Development Level

Tbio 3,281 | 10,625
Tdark 709 | 7,003
Tchem 675 | 1,890
Tclin 117 | 602

Collection

Eligible Kinase Proteins 63 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 206 | 633
preweaning lethality, incomple... 96 | 260
abnormal behavior 74 | 226
decreased lean body mass 67 | 195
embryonic lethality prior to t... 67 | 187
decreased total body fat amoun... 57 | 186
decreased body weight 55 | 174
embryonic lethality prior to o... 48 | 148
increased or absent threshold ... 48 | 128
decreased bone mineral content 47 | 157
abnormal embryo size 46 | 112
abnormal bone structure 42 | 131
decreased grip strength 42 | 123
decreased bone mineral density 41 | 126
increased circulating alkaline... 40 | 119
decreased body length 34 | 108
decreased circulating glucose ... 33 | 121
increased lean body mass 33 | 107
abnormal retina morphology 31 | 100
decreased circulating choleste... 31 | 85
hyperactivity 31 | 108
increased mean corpuscular hem... 30 | 93
hypoactivity 29 | 89
increased grip strength 28 | 83
increased mean corpuscular vol... 28 | 91
decreased circulating insulin ... 27 | 75
decreased circulating HDL chol... 26 | 77
increased bone mineral content 26 | 92
abnormal lens morphology 25 | 73
decreased circulating triglyce... 25 | 83
increased circulating HDL chol... 25 | 63
abnormal sleep behavior 24 | 63
increased fasted circulating g... 23 | 68
male infertility 23 | 62
decreased rib number 22 | 59
enlarged heart 22 | 111
decreased mean corpuscular vol... 21 | 50
increased circulating choleste... 21 | 53
decreased circulating serum al... 20 | 79
increased circulating chloride... 20 | 43
increased exploration in new e... 20 | 56
increased total body fat amoun... 20 | 57
short tibia 20 | 82
abnormal coat/hair pigmentatio... 19 | 54
decreased leukocyte cell numbe... 19 | 54
decreased lumbar vertebrae num... 18 | 62
decreased startle reflex 18 | 48
increased body weight 18 | 42
increased circulating sodium l... 18 | 71
abnormal neural tube closure 17 | 37
improved glucose tolerance 17 | 56
abnormal behavioral response t... 16 | 52
abnormal bone mineralization 16 | 55
abnormal retinal pigmentation 16 | 61
prenatal lethality prior to he... 16 | 64
thrombocytopenia 16 | 46
decreased circulating alkaline... 15 | 41
decreased fasted circulating g... 15 | 49
abnormal cranium morphology 14 | 32
decreased circulating LDL chol... 14 | 37
decreased prepulse inhibition 14 | 52
impaired glucose tolerance 14 | 52
increased bone mineral density 14 | 52
increased heart weight 14 | 37
increased hematocrit 14 | 36
increased leukocyte cell numbe... 14 | 37
increased sacral vertebrae num... 14 | 62
abnormal hindbrain development 13 | 24
abnormal spleen morphology 13 | 36
decreased circulating free fat... 13 | 39
decreased circulating total pr... 13 | 41
decreased hemoglobin content 13 | 53
increased erythrocyte cell num... 13 | 26
increased hemoglobin content 13 | 45
decreased circulating alanine ... 12 | 53
decreased eosinophil cell numb... 12 | 41
decreased neutrophil cell numb... 12 | 37
decreased threshold for audito... 12 | 32
abnormal gait 11 | 51
abnormal heart morphology 11 | 51
abnormal midbrain development 11 | 22
decreased T cell number 11 | 31
decreased circulating fructosa... 11 | 31
decreased erythrocyte cell num... 11 | 43
decreased heart weight 11 | 44
decreased mean corpuscular hem... 11 | 34
female infertility 11 | 34
increased blood urea nitrogen ... 11 | 44
increased startle reflex 11 | 38
limb grasping 11 | 35
small testis 11 | 37
abnormal eye morphology 10 | 38
abnormal rib morphology 10 | 28
abnormal seminal vesicle morph... 10 | 47
decreased caudal vertebrae num... 10 | 49
decreased circulating calcium ... 10 | 33
decreased circulating iron lev... 10 | 25
decreased hematocrit 10 | 25
increased circulating calcium ... 10 | 32
persistence of hyaloid vascula... 10 | 22

