Development Level

Tbio 191 | 10,625
Tchem 71 | 1,890
Tclin 15 | 602
Tdark 8 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 27 | 633
decreased lean body mass 10 | 195
abnormal behavior 9 | 226
decreased body length 9 | 108
decreased body weight 9 | 174
abnormal embryo size 8 | 112
decreased total body fat amoun... 8 | 186
increased grip strength 8 | 83
preweaning lethality, incomple... 8 | 260
increased bone mineral content 7 | 92
increased sacral vertebrae num... 7 | 62
decreased circulating HDL chol... 6 | 77
decreased leukocyte cell numbe... 6 | 54
decreased lumbar vertebrae num... 6 | 62
embryonic lethality prior to o... 6 | 148
increased circulating alkaline... 6 | 119
abnormal bone structure 5 | 131
decreased bone mineral density 5 | 126
short tibia 5 | 82
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased circulating serum al... 4 | 79
decreased hemoglobin content 4 | 53
embryonic lethality prior to t... 4 | 187
hypoactivity 4 | 89
abnormal bone mineralization 3 | 55
abnormal gait 3 | 51
abnormal neural tube closure 3 | 37
abnormal retina morphology 3 | 100
decreased circulating LDL chol... 3 | 37
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased mean corpuscular hem... 3 | 34
decreased mean corpuscular vol... 3 | 50
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
hyperactivity 3 | 108
increased B cell number 3 | 23
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating creatini... 3 | 29
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased total body fat amoun... 3 | 57
prenatal lethality prior to he... 3 | 64
vertebral transformation 3 | 12
abnormal coat/hair pigmentatio... 2 | 54
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal eye morphology 2 | 38
abnormal hindbrain development 2 | 24
abnormal maxilla morphology 2 | 16
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 14
abnormal vertebral arch morpho... 2 | 9
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 35
corneal opacity 2 | 25
decreased CD8-positive, alpha-... 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased effector memory CD8-... 2 | 24
decreased lactate dehydrogenas... 2 | 14
decreased respiratory quotient 2 | 12
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
impaired pupillary reflex 2 | 14
increased body length 2 | 20
increased body weight 2 | 42
increased circulating HDL chol... 2 | 63
increased circulating triglyce... 2 | 24
increased mean corpuscular hem... 2 | 25
increased monocyte cell number 2 | 27
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
male infertility 2 | 62
oligodactyly 2 | 14
shortened RR interval 2 | 19
tremors 2 | 34
vertebral fusion 2 | 23
abnormal embryo turning 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal tail movements 1 | 12
abnormal thoracic vertebrae mo... 1 | 16
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased circulating chloride... 1 | 32
decreased grip strength 1 | 123
embryonic growth retardation 1 | 28
female infertility 1 | 34
increased circulating magnesiu... 1 | 10
prenatal lethality 1 | 16

