Development Level

Tbio 238 | 10,625
Tchem 37 | 1,890
Tdark 27 | 7,003
Tclin 18 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 17 | 633
preweaning lethality, incomple... 8 | 260
enlarged heart 5 | 111
decreased erythrocyte cell num... 4 | 43
decreased lean body mass 4 | 195
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
increased blood urea nitrogen ... 4 | 44
abnormal bone mineralization 3 | 55
abnormal lens morphology 3 | 73
abnormal startle reflex 3 | 14
decreased body weight 3 | 174
decreased hematocrit 3 | 25
decreased hemoglobin content 3 | 53
embryonic lethality prior to t... 3 | 187
increased bone mineral density 3 | 52
increased or absent threshold ... 3 | 128
abnormal embryo size 2 | 112
abnormal locomotor activation 2 | 26
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating iron lev... 2 | 25
decreased circulating total pr... 2 | 41
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to o... 2 | 148
hyperactivity 2 | 108
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating amylase ... 2 | 13
increased circulating calcium ... 2 | 32
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
limb grasping 2 | 35
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal brain morphology 1 | 6
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
corneal opacity 1 | 25
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased mean corpuscular vol... 1 | 50
dilated heart left ventricle 1 | 10
enlarged ovary 1 | 1
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased granulocyte number 1 | 8
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
increased respiratory quotient 1 | 12
increased rib number 1 | 41
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
iris synechia 1 | 1
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
prolonged RR interval 1 | 2
short tibia 1 | 82
small superior vagus ganglion 1 | 20
small testis 1 | 37
trunk curl 1 | 15

Disease

osteosarcoma 200 | 7,933
ovarian cancer 188 | 8,492
Cancer 174 | 2,346
medulloblastoma, large-cell 163 | 6,234
glioblastoma 151 | 5,572
psoriasis 132 | 6,685
atypical teratoid / rhabdoid tumor 121 | 4,369
lung cancer 116 | 4,473
Breast cancer 100 | 3,099
Carcinoma 94 | 2,147
oligodendroglioma 92 | 2,849
primitive neuroectodermal tumor 91 | 3,031
pilocytic astrocytoma 83 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,988
malignant mesothelioma 80 | 3,163
invasive ductal carcinoma 77 | 2,950
ependymoma 73 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 73 | 2,956
lung adenocarcinoma 73 | 2,714
pediatric high grade glioma 72 | 2,712
non-small cell lung cancer 70 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
astrocytic glioma 67 | 2,241
subependymal giant cell astrocytoma 66 | 2,287
lung carcinoma 62 | 2,844
interstitial cystitis 61 | 2,299
pituitary cancer 58 | 1,972
adult high grade glioma 54 | 2,148
Pick disease 53 | 1,893
pancreatic cancer 53 | 2,300
ulcerative colitis 53 | 2,087
group 3 medulloblastoma 52 | 2,254
group 4 medulloblastoma 52 | 1,875
medulloblastoma 51 | 1,524
astrocytoma 50 | 1,493
tuberculosis 47 | 1,563
Intellectual disability 46 | 573
breast carcinoma 46 | 1,614
ductal carcinoma in situ 46 | 1,745
Rheumatoid Arthritis 38 | 1,171
sonic hedgehog group medulloblastoma 38 | 1,482
primary Sjogren syndrome 37 | 789
colon cancer 36 | 1,475
cystic fibrosis 36 | 1,670
posterior fossa group A ependymoma 35 | 1,511
posterior fossa group B ependymoma 35 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
acute quadriplegic myopathy 33 | 1,157
adrenocortical carcinoma 33 | 1,427
dermatomyositis 33 | 967
Multiple myeloma 32 | 1,328
juvenile dermatomyositis 32 | 1,189
Leukemia 31 | 88
Leukemia, Myelocytic, Acute 31 | 113
primary pancreatic ductal adenocarcinoma 30 | 1,271
cutaneous lupus erythematosus 29 | 1,056
Waldenstrons macroglobulinemia 28 | 765
Alzheimer's disease 27 | 644
acute myeloid leukemia 27 | 785
atypical teratoid/rhabdoid tumor 26 | 1,095
Atopic dermatitis 25 | 944
gastric carcinoma 25 | 832
Autistic Disorder 23 | 320
Prostatic Neoplasms 23 | 471
Schizophrenia 23 | 503
diabetes mellitus 23 | 1,663
progressive supranuclear palsy 23 | 674
nasopharyngeal carcinoma 21 | 1,056
aldosterone-producing adenoma 19 | 664
hepatocellular carcinoma 19 | 550
Renal Cell Carcinoma 18 | 199
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
spina bifida 18 | 1,064
Mammary Neoplasms 17 | 410
active Crohn's disease 17 | 918
non primary Sjogren syndrome sicca 17 | 840
tuberculosis and treatment for 6 months 17 | 686
Papillary thyroid carcinoma 16 | 37
fibroadenoma 16 | 557
Down syndrome 15 | 548
Polycystic Ovary Syndrome 14 | 335
LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3 13 | 20
Melanoma 13 | 261
chronic rhinosinusitis 13 | 512
esophageal adenocarcinoma 13 | 737
gastric cancer 13 | 436
urothelial carcinoma 13 | 318
Acquired metabolic disease 12 | 267
Cleft palate 12 | 125
Kidney disease 12 | 397
Multiple Sclerosis 12 | 498
Obesity 12 | 616
Sarcoma 12 | 49
chronic lymphocytic leukemia 12 | 244
cystic fibrosis and chronic rhinosinusitis 12 | 213
non-small cell lung carcinoma 12 | 413
Crohn's disease 11 | 304
Duchenne muscular dystrophy 11 | 602
inflammatory breast cancer 11 | 404
pancreatic carcinoma 11 | 567

Tissue

Digestive Tract 315 | 18,473
Endocrine System 315 | 18,512
Nervous System 315 | 18,561
Female tissues 313 | 18,647
Blood and immune system 312 | 17,995
Liver and Pancreas 312 | 18,136
Urinary Tract 312 | 18,444
Skin and soft tissues 311 | 18,115
Cardiovascular System 310 | 17,958
Male tissues 309 | 17,969
Respiratory system 302 | 17,484

Target Family

Non-IDG 174 | 11,969
Transcription Factor 61 | 1,400
Enzyme 32 | 4,146
Epigenetic 23 | 242
Kinase 20 | 634
TF/Epigenetic 3 | 38
Transporter 3 | 473
Ion Channel 2 | 341
Nuclear Receptor 2 | 48

UniProt Keyword

Chromosomal rearrangement 320 | 320
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Centromere protein K CENPK Tbio Non-IDG -1.21037 16.5 109
Fc receptor-like protein 4 FCRL4 Tbio Non-IDG -1.26291 20.2 96
Friend leukemia integration 1 transcription factor FLI1 Tbio Transcription Factor -1.80578 60.1 387
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.64327 44.9 16
Roundabout homolog 2 ROBO2 Tbio Non-IDG -1.86221 68.8 144
FGFR1 oncogene partner 2 FGFR1OP2 Tbio Non-IDG -1.02708 9.95 125
Leukemia inhibitory factor receptor LIFR Tchem Non-IDG -2.33661 212.2 213
AF4/FMR2 family member 4 AFF4 Tbio Transcription Factor -2.52668 332.1 141
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.60501 360.4 372