Development Level

Tbio 797 | 10,625
Tdark 201 | 7,003
Tchem 108 | 1,890
Tclin 24 | 602

Collection

Eligible Kinase Proteins 9 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 52 | 633
preweaning lethality, incomple... 28 | 260
decreased body weight 22 | 174
decreased total body fat amoun... 19 | 186
abnormal behavior 18 | 226
decreased lean body mass 18 | 195
embryonic lethality prior to t... 15 | 187
decreased bone mineral content 14 | 157
decreased bone mineral density 12 | 126
hyperactivity 12 | 108
increased or absent threshold ... 12 | 128
decreased circulating glucose ... 11 | 121
increased circulating alkaline... 11 | 119
abnormal bone structure 10 | 131
abnormal embryo size 10 | 112
decreased body length 10 | 108
decreased circulating choleste... 10 | 85
increased mean corpuscular hem... 10 | 93
increased mean corpuscular vol... 10 | 91
increased fasted circulating g... 9 | 68
increased lean body mass 9 | 107
abnormal retina morphology 8 | 100
abnormal sleep behavior 8 | 63
embryonic lethality prior to o... 8 | 148
improved glucose tolerance 8 | 56
increased circulating HDL chol... 8 | 63
abnormal bone mineralization 7 | 55
decreased grip strength 7 | 123
decreased mean corpuscular vol... 7 | 50
increased circulating chloride... 7 | 43
increased circulating choleste... 7 | 53
increased exploration in new e... 7 | 56
male infertility 7 | 62
abnormal behavioral response t... 6 | 52
abnormal lens morphology 6 | 73
absent pinna reflex 6 | 21
decreased circulating HDL chol... 6 | 77
decreased circulating serum al... 6 | 79
decreased circulating total pr... 6 | 41
increased hematocrit 6 | 36
short tibia 6 | 82
thrombocytopenia 6 | 46
abnormal coat/hair pigmentatio... 5 | 54
abnormal head morphology 5 | 10
hypoactivity 5 | 89
increased body weight 5 | 42
increased bone mineral content 5 | 92
increased leukocyte cell numbe... 5 | 37
abnormal cranium morphology 4 | 32
cardiovascular system phenotyp... 4 | 35
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating free fat... 4 | 39
decreased circulating fructosa... 4 | 31
decreased circulating iron lev... 4 | 25
decreased circulating potassiu... 4 | 17
decreased circulating triglyce... 4 | 83
decreased eosinophil cell numb... 4 | 41
decreased lumbar vertebrae num... 4 | 62
increased circulating sodium l... 4 | 71
increased grip strength 4 | 83
increased hemoglobin content 4 | 45
increased rib number 4 | 41
prenatal lethality prior to he... 4 | 64
vertebral fusion 4 | 23
abnormal coat appearance 3 | 25
abnormal embryo turning 3 | 15
abnormal humerus morphology 3 | 11
abnormal limb bud morphology 3 | 15
abnormal neural tube closure 3 | 37
abnormal optic disc morphology 3 | 10
abnormal pelvic girdle bone mo... 3 | 11
abnormal spleen morphology 3 | 36
convulsive seizures 3 | 11
corneal opacity 3 | 25
decreased CD4-positive, alpha ... 3 | 19
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating amylase ... 3 | 24
decreased circulating chloride... 3 | 32
decreased circulating insulin ... 3 | 75
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased startle reflex 3 | 48
embryonic growth retardation 3 | 28
impaired righting response 3 | 19
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating glucose ... 3 | 16
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 25
increased sacral vertebrae num... 3 | 62
increased total body fat amoun... 3 | 57
limb grasping 3 | 35
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22

