Development Level

Tbio 34 | 11,178
Tchem 18 | 1,885
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased circulating serum al... 2 | 82
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 37 | 8,297
Carcinoma 34 | 11,192
osteosarcoma 28 | 7,766
psoriasis 27 | 6,514
malignant mesothelioma 18 | 3,135
medulloblastoma, large-cell 18 | 6,086
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,911
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,204
lung cancer 17 | 4,607
Atherosclerosis 16 | 276
Autosomal recessive predisposition 16 | 1,407
Obesity 16 | 655
glioblastoma 16 | 5,635
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,902
Breast cancer 13 | 3,469
Lipid metabolism disorder 13 | 111
atypical teratoid / rhabdoid tumor 13 | 4,971
ductal carcinoma in situ 13 | 1,686
ependymoma 13 | 4,559
diabetes mellitus 12 | 1,683
invasive ductal carcinoma 12 | 2,867
lung carcinoma 12 | 2,755
oligodendroglioma 12 | 2,768
astrocytic glioma 11 | 2,530
pancreatic cancer 11 | 2,322
Kidney cancer 10 | 2,548
Seizures 10 | 584
interstitial cystitis 10 | 2,237
subependymal giant cell astrocytoma 10 | 2,230
Alzheimer's disease 9 | 640
Coronary artery disease 9 | 253
Epilepsy 9 | 775
Hypercholesterolemia 9 | 43
Intellectual disability 9 | 998
Pick disease 9 | 1,856
adrenocortical carcinoma 9 | 1,385
group 3 medulloblastoma 9 | 4,002
Cancer 8 | 2,388
Cognitive delay 8 | 596
Dull intelligence 8 | 634
Fatty liver disease 8 | 102
Global developmental delay 8 | 596
Hepatomegaly 8 | 280
Hypercholesterolemia, Familial 8 | 22
Hyperlipidemia 8 | 43
Low intelligence 8 | 634
Mental Retardation 8 | 634
Mental and motor retardation 8 | 596
Mental deficiency 8 | 634
Poor school performance 8 | 634
active Crohn's disease 8 | 882
group 4 medulloblastoma 8 | 1,806
Astrocytoma, Pilocytic 7 | 3,006
Carcinoma, Hepatocellular 7 | 217
Liver carcinoma 7 | 229
Neurodegenerative disease 7 | 402
Schizophrenia 7 | 1,136
Splenomegaly 7 | 186
Atopic dermatitis 6 | 915
Cardiovascular system disease 6 | 240
Failure to gain weight 6 | 359
Hypertensive disease 6 | 278
Kidney disease 6 | 411
Liver disease 6 | 227
Low density lipoprotein increased 6 | 8
Muscle hypotonia 6 | 562
Pediatric failure to thrive 6 | 359
Serum cholesterol raised 6 | 22
Strabismus 6 | 265
astrocytoma 6 | 1,113
primitive neuroectodermal tumor 6 | 2,957
tuberculosis 6 | 1,963
Cerebellar Ataxia 5 | 302
Cerebrovascular disease 5 | 223
Dementia 5 | 172
Down syndrome 5 | 480
Dyslipidemias 5 | 27
Familial hypercholesterolemia - homozygous 5 | 6
Hyperlipoproteinemia Type II 5 | 12
Hyperlipoproteinemia Type IIa 5 | 10
Hypertension 5 | 372
Hypertriglyceridemia result 5 | 35
Insulin Resistance 5 | 70
Myocardial Infarction 5 | 142
Steatohepatitis 5 | 44
active ulcerative colitis 5 | 736
acute quadriplegic myopathy 5 | 1,133
adult high grade glioma 5 | 3,701
breast carcinoma 5 | 1,589
chronic rhinosinusitis 5 | 505
esophageal adenocarcinoma 5 | 696
pituitary cancer 5 | 1,915
posterior fossa group B ependymoma 5 | 406
spina bifida 5 | 1,053
ulcerative colitis 5 | 1,765
Cholestasis 4 | 154
lung adenocarcinoma 4 | 2,627
nephrosclerosis 4 | 314
non-small cell lung cancer 4 | 2,799

Tissue

Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Male tissues 58 | 17,142
Female tissues 57 | 17,400
Blood and immune system 56 | 16,909
Liver and Pancreas 56 | 16,750
Skin and soft tissues 56 | 17,230
Urinary Tract 55 | 16,678
Nervous System 54 | 16,725
Cardiovascular System 52 | 15,192
Respiratory system 52 | 16,393

Target Family

Enzyme 28 | 4,145
Non-IDG 24 | 12,091
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 1 | 473

UniProt Keyword

Cholesterol metabolism 58 | 58
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein dispatched homolog 3 DISP3 Tbio Non-IDG -0.85544 7.52 127
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109
Phosphatidylcholine-sterol acyltransferase LCAT Tchem Enzyme -2.52851 336.6 270
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Apolipoprotein B-100 APOB Tchem Non-IDG -4.00022 10024.1 856
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tbio Enzyme -1.67608 43.7 137