Development Level

Tbio 37 | 11,651
Tchem 15 | 1,388
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased circulating serum al... 2 | 82
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 39 | 8,520
Carcinoma 36 | 11,493
osteosarcoma 30 | 7,950
psoriasis 29 | 6,694
medulloblastoma, large-cell 20 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
lung cancer 19 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
malignant mesothelioma 18 | 3,232
Atherosclerosis 17 | 291
glioblastoma 17 | 5,792
Autosomal recessive predisposition 16 | 1,442
Obesity 16 | 678
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Lipid metabolism disorder 14 | 114
atypical teratoid / rhabdoid tumor 14 | 5,112
Breast cancer 13 | 3,578
diabetes mellitus 13 | 1,728
ductal carcinoma in situ 13 | 1,745
ependymoma 13 | 4,679
lung carcinoma 13 | 2,843
Kidney cancer 12 | 2,613
invasive ductal carcinoma 12 | 2,951
oligodendroglioma 12 | 2,850
Seizures 11 | 596
astrocytic glioma 11 | 2,597
pancreatic cancer 11 | 2,398
Coronary artery disease 10 | 268
Epilepsy 10 | 792
Hypercholesterolemia 10 | 44
Intellectual disability 10 | 1,016
group 3 medulloblastoma 10 | 4,104
interstitial cystitis 10 | 2,312
subependymal giant cell astrocytoma 10 | 2,287
Alzheimer's disease 9 | 658
Carcinoma, Hepatocellular 9 | 228
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Hypercholesterolemia, Familial 9 | 23
Liver carcinoma 9 | 240
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Pick disease 9 | 1,894
Poor school performance 9 | 645
active Crohn's disease 9 | 922
adrenocortical carcinoma 9 | 1,428
group 4 medulloblastoma 9 | 1,855
Cancer 8 | 2,499
Fatty liver disease 8 | 103
Hepatomegaly 8 | 285
Hyperlipidemia 8 | 43
Astrocytoma, Pilocytic 7 | 3,081
Cardiovascular system disease 7 | 246
Neurodegenerative disease 7 | 414
Schizophrenia 7 | 1,160
Splenomegaly 7 | 190
Atopic dermatitis 6 | 952
Cerebrovascular disease 6 | 238
Failure to gain weight 6 | 365
Familial hypercholesterolemia - homozygous 6 | 7
Hyperlipoproteinemia Type IIa 6 | 11
Hypertensive disease 6 | 292
Kidney disease 6 | 430
Liver disease 6 | 237
Low density lipoprotein increased 6 | 8
Muscle hypotonia 6 | 571
Pediatric failure to thrive 6 | 365
Serum cholesterol raised 6 | 22
Strabismus 6 | 270
active ulcerative colitis 6 | 764
astrocytoma 6 | 1,146
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010
Arcus Senilis 5 | 11
Cerebellar Ataxia 5 | 304
Dementia 5 | 175
Down syndrome 5 | 499
Dyslipidemias 5 | 27
Gaucher disease type 1 5 | 180
Hypertension 5 | 396
Hypertriglyceridemia result 5 | 37
Insulin Resistance 5 | 72
Myocardial Infarction 5 | 151
Short stature 5 | 531
Small head 5 | 374
Steatohepatitis 5 | 44
acute quadriplegic myopathy 5 | 1,158
adult high grade glioma 5 | 3,801
breast carcinoma 5 | 1,638
chronic rhinosinusitis 5 | 512
esophageal adenocarcinoma 5 | 737
lung adenocarcinoma 5 | 2,716
pituitary cancer 5 | 1,972
posterior fossa group B ependymoma 5 | 416
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819

Tissue

Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Male tissues 58 | 17,142
Female tissues 57 | 17,400
Blood and immune system 56 | 16,909
Liver and Pancreas 56 | 16,750
Skin and soft tissues 56 | 17,230
Urinary Tract 55 | 16,678
Nervous System 54 | 16,725
Cardiovascular System 52 | 15,192
Respiratory system 52 | 16,393

Target Family

Enzyme 28 | 4,145
Non-IDG 24 | 12,091
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 1 | 473

UniProt Keyword

Cholesterol metabolism 58 | 58
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Apolipoprotein F APOF Tbio Non-IDG -1.45156 33.3 232
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
Isopentenyl-diphosphate Delta-isomerase 1 IDI1 Tbio Enzyme -1.60998 38.3 124
Isopentenyl-diphosphate delta-isomerase 2 IDI2 Tbio Enzyme -1.25123 20.8 84
Erlin-2 ERLIN2 Tbio Non-IDG -1.30418 19.6 167
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Farnesyl pyrophosphate synthase FDPS Tclin Enzyme -2.94323 876.8 272
Membrane-bound transcription factor site-2 protease MBTPS2 Tbio Enzyme -1.94015 86.1 119
Membrane-bound transcription factor site-1 protease MBTPS1 Tchem Enzyme -1.49326 34.9 64