Development Level

Tbio 142 | 11,445
Tdark 61 | 6,588
Tchem 14 | 1,598
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 3 | 126
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 6 | 298
male infertility 6 | 123
decreased grip strength 4 | 116
increased circulating chloride... 4 | 41
increased mean corpuscular hem... 4 | 96
abnormal embryo size 3 | 220
decreased body weight 3 | 161
hyperactivity 3 | 148
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
abnormal embryo turning 2 | 31
abnormal nail morphology 2 | 8
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased total body fat amoun... 2 | 134
long tibia 2 | 25
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating glycerol... 1 | 9
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 167 | 11,493
ependymoma 99 | 4,679
osteosarcoma 88 | 7,950
ovarian cancer 80 | 8,520
psoriasis 59 | 6,694
Kidney cancer 55 | 2,613
medulloblastoma, large-cell 52 | 6,241
glioblastoma 51 | 5,792
chronic rhinosinusitis 49 | 512
atypical teratoid / rhabdoid tumor 47 | 5,112
nasopharyngeal carcinoma 42 | 1,058
Polydactyly 40 | 107
group 3 medulloblastoma 39 | 4,104
Breast cancer 38 | 3,578
Nephronophthisis 36 | 80
Autosomal recessive predisposition 35 | 1,442
Ciliopathy 35 | 71
Primary ciliary dyskinesia 35 | 76
lung cancer 35 | 4,740
lung carcinoma 34 | 2,843
Intellectual disability 32 | 1,016
Retinitis Pigmentosa 32 | 226
adult high grade glioma 31 | 3,801
Bardet-Biedl syndrome 30 | 51
Obesity 30 | 678
malignant mesothelioma 30 | 3,232
lung adenocarcinoma 28 | 2,716
Situs Inversus 27 | 65
primitive neuroectodermal tumor 27 | 3,035
Joubert syndrome 26 | 66
Liver cancer 25 | 604
Nystagmus 24 | 317
Pick disease 24 | 1,894
astrocytic glioma 24 | 2,597
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Ciliary Motility Disorders 22 | 38
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Astrocytoma, Pilocytic 21 | 3,081
Congenital hypoplasia of penis 21 | 176
Short stature 21 | 531
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Meckel syndrome 20 | 46
oligodendroglioma 20 | 2,850
Electroretinogram abnormal 19 | 95
Kartagener Syndrome 19 | 38
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
pancreatic cancer 19 | 2,398
Fundus dystrophy 18 | 83
Hypertensive disease 18 | 292
Hypogonadism 18 | 173
group 4 medulloblastoma 18 | 1,855
invasive ductal carcinoma 18 | 2,951
pituitary cancer 18 | 1,972
Cataract 17 | 297
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Asphyxiating thoracic dystrophy 16 | 44
Cone dystrophy 16 | 71
Lens Opacities 16 | 231
Senior-Loken syndrome 16 | 22
Abnormality of retinal pigmentation 15 | 111
Cystic kidney disease 15 | 26
Increase in blood pressure 15 | 119
Male infertility 15 | 206
Retinal pigment epithelial abnormality 15 | 111
non-small cell lung cancer 15 | 2,890
pediatric high grade glioma 15 | 1,064
tuberculosis 15 | 2,010
Anteverted nostril 14 | 191
Glaucoma 14 | 239
Melanoma 14 | 711
Optic Atrophy 14 | 242
Retinal Degeneration 14 | 106
Ulnar polydactyly of fingers 14 | 47
interstitial cystitis 14 | 2,312
posterior fossa group B ependymoma 14 | 416
Bardet-Biedl syndrome 1 13 | 22
Blind Vision 13 | 111
Broad flat nasal bridge 13 | 236
Cerebellar Ataxia 13 | 304
Ciliary Dyskinesia, Primary, 1 13 | 27
Nasal bridge wide 13 | 236
cystic fibrosis and chronic rhinosinusitis 13 | 214
Blindness, Legal 12 | 110
Photodysphoria 12 | 121
Photophobia 12 | 121
Sensenbrenner syndrome 12 | 17
Sensorineural Hearing Loss (disorder) 12 | 284
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
progressive supranuclear palsy 12 | 676
Hydrocephalus 11 | 152
Multicystic Dysplastic Kidney 11 | 52
breast carcinoma 11 | 1,638
ductal carcinoma in situ 11 | 1,745
subependymal giant cell astrocytoma 11 | 2,287

Tissue

Endocrine System 215 | 18,159
Female tissues 204 | 17,400
Respiratory system 203 | 16,393
Skin and soft tissues 202 | 17,230
Male tissues 199 | 17,142
Digestive Tract 198 | 17,369
Nervous System 196 | 16,725
Urinary Tract 195 | 16,678
Blood and immune system 193 | 16,909
Liver and Pancreas 193 | 16,750
Cardiovascular System 169 | 15,192

Target Family

Non-IDG 169 | 12,091
Enzyme 26 | 4,145
Ion Channel 8 | 344
Kinase 6 | 634
GPCR 4 | 408
Transcription Factor 3 | 1,400
Transporter 2 | 473

UniProt Keyword

Cilium 218 | 218
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth arrest-specific protein 8 GAS8 Tbio Non-IDG -1.20822 17.3 102
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Myocilin MYOC Tbio Non-IDG -2.65916 482.8 169
Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 Tbio Non-IDG -1.46950 32.1 59
Transmembrane protein 17 TMEM17 Tbio Non-IDG 0.61 0.56 52
Rotatin RTTN Tbio Non-IDG -0.87856 9.51 13
Intraflagellar transport protein 25 homolog HSPB11 Tbio Non-IDG -1.40552 26.1 61
Cilia- and flagella-associated protein 100 CFAP100 Tdark Non-IDG -0.65665 4.18 113
WD repeat-containing protein 60 WDR60 Tbio Non-IDG -0.64761 3.98 23
Tubulin polyglutamylase TTLL5 TTLL5 Tbio Enzyme -0.67048 4.78 28