Disease

ovarian cancer 624 | 8,484
osteosarcoma 549 | 7,933
medulloblastoma, large-cell 488 | 6,234
glioblastoma 474 | 5,572
psoriasis 439 | 6,685
atypical teratoid / rhabdoid tumor 362 | 4,369
lung cancer 345 | 4,466
primitive neuroectodermal tumor 287 | 3,031
Breast cancer 278 | 3,094
malignant mesothelioma 260 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 255 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 252 | 2,988
pediatric high grade glioma 249 | 2,712
invasive ductal carcinoma 247 | 2,950
oligodendroglioma 239 | 2,849
pilocytic astrocytoma 239 | 3,086
non-small cell lung cancer 236 | 2,798
Carcinoma 219 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 212 | 2,956
lung adenocarcinoma 209 | 2,713
ependymoma 206 | 2,514
lung carcinoma 200 | 2,844
pancreatic cancer 198 | 2,300
group 3 medulloblastoma 186 | 2,254
posterior fossa group B ependymoma 184 | 1,530
astrocytic glioma 175 | 2,241
Pick disease 164 | 1,893
subependymal giant cell astrocytoma 164 | 2,287
ductal carcinoma in situ 155 | 1,745
Cancer 151 | 2,346
colon cancer 150 | 1,475
interstitial cystitis 149 | 2,299
group 4 medulloblastoma 143 | 1,875
adult high grade glioma 140 | 2,148
breast carcinoma 140 | 1,614
ulcerative colitis 140 | 2,087
adrenocortical carcinoma 137 | 1,427
pituitary cancer 129 | 1,972
medulloblastoma 128 | 1,524
sonic hedgehog group medulloblastoma 124 | 1,482
nasopharyngeal carcinoma 123 | 1,056
astrocytoma 120 | 1,493
tuberculosis 116 | 1,557
posterior fossa group A ependymoma 110 | 1,511
primary pancreatic ductal adenocarcinoma 109 | 1,271
atypical teratoid/rhabdoid tumor 100 | 1,095
spina bifida 93 | 1,064
cystic fibrosis 92 | 1,665
juvenile dermatomyositis 90 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 88 | 1,795
Atopic dermatitis 87 | 944
diabetes mellitus 86 | 1,663
acute quadriplegic myopathy 85 | 1,157
chronic rhinosinusitis 83 | 512
dermatomyositis 83 | 933
Multiple myeloma 79 | 1,327
Rheumatoid Arthritis 75 | 1,160
Intellectual disability 72 | 573
Waldenstrons macroglobulinemia 72 | 765
cutaneous lupus erythematosus 64 | 1,056
Endometriosis 63 | 535
gastric carcinoma 63 | 832
progressive supranuclear palsy 61 | 674
tuberculosis and treatment for 6 months 60 | 686
Duchenne muscular dystrophy 59 | 602
active Crohn's disease 59 | 918
non primary Sjogren syndrome sicca 57 | 840
primary Sjogren syndrome 54 | 789
esophageal adenocarcinoma 53 | 737
pancreatic carcinoma 50 | 567
acute myeloid leukemia 48 | 780
IGA Glomerulonephritis 47 | 454
Alzheimer's disease 46 | 644
Amyotrophic Lateral Sclerosis 46 | 431
hepatocellular carcinoma 46 | 532
Obesity 45 | 616
gastric cancer 44 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 42 | 499
Down syndrome 39 | 548
Microcephaly 39 | 149
fibroadenoma 39 | 557
active ulcerative colitis 38 | 477
Ciliopathy 37 | 57
Polydactyly 36 | 93
Retinitis pigmentosa 36 | 153
aldosterone-producing adenoma 36 | 664
hereditary spastic paraplegia 36 | 313
Joubert syndrome 35 | 61
Nephronophthisis 35 | 74
mucosa-associated lymphoid tissue lymphoma 35 | 480
Neurodegenerative disease 33 | 383
non-small cell lung carcinoma 32 | 413
Mammary Neoplasms 31 | 410
cystic fibrosis and chronic rhinosinusitis 31 | 213
Primary ciliary dyskinesia 30 | 73
Schizophrenia 30 | 501
inflammatory breast cancer 29 | 404
Polycystic Ovary Syndrome 28 | 332
Peripheral Neuropathy 26 | 303
Bardet-Biedl Syndrome 25 | 40

Tissue

Female tissues 1,122 | 18,647
Nervous System 1,122 | 18,561
Digestive Tract 1,121 | 18,473
Endocrine System 1,121 | 18,512
Male tissues 1,121 | 17,969
Blood and immune system 1,118 | 17,995
Liver and Pancreas 1,118 | 18,136
Urinary Tract 1,118 | 18,444
Cardiovascular System 1,115 | 17,958
Skin and soft tissues 1,110 | 18,115
Respiratory system 1,105 | 17,484

Target Family

Non-IDG 904 | 11,971
Enzyme 136 | 4,146
Kinase 70 | 634
Epigenetic 7 | 242
Ion Channel 5 | 341
Transcription Factor 5 | 1,400
Nuclear Receptor 2 | 48
GPCR 1 | 406

UniProt Keyword

Cytoskeleton 1,130 | 1,130
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Lymphoid-restricted membrane protein LRMP Tbio Non-IDG -1.17754 15.9 54
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139