Development Level

Tbio 3,636 | 11,651
Tdark 659 | 6,593
Tchem 531 | 1,388
Tclin 126 | 612

Collection

Kinase: IDG Consortium (Target... 65 | 125
Kinase: IDG Consortium (Comple... 25 | 37
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 326 | 979
preweaning lethality, incomple... 173 | 499
embryonic lethality prior to t... 100 | 278
abnormal behavior 93 | 298
abnormal embryo size 85 | 220
embryonic lethality prior to o... 81 | 239
abnormal bone structure 66 | 187
decreased total body fat amoun... 66 | 207
decreased body weight 55 | 161
enlarged heart 52 | 210
increased lean body mass 52 | 172
male infertility 48 | 123
decreased vertical activity 45 | 208
decreased bone mineral content 44 | 151
decreased lean body mass 44 | 135
increased circulating alkaline... 42 | 122
decreased bone mineral density 41 | 126
hyperactivity 41 | 148
hypoactivity 41 | 132
abnormal heart morphology 40 | 162
decreased grip strength 39 | 116
embryonic growth retardation 39 | 106
increased total body fat amoun... 39 | 134
abnormal seminal vesicle morph... 36 | 114
increased startle reflex 36 | 112
decreased circulating glucose ... 34 | 126
increased mean corpuscular hem... 34 | 96
cataract 32 | 92
decreased body length 32 | 101
increased bone mineral content 32 | 108
increased or absent threshold ... 32 | 101
increased mean corpuscular vol... 31 | 92
abnormal lens morphology 30 | 81
decreased circulating choleste... 30 | 93
prenatal lethality prior to he... 30 | 87
decreased mean corpuscular vol... 29 | 79
short tibia 28 | 97
decreased leukocyte cell numbe... 27 | 73
decreased lymphocyte cell numb... 27 | 83
impaired glucose tolerance 27 | 75
increased bone mineral density 27 | 72
increased fasted circulating g... 27 | 76
abnormal retina morphology 26 | 71
decreased circulating insulin ... 26 | 76
decreased circulating triglyce... 26 | 79
increased circulating HDL chol... 26 | 80
abnormal sleep behavior 25 | 70
decreased circulating serum al... 25 | 82
decreased startle reflex 25 | 75
decreased prepulse inhibition 24 | 82
thrombocytopenia 24 | 56
edema 23 | 59
decreased fasted circulating g... 22 | 65
female infertility 22 | 60
improved glucose tolerance 22 | 79
increased heart weight 22 | 62
abnormal eye morphology 21 | 68
abnormal spleen morphology 21 | 55
decreased circulating HDL chol... 21 | 68
small testis 21 | 58
abnormal coat-hair pigmentatio... 20 | 64
increased circulating sodium l... 20 | 71
increased grip strength 20 | 41
small superior vagus ganglion 20 | 74
increased circulating chloride... 19 | 41
increased circulating choleste... 19 | 66
increased hematocrit 19 | 46
increased monocyte cell number 19 | 63
decreased erythrocyte cell num... 18 | 62
decreased hemoglobin content 18 | 68
abnormal behavioral response t... 17 | 66
abnormal gait 17 | 69
abnormal skin morphology 17 | 50
hydrometra 17 | 53
increased neutrophil cell numb... 17 | 46
decreased mean corpuscular hem... 16 | 50
increased blood urea nitrogen ... 16 | 48
increased body length 16 | 32
increased mean platelet volume 16 | 45
abnormal cranium morphology 15 | 36
abnormal kidney morphology 15 | 65
abnormal neural tube closure 15 | 46
decreased blood urea nitrogen ... 15 | 51
decreased caudal vertebrae num... 15 | 53
decreased circulating total pr... 15 | 49
increased leukocyte cell numbe... 15 | 47
pallor 15 | 34
abnormal craniofacial morpholo... 14 | 33
decreased circulating LDL chol... 14 | 38
decreased circulating phosphat... 14 | 27
decreased heart left ventricle... 14 | 28
enlarged lymph nodes 14 | 37
increased erythrocyte cell num... 14 | 39
prolonged ST segment 14 | 36
abnormal bone mineralization 13 | 38
abnormal testis morphology 13 | 43
decreased hematocrit 13 | 46
increased hemoglobin content 13 | 45
prolonged QT interval 13 | 38
decreased circulating alanine ... 12 | 47

