Development Level

Tbio 881 | 11,445
Tdark 188 | 6,588
Tchem 86 | 1,598
Tclin 27 | 613

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 10 | 125
Kinase: IDG Consortium (Comple... 8 | 37
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 88 | 979
preweaning lethality, incomple... 54 | 499
abnormal behavior 27 | 298
embryonic lethality prior to t... 26 | 278
abnormal embryo size 22 | 220
decreased total body fat amoun... 22 | 207
male infertility 20 | 123
decreased body weight 19 | 161
abnormal bone structure 15 | 187
embryonic lethality prior to o... 15 | 239
increased circulating alkaline... 14 | 122
increased lean body mass 14 | 172
hyperactivity 13 | 148
increased fasted circulating g... 13 | 76
decreased body length 12 | 101
decreased bone mineral density 12 | 126
decreased circulating glucose ... 12 | 126
decreased bone mineral content 11 | 151
decreased lean body mass 11 | 135
increased total body fat amoun... 11 | 134
increased mean corpuscular vol... 10 | 92
abnormal behavioral response t... 9 | 66
cataract 9 | 92
decreased circulating choleste... 9 | 93
decreased circulating serum al... 9 | 82
decreased grip strength 9 | 116
embryonic growth retardation 9 | 106
hypoactivity 9 | 132
improved glucose tolerance 9 | 79
prenatal lethality prior to he... 9 | 87
short tibia 9 | 97
abnormal retina morphology 8 | 71
abnormal sleep behavior 8 | 70
impaired glucose tolerance 8 | 75
increased bone mineral content 8 | 108
increased mean corpuscular hem... 8 | 96
increased or absent threshold ... 8 | 101
decreased fasted circulating g... 7 | 65
decreased mean corpuscular vol... 7 | 79
increased circulating HDL chol... 7 | 80
increased circulating chloride... 7 | 41
increased hematocrit 7 | 46
thrombocytopenia 7 | 56
abnormal bone mineralization 6 | 38
abnormal coat-hair pigmentatio... 6 | 64
abnormal heart morphology 6 | 162
abnormal lens morphology 6 | 81
abnormal seminal vesicle morph... 6 | 114
absent pinna reflex 6 | 23
decreased circulating total pr... 6 | 49
decreased leukocyte cell numbe... 6 | 73
edema 6 | 59
female infertility 6 | 60
increased bone mineral density 6 | 72
increased startle reflex 6 | 112
small testis 6 | 58
abnormal eye morphology 5 | 68
abnormal kidney morphology 5 | 65
abnormal spleen morphology 5 | 55
cardiovascular system phenotyp... 5 | 36
corneal opacity 5 | 32
decreased lymphocyte cell numb... 5 | 83
decreased red blood cell distr... 5 | 41
decreased startle reflex 5 | 75
decreased vertical activity 5 | 208
enlarged heart 5 | 210
increased body length 5 | 32
increased circulating sodium l... 5 | 71
increased heart weight 5 | 62
increased hemoglobin content 5 | 45
pallor 5 | 34
small superior vagus ganglion 5 | 74
abnormal coat appearance 4 | 31
abnormal cornea morphology 4 | 31
abnormal cranium morphology 4 | 36
abnormal embryo turning 4 | 31
abnormal head morphology 4 | 10
abnormal neural tube closure 4 | 46
abnormal pericardium morpholog... 4 | 26
abnormal skin morphology 4 | 50
abnormal testis morphology 4 | 43
decreased blood urea nitrogen ... 4 | 51
decreased caudal vertebrae num... 4 | 53
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased circulating alanine ... 4 | 47
decreased circulating potassiu... 4 | 20
decreased mean corpuscular hem... 4 | 50
impaired righting response 4 | 26
increased blood urea nitrogen ... 4 | 48
increased circulating choleste... 4 | 66
increased leukocyte cell numbe... 4 | 47
prenatal lethality 4 | 28
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
vertebral fusion 4 | 23
abnormal limb bud morphology 3 | 17
decreased circulating free fat... 3 | 31
decreased spleen weight 3 | 10
increased monocyte cell number 3 | 63

