Development Level

Tbio 10 | 11,445
Tclin 3 | 613
Tchem 1 | 1,598

IMPC Phenotype

decreased bone mineral density 2 | 126
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal thoracic cage shape 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal zygomatic bone morpho... 1 | 3
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating thyroxin... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased urine creatinine lev... 1 | 3
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QRS complex duration 1 | 8
thrombocytopenia 1 | 56

Disease

Congenital hypothyroidism 14 | 26
Hypothyroidism 14 | 122
Goiter 11 | 38
Carcinoma 10 | 11,493
Muscle hypotonia 9 | 571
Abdomen distended 8 | 43
Coarse facial features 8 | 108
Cognitive delay 8 | 608
Constipation 8 | 181
Dyschezia 8 | 135
Global developmental delay 8 | 608
Icterus 8 | 82
Large bregma sutures 8 | 46
Large fontanelle 8 | 46
Large, late-closing fontanelle 8 | 46
Macroglossia 8 | 65
Mental and motor retardation 8 | 608
Thickened facial skin with coarse facial features 8 | 108
Umbilical hernia 8 | 93
Wide bregma sutures 8 | 46
Autosomal recessive predisposition 7 | 1,442
Fatigue 7 | 182
Hypersomnia 7 | 8
Short stature 7 | 531
psoriasis 7 | 6,694
Dull intelligence 6 | 645
Intellectual disability 6 | 1,016
Kidney cancer 6 | 2,613
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Thyroid Dyshormonogenesis 1 6 | 6
Cancer 5 | 2,499
osteosarcoma 5 | 7,950
Adenoma 4 | 167
Athyroidal hypothyroidism 4 | 5
Autoimmune thyroiditis 4 | 27
Dry skin 4 | 75
Feeding difficulties 4 | 127
Graves' disease 4 | 24
Growth delay 4 | 114
Growth failure 4 | 114
Growth retardation 4 | 115
Hyperthyroidism 4 | 53
Pendred Syndrome 4 | 22
Poor growth 4 | 114
Raised TSH level 4 | 8
Thyroid Agenesis 4 | 5
Thyroiditis 4 | 29
Thyrotoxicosis 4 | 38
Very poor growth 4 | 114
Xerosis 4 | 75
malignant mesothelioma 4 | 3,232
Abnormality of metabolism/homeostasis 3 | 134
Athyreosis 3 | 4
Exophthalmos 3 | 112
HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS 3 | 4
Melanoma 3 | 711
Muscle Weakness 3 | 170
Papillary thyroid carcinoma 3 | 43
Severe mental retardation (I.Q. 20-34) 3 | 99
Skin cancer 3 | 469
Thyroid Hypoplasia 3 | 4
Thyroid cancer 3 | 36
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
facioscapulohumeral dystrophy 3 | 288
ovarian cancer 3 | 8,520
uncontrolled asthma 3 | 56
urothelial carcinoma 3 | 318
Acquired metabolic disease 2 | 336
Autoimmune Diseases 2 | 67
Breast cancer 2 | 3,578
Celiac disease 2 | 116
Choanal Atresia 2 | 42
Delayed bone age 2 | 136
Diaphragmatic Hernia 2 | 40
Hernia, Diaphragmatic 2 | 40
Kidney disease 2 | 430
Lethargy 2 | 77
Liver cancer 2 | 604
Motor delay 2 | 147
No development of motor milestones 2 | 147
Papillary carcinoma 2 | 6
Sleep disturbances 2 | 37
Thyroid Neoplasm 2 | 37
Thyroid Neoplasms 2 | 34
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
non-small cell lung cancer 2 | 2,890
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Skin and soft tissues 13 | 17,230
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Urinary Tract 12 | 16,678
Cardiovascular System 11 | 15,192
Nervous System 11 | 16,725
Respiratory system 10 | 16,393

Target Family

Transcription Factor 5 | 1,400
Enzyme 4 | 4,145
Non-IDG 2 | 12,091
GPCR 1 | 408
Nuclear Receptor 1 | 48
Transporter 1 | 473

UniProt Keyword

Congenital hypothyroidism 14 | 14
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroglobulin TG Tbio Non-IDG -3.88676 7423.9 1081
Homeobox protein Nkx-2.1 NKX2-1 Tbio Transcription Factor -3.08631 1272.5 530
Sodium/iodide cotransporter SLC5A5 Tbio Transporter -3.03414 1016.4 360
Thyrotropin receptor TSHR Tclin GPCR -3.03356 1166.1 550
Thyroid peroxidase TPO Tclin Enzyme -2.83776 580.4 368
Homeobox protein Nkx-2.5 NKX2-5 Tbio Transcription Factor -2.79738 600.1 385
Thyroid hormone receptor alpha THRA Tclin Nuclear Receptor -2.72292 527.4 453
Paired box protein Pax-8 PAX8 Tbio Transcription Factor -2.64765 442.1 540
Dual oxidase 2 DUOX2 Tchem Enzyme -2.45061 251.8 126
Forkhead box protein E1 FOXE1 Tbio Transcription Factor -2.41790 254.9 187