Development Level

Tbio 293 | 11,651
Tchem 47 | 1,388
Tdark 22 | 6,593
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 38 | 979
embryonic lethality prior to t... 15 | 278
embryonic lethality prior to o... 14 | 239
preweaning lethality, incomple... 12 | 499
abnormal bone structure 8 | 187
abnormal embryo size 7 | 220
decreased body weight 7 | 161
male infertility 6 | 123
abnormal behavior 5 | 298
decreased bone mineral content 5 | 151
decreased bone mineral density 5 | 126
abnormal coat-hair pigmentatio... 4 | 64
abnormal heart morphology 4 | 162
abnormal retina morphology 4 | 71
decreased circulating alanine ... 4 | 47
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
hypoactivity 4 | 132
increased bone mineral density 4 | 72
increased circulating alkaline... 4 | 122
abnormal gait 3 | 69
corneal opacity 3 | 32
decreased circulating glucose ... 3 | 126
decreased circulating iron lev... 3 | 32
decreased circulating triglyce... 3 | 79
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
small testis 3 | 58
tremors 3 | 39
abnormal blood vessel morpholo... 2 | 5
abnormal bone mineralization 2 | 38
abnormal embryo turning 2 | 31
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
cataract 2 | 92
decreased body length 2 | 101
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased lactate dehydrogenas... 2 | 16
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
embryonic growth retardation 2 | 106
female infertility 2 | 60
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
pale yolk sac 2 | 25
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased eosinophil cell numb... 1 | 24
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
long tibia 1 | 25
prenatal lethality 1 | 28
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 254 | 11,493
ovarian cancer 222 | 8,520
osteosarcoma 201 | 7,950
medulloblastoma, large-cell 147 | 6,241
group 3 medulloblastoma 138 | 4,104
psoriasis 134 | 6,694
glioblastoma 122 | 5,792
lung cancer 122 | 4,740
atypical teratoid / rhabdoid tumor 117 | 5,112
Cancer 115 | 2,499
Breast cancer 105 | 3,578
malignant mesothelioma 96 | 3,232
primitive neuroectodermal tumor 92 | 3,035
ependymoma 81 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,291
Kidney cancer 76 | 2,613
adult high grade glioma 69 | 3,801
non-small cell lung cancer 62 | 2,890
Intellectual disability 58 | 1,016
oligodendroglioma 58 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,989
invasive ductal carcinoma 54 | 2,951
lung adenocarcinoma 54 | 2,716
Autosomal recessive predisposition 51 | 1,442
astrocytic glioma 51 | 2,597
Fanconi anemia 49 | 56
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Poor school performance 45 | 645
Short stature 45 | 531
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,955
Pick disease 44 | 1,894
Small head 40 | 374
Xeroderma pigmentosum 37 | 43
tuberculosis 36 | 2,010
juvenile dermatomyositis 35 | 1,187
pituitary cancer 35 | 1,972
Cockayne syndrome 34 | 60
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Mental and motor retardation 34 | 608
adrenocortical carcinoma 34 | 1,428
colon cancer 34 | 1,478
nasopharyngeal carcinoma 34 | 1,058
breast carcinoma 33 | 1,638
diabetes mellitus 33 | 1,728
Waldenstrons macroglobulinemia 32 | 765
Multiple myeloma 31 | 1,332
pancreatic cancer 31 | 2,398
Astrocytoma, Pilocytic 28 | 3,081
acute quadriplegic myopathy 28 | 1,158
ductal carcinoma in situ 28 | 1,745
Cryptorchidism 27 | 296
Rheumatoid arthritis 27 | 1,191
dermatomyositis 27 | 966
subependymal giant cell astrocytoma 27 | 2,287
progressive supranuclear palsy 26 | 676
Breast Neoplasms 24 | 445
Chromosome Breakage 24 | 36
Epilepsy 24 | 792
Mammary Neoplasms 24 | 425
hypopigmented skin patch 24 | 59
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
ulcerative colitis 24 | 1,819
Acquired scoliosis 23 | 281
Bloom syndrome 23 | 29
Curvature of spine 23 | 282
Atopic dermatitis 22 | 952
Seizures 22 | 596
astrocytoma 22 | 1,146
group 4 medulloblastoma 22 | 1,855
pediatric high grade glioma 22 | 1,064
Anemia 21 | 365
Increased chromosomal breakage 21 | 27
Muscle hypotonia 21 | 571
hepatocellular carcinoma 21 | 547
Ataxia telangiectasia 20 | 34
Decreased platelet count 20 | 111
Nijmegen breakage syndrome 20 | 24
Thrombocytopenia 20 | 197
Fatigue 19 | 182
Melanoma 19 | 711
Sensorineural Hearing Loss (disorder) 19 | 284
Strabismus 19 | 270
Almond-shaped eyes 18 | 23
Attention deficit hyperactivity disorder 18 | 278
Prostatic Neoplasms 18 | 495
acute myeloid leukemia 18 | 783
lung carcinoma 18 | 2,843
Alzheimer's disease 17 | 658
Depressive disorder 17 | 409
Fetal Growth Retardation 17 | 189
Infant, Small for Gestational Age 17 | 176
Intrauterine retardation 17 | 176
Leukopenia 17 | 72
Neurodegenerative disease 17 | 414
medulloblastoma 17 | 720
tuberculosis and treatment for 6 months 17 | 409

Tissue

Blood and immune system 366 | 16,909
Endocrine System 366 | 18,159
Female tissues 366 | 17,400
Nervous System 366 | 16,725
Skin and soft tissues 366 | 17,230
Urinary Tract 366 | 16,678
Digestive Tract 365 | 17,369
Liver and Pancreas 365 | 16,750
Male tissues 365 | 17,142
Respiratory system 365 | 16,393
Cardiovascular System 355 | 15,192

Target Family

Non-IDG 194 | 12,091
Enzyme 121 | 4,145
Kinase 22 | 634
Epigenetic 14 | 242
Transcription Factor 14 | 1,400
TF/Epigenetic 1 | 38

UniProt Keyword

DNA damage 366 | 366
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
DNA helicase MCM9 MCM9 Tbio Enzyme -1.14882 14.6 58
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194