Development Level

Tbio 1,398 | 11,651
Tdark 690 | 6,593
Tchem 53 | 1,388
Tclin 12 | 612

Collection

RFA-RM-18-021 18 | 328
Kinase: IDG Consortium (Target... 15 | 125
Kinase: IDG Consortium (Comple... 5 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 140 | 979
preweaning lethality, incomple... 62 | 499
embryonic lethality prior to t... 36 | 278
abnormal behavior 29 | 298
embryonic lethality prior to o... 27 | 239
abnormal bone structure 25 | 187
abnormal embryo size 24 | 220
decreased total body fat amoun... 24 | 207
increased lean body mass 24 | 172
male infertility 22 | 123
improved glucose tolerance 21 | 79
increased startle reflex 21 | 112
decreased body weight 20 | 161
increased total body fat amoun... 20 | 134
decreased bone mineral content 19 | 151
decreased body length 18 | 101
decreased circulating glucose ... 18 | 126
decreased bone mineral density 17 | 126
enlarged heart 17 | 210
increased circulating alkaline... 17 | 122
decreased lean body mass 15 | 135
decreased vertical activity 15 | 208
decreased circulating choleste... 14 | 93
hyperactivity 14 | 148
increased fasted circulating g... 14 | 76
decreased grip strength 13 | 116
hypoactivity 13 | 132
increased mean corpuscular hem... 13 | 96
increased or absent threshold ... 13 | 101
prenatal lethality prior to he... 13 | 87
abnormal retina morphology 12 | 71
decreased circulating insulin ... 12 | 76
decreased circulating serum al... 12 | 82
embryonic growth retardation 12 | 106
increased bone mineral content 12 | 108
decreased circulating alanine ... 11 | 47
decreased startle reflex 11 | 75
small testis 11 | 58
abnormal behavioral response t... 10 | 66
abnormal seminal vesicle morph... 10 | 114
cataract 10 | 92
decreased circulating alkaline... 10 | 46
impaired glucose tolerance 10 | 75
increased circulating sodium l... 10 | 71
decreased circulating HDL chol... 9 | 68
decreased erythrocyte cell num... 9 | 62
decreased lymphocyte cell numb... 9 | 83
increased mean corpuscular vol... 9 | 92
abnormal lens morphology 8 | 81
abnormal skin morphology 8 | 50
cardiovascular system phenotyp... 8 | 36
decreased circulating triglyce... 8 | 79
decreased leukocyte cell numbe... 8 | 73
decreased mean corpuscular vol... 8 | 79
decreased prepulse inhibition 8 | 82
increased circulating HDL chol... 8 | 80
short tibia 8 | 97
small superior vagus ganglion 8 | 74
abnormal heart morphology 7 | 162
decreased circulating LDL chol... 7 | 38
decreased circulating total pr... 7 | 49
decreased fasted circulating g... 7 | 65
decreased hematocrit 7 | 46
edema 7 | 59
enlarged spleen 7 | 41
hemorrhage 7 | 23
increased body length 7 | 32
increased bone mineral density 7 | 72
increased circulating chloride... 7 | 41
increased grip strength 7 | 41
increased heart weight 7 | 62
thrombocytopenia 7 | 56
abnormal coat-hair pigmentatio... 6 | 64
abnormal cranium morphology 6 | 36
abnormal eye morphology 6 | 68
abnormal gait 6 | 69
abnormal pericardium morpholog... 6 | 26
abnormal spleen morphology 6 | 55
abnormal testis morphology 6 | 43
decreased circulating aspartat... 6 | 34
decreased red blood cell distr... 6 | 41
female infertility 6 | 60
increased circulating choleste... 6 | 66
increased hemoglobin content 6 | 45
long tibia 6 | 25
prolonged QT interval 6 | 38
small spleen 6 | 19
tremors 6 | 39
abnormal placenta size 5 | 20
abnormal sleep behavior 5 | 70
decreased caudal vertebrae num... 5 | 53
decreased circulating creatini... 5 | 39
decreased circulating free fat... 5 | 31
decreased mean corpuscular hem... 5 | 50
decreased neutrophil cell numb... 5 | 42
enlarged lymph nodes 5 | 37
increased circulating creatini... 5 | 38
increased hematocrit 5 | 46
increased monocyte cell number 5 | 63
prolonged ST segment 5 | 36

