Development Level

Tbio 204 | 11,651
Tchem 61 | 1,388
Tclin 15 | 612
Tdark 10 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 55 | 979
preweaning lethality, incomple... 21 | 499
abnormal behavior 15 | 298
abnormal embryo size 14 | 220
decreased body weight 9 | 161
increased bone mineral density 9 | 72
embryonic lethality prior to o... 8 | 239
increased startle reflex 8 | 112
decreased leukocyte cell numbe... 7 | 73
decreased total body fat amoun... 7 | 207
embryonic lethality prior to t... 7 | 278
increased circulating alkaline... 7 | 122
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
decreased circulating glucose ... 6 | 126
decreased lean body mass 6 | 135
hypoactivity 6 | 132
increased bone mineral content 6 | 108
increased circulating HDL chol... 6 | 80
increased total body fat amoun... 6 | 134
abnormal retinal blood vessel ... 5 | 26
decreased body length 5 | 101
decreased prepulse inhibition 5 | 82
hyperactivity 5 | 148
increased mean corpuscular vol... 5 | 92
increased mean platelet volume 5 | 45
abnormal coat-hair pigmentatio... 4 | 64
abnormal gait 4 | 69
corneal opacity 4 | 32
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 68
decreased circulating serum al... 4 | 82
decreased erythrocyte cell num... 4 | 62
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
decreased red blood cell distr... 4 | 41
edema 4 | 59
impaired glucose tolerance 4 | 75
increased body length 4 | 32
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal cornea morphology 3 | 31
abnormal craniofacial morpholo... 3 | 33
abnormal lens morphology 3 | 81
abnormal maxilla morphology 3 | 17
abnormal retinal vasculature m... 3 | 27
abnormal tooth morphology 3 | 24
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased circulating total pr... 3 | 49
decreased heart left ventricle... 3 | 28
decreased neutrophil cell numb... 3 | 42
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
impaired pupillary reflex 3 | 26
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating triglyce... 3 | 42
male infertility 3 | 123
tremors 3 | 39
vertebral fusion 3 | 23
vertebral transformation 3 | 12
abnormal bone mineralization 2 | 38
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal neural tube closure 2 | 46
abnormal optic disc morphology 2 | 10
abnormal rib morphology 2 | 10
abnormal seminal vesicle morph... 2 | 114
abnormal vertebrae morphology 2 | 18
abnormal vertebral arch morpho... 2 | 9
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased mean platelet volume 2 | 25
decreased total retina thickne... 2 | 17
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
increased body weight 2 | 25
increased circulating choleste... 2 | 66
increased circulating phosphat... 2 | 26
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
irregularly shaped pupil 2 | 7
long tibia 2 | 25
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
small spleen 2 | 19
thrombocytosis 2 | 27

