Development Level

Tbio 347 | 10,625
Tdark 75 | 7,003
Tchem 45 | 1,890
Tclin 20 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 3 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 26 | 633
abnormal behavior 11 | 226
decreased grip strength 8 | 123
embryonic lethality prior to t... 8 | 187
increased or absent threshold ... 7 | 128
preweaning lethality, incomple... 7 | 260
decreased total body fat amoun... 6 | 186
hypoactivity 6 | 89
abnormal embryo size 5 | 112
decreased circulating glucose ... 5 | 121
increased body weight 5 | 42
increased mean corpuscular hem... 5 | 93
decreased bone mineral content 4 | 157
decreased circulating serum al... 4 | 79
decreased lean body mass 4 | 195
decreased prepulse inhibition 4 | 52
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
increased circulating sodium l... 4 | 71
prenatal lethality prior to he... 4 | 64
abnormal behavioral response t... 3 | 52
abnormal kidney morphology 3 | 30
decreased body weight 3 | 174
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased fasted circulating g... 3 | 49
decreased mean corpuscular hem... 3 | 34
decreased vertical activity 3 | 22
impaired glucose tolerance 3 | 52
increased circulating chloride... 3 | 43
increased circulating potassiu... 3 | 31
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 25
increased mean corpuscular vol... 3 | 91
increased neutrophil cell numb... 3 | 15
increased total body fat amoun... 3 | 57
abnormal bone structure 2 | 131
abnormal coat/ hair morphology 2 | 18
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal facial morphology 2 | 9
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal limb morphology 2 | 7
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating fructosa... 2 | 31
decreased circulating potassiu... 2 | 17
decreased circulating triglyce... 2 | 83
decreased gamma-delta T cell n... 2 | 18
decreased lymphocyte cell numb... 2 | 9
decreased mean corpuscular vol... 2 | 50
decreased total retina thickne... 2 | 20
enlarged epididymis 2 | 27
hemorrhage 2 | 12
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating aspartat... 2 | 17
increased circulating phosphat... 2 | 24
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
male infertility 2 | 62
thrombocytopenia 2 | 46
abnormal body wall morphology 1 | 7
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal motor capabilities/co... 1 | 4
abnormal retinal pigmentation 1 | 61
abnormal tail movements 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
enlarged ovary 1 | 1
enlarged spleen 1 | 26
increased CD4-positive, CD25-p... 1 | 18
increased circulating choleste... 1 | 53
iris synechia 1 | 1
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
straub tail 1 | 26
tremors 1 | 34