Disease

Carcinoma 1,543 | 11,493
ovarian cancer 1,031 | 8,520
osteosarcoma 971 | 7,950
medulloblastoma, large-cell 718 | 6,241
psoriasis 713 | 6,694
glioblastoma 695 | 5,792
ependymoma 626 | 4,679
atypical teratoid / rhabdoid tumor 608 | 5,112
group 3 medulloblastoma 528 | 4,104
lung cancer 509 | 4,740
adult high grade glioma 472 | 3,801
Kidney cancer 469 | 2,613
Breast cancer 440 | 3,578
primitive neuroectodermal tumor 381 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 376 | 2,989
malignant mesothelioma 376 | 3,232
oligodendroglioma 371 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 362 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 361 | 3,291
Astrocytoma, Pilocytic 359 | 3,081
invasive ductal carcinoma 328 | 2,951
astrocytic glioma 304 | 2,597
non-small cell lung cancer 303 | 2,890
lung adenocarcinoma 291 | 2,716
lung carcinoma 286 | 2,843
subependymal giant cell astrocytoma 261 | 2,287
Pick disease 259 | 1,894
pancreatic cancer 255 | 2,398
pituitary cancer 209 | 1,972
interstitial cystitis 206 | 2,312
group 4 medulloblastoma 203 | 1,855
tuberculosis 194 | 2,010
breast carcinoma 190 | 1,638
ductal carcinoma in situ 190 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 184 | 1,962
cystic fibrosis 171 | 1,696
nasopharyngeal carcinoma 169 | 1,058
Cancer 168 | 2,499
juvenile dermatomyositis 165 | 1,187
adrenocortical carcinoma 164 | 1,428
ulcerative colitis 164 | 1,819
spina bifida 162 | 1,074
acute quadriplegic myopathy 153 | 1,158
colon cancer 152 | 1,478
astrocytoma 141 | 1,146
diabetes mellitus 137 | 1,728
Rheumatoid arthritis 134 | 1,191
Liver cancer 129 | 604
dermatomyositis 124 | 966
pediatric high grade glioma 121 | 1,064
Multiple myeloma 120 | 1,332
progressive supranuclear palsy 120 | 676
Intellectual disability 118 | 1,016
Autosomal recessive predisposition 117 | 1,442
primary pancreatic ductal adenocarcinoma 117 | 1,109
Atopic dermatitis 107 | 952
Schizophrenia 107 | 1,160
Melanoma 97 | 711
chronic rhinosinusitis 97 | 512
non primary Sjogren syndrome sicca 96 | 891
acute myeloid leukemia 93 | 783
active Crohn's disease 90 | 922
medulloblastoma 85 | 720
aldosterone-producing adenoma 79 | 665
primary Sjogren syndrome 79 | 735
cutaneous lupus erythematosus 78 | 1,057
Skin cancer 75 | 469
gastric carcinoma 75 | 807
Amyotrophic lateral sclerosis 73 | 451
Endometriosis 73 | 540
Waldenstrons macroglobulinemia 72 | 765
esophageal adenocarcinoma 72 | 737
Dull intelligence 71 | 645
Low intelligence 71 | 645
Mental Retardation 71 | 645
Mental deficiency 71 | 645
Poor school performance 71 | 645
Alzheimer's disease 70 | 658
Endometrial cancer 67 | 311
posterior fossa group B ependymoma 66 | 416
Cognitive delay 63 | 608
Global developmental delay 63 | 608
Mental and motor retardation 63 | 608
active ulcerative colitis 63 | 764
fibroadenoma 62 | 559
Liver Cirrhosis, Experimental 59 | 769
autosomal dominant Emery-Dreifuss muscular dystrophy 59 | 510
Short stature 56 | 531
pancreatic carcinoma 55 | 562
Down syndrome 53 | 499
sonic hedgehog group medulloblastoma 53 | 467
Bipolar Disorder 51 | 666
tuberculosis and treatment for 6 months 51 | 409
Muscle hypotonia 50 | 571
hepatocellular carcinoma 49 | 547
hereditary spastic paraplegia 49 | 318
Epilepsy 48 | 792
Duchenne muscular dystrophy 47 | 601
Multiple Sclerosis 46 | 540
gastric cancer 46 | 459

Tissue

Endocrine System 2,060 | 18,159
Female tissues 2,005 | 17,400
Digestive Tract 1,984 | 17,369
Skin and soft tissues 1,981 | 17,230
Male tissues 1,966 | 17,142
Blood and immune system 1,943 | 16,909
Liver and Pancreas 1,943 | 16,750
Urinary Tract 1,932 | 16,678
Nervous System 1,926 | 16,725
Respiratory system 1,922 | 16,393
Cardiovascular System 1,794 | 15,192

Target Family

Non-IDG 1,779 | 12,091
Enzyme 207 | 4,145
Transcription Factor 47 | 1,400
Kinase 46 | 634
Epigenetic 36 | 242
Ion Channel 25 | 344
TF/Epigenetic 7 | 38
GPCR 3 | 408
Transporter 3 | 473

UniProt Keyword

Coiled coil 2,153 | 2,153
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Putative neuroblastoma breakpoint family member 5 NBPF5P Tdark Non-IDG 1.26 0.07 0
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
RanBP2-like and GRIP domain-containing protein 3 RGPD3 Tdark Non-IDG 0.00000 0
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314