Development Level

Tbio 159 | 11,651
Tdark 25 | 6,593
Tchem 14 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavioral response t... 4 | 66
embryonic lethality prior to t... 4 | 278
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
embryonic lethality prior to o... 3 | 239
increased lean body mass 3 | 172
abnormal maxilla morphology 2 | 17
abnormal sleep behavior 2 | 70
decreased anxiety-related resp... 2 | 12
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased grip strength 2 | 41
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased body length 1 | 32
increased body weight 1 | 25
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
short tibia 1 | 97
shortened QT interval 1 | 4
shortened RR interval 1 | 17
shortened ST segment 1 | 10
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

ovarian cancer 122 | 8,520
Carcinoma 94 | 11,493
osteosarcoma 79 | 7,950
lung cancer 72 | 4,740
medulloblastoma, large-cell 68 | 6,241
glioblastoma 62 | 5,792
psoriasis 62 | 6,694
atypical teratoid / rhabdoid tumor 56 | 5,112
group 3 medulloblastoma 44 | 4,104
Breast cancer 41 | 3,578
ependymoma 40 | 4,679
Multiple myeloma 39 | 1,332
adult high grade glioma 37 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
non-small cell lung cancer 36 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
invasive ductal carcinoma 31 | 2,951
lung adenocarcinoma 31 | 2,716
astrocytic glioma 29 | 2,597
malignant mesothelioma 29 | 3,232
subependymal giant cell astrocytoma 28 | 2,287
Cancer 27 | 2,499
oligodendroglioma 27 | 2,850
acute quadriplegic myopathy 26 | 1,158
pancreatic cancer 26 | 2,398
Waldenstrons macroglobulinemia 25 | 765
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
Astrocytoma, Pilocytic 24 | 3,081
primitive neuroectodermal tumor 24 | 3,035
colon cancer 22 | 1,478
diabetes mellitus 21 | 1,728
tuberculosis 21 | 2,010
juvenile dermatomyositis 18 | 1,187
Neurodegenerative disease 17 | 414
astrocytoma 17 | 1,146
dermatomyositis 17 | 966
interstitial cystitis 17 | 2,312
lung carcinoma 17 | 2,843
Autosomal recessive predisposition 16 | 1,442
Pick disease 16 | 1,894
cystic fibrosis 16 | 1,696
ulcerative colitis 16 | 1,819
acute myeloid leukemia 15 | 783
pituitary cancer 15 | 1,972
active Crohn's disease 14 | 922
group 4 medulloblastoma 14 | 1,855
non primary Sjogren syndrome sicca 14 | 891
Rheumatoid arthritis 13 | 1,191
ductal carcinoma in situ 13 | 1,745
HIV Infections 12 | 102
breast carcinoma 12 | 1,638
esophageal adenocarcinoma 12 | 737
hepatocellular carcinoma 12 | 547
Kidney cancer 11 | 2,613
adrenocortical carcinoma 11 | 1,428
Atopic dermatitis 10 | 952
Hypertrophic Cardiomyopathy 10 | 117
Parkinson's disease 10 | 392
Prostatic Neoplasms 10 | 495
pediatric high grade glioma 10 | 1,064
Duchenne muscular dystrophy 9 | 601
Intellectual disability 9 | 1,016
hereditary spastic paraplegia 9 | 318
pancreatic carcinoma 9 | 562
primary pancreatic ductal adenocarcinoma 9 | 1,109
spina bifida 9 | 1,074
Dystonia 8 | 164
chronic rhinosinusitis 8 | 512
gastric cancer 8 | 459
medulloblastoma 8 | 720
Acquired scoliosis 7 | 281
Breast Neoplasms 7 | 445
Curvature of spine 7 | 282
Down syndrome 7 | 499
Dull intelligence 7 | 645
Leigh disease 7 | 100
Low intelligence 7 | 645
Mammary Neoplasms 7 | 425
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Muscle hypotonia 7 | 571
Nystagmus 7 | 317
Poor school performance 7 | 645
Seizures 7 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
nasopharyngeal carcinoma 7 | 1,058
Amyotrophic lateral sclerosis 6 | 451
Bipolar Disorder 6 | 666
Cognitive delay 6 | 608
Epilepsy 6 | 792
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Multiple Sclerosis 6 | 540
Neuropathy 6 | 261
Short stature 6 | 531
Slow progression 6 | 89
Stomach Neoplasms 6 | 300
primary Sjogren syndrome 6 | 735
tuberculosis and treatment for 6 months 6 | 409

Tissue

Endocrine System 190 | 18,159
Digestive Tract 189 | 17,369
Female tissues 188 | 17,400
Blood and immune system 187 | 16,909
Liver and Pancreas 187 | 16,750
Male tissues 187 | 17,142
Urinary Tract 187 | 16,678
Nervous System 186 | 16,725
Respiratory system 186 | 16,393
Skin and soft tissues 186 | 17,230
Cardiovascular System 185 | 15,192

Target Family

Non-IDG 164 | 12,091
Enzyme 33 | 4,145
Transcription Factor 2 | 1,400
Transporter 1 | 473

UniProt Keyword

Chaperone 200 | 200
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
DnaJ homolog subfamily C member 22 DNAJC22 Tbio Non-IDG -1.84897 65.6 70
Proteasome assembly chaperone 1 PSMG1 Tbio Non-IDG -0.90381 8.14 122
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
DNL-type zinc finger protein DNLZ Tdark Non-IDG -0.90037 8.91 3
Activator of 90 kDa heat shock protein ATPase homolog 1 AHSA1 Tbio Enzyme -1.65208 50.3 564
DnaJ homolog subfamily C member 5B DNAJC5B Tdark Non-IDG -0.62006 4.33 67
BAG family molecular chaperone regulator 5 BAG5 Tbio Non-IDG -1.25287 18.4 376
DnaJ homolog subfamily C member 28 DNAJC28 Tbio Non-IDG -1.07807 10.5 94
Heat shock protein beta-8 HSPB8 Tbio Non-IDG -2.37457 247.4 439