Development Level

Tbio 216 | 11,651
Tchem 46 | 1,388
Tdark 26 | 6,593
Tclin 10 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 15 | 979
decreased vertical activity 11 | 208
preweaning lethality, incomple... 10 | 499
abnormal heart morphology 9 | 162
hypoactivity 8 | 132
abnormal behavior 7 | 298
enlarged heart 7 | 210
decreased bone mineral content 6 | 151
prolonged QT interval 6 | 38
prolonged ST segment 6 | 36
increased total body fat amoun... 5 | 134
decreased circulating glucose ... 4 | 126
hyperactivity 4 | 148
abnormal bone structure 3 | 187
abnormal eye morphology 3 | 68
abnormal locomotor behavior 3 | 24
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
abnormal vibrissa morphology 3 | 25
cataract 3 | 92
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased startle reflex 3 | 75
decreased total body fat amoun... 3 | 207
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal tail morphology 2 | 25
decreased T cell number 2 | 15
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased large unstained cell... 2 | 11
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
limb grasping 2 | 41
short tibia 2 | 97
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hydrometra 1 | 53
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 176 | 11,493
psoriasis 117 | 6,694
Cancer 103 | 2,499
ovarian cancer 101 | 8,520
osteosarcoma 93 | 7,950
ependymoma 87 | 4,679
lung cancer 87 | 4,740
glioblastoma 86 | 5,792
medulloblastoma, large-cell 84 | 6,241
atypical teratoid / rhabdoid tumor 78 | 5,112
Breast cancer 76 | 3,578
Astrocytoma, Pilocytic 73 | 3,081
lung carcinoma 70 | 2,843
malignant mesothelioma 68 | 3,232
diabetes mellitus 65 | 1,728
adult high grade glioma 62 | 3,801
group 3 medulloblastoma 57 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
oligodendroglioma 56 | 2,850
non-small cell lung cancer 55 | 2,890
interstitial cystitis 54 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
lung adenocarcinoma 54 | 2,716
pancreatic cancer 52 | 2,398
Kidney cancer 51 | 2,613
Obesity 50 | 678
cystic fibrosis 48 | 1,696
invasive ductal carcinoma 47 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,989
Schizophrenia 45 | 1,160
group 4 medulloblastoma 45 | 1,855
Hypertension 43 | 396
ulcerative colitis 43 | 1,819
astrocytic glioma 42 | 2,597
Autosomal recessive predisposition 41 | 1,442
primitive neuroectodermal tumor 41 | 3,035
Kidney disease 40 | 430
breast carcinoma 39 | 1,638
colon cancer 38 | 1,478
ductal carcinoma in situ 37 | 1,745
Bipolar Disorder 33 | 666
Melanoma 33 | 711
pituitary cancer 33 | 1,972
Alzheimer's disease 32 | 658
Depressive disorder 31 | 409
Alcoholic Intoxication, Chronic 27 | 289
Atherosclerosis 27 | 291
Diarrhea 27 | 253
Mental Depression 27 | 333
Coronary artery disease 26 | 268
Hypertensive disease 26 | 292
adrenocortical carcinoma 26 | 1,428
subependymal giant cell astrocytoma 26 | 2,287
Cerebrovascular disease 25 | 238
Skin cancer 25 | 469
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
tuberculosis 25 | 2,010
Arthritis 24 | 290
Pick disease 24 | 1,894
Heart disease 22 | 306
pediatric high grade glioma 22 | 1,064
Atopic dermatitis 21 | 952
Down syndrome 21 | 499
Liver Cirrhosis, Experimental 21 | 769
Osteoporosis 21 | 363
Rheumatoid arthritis 21 | 1,191
primary pancreatic ductal adenocarcinoma 21 | 1,109
Adenoma 20 | 167
Hypoglycemia 20 | 152
Multiple Sclerosis 20 | 540
fibroadenoma 20 | 559
Asthma 19 | 385
Liver disease 19 | 237
Autistic Disorder 18 | 364
Epilepsy 18 | 792
Hyperglycemia 18 | 137
Hypotension 18 | 82
Hypothyroidism 18 | 122
Liver cancer 18 | 604
Major Depressive Disorder 18 | 301
Pain agnosia 18 | 104
Vascular disease 18 | 319
nasopharyngeal carcinoma 18 | 1,058
Anemia 17 | 365
Mood Disorders 17 | 184
Seizures 17 | 596
Unipolar Depression 17 | 250
cutaneous lupus erythematosus 17 | 1,057
gastric carcinoma 17 | 807
juvenile dermatomyositis 17 | 1,187
Breast Neoplasms 16 | 445
Parkinson's disease 16 | 392
astrocytoma 16 | 1,146
esophageal adenocarcinoma 16 | 737
Constipation 15 | 181
Cushing's syndrome 15 | 48
Neuropathy 15 | 261
Polycystic ovary syndrome 15 | 360
active Crohn's disease 15 | 922
spina bifida 15 | 1,074

Tissue

Endocrine System 270 | 18,159
Digestive Tract 260 | 17,369
Female tissues 257 | 17,400
Skin and soft tissues 253 | 17,230
Male tissues 249 | 17,142
Nervous System 242 | 16,725
Urinary Tract 241 | 16,678
Blood and immune system 239 | 16,909
Liver and Pancreas 238 | 16,750
Respiratory system 228 | 16,393
Cardiovascular System 194 | 15,192

Target Family

Non-IDG 226 | 12,091
Enzyme 66 | 4,145
Kinase 4 | 634
GPCR 1 | 408
Transcription Factor 1 | 1,400

UniProt Keyword

Cleavage on pair of basic resi... 298 | 298
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587