Disease

ovarian cancer 172 | 8,484
osteosarcoma 159 | 7,933
medulloblastoma, large-cell 110 | 6,234
glioblastoma 101 | 5,572
psoriasis 95 | 6,685
Cancer 89 | 2,346
lung cancer 82 | 4,466
atypical teratoid / rhabdoid tumor 78 | 4,369
Carcinoma 75 | 2,147
malignant mesothelioma 69 | 3,162
primitive neuroectodermal tumor 69 | 3,031
Breast cancer 61 | 3,094
group 3 medulloblastoma 56 | 2,254
ependymoma 54 | 2,514
oligodendroglioma 52 | 2,849
medulloblastoma 46 | 1,524
pediatric high grade glioma 46 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
Rheumatoid Arthritis 40 | 1,160
Intellectual disability 38 | 573
Multiple myeloma 37 | 1,327
Pick disease 36 | 1,893
invasive ductal carcinoma 34 | 2,950
subependymal giant cell astrocytoma 34 | 2,287
astrocytoma 32 | 1,493
non-small cell lung cancer 32 | 2,798
juvenile dermatomyositis 30 | 1,189
lung adenocarcinoma 30 | 2,713
astrocytic glioma 29 | 2,241
tuberculosis 29 | 1,557
acute myeloid leukemia 28 | 780
pilocytic astrocytoma 28 | 3,086
sonic hedgehog group medulloblastoma 26 | 1,482
adult high grade glioma 25 | 2,148
group 4 medulloblastoma 25 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
acute quadriplegic myopathy 23 | 1,157
dermatomyositis 23 | 933
diabetes mellitus 23 | 1,663
pituitary cancer 21 | 1,972
Waldenstrons macroglobulinemia 20 | 765
adrenocortical carcinoma 20 | 1,427
lung carcinoma 20 | 2,844
spina bifida 20 | 1,064
atypical teratoid/rhabdoid tumor 19 | 1,095
progressive supranuclear palsy 19 | 674
Adenoid Cystic Carcinoma 18 | 99
ulcerative colitis 18 | 2,087
pancreatic cancer 17 | 2,300
tuberculosis and treatment for 6 months 17 | 686
ductal carcinoma in situ 16 | 1,745
colon cancer 15 | 1,475
Peripheral T-cell lymphoma 14 | 24
cystic fibrosis 14 | 1,665
Alzheimer's disease 13 | 644
Primary cutaneous T-cell lymphoma 13 | 24
breast carcinoma 13 | 1,614
interstitial cystitis 13 | 2,299
posterior fossa group B ependymoma 13 | 1,530
primary pancreatic ductal adenocarcinoma 13 | 1,271
posterior fossa group A ependymoma 12 | 1,511
Mammary Neoplasms 11 | 410
Autistic Disorder 10 | 320
Prostatic Neoplasms 10 | 471
aldosterone-producing adenoma 10 | 664
hepatocellular carcinoma 10 | 532
non primary Sjogren syndrome sicca 10 | 840
primary Sjogren syndrome 10 | 789
Amyotrophic Lateral Sclerosis 9 | 431
Bladder Neoplasm 9 | 109
Crohn's disease 9 | 304
Endometriosis 9 | 535
Sezary Syndrome 9 | 26
Schizophrenia 8 | 501
active Crohn's disease 8 | 918
esophageal adenocarcinoma 8 | 737
gastric cancer 8 | 430
nasopharyngeal carcinoma 8 | 1,056
Acquired metabolic disease 7 | 267
Congenital heart disease 7 | 63
IGA Glomerulonephritis 7 | 454
Kabuki syndrome 7 | 27
Leukemia 7 | 88
Liver carcinoma 7 | 217
Melanoma 7 | 261
Renal Cell Carcinoma 7 | 199
gastric carcinoma 7 | 832
Atopic dermatitis 6 | 944
Carcinoma, Transitional Cell 6 | 31
Coffin-Siris syndrome 6 | 17
Down syndrome 6 | 548
Immune system cancer 6 | 38
Male infertility 6 | 170
Obesity 6 | 616
Stomach Neoplasms 6 | 282
active ulcerative colitis 6 | 477
hereditary spastic paraplegia 6 | 313
systemic lupus erythematosus 6 | 156

Tissue

Blood and immune system 282 | 17,995
Endocrine System 282 | 18,512
Digestive Tract 281 | 18,473
Female tissues 281 | 18,647
Liver and Pancreas 281 | 18,136
Nervous System 281 | 18,561
Cardiovascular System 280 | 17,958
Male tissues 280 | 17,969
Skin and soft tissues 279 | 18,115
Urinary Tract 279 | 18,444
Respiratory system 277 | 17,484

Target Family

Epigenetic 120 | 242
Non-IDG 87 | 11,971
Enzyme 30 | 4,146
Transcription Factor 20 | 1,400
TF/Epigenetic 18 | 38
Kinase 9 | 634
Nuclear Receptor 1 | 48

UniProt Keyword

Chromatin regulator 285 | 285
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.39308 24.2 69
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Bromodomain-containing protein 2 BRD2 Tchem Epigenetic -2.42927 0.00000 306
PHD finger protein 20 PHF20 Tbio Epigenetic -2.79926 660.7 91