Development Level

Tbio 110 | 11,651
Tdark 16 | 6,593
Tchem 13 | 1,388

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 5 | 499
cataract 4 | 92
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
abnormal tail morphology 3 | 25
embryonic lethality prior to o... 3 | 239
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased fasted circulating g... 3 | 76
abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased heart left ventricle... 2 | 28
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged lymph nodes 2 | 37
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal retinal outer nuclear... 1 | 3
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
edema 1 | 59
female infertility 1 | 60
fusion of vertebral arches 1 | 7
hemorrhage 1 | 23
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
irregularly shaped pupil 1 | 7
microphthalmia 1 | 26
mydriasis 1 | 6
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small testis 1 | 58
syndactyly 1 | 23
thrombocytopenia 1 | 56
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 87 | 11,493
ovarian cancer 86 | 8,520
medulloblastoma, large-cell 80 | 6,241
group 3 medulloblastoma 75 | 4,104
glioblastoma 67 | 5,792
osteosarcoma 67 | 7,950
psoriasis 67 | 6,694
atypical teratoid / rhabdoid tumor 64 | 5,112
lung cancer 63 | 4,740
primitive neuroectodermal tumor 60 | 3,035
Breast cancer 59 | 3,578
non-small cell lung cancer 50 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
ependymoma 47 | 4,679
adrenocortical carcinoma 45 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,989
malignant mesothelioma 44 | 3,232
lung adenocarcinoma 41 | 2,716
adult high grade glioma 39 | 3,801
invasive ductal carcinoma 39 | 2,951
Cancer 31 | 2,499
oligodendroglioma 29 | 2,850
Kidney cancer 28 | 2,613
ductal carcinoma in situ 27 | 1,745
Endometriosis 24 | 540
astrocytic glioma 23 | 2,597
colon cancer 23 | 1,478
breast carcinoma 22 | 1,638
nasopharyngeal carcinoma 22 | 1,058
Atopic dermatitis 21 | 952
pancreatic cancer 20 | 2,398
Intellectual disability 19 | 1,016
Waldenstrons macroglobulinemia 18 | 765
pediatric high grade glioma 18 | 1,064
Multiple myeloma 17 | 1,332
Pick disease 17 | 1,894
subependymal giant cell astrocytoma 17 | 2,287
Astrocytoma, Pilocytic 16 | 3,081
dermatomyositis 15 | 966
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
ulcerative colitis 13 | 1,819
non primary Sjogren syndrome sicca 12 | 891
group 4 medulloblastoma 11 | 1,855
interstitial cystitis 11 | 2,312
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Rheumatoid arthritis 10 | 1,191
Short stature 10 | 531
Small head 10 | 374
lung carcinoma 10 | 2,843
Autosomal recessive predisposition 9 | 1,442
Dull intelligence 9 | 645
Hypoplastic mandible condyle 9 | 275
Low intelligence 9 | 645
Mandibular hypoplasia 9 | 275
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Micrognathism 9 | 275
Poor school performance 9 | 645
acute quadriplegic myopathy 9 | 1,158
primary Sjogren syndrome 9 | 735
astrocytoma 8 | 1,146
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
acute myeloid leukemia 7 | 783
juvenile dermatomyositis 7 | 1,187
progressive supranuclear palsy 7 | 676
Alzheimer's disease 6 | 658
Anteverted nostril 6 | 191
Cryptorchidism 6 | 296
Epilepsy 6 | 792
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Schizophrenia 6 | 1,160
gastric carcinoma 6 | 807
tuberculosis and treatment for 6 months 6 | 409
Amyotrophic lateral sclerosis 5 | 451
Congenital hypoplasia of penis 5 | 176
Cornelia de Lange syndrome 5 | 21
Delayed bone age 5 | 136
Down syndrome 5 | 499
Glaucoma 5 | 239
Hypoplastic feet 5 | 66
Infertility 5 | 188
Liver cancer 5 | 604
Male infertility 5 | 206
Melanoma 5 | 711
Microcephaly 5 | 166
Roberts syndrome 5 | 15
Small hand 5 | 36
Thin lips 5 | 49
active Crohn's disease 5 | 922
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
Attention deficit hyperactivity disorder 4 | 278
Bipolar Disorder 4 | 666
diabetes mellitus 4 | 1,728

Tissue

Endocrine System 139 | 18,159
Female tissues 137 | 17,400
Skin and soft tissues 137 | 17,230
Blood and immune system 136 | 16,909
Digestive Tract 136 | 17,369
Male tissues 136 | 17,142
Liver and Pancreas 134 | 16,750
Respiratory system 134 | 16,393
Urinary Tract 134 | 16,678
Nervous System 133 | 16,725
Cardiovascular System 127 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 10 | 4,145
Kinase 8 | 634
Epigenetic 7 | 242
Transcription Factor 4 | 1,400

UniProt Keyword

Centromere 139 | 139
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124
Dynactin subunit 5 DCTN5 Tdark Non-IDG -0.32495 0.71 53
F-box only protein 28 FBXO28 Tbio Non-IDG -0.76212 5.60 144
Centromere/kinetochore protein zw10 homolog ZW10 Tbio Non-IDG -1.64269 41.5 124
Heat shock factor protein 1 HSF1 Tbio Transcription Factor -2.27852 217.0 1246
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.73322 567.0 386
Spindle and kinetochore-associated protein 3 SKA3 Tbio Non-IDG -1.05597 12.3 132
Polyamine-modulated factor 1 PMF1 Tbio Non-IDG -0.62754 4.93 133