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Development Level

Tbio 127 | 11,445
Tdark 32 | 6,588
Tchem 4 | 1,598

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to t... 7 | 278
male infertility 6 | 123
abnormal behavior 4 | 298
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
increased mean corpuscular hem... 3 | 96
abnormal embryo turning 2 | 31
abnormal humerus morphology 2 | 11
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased grip strength 2 | 116
hydrometra 2 | 53
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased coping response 1 | 8
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
enlarged uterus 1 | 11
female infertility 1 | 60
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating glycerol... 1 | 9
increased circulating insulin ... 1 | 3
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
syndactyly 1 | 23
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 119 | 11,493
ovarian cancer 85 | 8,520
ependymoma 74 | 4,679
osteosarcoma 63 | 7,950
atypical teratoid / rhabdoid tumor 47 | 5,112
psoriasis 46 | 6,694
medulloblastoma, large-cell 44 | 6,241
glioblastoma 43 | 5,792
group 3 medulloblastoma 38 | 4,104
Polydactyly 37 | 107
lung cancer 37 | 4,740
Ciliopathy 34 | 71
Autosomal recessive predisposition 32 | 1,442
Kidney cancer 32 | 2,613
Breast cancer 31 | 3,578
Intellectual disability 31 | 1,016
Nephronophthisis 29 | 80
astrocytic glioma 29 | 2,597
primitive neuroectodermal tumor 28 | 3,035
chronic rhinosinusitis 27 | 512
Joubert syndrome 26 | 66
malignant mesothelioma 26 | 3,232
adult high grade glioma 24 | 3,801
nasopharyngeal carcinoma 24 | 1,058
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Astrocytoma, Pilocytic 22 | 3,081
Bardet-Biedl syndrome 22 | 51
oligodendroglioma 22 | 2,850
Nystagmus 21 | 317
Obesity 21 | 678
Retinitis Pigmentosa 21 | 226
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
lung carcinoma 21 | 2,843
Meckel syndrome 20 | 46
Primary ciliary dyskinesia 20 | 76
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Asphyxiating thoracic dystrophy 19 | 44
Pick disease 19 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
invasive ductal carcinoma 19 | 2,951
Short stature 18 | 531
non-small cell lung cancer 18 | 2,890
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
lung adenocarcinoma 17 | 2,716
tuberculosis 17 | 2,010
Congenital hypoplasia of penis 16 | 176
posterior fossa group B ependymoma 16 | 416
Hydrocephalus 15 | 152
group 4 medulloblastoma 15 | 1,855
Bardet-Biedl syndrome 1 14 | 22
Electroretinogram abnormal 14 | 95
Senior-Loken syndrome 14 | 22
Situs Inversus 14 | 65
subependymal giant cell astrocytoma 14 | 2,287
Cerebellar Ataxia 13 | 304
Fundus dystrophy 13 | 83
Hypertensive disease 13 | 292
Increase in blood pressure 13 | 119
Orofaciodigital syndrome 13 | 21
Ulnar polydactyly of fingers 13 | 47
Brachydactyly 12 | 156
Ciliary Motility Disorders 12 | 38
Familial aplasia of the vermis 12 | 19
Hypogonadism 12 | 173
Kartagener Syndrome 12 | 38
Optic Atrophy 12 | 242
interstitial cystitis 12 | 2,312
pediatric high grade glioma 12 | 1,064
Cancer 11 | 2,499
Cataract 11 | 297
Cleft Palate 11 | 271
Cryptorchidism 11 | 296
Lens Opacities 11 | 231
Multicystic Dysplastic Kidney 11 | 52
Muscle hypotonia 11 | 571
Sensenbrenner syndrome 11 | 17
Uranostaphyloschisis 11 | 167
colon cancer 11 | 1,478
pancreatic cancer 11 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
progressive supranuclear palsy 11 | 676
ulcerative colitis 11 | 1,819
Cone dystrophy 10 | 71
Long face 10 | 71
Meckel-Gruber syndrome 10 | 13
Retinal Degeneration 10 | 106
Rheumatoid arthritis 10 | 1,191
adrenocortical carcinoma 10 | 1,428
cystic fibrosis and chronic rhinosinusitis 10 | 214
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Retinal Dystrophies 9 | 33
Small head 9 | 374

Tissue

Endocrine System 162 | 18,159
Female tissues 161 | 17,400
Respiratory system 160 | 16,393
Skin and soft tissues 159 | 17,230
Digestive Tract 157 | 17,369
Male tissues 157 | 17,142
Nervous System 157 | 16,725
Urinary Tract 157 | 16,678
Blood and immune system 155 | 16,909
Liver and Pancreas 154 | 16,750
Cardiovascular System 142 | 15,192

Target Family

Non-IDG 140 | 12,091
Enzyme 13 | 4,145
Kinase 6 | 634
Transcription Factor 4 | 1,400

UniProt Keyword

Cilium biogenesis-degradation 163 | 163
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 17 TMEM17 Tbio Non-IDG 0.61 0.56 52
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.34455 143.0 113
Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 Tbio Non-IDG -1.46950 32.1 59
Dynein assembly factor 5, axonemal DNAAF5 Tbio Non-IDG -0.07918 1.36 54
Coiled-coil domain-containing protein 28B CCDC28B Tbio Non-IDG -0.62521 3.91 60
Serine/threonine-protein kinase Nek1 NEK1 Tchem Kinase -1.62443 47.0 85
TOG array regulator of axonemal microtubules protein 1 TOGARAM1 Tdark Non-IDG -0.23045 1.13 9