Development Level

Tbio 1,277 | 10,625
Tdark 756 | 7,003
Tchem 97 | 1,890
Tclin 12 | 602

Collection

Eligible Kinase Proteins 13 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 90 | 633
preweaning lethality, incomple... 26 | 260
decreased total body fat amoun... 25 | 186
embryonic lethality prior to t... 24 | 187
increased or absent threshold ... 24 | 128
decreased body weight 23 | 174
decreased lean body mass 22 | 195
abnormal behavior 21 | 226
embryonic lethality prior to o... 20 | 148
increased lean body mass 19 | 107
decreased circulating glucose ... 17 | 121
abnormal bone structure 16 | 131
decreased body length 15 | 108
decreased bone mineral content 15 | 157
decreased circulating insulin ... 14 | 75
increased mean corpuscular hem... 14 | 93
abnormal embryo size 12 | 112
decreased circulating choleste... 12 | 85
hyperactivity 12 | 108
improved glucose tolerance 12 | 56
increased bone mineral content 12 | 92
increased fasted circulating g... 12 | 68
male infertility 12 | 62
abnormal retina morphology 11 | 100
decreased circulating alanine ... 11 | 53
decreased circulating serum al... 11 | 79
increased circulating alkaline... 11 | 119
abnormal lens morphology 10 | 73
decreased grip strength 10 | 123
increased startle reflex 10 | 38
prenatal lethality prior to he... 10 | 64
short tibia 10 | 82
abnormal retinal pigmentation 9 | 61
decreased bone mineral density 9 | 126
decreased circulating HDL chol... 9 | 77
hypoactivity 9 | 89
increased grip strength 9 | 83
abnormal behavioral response t... 8 | 52
decreased circulating total pr... 8 | 41
decreased circulating triglyce... 8 | 83
decreased lumbar vertebrae num... 8 | 62
decreased rib number 8 | 59
enlarged heart 8 | 111
increased circulating sodium l... 8 | 71
increased mean corpuscular vol... 8 | 91
increased sacral vertebrae num... 8 | 62
increased total body fat amoun... 8 | 57
decreased caudal vertebrae num... 7 | 49
decreased circulating free fat... 7 | 39
decreased mean corpuscular vol... 7 | 50
decreased startle reflex 7 | 48
increased circulating HDL chol... 7 | 63
increased circulating choleste... 7 | 53
increased exploration in new e... 7 | 56
thrombocytopenia 7 | 46
abnormal bone mineralization 6 | 55
abnormal cranium morphology 6 | 32
abnormal sleep behavior 6 | 63
decreased circulating LDL chol... 6 | 37
decreased eosinophil cell numb... 6 | 41
hemorrhage 6 | 12
increased body weight 6 | 42
increased circulating chloride... 6 | 43
tremors 6 | 34
abnormal coat/ hair morphology 5 | 18
abnormal coat/hair pigmentatio... 5 | 54
decreased circulating aspartat... 5 | 27
decreased circulating calcium ... 5 | 33
decreased threshold for audito... 5 | 32
increased bone mineral density 5 | 52
increased heart weight 5 | 37
increased hemoglobin content 5 | 45
increased rib number 5 | 41
small testis 5 | 37
abnormal gait 4 | 51
abnormal neural tube closure 4 | 37
abnormal testis morphology 4 | 30
abnormal vocalization 4 | 21
cardiovascular system phenotyp... 4 | 35
decreased circulating alkaline... 4 | 41
decreased circulating chloride... 4 | 32
decreased circulating creatini... 4 | 31
decreased circulating potassiu... 4 | 17
decreased erythrocyte cell num... 4 | 43
decreased mean corpuscular hem... 4 | 34
decreased monocyte cell number 4 | 28
enlarged spleen 4 | 26
impaired glucose tolerance 4 | 52
increased B cell number 4 | 23
increased circulating creatini... 4 | 29
increased circulating phosphat... 4 | 24
increased mean corpuscular hem... 4 | 25
limb grasping 4 | 35
long tibia 4 | 13
polydactyly 4 | 22
abnormal coat appearance 3 | 25
decreased fasted circulating g... 3 | 49
increased erythrocyte cell num... 3 | 26
increased hematocrit 3 | 36
increased respiratory quotient 3 | 12

