Development Level

Tbio 225 | 10,625
Tchem 38 | 1,890
Tdark 22 | 7,003
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 25 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 9 | 187
decreased body weight 7 | 174
increased or absent threshold ... 5 | 128
decreased body length 4 | 108
hypoactivity 4 | 89
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal coat/hair pigmentatio... 3 | 54
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
male infertility 3 | 62
tremors 3 | 34
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal gait 2 | 51
abnormal retina morphology 2 | 100
decreased circulating aspartat... 2 | 27
decreased circulating glucose ... 2 | 121
decreased lactate dehydrogenas... 2 | 14
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
enlarged heart 2 | 111
hydrops fetalis 2 | 22
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
narrow eye opening 2 | 15
small testis 2 | 37
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal retinal blood vessel ... 1 | 18
abnormal retinal inner nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
hyperactivity 1 | 108
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased prepulse inhibition 1 | 21
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
small adrenal glands 1 | 15
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 175 | 8,484
osteosarcoma 162 | 7,933
medulloblastoma, large-cell 115 | 6,234
psoriasis 101 | 6,685
Cancer 92 | 2,346
lung cancer 92 | 4,466
glioblastoma 88 | 5,572
group 3 medulloblastoma 82 | 2,254
Breast cancer 79 | 3,094
primitive neuroectodermal tumor 76 | 3,031
malignant mesothelioma 73 | 3,162
atypical teratoid / rhabdoid tumor 66 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,289
non-small cell lung cancer 47 | 2,798
pediatric high grade glioma 47 | 2,712
lung adenocarcinoma 46 | 2,713
Carcinoma 45 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,988
oligodendroglioma 45 | 2,849
invasive ductal carcinoma 42 | 2,950
Fanconi's anemia 41 | 50
Pick disease 38 | 1,893
astrocytic glioma 37 | 2,241
ependymoma 35 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
Xeroderma pigmentosum 31 | 41
sonic hedgehog group medulloblastoma 31 | 1,482
Cockayne syndrome 29 | 54
Waldenstrons macroglobulinemia 29 | 765
adrenocortical carcinoma 28 | 1,427
atypical teratoid/rhabdoid tumor 27 | 1,095
colon cancer 27 | 1,475
juvenile dermatomyositis 26 | 1,189
Multiple myeloma 25 | 1,327
nasopharyngeal carcinoma 25 | 1,056
tuberculosis 25 | 1,557
diabetes mellitus 23 | 1,663
Rheumatoid Arthritis 22 | 1,160
acute quadriplegic myopathy 22 | 1,157
breast carcinoma 22 | 1,614
pancreatic cancer 22 | 2,300
pituitary cancer 22 | 1,972
progressive supranuclear palsy 22 | 674
Bloom syndrome 21 | 30
Intellectual disability 21 | 573
astrocytoma 21 | 1,493
dermatomyositis 21 | 933
Mammary Neoplasms 20 | 410
Peripheral Neuropathy 20 | 303
subependymal giant cell astrocytoma 20 | 2,287
ductal carcinoma in situ 19 | 1,745
Anemia 18 | 252
Neoplastic Syndromes, Hereditary 18 | 48
Nijmegen breakage syndrome 18 | 23
adult high grade glioma 18 | 2,148
medulloblastoma 18 | 1,524
pilocytic astrocytoma 18 | 3,086
ulcerative colitis 18 | 2,087
Ataxia telangiectasia 17 | 31
Fanconi Anemia 17 | 19
posterior fossa group A ependymoma 17 | 1,511
tuberculosis and treatment for 6 months 17 | 686
hepatocellular carcinoma 16 | 532
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Atopic dermatitis 15 | 944
IGA Glomerulonephritis 15 | 454
Photosensitive trichothiodystrophy 15 | 24
acute myeloid leukemia 15 | 780
posterior fossa group B ependymoma 15 | 1,530
Werner syndrome 14 | 29
group 4 medulloblastoma 14 | 1,875
Endometriosis 13 | 535
Lynch syndrome 13 | 33
Neurodegenerative disease 13 | 383
Prostatic Neoplasms 13 | 471
primary Sjogren syndrome 13 | 789
Hereditary Breast and Ovarian Cancer Syndrome 12 | 14
Malignant neoplasm of breast 12 | 63
Microcephaly 12 | 149
lung carcinoma 12 | 2,844
Adenoma 11 | 165
Colorectal Neoplasms 10 | 217
Stomach Neoplasms 10 | 282
pancreatic carcinoma 10 | 567
Alzheimer's disease 9 | 644
Amyotrophic Lateral Sclerosis 9 | 431
Aplastic anemia 9 | 18
Seckel syndrome 9 | 34
gastric cancer 9 | 430
inflammatory breast cancer 9 | 404
ovarian neoplasm 9 | 97
primary pancreatic ductal adenocarcinoma 9 | 1,271
Familial adenomatous polyposis 8 | 31
Melanoma 8 | 261
active Crohn's disease 8 | 918
cystic fibrosis 8 | 1,665
interstitial cystitis 8 | 2,299
non primary Sjogren syndrome sicca 8 | 840
spina bifida 8 | 1,064
Down syndrome 7 | 548

Tissue

Blood and immune system 288 | 17,995
Cardiovascular System 288 | 17,958
Digestive Tract 288 | 18,473
Female tissues 288 | 18,647
Liver and Pancreas 288 | 18,136
Male tissues 288 | 17,969
Nervous System 287 | 18,561
Endocrine System 286 | 18,512
Respiratory system 286 | 17,484
Skin and soft tissues 286 | 18,115
Urinary Tract 286 | 18,444

Target Family

Non-IDG 160 | 11,971
Enzyme 99 | 4,146
Kinase 11 | 634
Transcription Factor 10 | 1,400
Epigenetic 8 | 242

UniProt Keyword

DNA repair 288 | 288
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Fanconi anemia group B protein FANCB Tbio Non-IDG -2.31383 203.9 74
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225