Development Level

Tbio 33 | 10,625
Tchem 18 | 1,890
Tclin 6 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal forebrain development 1 | 18
abnormal hair growth 1 | 8
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 157
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
hydrometra 1 | 13
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
microphthalmia 1 | 15
preweaning lethality, incomple... 1 | 260
small adrenal glands 1 | 15
small epididymis 1 | 3
small seminal vesicle 1 | 6
small testis 1 | 37

Disease

ovarian cancer 37 | 8,484
osteosarcoma 30 | 7,933
psoriasis 29 | 6,685
medulloblastoma, large-cell 20 | 6,234
lung cancer 19 | 4,466
Atherosclerosis 18 | 275
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
glioblastoma 17 | 5,572
malignant mesothelioma 17 | 3,162
Obesity 15 | 616
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
Lipid metabolism disorder 14 | 102
diabetes mellitus 13 | 1,663
ductal carcinoma in situ 13 | 1,745
lung carcinoma 13 | 2,844
atypical teratoid / rhabdoid tumor 12 | 4,369
group 4 medulloblastoma 12 | 1,875
invasive ductal carcinoma 12 | 2,950
oligodendroglioma 12 | 2,849
Breast cancer 10 | 3,094
Coronary artery disease 10 | 240
interstitial cystitis 10 | 2,299
pancreatic cancer 10 | 2,300
subependymal giant cell astrocytoma 10 | 2,287
Alzheimer's disease 9 | 644
Liver carcinoma 9 | 217
Pick disease 9 | 1,893
active Crohn's disease 9 | 918
adrenocortical carcinoma 9 | 1,427
astrocytoma 9 | 1,493
ependymoma 9 | 2,514
Fatty liver disease 8 | 84
Hypercholesterolemia 8 | 27
Metabolic syndrome X 8 | 155
astrocytic glioma 8 | 2,241
Carcinoma 7 | 2,147
Cardiovascular system disease 7 | 194
Hyperlipidemia 7 | 25
Kidney disease 7 | 396
Neurodegenerative disease 7 | 383
pilocytic astrocytoma 7 | 3,086
posterior fossa group B ependymoma 7 | 1,530
Atopic dermatitis 6 | 944
Cancer 6 | 2,346
Hypercholesterolemia, Familial 6 | 16
Liver disease 6 | 219
pediatric high grade glioma 6 | 2,712
primitive neuroectodermal tumor 6 | 3,031
tuberculosis 6 | 1,557
ulcerative colitis 6 | 2,087
Cerebrovascular disease 5 | 231
Down syndrome 5 | 548
Gaucher disease type 1 5 | 171
active ulcerative colitis 5 | 477
acute quadriplegic myopathy 5 | 1,157
breast carcinoma 5 | 1,614
chronic rhinosinusitis 5 | 512
esophageal adenocarcinoma 5 | 737
group 3 medulloblastoma 5 | 2,254
lung adenocarcinoma 5 | 2,713
pituitary cancer 5 | 1,972
spina bifida 5 | 1,064
Adenocarcinoma 4 | 115
Amyloidosis 4 | 68
Antley-Bixler syndrome 4 | 15
Cardiovascular Diseases 4 | 50
Fatty Liver 4 | 48
Hydrolethalus syndrome 4 | 128
Hypertension 4 | 287
Insulin Resistance 4 | 48
Intellectual disability 4 | 573
Kidney Failure, Chronic 4 | 45
Peripheral Neuropathy 4 | 303
Smith-Lemli-Opitz syndrome 4 | 9
nephrosclerosis 4 | 329
non-small cell lung cancer 4 | 2,798
primary pancreatic ductal adenocarcinoma 4 | 1,271
Autistic Disorder 3 | 320
Cerebrovascular accident 3 | 44
Coronary heart disease 3 | 59
Dementia 3 | 129
Heart disease 3 | 279
Hypertensive disease 3 | 193
Multiple myeloma 3 | 1,327
Schizophrenia 3 | 501
Stomach Neoplasms 3 | 282
Type 2 diabetes mellitus 3 | 189
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 765
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
fibroadenoma 3 | 557
hereditary spastic paraplegia 3 | 313
juvenile dermatomyositis 3 | 1,189
nasopharyngeal carcinoma 3 | 1,056
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674

Tissue

Blood and immune system 57 | 17,995
Cardiovascular System 57 | 17,958
Digestive Tract 57 | 18,473
Endocrine System 57 | 18,512
Female tissues 57 | 18,647
Liver and Pancreas 57 | 18,136
Male tissues 57 | 17,969
Nervous System 57 | 18,561
Respiratory system 57 | 17,484
Skin and soft tissues 57 | 18,115
Urinary Tract 57 | 18,444

Target Family

Enzyme 28 | 4,146
Non-IDG 23 | 11,971
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 1 | 473

UniProt Keyword

Cholesterol metabolism 57 | 57
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Insulin-induced gene 1 protein INSIG1 Tbio Non-IDG -2.25313 177.3 136
NADH-cytochrome b5 reductase 3 CYB5R3 Tchem Enzyme -1.93440 89.2 241
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.04299 12.4 80
Erlin-2 ERLIN2 Tbio Non-IDG -1.24538 18.7 148
Apolipoprotein B receptor APOBR Tbio Non-IDG -0.96571 11.5 113
Apolipoprotein F APOF Tbio Non-IDG -1.48899 35.4 199
Proprotein convertase subtilisin/kexin type 9 PCSK9 Tclin Enzyme -3.06315 1328.4 406
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.66342 512.8 226