Development Level

Tbio 41 | 11,445
Tchem 10 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal gait 3 | 69
decreased fasted circulating g... 3 | 65
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal skin morphology 2 | 50
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hypoactivity 2 | 132
increased lean body mass 2 | 172
tremors 2 | 39
abnormal adrenal gland morphol... 1 | 1
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal motor capabilities-co... 1 | 5
abnormal outer ear morphology 1 | 3
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal thymus morphology 1 | 7
aorta dilation 1 | 3
cyanosis 1 | 7
decreased bone mineral density 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
prolonged QT interval 1 | 38
short tibia 1 | 97
shortened QT interval 1 | 4
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

Charcot-Marie-Tooth disease 51 | 62
Neuropathy 51 | 261
Neurodegenerative disease 50 | 414
Carcinoma 38 | 11,493
ovarian cancer 33 | 8,520
Distal sensory impairment 32 | 52
Distal limb muscle weakness due to peripheral neuropathy 26 | 62
Distal muscle weakness 26 | 62
Congenital pes cavus 25 | 88
Absent reflex 24 | 92
Absent tendon reflex 24 | 92
Autosomal recessive predisposition 24 | 1,442
Reflex, Deep Tendon, Absent 24 | 92
osteosarcoma 24 | 7,950
Decreased tendon reflex 23 | 122
Distal amyotrophy 21 | 51
lung cancer 21 | 4,740
psoriasis 19 | 6,694
glioblastoma 17 | 5,792
malignant mesothelioma 17 | 3,232
Decreased motor NCV 16 | 22
Onion bulb formation 16 | 19
Foot dorsiflexor weakness 15 | 27
Foot-drop 15 | 27
Gait, Drop Foot 15 | 24
medulloblastoma, large-cell 15 | 6,241
Slow progression 13 | 89
atypical teratoid / rhabdoid tumor 13 | 5,112
Decreased number of large and small myelinated fibers 12 | 20
Hammer Toe 12 | 23
Muscle hypotonia 12 | 571
ependymoma 12 | 4,679
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
non-small cell lung cancer 12 | 2,890
Breast cancer 11 | 3,578
Kidney cancer 11 | 2,613
Motor delay 11 | 147
No development of motor milestones 11 | 147
colon cancer 11 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Astrocytoma, Pilocytic 10 | 3,081
Gait abnormality 10 | 135
Multiple myeloma 10 | 1,332
Peripheral Neuropathy 10 | 134
breast carcinoma 10 | 1,638
group 3 medulloblastoma 10 | 4,104
invasive ductal carcinoma 10 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Acquired scoliosis 9 | 281
Curvature of spine 9 | 282
Highly variable severity 9 | 157
Pick disease 9 | 1,894
Variable expressivity 9 | 157
adult high grade glioma 9 | 3,801
astrocytoma 9 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
subependymal giant cell astrocytoma 9 | 2,287
Congenital deafness 8 | 185
Deafness 8 | 198
Hearing Loss, Partial 8 | 185
Polyneuropathy 8 | 64
Segmental demyelination/remyelination 8 | 8
cystic fibrosis 8 | 1,696
dermatomyositis 8 | 966
diabetes mellitus 8 | 1,728
hearing impairment 8 | 199
pancreatic cancer 8 | 2,398
Amyotrophic lateral sclerosis 7 | 451
Difficulty walking 7 | 28
Intellectual disability 7 | 1,016
Neurogenic Muscular Atrophy 7 | 139
Neurogenic muscle atrophy, especially in the lower limbs 7 | 139
Progressive disorder 7 | 142
Respiratory Insufficiency 7 | 132
Skeletal muscle atrophy 7 | 139
juvenile dermatomyositis 7 | 1,187
muscle degeneration 7 | 139
primary pancreatic ductal adenocarcinoma 7 | 1,109
ulcerative colitis 7 | 1,819
Alzheimer's disease 6 | 658
Cancer 6 | 2,499
Claw hand 6 | 26
Cognitive delay 6 | 608
EMG: neuropathic changes 6 | 15
Epilepsy 6 | 792
Global developmental delay 6 | 608
Infantile onset 6 | 238
Kyphoscoliosis deformity of spine 6 | 60
Mental and motor retardation 6 | 608
Muscle Cramp 6 | 55
Muscle weakness of limb 6 | 21
Respiratory function loss 6 | 121
Sensorineural Hearing Loss (disorder) 6 | 284
Small head 6 | 374
astrocytic glioma 6 | 2,597
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
tuberculosis 6 | 2,010

Tissue

Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Blood and immune system 51 | 16,909
Nervous System 51 | 16,725
Cardiovascular System 50 | 15,192

Target Family

Non-IDG 29 | 12,091
Enzyme 16 | 4,145
Kinase 3 | 634
Transcription Factor 2 | 1,400
Ion Channel 1 | 344
Transporter 1 | 473

UniProt Keyword

Charcot-Marie-Tooth disease 52 | 52
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Peripheral myelin protein 22 PMP22 Tbio Non-IDG -2.50612 344.4 262
Transient receptor potential cation channel subfamily V member 4 TRPV4 Tchem Ion Channel -2.86016 747.3 258
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 57.1 86
Myelin protein P0 MPZ Tbio Non-IDG -2.55919 360.1 301
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
MORC family CW-type zinc finger protein 2 MORC2 Tbio Non-IDG -1.12323 14.2 98