Disease

Carcinoma 3,223 | 11,493
ovarian cancer 2,670 | 8,520
osteosarcoma 2,332 | 7,950
medulloblastoma, large-cell 1,896 | 6,241
psoriasis 1,856 | 6,694
glioblastoma 1,782 | 5,792
atypical teratoid / rhabdoid tumor 1,584 | 5,112
lung cancer 1,516 | 4,740
ependymoma 1,441 | 4,679
group 3 medulloblastoma 1,277 | 4,104
adult high grade glioma 1,164 | 3,801
Breast cancer 1,125 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,013 | 3,291
malignant mesothelioma 972 | 3,232
primitive neuroectodermal tumor 963 | 3,035
oligodendroglioma 916 | 2,850
Astrocytoma, Pilocytic 905 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 905 | 2,989
invasive ductal carcinoma 902 | 2,951
non-small cell lung cancer 874 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 857 | 2,955
Cancer 854 | 2,499
Kidney cancer 825 | 2,613
astrocytic glioma 805 | 2,597
lung adenocarcinoma 784 | 2,716
lung carcinoma 779 | 2,843
pancreatic cancer 764 | 2,398
subependymal giant cell astrocytoma 756 | 2,287
Pick disease 623 | 1,894
interstitial cystitis 609 | 2,312
tuberculosis 570 | 2,010
group 4 medulloblastoma 566 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 550 | 1,962
pituitary cancer 535 | 1,972
ductal carcinoma in situ 531 | 1,745
ulcerative colitis 530 | 1,819
breast carcinoma 527 | 1,638
Multiple myeloma 513 | 1,332
cystic fibrosis 481 | 1,696
colon cancer 480 | 1,478
adrenocortical carcinoma 449 | 1,428
diabetes mellitus 445 | 1,728
acute quadriplegic myopathy 439 | 1,158
Autosomal recessive predisposition 418 | 1,442
astrocytoma 410 | 1,146
juvenile dermatomyositis 406 | 1,187
dermatomyositis 393 | 966
spina bifida 383 | 1,074
nasopharyngeal carcinoma 370 | 1,058
primary pancreatic ductal adenocarcinoma 362 | 1,109
Schizophrenia 361 | 1,160
Intellectual disability 358 | 1,016
Rheumatoid arthritis 347 | 1,191
Waldenstrons macroglobulinemia 336 | 765
cutaneous lupus erythematosus 308 | 1,057
pediatric high grade glioma 307 | 1,064
Atopic dermatitis 282 | 952
acute myeloid leukemia 260 | 783
non primary Sjogren syndrome sicca 258 | 891
primary Sjogren syndrome 251 | 735
active Crohn's disease 244 | 922
gastric carcinoma 236 | 807
progressive supranuclear palsy 235 | 676
esophageal adenocarcinoma 234 | 737
Liver Cirrhosis, Experimental 230 | 769
Dull intelligence 219 | 645
Low intelligence 219 | 645
Mental Retardation 219 | 645
Mental deficiency 219 | 645
Poor school performance 219 | 645
Melanoma 218 | 711
active ulcerative colitis 217 | 764
medulloblastoma 214 | 720
Cognitive delay 208 | 608
Global developmental delay 208 | 608
Mental and motor retardation 208 | 608
Epilepsy 207 | 792
aldosterone-producing adenoma 206 | 665
Alzheimer's disease 201 | 658
Amyotrophic lateral sclerosis 200 | 451
Bipolar Disorder 199 | 666
Liver cancer 197 | 604
Obesity 192 | 678
pancreatic carcinoma 188 | 562
chronic rhinosinusitis 183 | 512
Breast Neoplasms 180 | 445
Duchenne muscular dystrophy 179 | 601
hepatocellular carcinoma 177 | 547
Neurodegenerative disease 174 | 414
Short stature 169 | 531
Endometriosis 167 | 540
Mammary Neoplasms 166 | 425
autosomal dominant Emery-Dreifuss muscular dystrophy 163 | 510
Down syndrome 160 | 499
Muscle hypotonia 159 | 571
Prostatic Neoplasms 159 | 495
Seizures 159 | 596
fibroadenoma 154 | 559
gastric cancer 150 | 459
sonic hedgehog group medulloblastoma 139 | 467

Tissue

Endocrine System 4,817 | 18,159
Digestive Tract 4,724 | 17,369
Skin and soft tissues 4,720 | 17,230
Female tissues 4,713 | 17,400
Male tissues 4,688 | 17,142
Blood and immune system 4,660 | 16,909
Nervous System 4,635 | 16,725
Liver and Pancreas 4,625 | 16,750
Urinary Tract 4,621 | 16,678
Respiratory system 4,581 | 16,393
Cardiovascular System 4,417 | 15,192

Target Family

Non-IDG 3,065 | 12,091
Enzyme 1,206 | 4,145
Kinase 360 | 634
Transcription Factor 182 | 1,400
Epigenetic 61 | 242
Ion Channel 24 | 344
Transporter 21 | 473
Nuclear Receptor 16 | 48
TF/Epigenetic 9 | 38
GPCR 8 | 408

UniProt Keyword

Cytoplasm 4,952 | 4,952
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12