Disease

ovarian cancer 2,580 | 8,484
osteosarcoma 2,236 | 7,933
medulloblastoma, large-cell 1,843 | 6,234
psoriasis 1,808 | 6,685
glioblastoma 1,685 | 5,572
lung cancer 1,403 | 4,466
atypical teratoid / rhabdoid tumor 1,331 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 976 | 3,289
Breast cancer 951 | 3,094
primitive neuroectodermal tumor 941 | 3,031
malignant mesothelioma 926 | 3,162
pilocytic astrocytoma 893 | 3,086
oligodendroglioma 891 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 879 | 2,988
invasive ductal carcinoma 879 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 832 | 2,956
non-small cell lung cancer 832 | 2,798
pediatric high grade glioma 807 | 2,712
Cancer 798 | 2,346
ependymoma 774 | 2,514
lung adenocarcinoma 759 | 2,713
lung carcinoma 755 | 2,844
subependymal giant cell astrocytoma 737 | 2,287
pancreatic cancer 717 | 2,300
group 3 medulloblastoma 675 | 2,254
astrocytic glioma 672 | 2,241
Carcinoma 644 | 2,147
adult high grade glioma 631 | 2,148
Pick disease 605 | 1,893
ulcerative colitis 592 | 2,087
interstitial cystitis 589 | 2,299
group 4 medulloblastoma 550 | 1,875
ductal carcinoma in situ 517 | 1,745
astrocytoma 512 | 1,493
pituitary cancer 510 | 1,972
Multiple myeloma 502 | 1,327
breast carcinoma 502 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 480 | 1,795
medulloblastoma 473 | 1,524
posterior fossa group B ependymoma 473 | 1,530
colon cancer 470 | 1,475
cystic fibrosis 458 | 1,665
tuberculosis 448 | 1,557
adrenocortical carcinoma 432 | 1,427
acute quadriplegic myopathy 429 | 1,157
sonic hedgehog group medulloblastoma 426 | 1,482
posterior fossa group A ependymoma 405 | 1,511
diabetes mellitus 403 | 1,663
primary pancreatic ductal adenocarcinoma 402 | 1,271
juvenile dermatomyositis 396 | 1,189
dermatomyositis 382 | 933
spina bifida 363 | 1,064
nasopharyngeal carcinoma 352 | 1,056
Rheumatoid Arthritis 332 | 1,160
Waldenstrons macroglobulinemia 328 | 765
atypical teratoid/rhabdoid tumor 316 | 1,095
cutaneous lupus erythematosus 299 | 1,056
Atopic dermatitis 271 | 944
primary Sjogren syndrome 255 | 789
acute myeloid leukemia 250 | 780
non primary Sjogren syndrome sicca 240 | 840
gastric carcinoma 234 | 832
active Crohn's disease 231 | 918
progressive supranuclear palsy 228 | 674
esophageal adenocarcinoma 225 | 737
tuberculosis and treatment for 6 months 218 | 686
Intellectual disability 206 | 573
Alzheimer's disease 201 | 644
aldosterone-producing adenoma 195 | 664
pancreatic carcinoma 187 | 567
Amyotrophic Lateral Sclerosis 185 | 431
Duchenne muscular dystrophy 177 | 602
chronic rhinosinusitis 174 | 512
Obesity 173 | 616
hepatocellular carcinoma 168 | 532
Down syndrome 166 | 548
Endometriosis 161 | 535
Neurodegenerative disease 157 | 383
Mammary Neoplasms 156 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 156 | 499
Prostatic Neoplasms 148 | 471
fibroadenoma 148 | 557
IGA Glomerulonephritis 142 | 454
Schizophrenia 141 | 501
gastric cancer 136 | 430
active ulcerative colitis 132 | 477
hereditary spastic paraplegia 131 | 313
inflammatory breast cancer 130 | 404
mucosa-associated lymphoid tissue lymphoma 118 | 480
Parkinson's disease 117 | 364
Stomach Neoplasms 115 | 282
non-small cell lung carcinoma 113 | 413
Multiple Sclerosis 106 | 498
Crohn's disease 105 | 304
Peripheral Neuropathy 104 | 303
Polycystic Ovary Syndrome 103 | 332
Vascular disease 99 | 281
glioblastoma multiforme 99 | 347
sarcoidosis 99 | 358
tuberculosis and treatment for 3 months 97 | 327

Tissue

Female tissues 4,686 | 18,647
Endocrine System 4,678 | 18,512
Nervous System 4,678 | 18,561
Digestive Tract 4,677 | 18,473
Male tissues 4,663 | 17,969
Liver and Pancreas 4,656 | 18,136
Blood and immune system 4,649 | 17,995
Urinary Tract 4,648 | 18,444
Cardiovascular System 4,635 | 17,958
Skin and soft tissues 4,607 | 18,115
Respiratory system 4,579 | 17,484

Target Family

Non-IDG 2,947 | 11,971
Enzyme 1,178 | 4,146
Kinase 355 | 634
Transcription Factor 173 | 1,400
Epigenetic 61 | 242
Ion Channel 22 | 341
Transporter 19 | 473
Nuclear Receptor 14 | 48
TF/Epigenetic 7 | 38
GPCR 6 | 406

UniProt Keyword

Cytoplasm 4,782 | 4,782
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851