Development Level

Tbio 18 | 11,445
Tclin 4 | 613
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
decreased grip strength 2 | 116
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal stomach morphology 1 | 10
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased grip strength 1 | 41
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Craniosynostosis 23 | 74
Carcinoma 18 | 11,493
invasive ductal carcinoma 14 | 2,951
psoriasis 14 | 6,694
Frontal bossing 13 | 157
Orbital separation excessive 13 | 244
Skull malformation 13 | 38
ovarian cancer 13 | 8,520
Coronal craniosynostosis 12 | 14
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
osteosarcoma 12 | 7,950
Brachycephaly 11 | 88
Breast cancer 11 | 3,578
Broad cranium shape 11 | 88
Exophthalmos 11 | 112
Intellectual disability 11 | 1,016
Prominent eyes 11 | 96
Prominent globes 11 | 96
Protruding eyes 11 | 96
Short stature 11 | 531
Wide skull shape 11 | 88
Acquired scoliosis 10 | 281
Byzanthine arch palate 10 | 194
Cancer 10 | 2,499
Craniosynostoses 10 | 16
Curvature of spine 10 | 282
Decreased projection of midface 10 | 105
Dull intelligence 10 | 645
Hypotrophic midface 10 | 105
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Midface retrusion 10 | 105
Poor school performance 10 | 645
Small midface 10 | 105
Strabismus 10 | 270
lung cancer 10 | 4,740
malignant mesothelioma 10 | 3,232
oligodendroglioma 10 | 2,850
Acrocephaly 9 | 12
Autosomal recessive predisposition 9 | 1,442
Concave bridge of nose 9 | 195
Cryptorchidism 9 | 296
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
non-small cell lung cancer 9 | 2,890
Acrocephalosyndactylia 8 | 17
Astrocytoma, Pilocytic 8 | 3,081
Cleft Palate 8 | 271
Decreased projection of maxilla 8 | 66
Deficiency of upper jaw bones 8 | 66
Hypoplasia of the maxilla 8 | 66
Hypotrophic malar bone 8 | 129
Hypotrophic maxilla 8 | 66
Kidney cancer 8 | 2,613
Malar flattening 8 | 129
Maxillary retrognathia 8 | 66
Muscle hypotonia 8 | 571
Retrusion of upper jaw bones 8 | 66
Syndactyly of fingers 8 | 48
adult high grade glioma 8 | 3,801
breast carcinoma 8 | 1,638
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
Asymmetry of the posterior cranium 7 | 20
Bilateral fifth finger clinodactyly 7 | 110
Brachydactyly 7 | 156
Cloverleaf skull 7 | 7
Conductive hearing loss 7 | 123
Curvature of little finger 7 | 110
Downward slant of palpebral fissure 7 | 158
Epilepsy 7 | 792
Flattening of cranial vault 7 | 20
Flattening of head 7 | 20
Hydrocephalus 7 | 152
Low set ears 7 | 181
Plagiocephaly 7 | 20
Plagiocephaly, Nonsynostotic 7 | 20
Rhomboid shaped head 7 | 20
Seizures 7 | 596
Syndactyly of the toes 7 | 45
Synostotic Posterior Plagiocephaly 7 | 8
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Low-set, posteriorly rotated ears 6 | 110
Mental and motor retardation 6 | 608
Small head 6 | 374
Uranostaphyloschisis 6 | 167
ductal carcinoma in situ 6 | 1,745

Tissue

Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Skin and soft tissues 23 | 17,230
Blood and immune system 22 | 16,909
Respiratory system 22 | 16,393
Cardiovascular System 21 | 15,192
Urinary Tract 21 | 16,678

Target Family

Non-IDG 8 | 12,091
Transcription Factor 7 | 1,400
Enzyme 4 | 4,145
Kinase 4 | 634
Epigenetic 1 | 242

UniProt Keyword

Craniosynostosis 24 | 24
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
ETS domain-containing transcription factor ERF ERF Tbio Transcription Factor -2.42588 268.8 257
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Ephrin-B1 EFNB1 Tbio Non-IDG -2.26015 197.6 359
Homeobox protein aristaless-like 4 ALX4 Tbio Transcription Factor -1.77762 62.7 213
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Fibroblast growth factor receptor 3 FGFR3 Tclin Kinase -3.00731 1050.1 479
Transcription factor 12 TCF12 Tbio Transcription Factor -2.24606 159.8 253
Multiple epidermal growth factor-like domains protein 8 MEGF8 Tbio Non-IDG -0.21967 1.88 58