | 425
Anemia 20 | 365
Decreased platelet count 20 | 111
Epilepsy 20 | 792
Increased chromosomal breakage 20 | 27
Thrombocytopenia 20 | 197
ductal carcinoma in situ 20 | 1,745
subependymal giant cell astrocytoma 20 | 2,287
Muscle hypotonia 19 | 571
Nijmegen breakage syndrome 19 | 24
Seizures 19 | 596
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Almond-shaped eyes 18 | 23
astrocytoma 18 | 1,146
group 4 medulloblastoma 18 | 1,855
Ataxia telangiectasia 17 | 34
Fatigue 17 | 182
Leukopenia 17 | 72
Melanoma 17 | 711
Sensorineural Hearing Loss (disorder) 17 | 284
ulcerative colitis 17 | 1,819
Esophageal atresia with or without tracheoesophageal fistula 16 | 21
Fetal Growth Retardation 16 | 189
Infant, Small for Gestational Age 16 | 176
Intrauterine retardation 16 | 176
Irregular hyperpigmentation 16 | 33
Muscle Hypertonia 16 | 88
Photosensitivity of skin 16 | 51
Pyridoxine-responsive sideroblastic anemia 16 | 17
Radial aplasia/hypoplasia 16 | 29
Short palpebral fissure 16 | 38
Strabismus 16 | 270
Xeroderma pigmentosum group F 16 | 22
esophageal atresia/tracheoesophageal fistula 16 | 22
hepatocellular carcinoma 16 | 547
pediatric high grade glioma 16 | 1,064
Micrognathism 15 | 275

Tissue

Blood and immune system 306 | 16,909
Endocrine System 306 | 18,159
Female tissues 306 | 17,400
Nervous System 306 | 16,725
Skin and soft tissues 306 | 17,230
Urinary Tract 306 | 16,678
Digestive Tract 305 | 17,369
Liver and Pancreas 305 | 16,750
Male tissues 305 | 17,142
Respiratory system 305 | 16,393
Cardiovascular System 298 | 15,192

Target Family

Non-IDG 167 | 12,091
Enzyme 108 | 4,145
Kinase 11 | 634
Transcription Factor 11 | 1,400
Epigenetic 9 | 242

UniProt Keyword

DNA repair 306 | 306
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.44266 2522.8 1114