Disease

ovarian cancer 245 | 8,484
osteosarcoma 237 | 7,933
medulloblastoma, large-cell 200 | 6,234
glioblastoma 199 | 5,572
psoriasis 170 | 6,685
atypical teratoid / rhabdoid tumor 157 | 4,369
pilocytic astrocytoma 129 | 3,086
lung cancer 112 | 4,466
pediatric high grade glioma 108 | 2,712
oligodendroglioma 107 | 2,849
lung carcinoma 98 | 2,844
primitive neuroectodermal tumor 96 | 3,031
malignant mesothelioma 94 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,988
invasive ductal carcinoma 88 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 84 | 2,956
subependymal giant cell astrocytoma 84 | 2,287
Breast cancer 81 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 81 | 3,289
ependymoma 80 | 2,514
non-small cell lung cancer 75 | 2,798
lung adenocarcinoma 72 | 2,713
pancreatic cancer 70 | 2,300
astrocytic glioma 68 | 2,241
interstitial cystitis 67 | 2,299
astrocytoma 66 | 1,493
Pick disease 65 | 1,893
group 4 medulloblastoma 62 | 1,875
adult high grade glioma 60 | 2,148
posterior fossa group B ependymoma 58 | 1,530
Cancer 57 | 2,346
Carcinoma 55 | 2,147
pituitary cancer 55 | 1,972
tuberculosis 55 | 1,557
ulcerative colitis 53 | 2,087
medulloblastoma 52 | 1,524
posterior fossa group A ependymoma 52 | 1,511
primary pancreatic ductal adenocarcinoma 51 | 1,271
Multiple myeloma 50 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,795
diabetes mellitus 45 | 1,663
breast carcinoma 44 | 1,614
group 3 medulloblastoma 43 | 2,254
ductal carcinoma in situ 42 | 1,745
sonic hedgehog group medulloblastoma 42 | 1,482
spina bifida 41 | 1,064
acute quadriplegic myopathy 39 | 1,157
atypical teratoid/rhabdoid tumor 37 | 1,095
cystic fibrosis 36 | 1,665
Rheumatoid Arthritis 35 | 1,160
adrenocortical carcinoma 34 | 1,427
colon cancer 34 | 1,475
cutaneous lupus erythematosus 34 | 1,056
juvenile dermatomyositis 34 | 1,189
gastric carcinoma 32 | 832
dermatomyositis 30 | 933
aldosterone-producing adenoma 29 | 664
Alzheimer's disease 26 | 644
Schizophrenia 26 | 501
Waldenstrons macroglobulinemia 26 | 765
hepatocellular carcinoma 25 | 532
mucosa-associated lymphoid tissue lymphoma 25 | 480
Neurodegenerative disease 24 | 383
nasopharyngeal carcinoma 24 | 1,056
tuberculosis and treatment for 6 months 23 | 686
active Crohn's disease 22 | 918
acute myeloid leukemia 22 | 780
non primary Sjogren syndrome sicca 22 | 840
progressive supranuclear palsy 21 | 674
primary Sjogren syndrome 20 | 789
Atopic dermatitis 19 | 944
Down syndrome 19 | 548
Obesity 18 | 616
Parkinson's disease 18 | 364
esophageal adenocarcinoma 18 | 737
Amyotrophic Lateral Sclerosis 17 | 431
fibroadenoma 17 | 557
IGA Glomerulonephritis 16 | 454
pancreatic carcinoma 16 | 567
Duchenne muscular dystrophy 15 | 602
Multiple Sclerosis 15 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
chronic rhinosinusitis 15 | 512
inflammatory breast cancer 15 | 404
Intellectual disability 14 | 573
Asthma 13 | 349
Kidney disease 13 | 396
gastric cancer 13 | 430
hereditary spastic paraplegia 13 | 313
Epilepsy 12 | 346
Gaucher disease type 1 12 | 171
Atherosclerosis 11 | 275
Bipolar Disorder 11 | 266
Type 2 diabetes mellitus 11 | 189
glioblastoma multiforme 11 | 347
Dementia 10 | 129
Neuropathy 10 | 210
Vascular disease 10 | 281
active ulcerative colitis 10 | 477
tuberculosis and treatment for 3 months 10 | 327

Tissue

Nervous System 483 | 18,561
Liver and Pancreas 482 | 18,136
Digestive Tract 480 | 18,473
Endocrine System 480 | 18,512
Female tissues 480 | 18,647
Urinary Tract 479 | 18,444
Blood and immune system 478 | 17,995
Cardiovascular System 477 | 17,958
Male tissues 477 | 17,969
Skin and soft tissues 475 | 18,115
Respiratory system 472 | 17,484

Target Family

Non-IDG 335 | 11,971
Enzyme 93 | 4,146
Kinase 23 | 634
Transporter 15 | 473
Ion Channel 11 | 341
GPCR 8 | 406
Transcription Factor 2 | 1,400

UniProt Keyword

Cytoplasmic vesicle 487 | 487
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Vacuolar ATPase assembly integral membrane protein VMA21 VMA21 Tbio Enzyme 1.00 53
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Testis-expressed sequence 22 protein TEX22 Tdark Non-IDG 0.70 0.20 2
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 Tdark Non-IDG 0.27 0.56 5
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416