Disease

ovarian cancer 1,023 | 8,484
osteosarcoma 965 | 7,933
medulloblastoma, large-cell 710 | 6,234
psoriasis 709 | 6,685
glioblastoma 666 | 5,572
atypical teratoid / rhabdoid tumor 512 | 4,369
lung cancer 467 | 4,466
Carcinoma 414 | 2,147
primitive neuroectodermal tumor 379 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 373 | 2,988
oligodendroglioma 371 | 2,849
Breast cancer 368 | 3,094
malignant mesothelioma 364 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 359 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 358 | 3,289
pilocytic astrocytoma 358 | 3,086
invasive ductal carcinoma 326 | 2,950
pediatric high grade glioma 325 | 2,712
ependymoma 314 | 2,514
group 3 medulloblastoma 302 | 2,254
non-small cell lung cancer 294 | 2,798
lung adenocarcinoma 289 | 2,713
lung carcinoma 283 | 2,844
adult high grade glioma 265 | 2,148
Pick disease 258 | 1,893
subependymal giant cell astrocytoma 258 | 2,287
posterior fossa group B ependymoma 254 | 1,530
astrocytic glioma 251 | 2,241
pancreatic cancer 235 | 2,300
group 4 medulloblastoma 210 | 1,875
pituitary cancer 210 | 1,972
interstitial cystitis 205 | 2,299
astrocytoma 192 | 1,493
ductal carcinoma in situ 189 | 1,745
breast carcinoma 188 | 1,614
ulcerative colitis 184 | 2,087
sonic hedgehog group medulloblastoma 181 | 1,482
medulloblastoma 170 | 1,524
cystic fibrosis 167 | 1,665
nasopharyngeal carcinoma 167 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 163 | 1,795
Cancer 162 | 2,346
juvenile dermatomyositis 162 | 1,189
posterior fossa group A ependymoma 162 | 1,511
spina bifida 162 | 1,064
adrenocortical carcinoma 161 | 1,427
acute quadriplegic myopathy 152 | 1,157
colon cancer 150 | 1,475
tuberculosis 150 | 1,557
primary pancreatic ductal adenocarcinoma 137 | 1,271
diabetes mellitus 133 | 1,663
Rheumatoid Arthritis 131 | 1,160
atypical teratoid/rhabdoid tumor 131 | 1,095
dermatomyositis 123 | 933
progressive supranuclear palsy 119 | 674
Multiple myeloma 118 | 1,327
Atopic dermatitis 106 | 944
chronic rhinosinusitis 97 | 512
acute myeloid leukemia 92 | 780
non primary Sjogren syndrome sicca 92 | 840
active Crohn's disease 89 | 918
primary Sjogren syndrome 84 | 789
aldosterone-producing adenoma 79 | 664
cutaneous lupus erythematosus 79 | 1,056
gastric carcinoma 79 | 832
Intellectual disability 78 | 573
tuberculosis and treatment for 6 months 77 | 686
Alzheimer's disease 73 | 644
Amyotrophic Lateral Sclerosis 73 | 431
Endometriosis 73 | 535
esophageal adenocarcinoma 71 | 737
Waldenstrons macroglobulinemia 70 | 765
fibroadenoma 61 | 557
Schizophrenia 57 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 57 | 499
Down syndrome 56 | 548
pancreatic carcinoma 56 | 567
IGA Glomerulonephritis 54 | 454
hereditary spastic paraplegia 48 | 313
Duchenne muscular dystrophy 47 | 602
active ulcerative colitis 46 | 477
hepatocellular carcinoma 46 | 532
cystic fibrosis and chronic rhinosinusitis 45 | 213
non-small cell lung carcinoma 44 | 413
Neurodegenerative disease 43 | 383
glioblastoma multiforme 43 | 347
Multiple Sclerosis 42 | 498
gastric cancer 42 | 430
tuberculosis and treatment for 3 months 38 | 327
mucosa-associated lymphoid tissue lymphoma 36 | 480
Obesity 35 | 616
sarcoidosis 34 | 358
Neuropathy 33 | 210
inflammatory breast cancer 33 | 404
interstitial lung disease 33 | 291
Polycystic Ovary Syndrome 31 | 332
Acquired metabolic disease 30 | 267
facioscapulohumeral dystrophy 30 | 286
Parkinson's disease 29 | 364
Prostatic Neoplasms 29 | 471

Tissue

Female tissues 2,082 | 18,647
Digestive Tract 2,081 | 18,473
Endocrine System 2,081 | 18,512
Nervous System 2,080 | 18,561
Liver and Pancreas 2,076 | 18,136
Urinary Tract 2,070 | 18,444
Male tissues 2,068 | 17,969
Cardiovascular System 2,066 | 17,958
Blood and immune system 2,060 | 17,995
Skin and soft tissues 2,041 | 18,115
Respiratory system 2,036 | 17,484

Target Family

Non-IDG 1,769 | 11,971
Enzyme 208 | 4,146
Transcription Factor 46 | 1,400
Kinase 45 | 634
Epigenetic 36 | 242
Ion Channel 25 | 341
TF/Epigenetic 7 | 38
GPCR 3 | 406
Transporter 3 | 473

UniProt Keyword

Coiled coil 2,142 | 2,142
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Coiled-coil domain-containing protein 15 CCDC15 Tdark Non-IDG 0.00000 53
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Keratin, type II cytoskeletal 3 KRT3 Tbio Non-IDG -2.12849 126.8 100