Disease

Carcinoma 861 | 11,493
ovarian cancer 648 | 8,520
osteosarcoma 576 | 7,950
medulloblastoma, large-cell 506 | 6,241
glioblastoma 496 | 5,792
atypical teratoid / rhabdoid tumor 452 | 5,112
psoriasis 449 | 6,694
ependymoma 439 | 4,679
group 3 medulloblastoma 379 | 4,104
lung cancer 376 | 4,740
Breast cancer 342 | 3,578
adult high grade glioma 315 | 3,801
primitive neuroectodermal tumor 293 | 3,035
Kidney cancer 277 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 267 | 3,291
malignant mesothelioma 266 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 260 | 2,989
non-small cell lung cancer 253 | 2,890
invasive ductal carcinoma 252 | 2,951
oligodendroglioma 248 | 2,850
Astrocytoma, Pilocytic 246 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 222 | 2,955
lung adenocarcinoma 217 | 2,716
pancreatic cancer 217 | 2,398
lung carcinoma 208 | 2,843
astrocytic glioma 206 | 2,597
subependymal giant cell astrocytoma 172 | 2,287
Pick disease 169 | 1,894
Cancer 162 | 2,499
ductal carcinoma in situ 157 | 1,745
interstitial cystitis 154 | 2,312
colon cancer 152 | 1,478
breast carcinoma 146 | 1,638
tuberculosis 146 | 2,010
adrenocortical carcinoma 143 | 1,428
pituitary cancer 139 | 1,972
group 4 medulloblastoma 137 | 1,855
ulcerative colitis 136 | 1,819
Autosomal recessive predisposition 133 | 1,442
nasopharyngeal carcinoma 130 | 1,058
Intellectual disability 129 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,962
astrocytoma 99 | 1,146
spina bifida 99 | 1,074
cystic fibrosis 97 | 1,696
diabetes mellitus 94 | 1,728
juvenile dermatomyositis 94 | 1,187
primary pancreatic ductal adenocarcinoma 93 | 1,109
chronic rhinosinusitis 91 | 512
acute quadriplegic myopathy 90 | 1,158
dermatomyositis 89 | 966
Atopic dermatitis 88 | 952
pediatric high grade glioma 84 | 1,064
Dull intelligence 83 | 645
Low intelligence 83 | 645
Mental Retardation 83 | 645
Mental deficiency 83 | 645
Poor school performance 83 | 645
Liver cancer 82 | 604
Multiple myeloma 81 | 1,332
Schizophrenia 79 | 1,160
Rheumatoid arthritis 77 | 1,191
Waldenstrons macroglobulinemia 74 | 765
Cognitive delay 73 | 608
Global developmental delay 73 | 608
Mental and motor retardation 73 | 608
Melanoma 67 | 711
cutaneous lupus erythematosus 65 | 1,057
gastric carcinoma 64 | 807
Endometriosis 63 | 540
progressive supranuclear palsy 63 | 676
active Crohn's disease 60 | 922
Duchenne muscular dystrophy 59 | 601
non primary Sjogren syndrome sicca 59 | 891
Short stature 58 | 531
esophageal adenocarcinoma 55 | 737
primary Sjogren syndrome 55 | 735
Obesity 53 | 678
medulloblastoma 53 | 720
Small head 52 | 374
Amyotrophic lateral sclerosis 50 | 451
pancreatic carcinoma 50 | 562
Liver Cirrhosis, Experimental 49 | 769
Muscle hypotonia 49 | 571
acute myeloid leukemia 49 | 783
hepatocellular carcinoma 49 | 547
posterior fossa group B ependymoma 49 | 416
Skin cancer 47 | 469
gastric cancer 47 | 459
active ulcerative colitis 46 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 510
Alzheimer's disease 45 | 658
Epilepsy 45 | 792
Microcephaly 44 | 166
Ciliopathy 43 | 71
Endometrial cancer 42 | 311
Retinitis Pigmentosa 42 | 226
tuberculosis and treatment for 6 months 42 | 409
Joubert syndrome 40 | 66
Polydactyly 40 | 107

Tissue

Endocrine System 1,170 | 18,159
Female tissues 1,151 | 17,400
Male tissues 1,147 | 17,142
Skin and soft tissues 1,147 | 17,230
Digestive Tract 1,137 | 17,369
Blood and immune system 1,136 | 16,909
Nervous System 1,136 | 16,725
Urinary Tract 1,136 | 16,678
Respiratory system 1,130 | 16,393
Liver and Pancreas 1,126 | 16,750
Cardiovascular System 1,063 | 15,192

Target Family

Non-IDG 947 | 12,091
Enzyme 143 | 4,145
Kinase 71 | 634
Epigenetic 7 | 242
Transcription Factor 6 | 1,400
Ion Channel 5 | 344
Nuclear Receptor 2 | 48
GPCR 1 | 408

UniProt Keyword

Cytoskeleton 1,182 | 1,182
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Nck-associated protein 5-like NCKAP5L Tdark Non-IDG -0.22123 2.83 11
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
A-kinase anchor protein 11 AKAP11 Tbio Enzyme -1.02415 11.7 38