Disease

Carcinoma 225 | 11,493
ovarian cancer 176 | 8,520
osteosarcoma 164 | 7,950
medulloblastoma, large-cell 114 | 6,241
glioblastoma 105 | 5,792
group 3 medulloblastoma 103 | 4,104
psoriasis 97 | 6,694
Cancer 95 | 2,499
lung cancer 91 | 4,740
atypical teratoid / rhabdoid tumor 89 | 5,112
Kidney cancer 83 | 2,613
Breast cancer 77 | 3,578
ependymoma 74 | 4,679
malignant mesothelioma 74 | 3,232
primitive neuroectodermal tumor 70 | 3,035
oligodendroglioma 53 | 2,850
adult high grade glioma 51 | 3,801
Intellectual disability 47 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
Rheumatoid arthritis 41 | 1,191
astrocytic glioma 39 | 2,597
Multiple myeloma 38 | 1,332
Pick disease 37 | 1,894
tuberculosis 37 | 2,010
subependymal giant cell astrocytoma 35 | 2,287
invasive ductal carcinoma 34 | 2,951
non-small cell lung cancer 34 | 2,890
lung adenocarcinoma 32 | 2,716
juvenile dermatomyositis 31 | 1,187
acute myeloid leukemia 28 | 783
Astrocytoma, Pilocytic 27 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Dull intelligence 26 | 645
Liver cancer 26 | 604
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
acute quadriplegic myopathy 25 | 1,158
astrocytoma 25 | 1,146
dermatomyositis 25 | 966
medulloblastoma 24 | 720
pancreatic cancer 24 | 2,398
Schizophrenia 23 | 1,160
group 4 medulloblastoma 23 | 1,855
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
Muscle hypotonia 22 | 571
adrenocortical carcinoma 22 | 1,428
diabetes mellitus 22 | 1,728
pediatric high grade glioma 22 | 1,064
Short stature 21 | 531
Waldenstrons macroglobulinemia 21 | 765
pituitary cancer 21 | 1,972
spina bifida 21 | 1,074
lung carcinoma 20 | 2,843
progressive supranuclear palsy 20 | 676
Epilepsy 19 | 792
Adenoid Cystic Carcinoma 18 | 99
Carcinoma, Adenoid Cystic 18 | 99
ulcerative colitis 18 | 1,819
Seizures 17 | 596
Cryptorchidism 16 | 296
Small head 16 | 374
ductal carcinoma in situ 16 | 1,745
Alzheimer's disease 15 | 658
colon cancer 15 | 1,478
cystic fibrosis 15 | 1,696
Peripheral T-cell lymphoma 14 | 25
Strabismus 14 | 270
Autistic Disorder 13 | 364
Breast Neoplasms 13 | 445
Immune system cancer 13 | 140
Primary cutaneous T-cell lymphoma 13 | 29
Prostatic Neoplasms 13 | 495
breast carcinoma 13 | 1,638
hearing impairment 13 | 199
interstitial cystitis 13 | 2,312
Congenital deafness 12 | 185
Deafness 12 | 198
Hearing Loss, Partial 12 | 185
Mammary Neoplasms 12 | 425
Melanoma 12 | 711
Neurodevelopmental Disorders 12 | 70
Urinary Bladder Neoplasms 12 | 114
primary pancreatic ductal adenocarcinoma 12 | 1,109
Amyotrophic lateral sclerosis 11 | 451
Bladder Neoplasm 11 | 112
Blepharoptosis 11 | 231
Broad flat nasal bridge 11 | 236
Concave bridge of nose 11 | 195
Crohn's disease 11 | 321
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Endometrial cancer 11 | 311
Large intestine cancer 11 | 126
Nasal bridge wide 11 | 236

Tissue

Endocrine System 288 | 18,159
Blood and immune system 286 | 16,909
Digestive Tract 285 | 17,369
Liver and Pancreas 285 | 16,750
Skin and soft tissues 285 | 17,230
Female tissues 284 | 17,400
Male tissues 284 | 17,142
Respiratory system 283 | 16,393
Urinary Tract 283 | 16,678
Nervous System 281 | 16,725
Cardiovascular System 275 | 15,192

Target Family

Epigenetic 121 | 242
Non-IDG 91 | 12,091
Enzyme 30 | 4,145
Transcription Factor 20 | 1,400
TF/Epigenetic 18 | 38
Kinase 9 | 634
Nuclear Receptor 1 | 48

UniProt Keyword

Chromatin regulator 290 | 290
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
E1A-binding protein p400 EP400 Tbio Non-IDG -1.47248 27.6 69
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Lysine-specific demethylase 4E KDM4E Tchem Epigenetic -0.86891 5.72 23
NAD-dependent protein deacetylase sirtuin-7 SIRT7 Tbio Epigenetic -2.22094 153.0 348
SET domain-containing protein 5 SETD5 Tbio Epigenetic -0.91515 9.39 43
WW domain-containing adapter protein with coiled-coil WAC Tbio Non-IDG -1.93384 84.9 87
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
Calcineurin-binding protein cabin-1 CABIN1 Tbio Non-IDG -3.37173 2194.3 57
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693