Development Level

Tbio 252 | 11,651
Tchem 26 | 1,388
Tdark 26 | 6,593
Tclin 20 | 612

Collection

Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 13 | 499
abnormal embryo size 6 | 220
abnormal seminal vesicle morph... 6 | 114
decreased prepulse inhibition 6 | 82
decreased total body fat amoun... 6 | 207
enlarged heart 5 | 210
increased startle reflex 5 | 112
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
decreased erythrocyte cell num... 4 | 62
decreased hematocrit 4 | 46
decreased leukocyte cell numbe... 4 | 73
embryonic lethality prior to t... 4 | 278
impaired glucose tolerance 4 | 75
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal startle reflex 3 | 15
decreased body weight 3 | 161
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased vertical activity 3 | 208
edema 3 | 59
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased mean corpuscular hem... 3 | 96
increased neutrophil cell numb... 3 | 46
thrombocytopenia 3 | 56
abnormal craniofacial morpholo... 2 | 33
abnormal locomotor activation 2 | 16
abnormal lung morphology 2 | 26
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
cataract 2 | 92
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased mean corpuscular vol... 2 | 79
decreased threshold for audito... 2 | 26
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
male infertility 2 | 123
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
enlarged ovary 1 | 2
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
iris synechia 1 | 3
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 237 | 11,493
osteosarcoma 202 | 7,950
ovarian cancer 190 | 8,520
Cancer 179 | 2,499
medulloblastoma, large-cell 165 | 6,241
glioblastoma 160 | 5,792
atypical teratoid / rhabdoid tumor 139 | 5,112
psoriasis 134 | 6,694
lung cancer 130 | 4,740
ependymoma 127 | 4,679
Breast cancer 121 | 3,578
group 3 medulloblastoma 115 | 4,104
adult high grade glioma 101 | 3,801
oligodendroglioma 94 | 2,850
Kidney cancer 93 | 2,613
primitive neuroectodermal tumor 93 | 3,035
Astrocytoma, Pilocytic 82 | 3,081
malignant mesothelioma 82 | 3,232
astrocytic glioma 81 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 81 | 2,989
invasive ductal carcinoma 77 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 75 | 2,955
lung adenocarcinoma 73 | 2,716
non-small cell lung cancer 71 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 69 | 3,291
subependymal giant cell astrocytoma 68 | 2,287
lung carcinoma 63 | 2,843
interstitial cystitis 62 | 2,312
pituitary cancer 59 | 1,972
Intellectual disability 57 | 1,016
pancreatic cancer 57 | 2,398
tuberculosis 54 | 2,010
Pick disease 53 | 1,894
group 4 medulloblastoma 50 | 1,855
breast carcinoma 47 | 1,638
ductal carcinoma in situ 46 | 1,745
ulcerative colitis 46 | 1,819
Schizophrenia 43 | 1,160
astrocytoma 40 | 1,146
Dull intelligence 37 | 645
Low intelligence 37 | 645
Mental Retardation 37 | 645
Mental deficiency 37 | 645
Poor school performance 37 | 645
Rheumatoid arthritis 37 | 1,191
cystic fibrosis 37 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
colon cancer 36 | 1,478
Multiple myeloma 34 | 1,332
acute quadriplegic myopathy 33 | 1,158
adrenocortical carcinoma 33 | 1,428
dermatomyositis 33 | 966
primary Sjogren syndrome 33 | 735
Leukemia, Myelocytic, Acute 32 | 120
juvenile dermatomyositis 32 | 1,187
Leukemia 29 | 104
cutaneous lupus erythematosus 29 | 1,057
Alzheimer's disease 28 | 658
Epilepsy 28 | 792
Waldenstrons macroglobulinemia 28 | 765
pediatric high grade glioma 28 | 1,064
primary pancreatic ductal adenocarcinoma 28 | 1,109
Autistic Disorder 27 | 364
Short stature 27 | 531
Autosomal recessive predisposition 26 | 1,442
Melanoma 26 | 711
Prostatic Neoplasms 26 | 495
acute myeloid leukemia 26 | 783
Atopic dermatitis 25 | 952
Bipolar Disorder 25 | 666
gastric carcinoma 25 | 807
Cognitive delay 23 | 608
Global developmental delay 23 | 608
Liver cancer 23 | 604
Mental and motor retardation 23 | 608
Muscle hypotonia 23 | 571
Seizures 23 | 596
progressive supranuclear palsy 23 | 676
diabetes mellitus 22 | 1,728
Skin cancer 21 | 469
Small head 21 | 374
medulloblastoma 21 | 720
non primary Sjogren syndrome sicca 21 | 891
Leukemia, Myeloid, Acute 20 | 105
Lymphoid leukemia 20 | 160
Renal Cell Carcinoma 20 | 214
nasopharyngeal carcinoma 20 | 1,058
Somatic mutation 19 | 61
aldosterone-producing adenoma 19 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
hepatocellular carcinoma 19 | 547
Breast Neoplasms 18 | 445
spina bifida 18 | 1,074
Blepharoptosis 17 | 231
Immune system cancer 17 | 140
Liver Cirrhosis, Experimental 17 | 769
Mammary Neoplasms 17 | 425
active Crohn's disease 17 | 922
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275

Tissue

Digestive Tract 310 | 17,369
Endocrine System 310 | 18,159
Male tissues 308 | 17,142
Skin and soft tissues 307 | 17,230
Female tissues 306 | 17,400
Blood and immune system 303 | 16,909
Nervous System 302 | 16,725
Urinary Tract 301 | 16,678
Liver and Pancreas 300 | 16,750
Respiratory system 296 | 16,393
Cardiovascular System 289 | 15,192

Target Family

Non-IDG 176 | 12,091
Transcription Factor 61 | 1,400
Enzyme 33 | 4,145
Epigenetic 23 | 242
Kinase 20 | 634
Ion Channel 3 | 344
TF/Epigenetic 3 | 38
Transporter 3 | 473
Nuclear Receptor 2 | 48

UniProt Keyword

Chromosomal rearrangement 324 | 324
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Nuclear receptor coactivator 4 NCOA4 Tbio Non-IDG -2.20245 136.0 283
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 CHCHD7 Tdark Non-IDG -1.37776 18.2 39
T-cell leukemia/lymphoma protein 1B TCL1B Tdark Non-IDG -1.17863 16.3 34
PHD finger protein 23 PHF23 Tbio Epigenetic -0.51820 3.24 45
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
Dynein assembly factor 4, axonemal DNAAF4 Tbio Non-IDG -1.67209 48.6 216
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.52487 33.2 60
T-cell surface protein tactile CD96 Tbio Non-IDG -2.05505 111.7 205