Development Level

Tbio 267 | 10,625
Tchem 54 | 1,890
Tdark 23 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 28 | 633
embryonic lethality prior to o... 9 | 148
embryonic lethality prior to t... 9 | 187
decreased body weight 8 | 174
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
decreased body length 5 | 108
increased or absent threshold ... 5 | 128
decreased bone mineral content 4 | 157
decreased circulating triglyce... 4 | 83
hypoactivity 4 | 89
abnormal bone structure 3 | 131
abnormal coat/hair pigmentatio... 3 | 54
abnormal gait 3 | 51
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased circulating glucose ... 3 | 121
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
increased fasted circulating g... 3 | 68
male infertility 3 | 62
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal lens morphology 2 | 73
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating iron lev... 2 | 25
decreased lactate dehydrogenas... 2 | 14
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
enlarged heart 2 | 111
hydrops fetalis 2 | 22
hyperactivity 2 | 108
increased bone mineral density 2 | 52
increased circulating glucose ... 2 | 16
increased circulating iron lev... 2 | 25
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
narrow eye opening 2 | 15
polydactyly 2 | 22
small testis 2 | 37
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 18
abnormal retinal inner nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating phosphat... 1 | 15
decreased eosinophil cell numb... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased thoracic vertebrae n... 1 | 7
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
short tibia 1 | 82
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 209 | 8,484
osteosarcoma 194 | 7,933
medulloblastoma, large-cell 143 | 6,234
psoriasis 127 | 6,685
lung cancer 113 | 4,466
glioblastoma 112 | 5,572
Cancer 107 | 2,346
group 3 medulloblastoma 98 | 2,254
Breast cancer 96 | 3,094
malignant mesothelioma 90 | 3,162
primitive neuroectodermal tumor 89 | 3,031
atypical teratoid / rhabdoid tumor 86 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 73 | 3,289
pediatric high grade glioma 62 | 2,712
non-small cell lung cancer 59 | 2,798
Carcinoma 56 | 2,147
oligodendroglioma 56 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,988
invasive ductal carcinoma 52 | 2,950
lung adenocarcinoma 51 | 2,713
astrocytic glioma 46 | 2,241
ependymoma 45 | 2,514
Fanconi's anemia 43 | 50
Pick disease 43 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,956
sonic hedgehog group medulloblastoma 39 | 1,482
juvenile dermatomyositis 35 | 1,189
adrenocortical carcinoma 34 | 1,427
nasopharyngeal carcinoma 34 | 1,056
colon cancer 33 | 1,475
pituitary cancer 33 | 1,972
atypical teratoid/rhabdoid tumor 32 | 1,095
Xeroderma pigmentosum 31 | 41
diabetes mellitus 31 | 1,663
tuberculosis 31 | 1,557
Waldenstrons macroglobulinemia 30 | 765
Cockayne syndrome 29 | 54
pancreatic cancer 29 | 2,300
Multiple myeloma 28 | 1,327
acute quadriplegic myopathy 28 | 1,157
Rheumatoid Arthritis 27 | 1,160
adult high grade glioma 27 | 2,148
breast carcinoma 27 | 1,614
ductal carcinoma in situ 27 | 1,745
subependymal giant cell astrocytoma 27 | 2,287
ulcerative colitis 27 | 2,087
astrocytoma 26 | 1,493
Intellectual disability 25 | 573
dermatomyositis 25 | 933
progressive supranuclear palsy 25 | 674
pilocytic astrocytoma 24 | 3,086
Bloom syndrome 23 | 30
Mammary Neoplasms 23 | 410
Atopic dermatitis 22 | 944
Peripheral Neuropathy 22 | 303
medulloblastoma 22 | 1,524
posterior fossa group A ependymoma 22 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
tuberculosis and treatment for 6 months 21 | 686
Ataxia telangiectasia 20 | 31
Neoplastic Syndromes, Hereditary 20 | 48
IGA Glomerulonephritis 19 | 454
Nijmegen breakage syndrome 19 | 23
group 4 medulloblastoma 19 | 1,875
hepatocellular carcinoma 19 | 532
Anemia 18 | 252
acute myeloid leukemia 18 | 780
lung carcinoma 18 | 2,844
posterior fossa group B ependymoma 18 | 1,530
Fanconi Anemia 17 | 19
Prostatic Neoplasms 17 | 471
Werner syndrome 16 | 29
Endometriosis 15 | 535
Microcephaly 15 | 149
Neurodegenerative disease 15 | 383
Photosensitive trichothiodystrophy 15 | 24
cystic fibrosis 14 | 1,665
non primary Sjogren syndrome sicca 14 | 840
primary Sjogren syndrome 14 | 789
Alzheimer's disease 13 | 644
Lynch syndrome 13 | 33
Stomach Neoplasms 13 | 282
primary pancreatic ductal adenocarcinoma 13 | 1,271
spina bifida 13 | 1,064
Adenoma 12 | 165
Amyotrophic Lateral Sclerosis 12 | 431
Hereditary Breast and Ovarian Cancer Syndrome 12 | 14
Malignant neoplasm of breast 12 | 63
interstitial cystitis 12 | 2,299
Adenoid Cystic Carcinoma 11 | 99
Colorectal Neoplasms 11 | 217
Seckel syndrome 11 | 34
gastric cancer 11 | 430
pancreatic carcinoma 11 | 567
Lung Neoplasms 10 | 171
inflammatory breast cancer 10 | 404
ovarian neoplasm 10 | 97
Down syndrome 9 | 548
active Crohn's disease 9 | 918
hereditary spastic paraplegia 9 | 313

Tissue

Blood and immune system 347 | 17,995
Cardiovascular System 347 | 17,958
Digestive Tract 347 | 18,473
Female tissues 347 | 18,647
Liver and Pancreas 347 | 18,136
Male tissues 347 | 17,969
Nervous System 346 | 18,561
Endocrine System 345 | 18,512
Urinary Tract 345 | 18,444
Respiratory system 344 | 17,484
Skin and soft tissues 343 | 18,115

Target Family

Non-IDG 188 | 11,971
Enzyme 110 | 4,146
Kinase 22 | 634
Epigenetic 13 | 242
Transcription Factor 13 | 1,400
TF/Epigenetic 1 | 38

UniProt Keyword

DNA damage 347 | 347
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Fanconi anemia group B protein FANCB Tbio Non-IDG -2.31383 203.9 74
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225