Development Level

Tbio 288 | 11,651
Tdark 69 | 6,593
Tchem 31 | 1,388

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 7 | 298
embryonic lethality prior to t... 7 | 278
increased startle reflex 7 | 112
male infertility 7 | 123
decreased total body fat amoun... 6 | 207
embryonic lethality prior to o... 6 | 239
abnormal bone structure 5 | 187
decreased body weight 5 | 161
decreased circulating choleste... 5 | 93
female infertility 5 | 60
increased fasted circulating g... 5 | 76
abnormal embryo size 4 | 220
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased circulating alanine ... 4 | 47
increased circulating HDL chol... 4 | 80
increased lean body mass 4 | 172
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal lens morphology 3 | 81
abnormal tail morphology 3 | 25
decreased blood urea nitrogen ... 3 | 51
decreased circulating HDL chol... 3 | 68
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased prepulse inhibition 3 | 82
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
hemorrhage 3 | 23
increased circulating alkaline... 3 | 122
increased circulating chloride... 3 | 41
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
shortened RR interval 3 | 17
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal spinal cord morpholog... 2 | 9
corneal opacity 2 | 32
decreased basophil cell number 2 | 16
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart left ventricle... 2 | 28
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased total retina thickne... 2 | 17
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
increased thermal nociceptive ... 2 | 9
irregularly shaped pupil 2 | 7
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
vertebral transformation 2 | 12
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal vertebrae morphology 1 | 18
decreased caudal vertebrae num... 1 | 53
decreased mean corpuscular hem... 1 | 31
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26

Disease

Carcinoma 247 | 11,493
ovarian cancer 209 | 8,520
osteosarcoma 175 | 7,950
medulloblastoma, large-cell 164 | 6,241
psoriasis 151 | 6,694
group 3 medulloblastoma 143 | 4,104
atypical teratoid / rhabdoid tumor 133 | 5,112
lung cancer 133 | 4,740
Breast cancer 132 | 3,578
glioblastoma 132 | 5,792
primitive neuroectodermal tumor 108 | 3,035
malignant mesothelioma 96 | 3,232
ependymoma 92 | 4,679
non-small cell lung cancer 92 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 91 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,989
lung adenocarcinoma 88 | 2,716
adult high grade glioma 83 | 3,801
invasive ductal carcinoma 82 | 2,951
Cancer 75 | 2,499
Kidney cancer 73 | 2,613
adrenocortical carcinoma 67 | 1,428
oligodendroglioma 59 | 2,850
ductal carcinoma in situ 56 | 1,745
colon cancer 51 | 1,478
astrocytic glioma 50 | 2,597
breast carcinoma 50 | 1,638
pancreatic cancer 47 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,955
Intellectual disability 43 | 1,016
Pick disease 40 | 1,894
nasopharyngeal carcinoma 40 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
subependymal giant cell astrocytoma 39 | 2,287
Waldenstrons macroglobulinemia 37 | 765
Multiple myeloma 36 | 1,332
Endometriosis 34 | 540
pediatric high grade glioma 34 | 1,064
Astrocytoma, Pilocytic 32 | 3,081
pituitary cancer 32 | 1,972
Atopic dermatitis 31 | 952
group 4 medulloblastoma 29 | 1,855
Rheumatoid arthritis 28 | 1,191
dermatomyositis 27 | 966
ulcerative colitis 27 | 1,819
acute quadriplegic myopathy 26 | 1,158
juvenile dermatomyositis 26 | 1,187
lung carcinoma 25 | 2,843
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Poor school performance 24 | 645
non primary Sjogren syndrome sicca 24 | 891
diabetes mellitus 22 | 1,728
Cognitive delay 21 | 608
Global developmental delay 21 | 608
Mental and motor retardation 21 | 608
Schizophrenia 21 | 1,160
Short stature 21 | 531
Small head 21 | 374
acute myeloid leukemia 21 | 783
interstitial cystitis 20 | 2,312
Autosomal recessive predisposition 19 | 1,442
astrocytoma 19 | 1,146
primary Sjogren syndrome 19 | 735
progressive supranuclear palsy 19 | 676
tuberculosis 19 | 2,010
cystic fibrosis 18 | 1,696
Infertility 17 | 188
Liver cancer 17 | 604
Male infertility 17 | 206
gastric cancer 17 | 459
Hypoplastic mandible condyle 16 | 275
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
pancreatic carcinoma 16 | 562
non-small cell lung carcinoma 15 | 317
tuberculosis and treatment for 6 months 15 | 409
gastric carcinoma 14 | 807
hepatocellular carcinoma 14 | 547
Breast Neoplasms 13 | 445
Fetal Growth Retardation 13 | 189
Infant, Small for Gestational Age 13 | 176
Intrauterine retardation 13 | 176
Mammary Neoplasms 13 | 425
Microcephaly 13 | 166
cutaneous lupus erythematosus 13 | 1,057
medulloblastoma 13 | 720
spina bifida 13 | 1,074
Alzheimer's disease 12 | 658
Cryptorchidism 12 | 296
Epilepsy 12 | 792
primary pancreatic ductal adenocarcinoma 12 | 1,109
Autistic Disorder 11 | 364
Down syndrome 11 | 499
inflammatory breast cancer 11 | 286
Bipolar Disorder 10 | 666
Muscle hypotonia 10 | 571
aldosterone-producing adenoma 10 | 665

Tissue

Endocrine System 382 | 18,159
Female tissues 373 | 17,400
Digestive Tract 369 | 17,369
Blood and immune system 367 | 16,909
Skin and soft tissues 367 | 17,230
Male tissues 366 | 17,142
Liver and Pancreas 359 | 16,750
Nervous System 359 | 16,725
Urinary Tract 359 | 16,678
Respiratory system 358 | 16,393
Cardiovascular System 342 | 15,192

Target Family

Non-IDG 270 | 12,091
Enzyme 46 | 4,145
Epigenetic 33 | 242
Transcription Factor 24 | 1,400
Kinase 10 | 634
TF/Epigenetic 4 | 38
Nuclear Receptor 1 | 48

UniProt Keyword

Chromosome 388 | 388
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meiosis-specific protein MEI4 MEI4 Tdark Non-IDG 0.00000 7
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Protein KASH5 CCDC155 Tdark Non-IDG -0.58600 3.79 39
GTP-binding protein 10 GTPBP10 Tdark Non-IDG -0.23899 1.73 121
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Protamine-2 PRM2 Tbio Non-IDG -2.03817 103.5 37
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124
CST complex subunit TEN1 TEN1 Tbio Non-IDG -2.18182 142.0 8